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Exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic tumors

Acta Pharmaceutica Sinica B 2024年第7期14卷 3009-3026页

作者： Saini Setua Shabia Shabir Poornima Shaji Ana Martinez Bulnes Anupam Dhasmana Swathi Holla nivesh k.mittal Nirakar Sahoo Tripti Saini Francesco Giorgianni Mohammad Sikander Andrew E.Massey Bilal B.Hafeez Manish k.Tripathi Vincent P.Diego Meena Jaggi Junming Yue Nadeem Zafar Murali M.Yallapu Stephen W.Behrman Sheema khan Subhash C.Chauhan Department of Pharmaceutical Sciences College of Pharmacyand College of MedicineUniversity of Tennessee Health Science Center(UTHSC)MemphisTN 36163USA Department of Computer Science Islamic University of Science and TechnologyAwantiporaJ&K 192122India Department of Immunology and Microbiology School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX 78504USA South Texas Center of Excellence in Cancer Research School of Medicinethe University of Texas Rio Grande ValleyMcAllenTX 78504USA Himalayan School of Biosciences and Cancer Research Institute Himalayan Institute of Medical SciencesSwami Rama Himalayan UniversityDehradun 248016India Plough Center for Sterile Drug Delivery Solutions UTHSCMemphisTN 38104USA Department of Biology College of SciencesUTRGVMcAllenTX 78539USA National Institute of Biomedical Imaging and Bioengineering(NIBIB) National Institutes of HealthBethesdaMD 20892USA South Texas Diabetes and Obesity Institute UTRGVMcAllenTX 78504USA Dept.of Laboratory Medicine&Pathology University of WashingtonSeattleWA 98195USA Department of Surgery Baptist Memorial Medical EducationBaptist Memorial HospitalMemphisTN 38120USA Baptist Health Sciences University MemphisTN 38104USA

The application of extracellular vesicles,particularly exosomes(EXs),is rapidly expanding in the field of medicine,owing to their remarkable properties as natural carriers of biological *** study investigates utilization of exosomes derived from stromal cells of tumor adjacent normal tissues(NAF-EXs)for personalized medicine,which can be derived at the time of diagnosis by endoscopic ***,we show that exosomes(EXs)derived from NAFs demonstrate differential bio-physical characteristics,efficient cellular internalization,drug loading efficiency,pancreatic tumor targeting and delivery of ***-derived EXs(NAF-EXs)were used for loading ormeloxifene(ORM),a potent anti-cancer and desmoplasia inhibitor as a model *** found that ORM maintains normal fibroblast cell phenotype and renders them incompatible to be triggered for a CAF-like phenotype,which may be due to regulation of Ca^(2+) influx in fibroblast ***-EXs-ORM effectively blocked oncogenic signaling pathways involved in desmoplasia and epithelial mesenchymal transition(EMT)and repressed tumor growth in xenograft mouse *** conclusion,our data suggests preferential tropism of NAF-EXs for PDAC tumors,thus imply feasibility of developing a novel personalized medicine for PDAC patients using autologous NAF-EXs for improved therapeutic outcome of anti-cancer ***,it provides the opportunity of utilizing this biological scaffold for effective therapeutics in combination with standard therapeutic regimen.

关键词： Pancreatic cancer Tumor adjacent normal tissue fibroblasts(NAF) Desmoplasia Extracellular vesicles Exosomes Tumor targeting Ormeloxifene Personalized medicine

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Barriers in early detection of colorectal cancer and exploring potential solutions

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World Journal of Clinical Oncology 2024年第7期15卷 811-817页

作者： Maryam Aleissa Ernesto Raul Drelichman Vijay k.mittal Jasneet Singh Bhullar Department of Surgery Ascension Providence HospitalMichigan State University College of Human MedicineSouthfieldMI 48075United States College of Medicine Princess Norah University HospitalRiyadh 11564Saudi Arabia

This editorial discusses the literature review article by Tonini and Zanni,the paper was published in January 2024,and the authors provided very interesting conclusions regarding existing barriers to the early diagnosis of colon *** cancers do not have identifiable precursors,or there are currently no screening tests to find ***,these cancers do not have preventive screening *** detection is crucial for reducing mortality rates by identifying cancer at an earlier stage through screening,as opposed to no *** cancer develops from precancerous lesions,which can be detected early and potentially prevented and *** detection leads to improved survival rates,decreased complications,and reduced healthcare *** editorial provides a brief description of the biology of colon cancer,emphasizing the contrast in outcomes between early detection and late *** also describe screening programs around the globe and examine the barriers in each ***,we explore potential future solutions to enhance inclusion in screening programs and improve patient compliance.

