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回热器对跨临界CO_2热泵系统性能的影响

西南交通大学学报 2012年第4期47卷 634-638页

作者：金东旭王平小山繁高田信夫大连理工大学能源与动力学院辽宁大连116024 九州大学综合理工学研究院

为了研究跨临界CO2热泵热水系统中,回热器传热面积对系统性能的影响,在不同的制冷剂充注量条件下实验研究了CO2热泵系统的性能.实验中,通过调节变频压缩机频率与电子膨胀阀开启度,保持了一定的制热量与蒸发器出口过热度.实验结果表明:... 详细信息

为了研究跨临界CO2热泵热水系统中,回热器传热面积对系统性能的影响,在不同的制冷剂充注量条件下实验研究了CO2热泵系统的性能.实验中,通过调节变频压缩机频率与电子膨胀阀开启度,保持了一定的制热量与蒸发器出口过热度.实验结果表明:在最佳制冷剂充注量条件下,随着回热器传热面积的增加,压缩机的压缩比下降,排气温度与吸气温度上升.采用回热器可以提高系统的最大制热系数,当回热器的无量纲传热面积为0.2时,可使最大制热系数提高约3.2%～5.1%.

关键词： CO2 热泵回热器性能

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跨临界CO_2热泵热水器的性能

西南交通大学学报 2010年第5期45卷 680-684页

作者：金东旭小山繁薛隽高田信夫大连理工大学能源与动力学院辽宁大连116024 九州大学综合理工学研究院

为了研究跨临界CO2热泵热水器制冷剂充注量对制热系数的影响,通过调节变频压缩机频率与电子膨胀阀脉冲,在制热量与压缩机入口过热度一定的条件下,对制热系数、压缩比、吸气和排气压力等与制冷剂充注量的关系进行了实验研究.结果表明:随... 详细信息

为了研究跨临界CO2热泵热水器制冷剂充注量对制热系数的影响,通过调节变频压缩机频率与电子膨胀阀脉冲,在制热量与压缩机入口过热度一定的条件下,对制热系数、压缩比、吸气和排气压力等与制冷剂充注量的关系进行了实验研究.结果表明:随着制冷剂充注量的增加,压缩机的排气压力上升,气体冷却器出口制冷剂的温度下降;随着蒸发器中热源水入口温度的上升,吸气压力上升,压缩比和排气温度下降;最大制热系数随热源水入口温度的上升而增大.当热源水入口温度为15℃且压缩机入口过热度为5℃时,系统的最大制热系数为3.25,最佳制冷剂充注量为1.7 kg.

关键词： CO2 制冷剂跨临界循环热泵性能

Vonoprazan 10 mg or 20 mg *** 15 mg as maintenance therapy in Asian patients with healed erosive esophagitis:A randomized controlled trial

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Chinese Medical Journal 2024年第8期137卷 962-971页

作者： Yinglian Xiao Jiaming Qian Shutian Zhang Ning Dai Hoon Jai Chun Chengtang Chiu Chui Fung Chong nobuo Funao Yuuichi Sakurai Jessica D.Eisner Li Xie Minhu Chen Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510062China Department of Gastroenterology Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100006China Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Gastroenterology Sir Run Run Shaw HospitalSchool of Medicine Zhejiang UniversityHangzhouZhejiang 310020China Department of Internal Medicine Korea University Anam HospitalKorea University College of Medicine73 Goryeodae-roSeongbuk-guSeoul 02841Republic of Korea Department of Gastroenterology&Hepatology Linkou Medical CenterChang Gung Memorial HospitalTaoyuanTaiwan 33353China College of Medicine Chang Gung UniversityTaoyuanTaiwan 33353China Takeda Development Center Asia Singapore 018981Singapore Takeda Pharmaceutical Company Chuo-kuOsaka 540-8645Japan Takeda Pharmaceuticals International Company CambridgeMA02142 USA China Medical Team Takeda ChinaBeijing 100027China Hoffmann-La Roche Basel4070 Switzerland Abbott Laboratories Lake ForestIL 60045USA

