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Journal of Environmental Sciences 2022年第5期34卷 173-189页

作者： Sayaka Yanagida Takumi Yajima Takahiro Takei nobuhiro Kumada Center for Crystal Science and Technology University of YamanashiKofu 400-8511Japan Advanced Materials Development Sector Tokyo Metropolitan Industrial Technology Research Institute2-4-10AomiKoto-kuTokyo 135-0064Japan

All-solid-state Z-scheme photocatalysts,containing Cu_(2)O,TiO_(2)(rutile),and Au as the elec-tron mediator,were prepared and applied to the reduction of Cr(Ⅵ)in aqueous *** Cu_(2)O-Au-TiO_(2) composites were prepared by loading Au core-Cu_(2)O shell hemisphere particles on TiO_(2)(rutile)nanorods using a two-step photocatalytic deposition ***-der ultraviolet-visible(UV-vis)light illumination,the Cu_(2)O-Au-TiO_(2) composites exhibited higher photocatalytic Cr(Ⅵ)reduction activities than those exhibited by single TiO_(2)(rutile)and Cu_(2)*** this reaction,a precipitate containing Cr,which was considered to be Cr(OH)_(3),was deposited site-selectively on the Au core-Cu_(2)O shell particles of the composites,indi-cating that the reduction site of the composite was Cu_(2)O,and the reaction proceeded accord-ing to the *** Cu_(2)O-Au-TiO_(2) composites also exhibited photocatalytic activity under visible light *** oxidation state of Cu in the Cu_(2)O-Au-TiO_(2) composite gradually changed from Cu(Ⅰ)to Cu(Ⅱ)during the photocatalytic Cr(Ⅵ)*** the composite maintained its high photocatalytic performance even after *** role of Au in the Cu_(2)O-Au-TiO_(2) composite was examined by comparing the properties of the Cu_(2)O-Au-TiO_(2) composite with those of the Cu_(2)O-TiO_(2) composite prepared via direct Cu_(2)O deposition on TiO_(2).

关键词： Cu_(2)O TiO_(2)(rutile) Z-scheme Photocatalyst Chromium

Discovery of new hazimycin congeners from Kitasatospora sp.P07101

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Acta Pharmaceutica Sinica B 2015年第6期5卷 564-568页

作者： nobuhiro Koyama Hirofumi Sato Hiroshi Tomoda Graduate School of Pharmaceutical Sciences Kitasato University

In an analytical study of microbial broths,the actinomycete strain Kitasatospora sp.P07101 was found to produce three new congeners,which were designated hazimycins B(1),C(2),and D(3),together with the previously reported hazimycin(renamed hazimycin A(4)).The structures of these hazimycins were examined using various spectroscopic methods including nuclear magnetic resonance(NMR),and the results revealed that 1–3 were analogues of hazimycin with the replacement of one of the two isonitrile groups in 4 by an NH-formyl group in 1,the two isonitrile groups and an amide group by two NH-formyl groups and a nitrile group in 2,and the two isonitrile groups and two amide groups by two NH-formyl groups and two nitrile groups in *** hazimycin A exhibited moderate antimicrobial activities against Gram-positive bacteria and Candida *** results indicated that the presence of two isonitrile groups in the hazimycin structure is essential for antimicrobial activity.

关键词： Hazimycin Isonitrile Nitrile Microbial metabolites Kitasatospora

Selective synthesis of carbon monoxide via formates in reverse water–gas shift reaction over alumina-supported gold catalyst

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Journal of Energy Chemistry 2016年第2期25卷 304-308页

作者： nobuhiro Ishito Kenji Hara Kiyotaka Nakajima Atsushi Fukuoka Institute for Catalysis Hokkaido University Graduate School of Chemical Sciences and Engineering Hokkaido University School of Engineering Tokyo University of Technology

Thermal decomposition of formic acid on SiO2, CeO2 and γ-Al2O3 was studied as an elementary step of reverse water–gas shit reaction（RWGS） over supported Au catalysts. γ-Al2O3 showed the highest CO selectivity among the tested oxides in the decomposition of formic acid. Infrared spectroscopy showed the formation of four formate species on γ-Al2O3： three η~1-type and one μ~2-type species, and these formates decomposed to CO at 473 K or higher. Au-loaded γ-Al2O3 samples were prepared by a depositionprecipitation method and used as catalysts for RWGS. The supported Au catalyst gave CO with high selectivity over 99% from CO2 and H2, which is attributed to the formation of formates on Au and subsequent decomposition to CO on γ-Al2O3.