关键词： Colon cancer Rectal cancer Early detection

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Outcomes and efficacy of magnetic resonance imaging-compatible sacral nerve stimulator for management of fecal incontinence: A multi-institutional study

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World Journal of Radiology 2024年第2期16卷 32-39页

作者： Binit katuwal Amy Thorsen kunal kochar Ryba Bhullar Ray king Ernesto Raul Drelichman Vijay k.mittal Jasneet Singh Bhullar Department of Surgery Ascension Providence HospitalMichigan State University College of Human MedicineSouthfieldMI 48075United States Department of Colon and Rectal surgery Alina Health Abbott Northwestern HospitalMinneapolisMN 55407United States Colon and Rectal Surgery Advocate Illinois MasonicPark RidgeIL 60068United States Volunteer Student Department of ResearchAscension Providence HospitalSouthfieldMI 48075United States Colon and Rectal Surgery University of WisconsinMadisonWI 53715United States General and Colorectal Surgery Ascension Providence HospitalMichigan State University College of Human MedicineSouthfieldMI 48075United States Department of Surgery Department of Medical EducationAscension Providence HospitalMichigan State University College of Human MedicineSouthfieldMI 48075United States

BACkGROUND Fecal incontinence(FI)is an involuntary passage of fecal matter which can have a significant impact on a patient’s quality of *** modalities of treatment exist for *** nerve stimulation is a well-established treatment for *** the increased need of magnetic resonance imaging(MRI)for diagnostics,the In-terStim which was previously used in sacral nerve stimulation was limited by MRI *** MRI-compatible InterStim was approved by the United States Food and Drug Administration in August 2020 and has been widely *** To evaluate the efficacy,outcomes and complications of the MRI-compatible *** Data of patients who underwent MRI-compatible Medtronic InterStim placement at UPMC Williamsport,University of Minnesota,Advocate Lutheran General Hospital,and University of Wisconsin-Madison was pooled and *** demographics,clinical features,surgical techniques,complications,and outcomes were *** the Reporting of Observational studies in Epidemiology(STROBE)cross-sectional reporting guidelines were *** Seventy-three patients had the InterStim *** mean age was 63.29±12.2 ***-seven(78.1%)patients were females and forty-two(57.5%)patients had *** addition to incontinence,overlapping symptoms included diarrhea(23.3%),fecal urgency(58.9%),and urinary incontinence(28.8%).Fifteen(20.5%)patients underwent Peripheral Nerve Evaluation before proceeding to definite implant ***-two(43.8%)patients underwent rechargeable InterStim ***(4.1%)patients needed removal of the *** of the external lead connection was observed in 7(9.6%)patients after the stage I *** explanation for one patient was due to ***(9.6%)patients had other complications like nerve pain,hematoma,infection,lead fracture,and *** mean follow-up was 6.62±3.5 ***-eight(93.2%)patients reported significant improvement of symptoms on

关键词： Fecal incontinence Sacral nerve stimulation InterStim Magnetic resonance imaging Sacral neuromodulation

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knowledge and attitude on childhood cancer survivorship among healthcare trainees:a multicentre study from India

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Family Medicine and Community Health 2024年第S2期12卷 34-43页

作者： Amritesh Grewal Bhavik Bansal Chetanya mittal Hardik Gupta Archana Sasi Prasanth Ganesan Aashima Dabas Puneet Sahi Lakshmi Ramamoorthy Hmar Thiak Lalthanthuami Jaikumar Ramamoorthy Arwachi Sindhu Suyash Arora Anumeha Bhukya Muthumani Hepzibah kanchana Devi karthick krishnamurthy Sanjeet k Rai Nikhil Mehta komal Antil Sameer Bakhshi Shuvadeep Ganguly Medical Student All India Institute of Medical SciencesNew DelhiDelhiIndia Department of Medical Oncology Dr.B.R.A.Institute Rotary Cancer HospitalAll India Institute of Medical SciencesNew DelhiDelhiIndia Department of Medical Oncology Jawaharlal Institute of Postgraduate Medical Education and ResearchPuducherryPuducherryIndia Department of Pediatrics Lok Nayak HospitalNew DelhiDelhiIndia Department of Pediatrics Maulana Azad Medical CollegeNew DelhiDelhiIndia College of Nursing Jawaharlal Institute of Postgraduate Medical Education and ResearchPuducherryPuducherryIndia Department of Pediatrics Jawaharlal Institute of Postgraduate Medical Education and ResearchPuducherryPuducherryIndia Medical Student Maulana Azad Medical CollegeNew DelhiDelhiIndia Department of Surgical Disciplines All India Institute of Medical SciencesNew DelhiDelhiIndia Department of Dermatology and Venereology All India Institute of Medical SciencesNew DelhiDelhiIndia College of Nursing All India Institute of Medical SciencesNew DelhiDelhiIndia