Background:Erosive esophagitis(EE)is a gastroesophageal reflux disease characterized by mucosal breaks in the *** pump inhibitors are widely used as maintenance therapy for EE,but many patients still *** this trial,we evaluated the noninferiority of vonoprazan *** as maintenance therapy in patients with healed ***:We performed a double-blind,double-dummy,multicenter,phase 3 clinical trial among non-Japanese Asian adults with endoscopically confirmed healed EE from April 2015 to February *** from China,South Korea,and Malaysia were randomized to vonoprazan 10 mg or 20 mg once daily or lansoprazole 15 mg once daily for 24 *** primary endpoint was endoscopically confirmed EE recurrence rate over 24 weeks with a noninferiority margin of 10%using a two-sided 95%confidence interval(CI).Treatment-emergent adverse events(TEAEs)were ***:Among 703 patients,EE recurrence was observed in 24/181(13.3%)and 21/171(12.3%)patients receiving vonoprazan 10 mg or 20 mg,respectively,and 47/184(25.5%)patients receiving lansoprazole(differences:-12.3%[95%CI,-20.3%to-4.3%]and-13.3%[95%CI,-21.3%to-5.3%],respectively),meeting the primary endpoint of noninferiority to lansoprazole in preventing EE recurrence at 24 *** of superiority(upper bound of 95%CI<0%)was also *** 12 weeks,endoscopically confirmed EE recurrence was observed in 5/18,2/20,and 7/20 of patients receiving vonoprazan 10 mg,vonoprazan 20 mg,and lansoprazole,*** were experienced by 66.8%(157/235),69.0%(156/226),and 65.3%(158/242)of patients receiving vonoprazan 10 mg,vonoprazan 20 mg,and lansoprazole,*** most common TEAE was upper respiratory tract infection in 12.8%(30/235)and 12.8%(29/226)patients in vonoprazan 10 mg and 20 mg groups,respectively and 8.7%(21/242)patients in lansoprazole ***:Vonoprazan maintenance therapy was well-tolerated and noninferior to lansoprazole for preventing EE recurrence i

关键词： Erosive esophagitis Lansoprazole Maintenance therapy Potassium-competitive acid blockers Vonoprazan

ELASTOMERIC SEISMIC-PROTECTION ISOLATORS FOR BUILDINGS AND BRIDGES

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Chinese Journal of Polymer Science 2013年第1期31卷 50-57页

作者： Toshio Nishi nobuo Murota International Division Tokyo Institute of Technology Department of Seismic Isolation &Vibration Control Development

A giant earthquake of magnitude 9.0 occurred in Pacific Ocean off of Tohoku District Japan on March 11,2011. The highest seismic intensity of 7 in JMA scale was recorded in Miyagi. In the Tohoku district, around 230 buildings are seismically isolated （hereafter, SI） mainly by elastomeric isolators （seismic rubber bearings）. According to the official survey reports by several organizations （for example）, the records of those buildings have verified the effectiveness of the seismic isolation. The response acceleration of the SI buildings was reduced by 30% to 50% of the input ground acceleration. Additionally, the difference of the conditions inside the room between SI and the fixed-base buildings was obvious as well as the damage in main structures of the buildings. The displacements of the isolators by the earthquake were around 200 mm according to the records of the instruments. As a result, the performance of SI buildings and the elastomeric isolators in the Tohoku District -- Off the Pacific Ocean Earthquake 2011 were excellent, and the efficiency of the seismic isolation was verified by the records of many buildings in wide area.

关键词： Elastomeric isolator Seismic isolation Rubber bearing.

Ceramide induces apoptosis in human lung adenocarcinoma A549 cells through mitogen-activated protein kinases

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Acta Pharmacologica Sinica 2007年第3期28卷 439-445页

作者： nobuo MURATA Tatsuo YAMAKAWA Department of Surgery Mini-invasive surgery CenterTeikyo University Mizonokuchi HospitalKawasaki 213-8507Japan

Aim:To provide experimental data for further research on the signal transductionof apoptosis in lung adenocarcinoma cells,we examined the effects of exogenousC2-ceramide administration on several members of the mitogen-activated proteinkinase(MAPK)superfamily and caspase-3 in A549 ***:Cell viabilityand apoptosis were analyzed by cell counting kit-8 assay and flow *** MAPK and caspase-3 proteins were detected by Western ***:C2-ceramide selectively altered the phosphorylation state &members ofthe MAPK superfamily,causing hyperphosphorylation ofmitogen-activated pro-tein kinase kinase(MEK)1/2 and the p38 MAPK,but not affecting the phosphory-lation ofextracellular signal-regulated kinase 1/2 and the c-Jun N-terminal ***-203580(a p38 MAPK inhibitor)and p38 siRNA,but not U0126(a MEKinhibitor),partially rescued cell death induced by C2-ceramide.C2-ceramide promoted theactivation of ***:Exogenous C2-ceramide induced apoptosisin human lung adenocarcinoma A549 *** activation of MAPK and caspase-3were involved in the mechanisms ofC2-ceramide-induced apoptosis in A549 cells.

