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Fluorescence Studies of Telomere Maintenance Proteins Reveal Protein-DNA Interaction Dynamics at the Single-molecule Level

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Fluorescence Studies of Telomere Maintenance Proteins Reveal...

第十七届国际生物物理大会;第十二届中国生物物理大会

作者： noah Buncher Greg Gibson Robert Keller Bennett Van Houten Simon C.Watkins Patricia L.Opresko Neil Kad Department of Environmental and Occupational Health University of Pittsburgh Graduate School of Public HealthPittsburghPA 15219 Center for Biologic Imaging University of PittsburghPittsburgh15261 Department of Biology University of EssexColchesterEssex C04 3SQ UK Department of Pharmacology and Chemical Biology University of Pittsburgh School of Medicine The University of Pittsburgh Cancer Institute Hillman Cancer CenterPittsburghPennsylvania 15213 Department of Biology University of EssexColchesterEssex CO4 3SQ UK

Telomeres are nucleoprotein structures that cap the ends of linear *** telomeres are important contributing factors in aging and *** a typical human somatic cell,the telomeric repeat sequence TTAGGG is approximately 2-15 kb in length with a 3' single stranded overhang of 100-200 nt.A specialized protein complex called shelterin binds and protects the human telomeric *** humans,this

关键词： Telomere single-molecule fluorescence atomic force microscopy protein-DNA interactions TRF2

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IPO也救不了旧金山楼市

商业周刊（中文版） 2021年第3期 25-27页

作者： Sophie Alexander Patrick Clark noah Buhayar 徐安琪(译) 不详

科技股一路飙升,备受瞩目的首次公幵发行(IPO)也将造就大批百万富翁。但在旧金山,繁荣期已经过去。新冠疫情反弹使这个科技中心重回封锁状态。办公室里空无一人,居家办公成为常态。虽然在通常情况下,旧金山本地公司Airbnb Inc和DoorDash... 详细信息

科技股一路飙升,备受瞩目的首次公幵发行(IPO)也将造就大批百万富翁。但在旧金山,繁荣期已经过去。新冠疫情反弹使这个科技中心重回封锁状态。办公室里空无一人,居家办公成为常态。虽然在通常情况下,旧金山本地公司Airbnb Inc和DoorDash Inc上市会导致大量财富流入,但现如今,很多员工已迁往市郊、太浩湖(Lake Tahoe)甚至更远的地方。

关键词： IPO 繁荣期旧金山科技股

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40天玩转移动营销

作者： (美)雷切尔·帕斯卡(Rachel Pasqua) (美)诺亚·埃尔金(noah Elkin)

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IPO也救不了旧金山楼市

商业周刊（中文版） 2020年第24期 23-24页

作者： Sophie Alexander Patrick Clark noah Buhayar 徐安琪(译) 不详

科技股一路飙升,备受瞩目的首次公开发行(IP0)也将造就大批百万富翁。但在旧金山,繁荣期已经过去。新冠疫情反弹使这个科技中心重回封锁状态。办公室里空无一人,居家办公成为常态。虽然在通常情况下,旧金山本地公司Airbnb Inc和DoorDash... 详细信息

科技股一路飙升,备受瞩目的首次公开发行(IP0)也将造就大批百万富翁。但在旧金山,繁荣期已经过去。新冠疫情反弹使这个科技中心重回封锁状态。办公室里空无一人,居家办公成为常态。虽然在通常情况下,旧金山本地公司Airbnb Inc和DoorDash Inc上市会导致大量财富流人,但现如今,很多员工已迁往市郊、太浩湖(Lake Tahoe)甚至更远的地方。

关键词：首次公开发行繁荣期 IPO 旧金山

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米尔斯坦堂

城市环境设计 2014年第6期83卷 122-129页

作者： Jason Long Michael Smith Troy Schaum Charles Berman AmparoCasani noah Shepherd

AAP学院米尔斯坦堂是位于纽约州伊萨卡市久负盛名的康奈尔大学建筑艺术和规划学院(简称"AAP学院")近百年来新建的第一栋建筑。但新建筑并没有独立于学院原有建筑,而是设计为与原有建筑室内外各层面相接的综合体。约4 400m2的空间内包含... 详细信息

AAP学院米尔斯坦堂是位于纽约州伊萨卡市久负盛名的康奈尔大学建筑艺术和规划学院(简称"AAP学院")近百年来新建的第一栋建筑。但新建筑并没有独立于学院原有建筑,而是设计为与原有建筑室内外各层面相接的综合体。约4 400m2的空间内包含了工作室、展廊、评图室以及第一个专属礼堂等学院特别需要的空间。学院原有的4栋建筑位于校园北部边

关键词：米尔斯坦校园学院建筑悬臂式

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“最佳”首席财务官的特质

中国总会计师 2015年第4期 152-154页

作者： noah P.Barsky Anthony H.Catanach Jr. 美国注册管理会

如果您经常阅读商业文章,就会知道已经有人指出,市场动荡造成的绩效压力是导致CFO不堪重负、流动率不断提高的重要原因。但最近的研究结果显示,流动率屡创新高也可能是因为企业需要更优秀的CFO,以便应对不断变化的市场结构和新战略。因... 详细信息