关键词： Reverse water–gas shift reaction Carbon dioxide Hydrogen Formate Carbon monoxide Alumina Gold

Better Platooning toward Autonomous Driving:Inter-Vehicle Communications with Directional Antenna

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China Communications 2021年第7期18卷 44-57页

作者： Xiaoyan Wang Diquan Wang nobuhiro Ariyasu Masahiro Umehira Graduate School of Science and Engineering Ibaraki UniversityHitachi 316-8511Japan Japan Hi-Think Corporation Kyoto 600-8815Japan Hitachi Automotive Systems Ltd.Hitachinaka 312-8503Japan

Recently,in the researches on vehicular Internet-of-Things(IoT),platooning have received lots of attentions due to its potential to improve the fuel efficiency and driving *** is a group of vehicles that act as smart agents,they travel collaboratively by following the leading human-driven vehicle.A vehicle in the platoon utilizes radar and wireless communication to share important information to other vehicles in the same platoon such as speed and acceleration,to realize the safe and efficient *** quality of wireless communication is of great importance to manage and maintain the ***,in a scenario that a large number of vehicles exist,communication delay and packet loss caused by channel congestion may endanger the safe intervehicle *** this paper,we introduce intervehicle communication with directional antenna into *** extensive simulations,we evaluate the packet delay and inter-vehicle distance in both normal driving and braking scenarios,and verify the usefulness of directional antenna in platooning for vehicular IoT.

关键词： vehicular IoT inter-vehicle communications directional antenna platoon safety

Autism spectrum disorder model mice: Focus on copy number variation and epigenetics

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Science China(Life Sciences) 2015年第10期58卷 976-984页

作者： nobuhiro NAKAI Susumu OTSUKA Jihwan MYUNG Toru TAKUMI Graduate School of Biomedical Sciences Hiroshima University Graduate School of Biostudies Kyoto University RIKEN Brain Science Institute Core Research for Evolutional Science and Technology Japan Science and Technology Agency

Autism spectrum disorder(ASD) is gathering concerns in socially developed countries. ASD is a neuropsychiatric disorder of genetic origin with high prevalence of 1%–2%. The patients with ASD characteristically show impaired social skills. Today, many genetic studies identify numerous susceptible genes and genetic loci associated with ASD. Although some genetic factors can lead to abnormal brain function linked to ASD phenotypes, the pathogenic mechanism of ASD is still unclear. Here, we discuss a new mouse model for ASD as an advanced tool to understand the mechanism of ASD.

关键词： copy number variations DNA methylation histone modification ASD model mouse

Repair Effect of Hot Work Tool Steel by Laser-Melting Process

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Journal of Materials Science & Technology 2003年第z1期19卷 91-93页

作者： Yahong SUN Satoshi HANAKI Hitoshi UCHIDA Hisakichi SUNADA nobuhiro tsujiI Graduate School of Engineering Himeji Institute of Technology 2167ShoshaHimeji 671-2201Japan Technical Research Laboratories Sanyo Special Steel Co.LTD.3007NakajimaShikama-kuHimeji 672-8677Japan

Both wear and crack due to heat checking in hot work tool steel are major failure *** is desirable to find amethod to lengthen the tool life while reducing manufacturing *** paper suggests a method to improve toollife for hot work tool steel(SKD6)with crack by laser-melting *** method has been evaluated using theimpact and fatigue test *** is demonstrated that a repair of the crack by a laser-melting process is effectivefor life extension of the damaged tool.