关键词： ceramide apoptosis mitogen-activated protein kinases A549 cells

Recent Advancement in Optical Fiber Sensing for Aerospace Composite Structures

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Photonic Sensors 2013年第4期3卷 345-354页

作者： Shu MINAKUCHI nobuo TAKEDA Graduate School of Frontier Sciences The University of Tokyo 5-1-5 Kashiwanoha Kashiwa-shi Chiba 277-8561Japan

Optical fiber sensors have attracted considerable attention in health monitoring of aerospace composite structures. This paper briefly reviews our recent advancement mainly in Brillouin-based distributed sensing. Damage detection, life cycle monitoring and shape reconstruction systems applicable to large-scale composite structures are presented, and new technical concepts, ＂smart crack arrester＂ and ＂hierarchical sensing system＂, are described as well, highlighting the great potential of optical fiber sensors for the structural health monitoring （SHM） field.

关键词： Carbon fiber reinforced plastic (CFRP) Brillouin-based system fiber Bragg grating (FBG)

Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses

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Cancer Communications 2024年第2期44卷 287-293页

作者： Kouya Shiraishi Atsushi Takahashi Yukihide Momozawa Yataro Daigo Syuzo Kaneko Takahisa Kawaguchi Hideo Kunitoh Shingo Matsumoto Hidehito Horinouchi Akiteru Goto Takayuki Honda Kimihiro Shimizu Masahiro Torasawa Daisuke Takayanagi Motonobu Saito Akira Saito Yuichiro Ohe Shun-ichi Watanabe Koichi Goto Masahiro Tsuboi Katsuya Tsuchihara Sadaaki takata Tomomi Aoi Atsushi Takano Masashi Kobayashi Yohei Miyagi Kazumi Tanaka Hiroyuki Suzuki Daichi Maeda Takumi Yamaura Maiko Matsuda Yoko Shimada Takaaki Mizuno Hiromi Sakamoto Teruhiko Yoshida Yasushi Goto Tatsuya Yoshida Taiki Yamaji Makoto Sonobe Shinichi Toyooka Kazue Yoneda Katsuhiro Masago Fumihiro Tanaka Megumi Hara nobuo Fuse Satoshi S.Nishizuka Noriko Motoi Norie Sawada Yuichiro Nishida Kazuki Kumada Kenji Takeuchi Kozo Tanno Yasushi Yatabe Kuniko Sunami Tomoyuki Hishida Yasunari Miyazaki Hidemi Ito Mitsuhiro Amemiya Hirohiko Totsuka Haruhiko Nakayama Tomoyuki Yokose Kazuyoshi Ishigaki Toshiteru Nagashima Yoichi Ohtaki Kazuhiro Imai Ken Takasawa Yoshihiro Minamiya Kazuma Kobayashi Kenichi Okubo Kenji Wakai Atsushi Shimizu Masayuki Yamamoto Motoki Iwasaki Koichi Matsuda Johji Inazawa Yuichi Shiraishi Hiroyoshi Nishikawa Yoshinori Murakami Michiaki Kubo Fumihiko Matsuda Yoichiro Kamatani Ryuji Hamamoto Keitaro Matsuo Takashi Kohno Division of Genome Biology National Cancer Center Research InstituteTokyoJapan Department of Clinical Genomics National Cancer Center Research InstituteTokyoJapan Laboratory for Statistical Analysis Center for Integrative Medical SciencesRIKENYokohamaJapan Department of Genomic Medicine Research InstituteNational Cerebral and Cardiovascular CenterOsakaJapan Laboratory for Genotyping Development Center for Integrative Medical SciencesRIKENYokohamaJapan Center for Antibody and Vaccine Therapy Research HospitalInstitute of Medical ScienceThe University of TokyoTokyoJapan Department of Medical Oncology and Cancer Center and Center for Advanced Medicine against CancerShiga University of Medical ScienceOtsuJapan Division of Medical AI Research and Development National Cancer Center Research InstituteTokyoJapan Center for Genomic Medicine Graduate School of MedicineKyoto UniversityKyotoJapan Department of Medical Oncology Japanese Red Cross Medical CenterTokyoJapan Department of Thoracic Oncology National Cancer Center Hospital EastJapan Department of Thoracic Oncology National Cancer Center HospitalTokyoJapan Department of Cellular and Organ Pathology Graduate School of MedicineAkita UniversityAkitaJapan Department of Respiratory Medicine Tokyo Medical and Dental UniversityBunkyo-kuTokyoJapan Division of General Thoracic Surgery Department of SurgeryShinshu University School of MedicineMatsumotoNaganoJapan Department of General Surgical Science Division of General Thoracic SurgeryGunma University Graduate School of MedicineIntegrative Center of General SurgeryGunma University HospitalGunmaJapan Department of Gastrointestinal Tract Surgery Fukushima Medical University School of MedicineFukushimaJapan StaGen Co. LtdTokyoJapan Division of Thoracic Surgery National Cancer Center HospitalTokyoJapan Department of Thoracic Surgery National Cancer Center Hospital EastChibaJapan Division of Translational Informatics Exploratory Oncology Research and Clinical Trial Center(EPOC

