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Treating acute low back pain with acupuncture:A randomized controlled study protocol to compare the effectiveness between distal and local acupoints

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Journal of Traditional Chinese Medical Sciences 2024年第3期11卷 351-356页

作者： Singleung Chan Shukyan Lam Sinyin Ho Wanyi Au Poyi Lin Waiming Chan Taking yu Shungchi tam Bacon F.L.Ng Linda L.D.Zhong Pok Oi Hospital Hong Kong Baptist University Chinese Medicine Clinic Cum Training and Research CentreHong Kong 999077China Chinese Medicine Department Hong Kong Hospital AuthorityHong Kong 999077China School of Chinese Medicine Hong Kong Baptist UniversityHong Kong 999077China School of Biological Sciences Nanyang Technological University637551Singapore

Objective To compare the efficacy of using“distal acupoints only”vs.“local acupoints mainly combined with distal acupoints”in cases of acute low back pain(ALBP).Methods A total of 102 eligible patients aged 18–65 years with ALBP lasting less than 6 weeks will be randomized in a 1:1 ratio to the distal acupoints only group(DPOG)and the local acupoints mainly combined with the distal acupoints group(LPMG).During a 4-week treatment period,patients in the DPOG will receive acupuncture at distal acupoints only(Houxi[SI 3]and yaotongxue[EX-UE 7])twice a week,while those in the LPMG group will receive acupuncture at local acupoints(mainly Shenshu[BL 23]and Dachangshu[BL 25])combined with distal points(Weizhong[BL 40]).The patients in both groups will be evaluated at every session of treatment,and the follow-up will be performed for 3 *** primary outcome measure will be the change in ALBP intensity,assessed using visual analogue scale scores before and after *** secondary outcome measure will be the evaluation of functional disability using the Oswestry Disability *** This study compares the DPOG and LPMG to explore the feasibility of the DPOG in the treatment of ALBP.

关键词： Acupuncture Acute low back pain Motion style acupuncture Activating qi acupuncture Distal acupoints Local acupoints

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Artificial intelligence-driven radiomics study in cancer:the role of feature engineering and modeling

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Military Medical Research 2024年第1期11卷 115-147页

作者： yuan-Peng Zhang Xin-yun Zhang yu-Ting Cheng Bing Li Xin-Zhi Teng Jiang Zhang Saikit Lam Ta Zhou Zong-Rui Ma Jia-Bao Sheng Victor CWtam Shara WyLee Hong Ge Jing Cai Department of Medical Informatics Nantong UniversityNantong 226001JiangsuChina Department of Health Technology and Informatics the Hong Kong Polytechnic UniversityHong Kong 999077China The Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518000GuangdongChina Department of Radiation Oncology the Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer HospitalZhengzhou 450008China

Modern medicine is reliant on various medical imaging technologies for non-invasively observing patients’***,the interpretation of medical images can be highly subjective and dependent on the expertise of ***,some potentially useful quantitative information in medical images,especially that which is not visible to the naked eye,is often ignored during clinical *** contrast,radiomics performs high-throughput feature extraction from medical images,which enables quantitative analysis of medical images and prediction of various clinical *** have reported that radiomics exhibits promising performance in diagnosis and predicting treatment responses and prognosis,demonstrating its potential to be a non-invasive auxiliary tool for personalized ***,radiomics remains in a developmental phase as numerous technical challenges have yet to be solved,especially in feature engineering and statistical *** this review,we introduce the current utility of radiomics by summarizing research on its application in the diagnosis,prognosis,and prediction of treatment responses in patients with *** focus on machine learning approaches,for feature extraction and selection during feature engineering and for imbalanced datasets and multi-modality fusion during statistical ***,we introduce the stability,reproducibility,and interpretability of features,and the generalizability and interpretability of ***,we offer possible solutions to current challenges in radiomics research.

关键词： Artificial intelligence Radiomics Feature extraction Feature selection Modeling Interpretability Multimodalities Head and neck cancer

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蜂花粉中多酚类化合物的研究进展

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中国蜂业 2024年第4期75卷 36-42页

作者：蔡雯雯(编译) 董捷乔(编译) 江涛(编译) Qiao J Zhang y Haubruge E 哈尔滨商业大学食品工程学院哈尔滨150076 资源昆虫高效养殖与利用全国重点实验室中国农业科学院蜜蜂研究所北京100093 不详

蜂花粉是由蜜蜂采集加工而成的花粉团状物,其富含大量的生物活性物质,包括多糖、蛋白质、脂质、多酚等,具有较高的药用功效和食用价值。多项研究表明多酚类化合物具有特定的抗氧化、抗菌、抗糖尿病、抗高血脂以及抗炎等作用。蜂花粉的... 详细信息

