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Landfill Siting Evaluation Using GIS and Multi-Criteria Decision-Making Method: A Case Study: Dammam Municipal Solid Waste Landfill

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Journal of Geographic Information System 2021年第4期13卷 508-522页

作者： nora Al Khaldi Firdos Almadani Sara Ouerghi Department of Geography and GIS Faculty of Arts & Humanities King Abdulaziz University Jeddah Saudi Arabia

Waste landfills are a prominent global issue that does not concern a country without the other because of its long-term effects especially in the environmental aspect. As these pose an environmental threat to water, air and soil;and directly affect human life and health. Accordingly, this research uses the integration of Geographic Information Systems (GIS) and Multi-Criteria Decision-Making (MCDM) approaches to assess the location of the municipal solid waste dump in Dammam, which was established in (2000AD) twenty years ago, due to the lack of recent studies assessing the current status of the landfill and whether it is in a suitable location and keeps pace with the population and urbanization increase in the region. For this purpose, the researchers are using the tools and techniques of GIS to evaluate eight criteria on the study area. The required standards were directed to the landfill site and transformed into maps that represent the most important economic, social, environmental, geological, geomorphological and Public Acceptance standards. These standards have been processed using the tools of spatial and statistical analyses. Analytic Hierarchy Process (AHP) is implemented in geographical information system for building the suitable cartographic model, and thus allowed to determine the suitable degree of Dammam municipal solid waste landfill site in light of the study criteria. The study concluded that the current landfill site achieves a good degree of suitability, as it achieved 63% measured against the quality standards set by the study, and that the current landfill site conforms to most of the criteria in this study to a good degree. But it violates two standards, which are distance from wells standard and distance between landfill and the center of waste generation standard.

关键词： Landfill Site Criteria Weights GIS Analytic Hierarchy Process (AHP)

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hsa-mir-183 is frequently methylated and related to poor survival in human hepatocellular carcinoma

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World Journal of Gastroenterology 2017年第9期23卷 1568-1575页

作者： Sumadi Lukman Anwar Till Krech Britta Hasemeier Elisa Schipper nora Schweitzer Arndt Vogel Hans Kreipe Reena Buurman Britta Skawran Ulrich Lehmann Ulrich Lehmann Institute of PathologyMedizinische Hochschule Hannover Department of Surgery Faculty of Medicine Universitas Gadjah Mada Department of Gastroenterology Hepatology and EndocrinologyMedizinische Hochschule Hannover Institute of Human Genetics Medizinische Hochschule Hannover

To screen clinically relevant microRNAs (miRNAs) silenced by DNA methylation in human hepatocellular carcinoma (HCC).METHODSKnockdown of DNA methyltransferases (DNMTs) using siRNAs and miRNA profiling in HCC cell lines were performed to identify DNA hypermethylation-mediated miRNA downregulation. Confirmation using individual quantitative real-time PCR (qRT-PCR) assays was then performed followed by DNA methylation quantification at the promoter of the miRNA genes. Quantification of DNA methylation and miRNA expression was then performed in primary HCC tumor samples and related with clinicopathological *** profiling after DNMT knockdown in HCC cell lines revealed upregulation of miR-23, miR-25 and miR-183. After qRT-PCR confirmation and CpG island methylation quantification of these miRNAs in cell lines, further analysis in primary HCC specimens showed that hsa-miR-183 is hypermethylated in 30% of HCC (n = 40). Expression of mature miR-183 showed an inverse correlation with DNA methylation levels. In HCC cells, DNMT knockdown and 5-aza-2’-deoxycytidine treatment reduced methylation and stimulated expression of miR-183. In HCC patients, hypermethylation at hsa-miR-183 promoter significantly correlates with poor survival (log-rank test P = 0.03). DNA methylation analysis in healthy liver, benign liver tumors (hepatocellular adenoma and focal nodular hyperplasia) and their corresponding adjacent tissues showed absence of hypermethylation supporting the notion that aberrant methylation at hsa-miR-183 is specific for the malignant transformation of *** data indicate that hypermethylation of hsa-miR-183 is a frequent event in HCC and potentially useful as a novel surrogate diagnostic and prognostic marker.