如果您经常阅读商业文章,就会知道已经有人指出,市场动荡造成的绩效压力是导致CFO不堪重负、流动率不断提高的重要原因。但最近的研究结果显示,流动率屡创新高也可能是因为企业需要更优秀的CFO,以便应对不断变化的市场结构和新战略。因此,围绕CFO的能力出现诸多争议也就不足为奇了。（请参阅《优秀CFO的特质》一文,作者：Andrew Sawers,***,2012年5月18日。）那么到底什么才重要？

关键词：首席财务官特质市场结构 CFO 企业需要流动率商业

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“最佳”CFO的特质

新理财（公司理财） 2013年第10期 102-103页

作者： noah P.Barsky Anthony H.Catanach Jr.

市场混乱让CFO的更替如走马灯一般频繁，也改变了备受追捧的财务技能。动荡带来变化，市场动荡也造成了企业高级管理层的更迭。

关键词： CFO 企业高级管理层特质市场混乱财务技能马灯

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PICOT promotes T lymphocyte proliferation by down-regulating cyclin D2 expression

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World Journal of Immunology 2020年第1期10卷 1-12页

作者： Pinakin Pandya noah Isakov The Shraga Segal Department of Microbiology Immunology and GeneticsFaculty of Health Sciences and the Cancer Research CenterBen Gurion University of the NegevBeer Sheva 84105Israel Department of Computational and System biology UPMC Hillman Cancer CenterUniversity of PittsburghSchool of MedicinePittsburghPA 15232United States

The mammalian protein kinase C-interacting cousin of thioredoxin(PICOT;also termed glutaredoxin 3)is a multi-domain monothiol glutaredoxin that is involved in a wide variety of signaling pathways and biological *** is required for normal and transformed cell growth and is critical for embryonic *** studies in T lymphocytes demonstrated that PICOT can translocate to the nucleus and interact with embryonic ectoderm development,a polycomb group protein and a core component of the polycomb repressive complex 2,which contributes to the maintenance of transcriptional repression and chromatin ***,PICOT was found to interact with chromatin-bound embryonic ectoderm development and alter the extent of histone 3 lysine 27 trimethylation at the promoter region of selected polycomb repressive complex 2 target *** knockdown in Jurkat T cells led to increased histone 3 lysine 27 trimethylation at the promoter region of CCND2,a cell cycle-regulating gene which encodes the cyclin D2 *** a result,the expression levels of CCND2 mRNA and protein levels were reduced,concomitantly with inhibition of the cell growth *** of multiple data sets from the Cancer Genome Atlas revealed that a high expression of PICOT correlated with a low expression of CCND2 in a large number of human *** addition,this parameter correlated with poor patient survival,suggesting that the ratio between PICOT/CCND2 mRNA levels might serve as a predictor of patient survival in selected types of human cancer.

关键词： Protein kinase C-interacting cousin of thioredoxin Glutaredoxin 3 Cyclin D2 Histone methylation T lymphocyte Histone 3 lysine 27 trimethylation

On Farm Demonstration,Testing and Evaluation of Maize Sheller in Meru County

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Journal of Agricultural Science and Technology(B) 2021年第3期11卷 126-134页

作者： Richard Njue noah Wawire The Department of Agricultural Mechanization Agricultural Mechanization Research InstituteMachakosP.O.Box 340-90100Kenya

Maize shelling activity by the small scale farmers is done manually by either stripping with fingers,beating bagged cops with sticks or rubbing two cobs against each *** forms part of maize post-harvest losses which span from harvesting to *** objective of this research was to demonstrate,test and evaluate the maize shellers in Meru *** scope applied to one diesel(control)and three locally fabricated gasoline-powered throw-in type maize shellers and was performed on-farm at three different commercial villages(CVs).Traditional methods of shelling were compared to motorized shellers followed by the comparison between the 8 horsepower(hp)diesel(control)and 5 hp locally fabricated gasoline-powered *** average shelling capacity(1,384 kg/h)and shelling efficiency(97.8%)of the locally fabricated shellers were lower as compared to the control(2,138 kg/h)with a shelling efficiency of 99.93%.The average scattering losses for the locally fabricated shellers were high(12.6%)compared to the control(0.053%).The analysis of variance(ANOVA)revealed control had the highest mean(9.23)and p value>0.05 hence more efficient compared to locally fabricated(9.15).The shellers lacked the cleaning component,hence shelled maize required cleaning by winnowing manually and were not gender friendly since women and people enabled differently(PED)could not operate the machine due to height of the feeding hopper compared to *** took traditional methods longer(59.4 s)to perform a shelling operation compared to using motorized shellers(15 s).The efficient control sheller demonstrated reduced farmers’drudgery and post-harvest losses and was recommended for use by the small scale farmers in the county.

关键词： Shelling fabricated traditional horsepower farmers