蜂花粉是由蜜蜂采集加工而成的花粉团状物,其富含大量的生物活性物质,包括多糖、蛋白质、脂质、多酚等,具有较高的药用功效和食用价值。多项研究表明多酚类化合物具有特定的抗氧化、抗菌、抗糖尿病、抗高血脂以及抗炎等作用。蜂花粉的多酚类化合物,特别是酚胺和黄酮苷已成为近期研究重点,也是蜂花粉发挥重要活性功能的主要成分。本文综述了近年来世界各地不同种类的蜂花粉中多酚类化合物的成分及含量,为蜂花粉后续研究提供参考。

关键词：蜂花粉多酚含量

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Fertiles tierras para el intercambio

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今日中国（西文版） 2024年第1期 18-20页

作者： LUO ZHlZHl y GAO LEl

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Hybrid-Vlasov simulation of soft X-ray emissions at the Earth’s dayside magnetospheric boundaries

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Earth and Planetary Physics 2024年第1期8卷 70-88页

作者： M.Grandin H.K.Connor S.Hoilijoki M.Battarbee y.Pfau-Kempf U.Ganse K.Papadakis M.Palmroth Department of Physics University of HelsinkiHelsinkiFinland NASA Goddard Space Flight Center GreenbeltMD20771USA Space and Earth Observation Centre Finnish Meteorological InstituteHelsinkiFinland

Solar wind charge exchange produces emissions in the soft X-ray energy range which can enable the study of near-Earth space regions such as the magnetopause,the magnetosheath and the polar cusps by remote sensing *** Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)and Lunar Environment heliospheric X-ray Imager(LEXI)missions aim to obtain soft Xray images of near-Earth space thanks to their Soft X-ray Imager(SXI)*** earlier modeling works have already simulated soft X-ray images as might be obtained by SMILE SXI during its mission,the numerical models used so far are all based on the magnetohydrodynamics description of the space *** investigate the possible signatures of ion-kinetic-scale processes in soft Xray images,we use for the first time a global hybrid-Vlasov simulation of the geospace from the Vlasiator *** simulation is driven by fast and tenuous solar wind conditions and purely southward interplanetary magnetic *** first produce global X-ray images of the dayside near-Earth space by placing a virtual imaging satellite at two different locations,providing meridional and equatorial *** then analyze regional features present in the images and show that they correspond to signatures in soft X-ray emissions of mirrormode wave structures in the magnetosheath and flux transfer events(FTEs)at the *** results suggest that,although the time scales associated with the motion of those transient phenomena will likely be significantly smaller than the integration time of the SMILE and LEXI imagers,mirror-mode structures and FTEs can cumulatively produce detectable signatures in the soft X-ray *** instance,a local increase by 30%in the proton density at the dayside magnetopause resulting from the transit of multiple FTEs leads to a 12%enhancement in the line-of-sight-and time-integrated soft X-ray emissivity originating from this ***,a proton density increase by 14%in the magnetosheath

关键词： magnetosphere magnetosheath numerical simulation SMILE LEXI soft X-ray emissions hybrid-Vlasov model polar cusp flux transfer events mirror-mode waves

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Chronic hepatitis B virus infection in Eastern Ethiopia:Clinical characteristics and determinants of cirrhosis

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World Journal of Hepatology 2024年第7期16卷 995-1008页

作者： Nejib y Ismael Semir A Usmael Nega B Belay Hailemichael Desalegn Mekonen Asgeir Johannessen Stian MS Orlien Haramaya University College of Health and Medical SciencesHarar 252Ethiopia Aklilu Lemma Institute of Pathobiology Addis Ababa UniversityAddis Ababa 1000Ethiopia Regional Centre for Imported and Tropical Diseases Oslo University HospitalOslo 0450UllevålNorway Internal Medicine Gastroenterology and Hepatology UnitSaint Paul’s Hospital Millennium Medical CollegeAddis Ababa 1000Ethiopia Department of Infectious Disease Vestfold Hospital TrustTønsberg 3103Norway Institute of Clinical Medicine Oslo UniversityOslo 0318Norway Department of PediatricsOslo UniversityOslo 0450UllevålNorway