关键词： Hot work tool steel Laser-melting process Impact test Fatigue test Fractography

Human platelets inhibit liver fibrosis in severe combined immunodeficiency mice

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World Journal of Gastroenterology 2013年第32期19卷 5250-5260页

作者： Kazuhiro Takahashi Soichiro Murata Kiyoshi Fukunaga nobuhiro Ohkohchi Department of Surgery University of Tsukuba

AIM:To investigate the role of human platelets in liver ***:Severe combined immunodeficiency(SCID)mice were administered CCl4and either phosphate-buffered saline(PBS group)or human platelet transfusions(hPLT group).Concentrations of hepatocyte growth factor(HGF),matrix metallopeptidases(MMP)-9,and transforming growth factor-β(TGF-β)in the liver tissue were compared between the PBS and the hPLT groups by enzyme-linked immunosorbent assay(ELISA)and Western *** effects of a human platelet transfusion on liver fibrosis included the fibrotic area,hydroxyproline content,and-smooth muscle actin(α-SMA)expression,which were evaluated by picrosirius red staining,ELISA,and immunohistochemical staining using an anti-mouse-SMA antibody,*** of mesenchymal-epithelial transition factor(Met)and SMAD3,downstream signals of HGF and TGF-β,were compared between the two groups by Western blotting and were quantified using *** apoptosis was evaluated by terminal deoxynucleotidyl transferase dUTP nick end ***,the accumulation of human platelets in the liver 2 h after platelet transfusion was compared between normal and fibrotic livers by immunohistochemical staining using an anti-human CD41 ***:The fibrotic area and hydroxyproline content in the liver were both significantly lower in the hPLT group when compared to the PBS group(fibrotic area,1.7%±0.6%vs 2.5%±0.6%,P=0.03;hydroxyproline content,121±26 ng/g liver vs 156±47 ng/g liver,P=0.04).There was less α-smooth muscle actin staining in the hPLT group than in the PBS group(0.5%±0.1%vs 0.8%±0.3%,P=0.02).Hepatic expression levels of mouse HGF and MMP-9were significantly higher in the hPLT group than in the PBS group(HGF,109±13 ng/g liver vs 88±22 ng/g liver,P=0.03;MMP-9,113%±7%/GAPDH vs 92%±11%/GAPDH,P=0.04).In contrast,the concentration of mouse TGF-β in the liver tissue was significantly lower in the hPLT group than in the PBS group(22±5ng/g

关键词： Human platelet Liver fibrosis Hepatocyte apoptosis Hepatocyte growth factor Transforming growth factor-β Matrix metallopeptidases

Wastewater degradation by iron/copper nanoparticles and the microorganism growth rate

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Journal of Environmental Sciences 2018年第12期30卷 19-31页

作者： Tareq W.M.Amen Osama Eljamal Ahmed M.E.Khalil nobuhiro Matsunaga Earth System Science and Technology Interdisciplinary Graduate School of Engineering Sciences Kyushu University Department of Chemical Engineering Faculty of Engineering Cairo University

Nowadays, trends in wastewater treatment by zero-valent iron（ZVI） were turned to use bimetallic NZVI particles by planting another metal onto the ZVI surface to increase its reactivity. Nano size zero-valent iron/copper（NZVI/Cu0） bimetallic particles were synthesized in order to examine its toxicity effects on the wastewater microbial life, kinetics of phosphorus, ammonia stripping and the reduction of chemical oxygen demand（COD）.Various concentrations of NZVI/Cu0 and operation conditions both aerobic and anaerobic were investigated and compared with pure NZVI experiment. The results showed that addition10 mg/L of NZVI/Cu0 significantly increased the numbers of bacteria colonies under anaerobic condition, conversely it inhibited bacteria activity with the presence of oxygen. Furthermore,the impact of nanoparticles on ammonia stripping and phosphorus removal was also linked to the emitted iron ions electrons. It was found that dosing high concentration of bimetallic NZVI/Cu0 has a negative effect on ammonia stripping regardless of the aeration condition. In comparison to control, dosing only 10 mg/L NZVI/Cu0, the phosphorus removal increased sharply both under aerobic and anaerobic conditions, these outcomes were obtained as a result of complete dissolution of bimetallic nanoparticles which formed copper-iron oxides components that are attributed to increasing the phosphorus adsorption rate.

