Autism spectrum disorder model mice: Focus on copy number variation and epigenetics

作     者：Nobuhiro NAKAI Susumu OTSUKA Jihwan MYUNG Toru TAKUMI 

作者机构：Graduate School of Biomedical Sciences Hiroshima University Graduate School of Biostudies Kyoto University RIKEN Brain Science Institute Core Research for Evolutional Science and Technology Japan Science and Technology Agency 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2015年第58卷第10期

页      面：976-984页

核心收录：

学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：supported in part by a grant from Japan Society for the Promotion of Science and Ministry of Education Culture Sports Science and Technology KAKENHI Core Research for Evolutional Science and Technology Strategic International Cooperative Program of Japan Science and Technology Agency and by research grants from Takeda Science Foundation the Naito Foundation and Terumo Life Science Foundation 

主　　题：copy number variations DNA methylation histone modification ASD model mouse 

摘      要：Autism spectrum disorder(ASD) is gathering concerns in socially developed countries. ASD is a neuropsychiatric disorder of genetic origin with high prevalence of 1%–2%. The patients with ASD characteristically show impaired social skills. Today, many genetic studies identify numerous susceptible genes and genetic loci associated with ASD. Although some genetic factors can lead to abnormal brain function linked to ASD phenotypes, the pathogenic mechanism of ASD is still unclear. Here, we discuss a new mouse model for ASD as an advanced tool to understand the mechanism of ASD.