BACKGROUND Chronic hepatitis B(CHB)virus infection is a major cause of liver-associated morbidity and mortality,particularly in low-income countries.A better understanding of the epidemiological,clinical,and virological characteristics of CHB will guide appropriate treatment strategies and improve the control and management of CHB in *** To investigate the characteristics of CHB in Eastern Ethiopia and assess the efficacy and safety of antiviral *** This cohort study included 193 adults who were human immunodeficiency virus-negative with CHB between June 2016 and December *** assessments included chemistry,serologic,and viral markers.χ^(2) tests,Mann-Whitney U tests,and logistic regression analyses were used to identify the determinants of *** disoproxil fumarate(TDF)was initiated using treatment criteria from the Ethiopian CHB pilot *** A total of 132 patients(68.4%)were men,with a median age of 30 years[interquartile range(IQR):24-38].At enrollment,60(31.1%)patients had cirrhosis,of whom 35(58.3%)had decompensated *** use,hepatitis B envelope antigen positivity,and a high viral load were independently associated with ***,66 patients(33.4%)fulfilled the treatment criteria and 59(30.6%)started *** 29 patients who completed 24 months of treatment,the median aspartate aminotransferase to platelet ratio index declined from 1.54(IQR:0.66-2.91)to 1.10(IQR:0.75-2.53)(P=0.002),and viral suppression was achieved in 80.9%and 100%of patients after 12 months and 24 months of treatment,*** the treated patients,12(20.3%)died within the first 6 months of treatment,of whom 8 had decompensated *** This study highlights the high prevalence of cirrhosis,initial mortality,and the efficacy of TDF *** up measures to prevent and control CHB infections in Ethiopia is crucial.

关键词： Chronic hepatitis B Cirrhosis Cohort study Resource-limited settings Sub-Saharan Africa

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Ground-state mass of ^(22)Al and test of state-of-the-art ab initio calculations

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Chinese Physics C 2024年第3期48卷 72-78页

作者：孙铭泽于越王新鹏王猛李健国张玉虎 K.Blaum 陈祖毅陈瑞九邓涵宇付超义葛文文黄文嘉焦红扬李红蕙李宏福罗胤芳廖挺 yuALitvinov 司敏帅鹏史金阳王茜邢元明徐星徐瑚珊许甫荣袁琪 T.yamaguchi 颜鑫亮杨建成原有进周小红周旭张敏曾奇 CAS Key Laboratory of High Precision Nuclear Spectroscopy Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Max-Planck-Institut für Kernphysik Saupfercheckweg 169117 HeidelbergGermany GSI Helmholtzzentrum für Schwerionenforschung Planckstraße 164291 DarmstadtGermany Advanced Energy Science and Technology Guangdong Laboratory Huizhou516007China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Department of Physics Saitama UniversitySaitama 338-8570Japan School of Nuclear Science and Engineering East China University of TechnologyNanchang 330013China

The ground-state mass excess of the T_(z)=−2 drip-line nucleus ^(22)Al is measured for the first time as 18103(10)keV using the newly-developed Bρ-defined isochronous mass spectrometry method at the cooler storage ring in *** new mass excess value allowed us to determine the excitation energies of the two low-lying 1+states in ^(22)Al with significantly reduced uncertainties of 51 *** compared to the analogue states in its mirror nucleus ^(22)F,the mirror energy differences of the two 1^(+)states in the ^(22)Al-^(22)F mirror pair are determined to be−625(51)keV and−330(51)*** excitation energies and mirror energy differences are used to test the state-of-the-art ab initio valence-space in-medium similarity renormalization group calculations with four sets of interactions derived from the chiral effective field *** mechanism leading to the large mirror energy differences is investigated and attributed to the occupation of theπs_(1/2) orbital.

关键词： nuclear mass Bρ-defined IMS mirror energy difference ab initio VS-IMSRG calculations chiral interactions

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基于极限分析上限法的地震作用下分层地基盾构隧道开挖面稳定性研究

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岩土力学 2024年第4期45卷 1201-1213页

作者：张治国罗杰朱正国 PAN y T 孙苗苗上海理工大学环境与建筑学院上海200093 石家庄铁道大学省部共建交通工程结构力学行为与系统安全国家重点实验室河北石家庄050043 新加坡国立大学土木与环境工程系新加坡119077 浙大城市学院土木工程系浙江杭州310015 浙大城市学院城市基础设施智能化浙江省工程研究中心浙江杭州310015

目前针对盾构隧道开挖面稳定性的研究还较少考虑土体分层特性和地震作用的耦合影响,因此构建了一种在分层土体中考虑地震作用的开挖面三维对数螺旋破坏模型进行研究。首先,将地震引起的动态响应通过拟静力法简化为水平和竖直两个方向上... 详细信息