关键词： hsa-miR-183 DNA methylation DNMT knockdown microRNA microarray

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Effect of Potassium on Sol-Gel Cerium and Lanthanum Oxide Catalysis for Soot Combustion

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Modern Research in Catalysis 2015年第3期4卷 68-77页

作者： Daniela Salinas Gina Pecchi Vicente Rodríguez José Luis García fierro Department of Physical Chemistry Faculty of Sciences University of Concepcion Concepcion Chile Institute of Catalysis and Petrochemistry ICP-CSIC Cantoblanco Madrid Spain

The catalytic activity in the soot combustion is reported for a series of potassium-promoter alumina supported catalysts prepared by the sol-gel method to be used in the catalytic combustion of soot. The studied systems correspond to CeO2-Al2O3 and La2O3-Al2O3 with charges of 3 and 5 wt% of CeO2 and La2O3. Potassium impregnation is performed to reach 3 atoms of K per nm2 of the mixed oxide. The effect of the potassium incorporation increases its reducibility, decreases the surface area and forms a new type of oxygen that is stronger than the oxygen in mixed oxides with similar chemical nature. The existence of potassium oxides, K2O and oxygen responsible for the vacancies and/or lattice defects (O2−) are related to good catalytic activity. Additionally, the presence of alkali affects the structural and textural characteristics of the catalyst, promoting the catalytic activity in soot combustion.

关键词： Sol-Gel Potassium Cerium Lanthanum Soot Combustion

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Hematological abnormalities in liver cirrhosis

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World Journal of Hepatology 2024年第9期16卷 1229-1244页

作者： Oscar Manuel fierro-Angulo JoséAlberto González-Regueiro Ariana Pereira-García Astrid Ruiz-Margáin Fernando Solis-Huerta Ricardo Ulises Macías-Rodríguez Department of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico 14080Mexico Department of Hematology Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico 14080Mexico

Hematological abnormalities are common in cirrhosis and are associated with various pathophysiological *** have documented a prevalence of thrombocytopenia,leukopenia,and anemia in patients with compensated cirrhosis of 77.9%,23.5%,and 21.1%,*** abnormalities carry significant clinical implications,including considerations for invasive procedures,infection risk,bleeding risk,and ***,cirrhosis was believed to predispose patients to bleeding due to alterations observed in classical coagula-tion tests such as prothrombin time,partial thromboplastin time,international normalized ratio,and ***,this understanding has evol-ved,and cirrhosis patients are now also acknowledged as being at a high risk for thrombotic *** in cirrhosis patients presents a complex pheno-type,with procoagulant and anticoagulant abnormalities offsetting each *** multifactorial phenomenon is inadequately reflected by routine laboratory *** complications are more prevalent in decompensated cirrhosis and may correlate with disease *** is primarily associated with portal hypertension,endothelial dysfunction,mechanical vessel injury,dissem-inated intravascular coagulation,endotoxemia,and renal *** review comprehensively outlines hematologic index abnormalities,mechanisms of hemostasis,coagulation,and fibrinolysis abnormalities,limitations of laboratory testing,and clinical manifestations of bleeding and thrombosis in patients with liver cirrhosis.

关键词： Cirrhosis Anemia Leukopenia Thrombocytopenia Coagulopathy Bleeding Thrombosis

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Recovery rates and long-term olfactory dysfunction following COVID-19 infection

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 121-128页

作者： Melanie Dias Zara Shaida nora Haloob Claire Hopkins ENT Department Guy's HospitalLondonUK

Objectives:Olfactory dysfunction is one of the most recognized symptoms of COVID-19,significantly impacting quality of life,particularly in cases where recovery is *** review aims to explore patterns of olfactory recovery post-COVID-19 infection,with particular focus on delayed *** Sources:Published literature in the English language,including senior author's own work,online and social media platforms,and patients'anecdotal ***:A comprehensive review of the literature was undertaken by the authors with guidance from the senior author with expertise in the field of ***:Based on self-report,an estimated 95%of patients recover their olfactory function within 6 months post-COVID-19 ***,psychophysical testing detects higher rates of persistent olfactory *** has been found to continue for at least 2 years postinfection;negative prognostic indicators include severe olfactory loss in the acute phase,female sex,and older *** in quantitative and qualitative disturbance in prolonged cases likely reflects both peripheral and central pathophysiological *** of many of the reviewed studies reflect lack of psychophysical testing and baseline olfactory ***:Post-COVID-19 olfactory dysfunction remains a significant health and psychosocial *** evidence is improving awareness and knowledge among clinicians to better support patients through their olfactory rehabilitation,with hope of recovery after several months or *** research is needed to better understand the underlying pathogenesis of delayed recovery,identify at risk individuals earlier in the disease course,and develop therapeutic targets.