关键词： Iron bimetallic Wastewater biodegradation Bacterial life Contaminants removal

Potentiality of immunotherapy against hepatocellular carcinoma

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World Journal of Gastroenterology 2015年第36期21卷 10314-10326页

作者： nobuhiro Tsuchiya Yu Sawada Itaru Endo Yasushi Uemura Tetsuya Nakatsura Division of Cancer Immunotherapy Exploratory Oncology Research and Clinical Trial CenterNational Cancer Center Department of Gastroenterological Surgery Graduate School of MedicineYokohama City University

Hepatocellular carcinoma(HCC),the predominant form of primary liver cancer,is the fifth most common cancer worldwide and the second leading cause of cancer-related death. Despite the high incidence,treatment options remain limited for advanced HCC,and as a result prognosis continues to be poor. Current therapeutic options,surgery,chemotherapy and radiotherapy,have only modest efficacy. New treatment modalities to prolong survival and to minimize the risk of adverse response are desperately needed for patients with advanced HCC. Tumor immunotherapy is a promising,novel treatment strategy that may lead to improvements in both treatment-associated toxicity and outcome. The strategies have developed in part through genomic studies that have yielded candidate target molecules and in part through basic biology studies that have defined the pathways and cell types regulating immune response. Here,we summarize the various types of HCC immunotherapy and argue that the newfound field of HCC immunotherapy might provide critical advantages in the effort to improve prognosis of patients with advanced HCC. Already several immunotherapies,such as tumor-associated antigen therapy,immune checkpoint inhibitors and cell transfer immunotherapy,have demonstrated safety and feasibility in HCC patients. Unfortunately,immunotherapy currently has low efficacy in advanced stage HCC patients; overcoming this chal lenge will place immunotherapy at the forefront of HCC treatment,possibly in the near future.

关键词： Cell transfer immunotherapy Cytokine therapy Hepat

Characteristics of multiple nodules in a patient with pulmonary Langerhans cell histiocytosis: A case report

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World Journal of Clinical Cases 2019年第17期7卷 2519-2525页

作者： nobuhiro Kanaji Yoshimasa Tokunaga Ryou Ishikawa Naoki Watanabe Norimitsu Kadowaki Department of Internal Medicine Division of HematologyRheumatology and Respiratory MedicineFaculty of MedicineKagawa UniversityKagawa 761-0793Japan Department of General Thoracic Surgery Breast and Endocrinological SurgeryFaculty of MedicineKagawa UniversityKagawa 761-0793Japan Department of Diagnostic Pathology Faculty of MedicineKagawa UniversityKagawa 761-0793Japan

BACKGROUND The common computed tomography findings of pulmonary Langerhans cell histiocytosis (PLCH) are multiple cysts and micronodules predominantly in middle to upper lung ***-cystic nodules and large nodules are atypical findings of *** SUMMARY The patient was a 48-year-old Japanese man with a smoking history (20 cigarettes/d,28 years) and no *** nodules existed in all lung lobes,predominantly in the right lower *** nodules seemed to be distributed randomly,and others were adjacent to *** nodules were solid;some small ones were *** largest nodule was 22 mm in *** metastatic lung tumors were suspected,thoracoscopic lung biopsy led to the diagnosis of *** 6 months after he quit smoking,all nodules had almost *** investigated the characteristics of nodules at diagnosis in *** 349 nodules in total,116 were in upper and 199 were in lower ***-six (27.5%) were cystic;the remaining 253 (72.5%) were *** prevalence of cystic nodules was higher in upper lobes than in lower lobes (right upper 37.5% vs lower 18.2%,P = 0.0068;left upper 48.1% vs lower 24.4%,P = 0.0078).The average size (dia.) of cystic nodules was smaller than that of noncystic nodules (5.03 mm vs 7.40 mm,respectively,P < 0.0001).CONCLUSION Although multiple non-cystic nodules including large nodules (over 20 mm) are atypical,PLCH should be included in differential *** presence of small cystic nodules predominantly in upper lobes and asymptomatic situation are also important for differential diagnoses to distinguish from metastatic cancers.

关键词： Langerhans cell histiocytosis Multiple Non-cystic Nodule Distribution Size Case report