Dear editor,Lung carcinoma is responsible for the highest fatal-ity rate among cancer-related deaths globally,with lung adenocarcinoma(LADC)emerging as the prevailing sub-type.

关键词： adenocarcinoma lung Lung

Analysis of Sparse Quasi-Newton Updates with Positive Definite Matrix Completion

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Journal of the Operations Research Society of China 2014年第1期2卷 39-56页

作者： Yu-Hong Dai nobuo Yamashita State Key Laboratory of Scientific and Engineering Computing Institute of Computational Mathematics and Scientific/Engineering ComputingAcademy of Mathematics and Systems ScienceChinese Academy of SciencesP.O.Box 2719Beijing 100080People’s Republic of China Department of Applied Mathematics and Physics Graduate School of InformaticsKyoto UniversityKyoto 606-8501Japan

Based on the idea of maximum determinant positive definite matrix completion,Yamashita(Math Prog 115(1):1–30,2008)proposed a new sparse quasi-Newton update,called MCQN,for unconstrained optimization problems with sparse Hessian *** exchange of the relaxation of the secant equation,the MCQN update avoids solving difficult subproblems and overcomes the ill-conditioning of approximate Hessian ***,local and superlinear convergence results were only established for the MCQN update with the DFP *** this paper,we extend the convergence result to the MCQN update with the whole Broyden’s convex *** results are also reported,which suggest some efficient ways of choosing the parameter in the MCQN update the Broyden’s family.

关键词： Quasi-Newton method Large-scale problems Sparsity Positive definite matrix completion Superlinear convergence

A method for estimating the fraction of mineral dust in particulate matter using PM2.5-to-PM10 ratios

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Particuology 2016年第5期14卷 114-120页

作者： nobuo Sugimoto Atsushi Shimizu Ichiro Matsui Masataka Nishikawa Center for Environmental Measurement and Analysis National Institute for Environmental Studies 16-20nogawa Tsukuba 305-8506 Japan Tokyo University of Science Environmental Safety Center 1-3 Kagurazaka Shinjuku-ku Tokyo 162-8601Japan

A simple method for estimating the contributions of mineral dust to PM2.5, PM10, or TSP is presented. The method is based on the assumption of external mixing of two types of particles with different PM2.5/PM10 ratios, The method was applied to local and transported dust events observed in Tsukuba, Japan, and was compared with collocated polarization lidar measurements. The method was then applied to three dust events that occurred in Oki, Rishiri, and Ochiishi,Japan, in 2012. The results showed that the method was useful for detecting mineral dust and for qualitatively describing the mixing of dust with anthropogenic aerosols.

关键词： Mineral dust PM2.5 dust fraction PM2.5 to PM10 ratio Atmospheric mixing Lidar Depolarization ratio