关键词： anosmia COVID-19 olfaction parosmia recovery

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Photoreceptor-Mediated Bending towards UV-B in Arabidopsis

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Molecular Plant 2014年第6期7卷 1041-1052页

作者： Filip Vandenbussche Kimberley Tilbrook Ana Carolina fierro Kathleen Marchal Dirk Poelman Dominique Van Der Straeten Roman UIm boratory of Functional Plant Biology Department of Physiology Faculty of Sciences Ghent University B-9000 Ghent Belgium Department of Botany and Plant Biology Sciences III University of Geneva CH-1211 Geneva 4 Switzerland Department of Microbial and Molecular Systems Faculty of Bioscience Engineering KU Leuven B-3001 Heverlee Belgium Department of Plant Biotechnology and Bioinformatics Faculty of Sciences Ghent University B-9000 Ghent Belgium Department of Information Technology IMinds Faculty of Sciences Ghent University B-go00 Ghent Belgium Lumilab Department of Solid State Sciences Faculty of Sciences Ghent University B-9000 Ghent Belgium

Plants reorient their growth towards light to optimize photosynthetic light capture--a process known as phototropism. Phototropins are the photoreceptors essential for phototropic growth towards blue and ultraviolet-A （UV- A） light. Here we detail a phototropic response towards UV-B in etiolated Arabidopsis seedlings. We report that early differential growth is mediated by phototropins but clear phototropic bending to UV-B is maintained in photl phot2 double mutants. We further show that this phototropin-independent phototropic response to UV-B requires the UVoB photoreceptor UVR8. Broad UV-B-mediated repression of auxin-responsive genes suggests that UVR8 regulates directional bending by affecting auxin signaling. Kinetic analysis shows that UVR8-dependent directional bending occurs later than the phototropin response. We conclude that plants may use the full short-wavelength spectrum of sunlight to efficiently reorient photosynthetic tissue with incoming light.

关键词： phototropism UV-B auxin UVR8 Arabidopsis,

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Radiative transition

Radiative transition

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作者： nora Brambilla Antonio Vairo

＜正＞4.2.1 Introduction Radiative transitions historically have played important roles in establishing new quarkonium *** today,these simple processes are still of considerable exper- imental and theoretical *** the theoretical side,the photon serves as a clean probe to internal structrue of quarkonium,therefore a thorough understanding of these

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Fluorometric Viability Assessment of Capacitated and Acrosome-Reacted Boar Spermatozoa by Flow Cytometry

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Optics and Photonics Journal 2013年第1期3卷 40-44页

作者： Reyna fierro Humberto Gonzalez-Marquez Rocio Ortiz Jerome Chevrier Bernard Foliguet Departamento de Ciencias de la Salud Universidad Autonoma Metropolitana-IztapalapaMexico CityMexico Laboratoire d’Histologie Embryologie et Microscopie ElectroniqueUniversite LorraineNancyFrance

Sperm capacitation involves functional changes, such as the removal or appearance of specific molecules and changes in the plasma membrane;the acrosome reaction (AR) is an exocytotic event induced by calcium influx, enabling the spermatozoa to penetrate the zona pellucida. These processes can be achieved only if the spermatozoa have good viability;indeed, determination of sperm viability is used for the assessment of semen quality. Membrane integrity and mitochondrial activity are important viability parameters of spermatozoa and fluorescent techniques based on membrane permeability to dyes have been developed to determine these parameters. The aim of this work was to determine the viability of boar sperm (fresh, one hour of capacitation induction and 20 min of AR induction) by flow cytometry using propidium iodide (PI) (1.25 μg/mL) and rhodamine 123 (R123) (0.20 μg/mL). Aliquots of 5 × 105 sperm were incubated with each fluorochrome separately and simultaneously for 10 or 20 min, respectively, at 38℃. The proportion of labeled spermatozoa and their fluorescence intensities were measured using a flow cytometer. The fluorescence index (FI) with PI gradually increased during the incubation and we found significant differences between all the groups. With R123, the FI increased in the capacitated sperm but decreased in the acrosome-reacted sperm, with significant differences between the fresh and capacitated spermatozoa. Our results suggest that the increase in the R123 fluorescence intensity in capacitated spermatozoa is due to changes in the mitochondrial membrane activity because the spermatozoa experienced changes in membrane fluidity and flagellar activation during capacitation. The use of fluorochromes and flow cytometry is a good tool for monitoring many markers of sperm function. Although capacitation and AR processes have been well studied, there is still much information to be elucidated with regard to these complex processes.