目前针对盾构隧道开挖面稳定性的研究还较少考虑土体分层特性和地震作用的耦合影响,因此构建了一种在分层土体中考虑地震作用的开挖面三维对数螺旋破坏模型进行研究。首先,将地震引起的动态响应通过拟静力法简化为水平和竖直两个方向上的惯性力作用;其次,在均质土体中的三维对数螺旋破坏机制的基础上,将其改进为适用于分层土体的三维对数螺旋破坏机制;再次,根据上限定理,在虚功率方程中引入地震惯性力所做功率,得到考虑土体分层特性和地震作用条件下的盾构隧道开挖面支护力的上限解;最后,将上限理论解与三维数值模拟结果和既有模型试验结果进行对比,得到了较好的一致性。此外,针对水平地震加速度系数和地层厚度对关键物理特征进行了影响因素分析。结果表明,当比例系数ζ>0时,极限支护力随水平地震加速度系数的增大显著增大;当ζ<0时,极限支护力随水平地震加速度系数增大而增大的趋势减弱。当水平地震加速度系数kh=0时,即在无地震作用情况下,归一化极限支护力不随ζ的变化而变化;在上硬下软土层中,下部土层厚度比的增大会引起极限支护力的增大,在上软下硬土层中,下部土层厚度比的增大会引起极限支护力的减小。

关键词：盾构隧道开挖面稳定性地震作用分层土体上限定理

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A novel recombinant,VPAC2-selective agonist enhancing insulin release and glucose disposal

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Acta Pharmacologica Sinica 2007年第4期28卷 526-533页

作者： Ngai-lik tam Bio-engineering Institute of Ji-nan University

Aim:To obtain the recombinant,VPAC2-selective ( VPAC2:type 3 receptor ofpituitary adenylate cyclase activating polypeptide which shared by vasoactiveintestinal peptide) agonist with effects on glucose disposal by intein-mediated,single column ***:A gene encoding 32-amino acid peptidenamed rMBAy was designed and synthesized and cloned into Escherichia coliexpression vector,pKyB (NEB,USA).The recombinant vector was transferredinto E coli ER2566 strain and the target protein was overexpressed as a fusion tothe N-terminus of a self-cleavable affinity *** the fusion protein was puri-fled by chitin-affinity chromatography,the self-cleavage activity of the intein wasinduced by β-mercaptoethanol and the target peptide,rMBAy,was released fromthe chitin-bound intein ***:Approximately 53 mg rMBAy with the purityover 95% was obtained by single column purification from 1 L induced culturefermented in 5 L *** results of the competitive binding assay andcAMP accumulation assay indicated that the recombinant rMBAy had specialbinding selectivity and potency for *** recombinant peptide,rMBAy,enhanced insulin release and decreased the plasma glucose level after intraperito-neal injection (50 ng/kg) with a high concentration of glucose (1.8 mmol/kg) in theNIH ***:An efficient production procedure of a recombinant VPAC2-selective agonist with corresponding effects on glucose disposal was established.

关键词： intein recombinant VPAC2 agonist insulin

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城市蓝绿空间降温绩效评估及提升策略——以北京市为例

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地理科学 2024年第8期44卷 1376-1386页

作者：李建春 Chen y Wendy 袁文华山东师范大学商学院山东济南250358 香港大学地理系中国香港999077

绿地和水体对缓解热岛效应和改善生态环境效果显著,但因城市空间稀缺导致建设机会成本高,提升蓝绿空间绩效研究亟需深化。本文构建基于成本−收益分析的降温绩效评估模型,定量测量不同规模和类型的蓝绿空间斑块降温效果,以北京市为研究区... 详细信息

绿地和水体对缓解热岛效应和改善生态环境效果显著,但因城市空间稀缺导致建设机会成本高,提升蓝绿空间绩效研究亟需深化。本文构建基于成本−收益分析的降温绩效评估模型,定量测量不同规模和类型的蓝绿空间斑块降温效果,以北京市为研究区,利用2010—2020年3期土地利用与地表温度数据,评估大于1 hm^(2)蓝绿空间辐射范围的降温绩效。主要研究结论如下:①研究期内北京市蓝绿空间面积不断增加,呈现由小型面积(Ac)(1≤Ac<2 hm^(2))为主向中型(2≤Ac<10 hm^(2))和大型(Ac≥10 hm^(2))转变;水域持续增加,而林地、草地和混合类型减少;三环以内老城区面积基本持平,而四环减少、五环增多。②根据缓冲区降温模型,北京市蓝绿空间的降温区范围不断增加,从类型结构上看,大中型蓝绿空间形成的降温区增加,而小型蓝绿空间的降温区减少;林地面积虽然减少,但其降温区面积却在增加,而水体降温区面积增长不及自身面积增长。③不同类型蓝绿空间绩效水平呈现先上升后降低的特征,小型和中型混合类型、大型水体的降温绩效比其他同等规模的绩效更好。因此,优化蓝绿规模和类型结构、调整空间形态布局、改善生态空间质量对充分发挥蓝绿空间降温效应起到重要作用,为城市生态环境改善与可持续发展提供新思路。

关键词：蓝绿空间成本−收益分析降温绩效生态福祉

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