Fluorescence Studies of Telomere Maintenance Proteins Reveal Protein-DNA Interaction Dynamics at the Single-molecule Level
作者单位：Department of Environmental and Occupational HealthUniversity of Pittsburgh Graduate School of Public HealthPittsburghPA 15219 Center for Biologic ImagingUniversity of PittsburghPittsburgh15261 Department of BiologyUniversity of EssexColchesterEssex C04 3SQ UK Department of Pharmacology and Chemical BiologyUniversity of Pittsburgh School of Medicine The University of Pittsburgh Cancer InstituteHillman Cancer CenterPittsburghPennsylvania 15213 Department of BiologyUniversity of EssexColchesterEssex CO4 3SQ UK
会议名称：《第十七届国际生物物理大会;第十二届中国生物物理大会》
会议日期：2011年
学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术]
关 键 词：Telomere single-molecule fluorescence atomic force microscopy protein-DNA interactions TRF2
摘 要：Telomeres are nucleoprotein structures that cap the ends of linear *** telomeres are important contributing factors in aging and *** a typical human somatic cell,the telomeric repeat sequence TTAGGG is approximately 2-15 kb in length with a 3 single stranded overhang of 100-200 nt.A specialized protein complex called shelterin binds and protects the human telomeric *** humans,this