关键词： Boar Sperm Flow Cytometry Propidium Iodide Rhodamine 123 Viability

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Robust Deep Learning Model for Black Fungus Detection Based on Gabor Filter and Transfer Learning

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Computer Systems Science & Engineering 2023年第11期47卷 1507-1525页

作者： Esraa Hassan Fatma M.Talaat Samah Adel Samir Abdelrazek Ahsan Aziz Yunyoung Nam nora El-Rashidy Machine Learning and Information Retrieval Department Faculty of Artificial IntelligenceKafrelsheikh UniversityKafrelsheikhEgypt Electronics and Communication Engineering Department Faculty of Engineering Horus UniversityDamiettaEgypt Information Systems Department Faculty of Computers and InformationMansoura UniversityMansoura35516Egypt Department of ICT Convergence Soonchunhyang UniversityAsanKorea

Black fungus is a rare and dangerous mycology that usually affects the brain and lungs and could be life-threatening in diabetic ***,some COVID-19 survivors,especially those with co-morbid diseases,have been susceptible to black ***,recovered COVID-19 patients should seek medical support when they notice mucormycosis *** paper proposes a novel ensemble deep-learning model that includes three pre-trained models:reset(50),VGG(19),and *** approach is medically intuitive and efficient compared to the traditional deep learning *** image dataset was aggregated from various resources and divided into two classes:a black fungus class and a skin infection *** the best of our knowledge,our study is the first that is concerned with building black fungus detection models based on deep learning *** proposed approach can significantly improve the performance of the classification task and increase the generalization ability of such a binary classification *** to the reported results,it has empirically achieved a sensitivity value of 0.9907,a specificity value of 0.9938,a precision value of 0.9938,and a negative predictive value of 0.9907.

关键词： Black fungus COVID-19 Transfer learning pre-trained models medical image

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Stroke in COVID-19: a single-centre initial experience in a hotspot of the pandemic

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Stroke & Vascular Neurology 2020年第4期5卷 331-336页

作者： Ivo Bach Pratibha Surathi nora Montealegre Osama Abu-Hadid Sara Rubenstein Sviatoslav Redko Siddharth Gupta Machteld Hillen Pratit Patel Priyank Khandelwal Adham Kamel Department of Neurology and Neurosciences New Jersey Medical SchoolNewarkNew JerseyUSA Department of Neurological Surgery New Jersey Medical SchoolNewarkNew JerseyUSA

Background COVID-19,caused by SARS-CoV-2,is a global pandemic that has been an immense burden on healthcare systems all over the *** patients may be at higher risk for acute ischaemic stroke(AIS).We present our experience with AIS in patients with *** We reviewed all patients admitted to our hospital during a 6-week period with a positive nasopharyngeal swab test for *** these patients,we identified *** reviewed the demographics,clinical,laboratory,imaging characteristics,treatments received and outcomes of AIS in patients with *** We identified 683 patients admitted with COVID-19 during the study period,of which 20 patients had ***-vessel occlusion(LVO)was noted in 11 patients(55%).Intravenous alteplase was administered in four patients(20%)and mechanical thrombectomy was performed in five patients(25%).Respiratory symptoms preceded the onset of AIS in most of the patients(70%)by 1 to 21 *** in patients with AIS was 50%compared with 26%of all COVID-19 *** of these patients died due to non-neurological causes(70%).Three patients with AIS had clinical and imaging findings consistent with COVID-19,but were negative for multiple nasopharyngeal swab *** LVO was more common in patients with AIS and *** had more severe disease and higher mortality *** of the patients had respiratory symptoms preceding AIS by days to *** could explain certain patients with clinical picture of COVID-19 but negative nasopharyngeal swab tests.

关键词： admitted nasopharyngeal acute

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