Background The proportion of childhood cancer survivors(CCS)in low/middle-income countries(LMICs)is *** often develop several physical and psycho-social long-term adverse effects,with unique healthcare *** healthcare providers(primary care physicians(PCPs)),especially in LMICs,are often not equipped to handle survivorship *** study aimed to assess knowledge,and attitude among trainee healthcare providers concerning major issues of paediatric survivorship *** A multi-centre,cross-sectional,questionnaire-based study was conducted among nursing and medical undergraduate students,and postgraduate medical residents across three tertiary-care teaching hospitals in India—All India Institute of Medical Sciences,New Delhi;Jawaharlal Institute of Postgraduate Medical Education and Research,Puducherry;and Maulana Azad Medical College,New Delhi.A questionnaire with total of 24 questions(14 knowledge-based and 10 attitude-based)was finalised after validation by expert review and *** major domains covered in the questionnaire included knowledge and attitude regarding long-term adverse effects and psychosocial,employment-related issues faced by the *** was administered to the study participants *** knowledge-based questions had true/false responses(scored as 0 or 1 if incorrect or correct,respectively).Attitude-based questions were scored as 5-point Likert *** Total 898 responses were collected(median age:21 years,64%(576/898)female).Among the respondents,44%were undergraduate medical students,42%were nursing students and 14%were postgraduate medical *** mean(SD)of knowledge score was 8.72(2.04)(out of 14).On multivariable analysis,only discipline of training predicted knowledge scores regarding survivorship *** medical residents(9.08)as well as undergraduate medical students(8.85),had significantly higher mean knowledge scores than nursing students(8.47)(p=0.004).Two questions were

关键词： centre handle false

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Integrated search technique for parameter determination of SVM for speech recognition

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Journal of Central South University 2016年第6期23卷 1390-1398页

作者： Teena mittal R.k.Sharma Department of Electronics and Communication Engineering Thapar University Department of Computer Science and Engineering Thapar University

Support vector machine(SVM)has a good application prospect for speech recognition problems;still optimum parameter selection is a vital issue for *** improve the learning ability of SVM,a method for searching the optimal parameters based on integration of predator prey optimization(PPO)and Hooke-Jeeves method has been *** PPO technique,population consists of prey and predator *** prey particles search the optimum solution and predator always attacks the global best prey *** solution obtained by PPO is further improved by applying Hooke-Jeeves *** method is applied to recognize isolated words in a Hindi speech database and also to recognize words in a benchmark database TI-20 in clean and noisy environment.A recognition rate of 81.5%for Hindi database and 92.2%for TI-20 database has been achieved using proposed technique.

关键词： support vector machine (SVM) predator prey optimization speech recognition Mel-frequency cepstral coefficients wavelet packets Hooke-Jeeves method

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Impact of source and drain contact thickness on the performance of organic thin film transistors

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Journal of Semiconductors 2014年第12期35卷 21-27页

作者： Poornima mittal Y.S.Negi R.k.Singh Department of Electronics & Communication Engineering Graphic Era UniversityDehradun–248002 India Department of Electronics & Communication Engineering Uttarakhand Technical UniversityDehradun–248002 India Department of Polymer and Process Engineering Indian Institute of Technology Roorkee–246776 India

This paper analyzes the impact of source（ts） and drain（td） contact thicknesses on top contact（TC） and bottom contact（BC） organic thin film transistors（OTFTs） with a gate in the bottom, using a benchmarked industry standard Atlas 2-D numerical device simulator. The parameters including drive current（Ids）, mobility（μ）, threshold voltage（Vt）and current on-off ratio（ION/IOFF） are analyzed from the device physics point of view on different electrode thicknesses, ranging from infinitesimal to 50 nm, for both top and bottom contact structures. Observations demonstrate that the performance of the BC structure is more affected by scaling of ts=din comparison to its counterpart. In the linear region, the mobility is almost constant at all the values of ts=dfor both structures. However,an increment of 18% and 83% in saturation region mobility is found for TC andBC structures, respectively with scaling down ts=dfrom 50–0 nm. Besides this, the current on-off ratio increases more sharply in the BC *** analysis simplifies a number of issues related to the design and fabrication of organic material based devices and circuits.

关键词： contact thickness organic semiconductor organic thin film transistor bottom contact top contact structure

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Utilization of pulp and paper industrial wastewater for production of polyhydroxybutyrate by Bacillus sonorensis NAM5

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Systems Microbiology and Biomanufacturing 2023年第4期3卷 805-818页

作者： Mahak.mittal Anish Bhuwal Poonam Sharma Neeraj k.Aggarwal Laboratory of Fermentation Technology Department of MicrobiologyKurukshetraHaryana 136119India

Given the environmental pollution caused by petroleum-based plastics,finding alternative substitutes for sustainability has become ***(PHB),a storage food material that is accumulated by several bacteria,is biodegrad-able,safe,environment friendly and comparable to conventional ***,scale-up is an issue due to high produc-tion *** replacement using renewable,plentiful,sustainable and low-cost carbon sources derived from industrial waste facilitates waste reduction,while also enabling the synthesis of value-added *** this context,inexpensive pulp and paper industrial waste as carbon source was exploited for production of PHB by using previously isolated(Source:hot springs of Manikarn,Himachal Pradesh,India)thermophilic bacteria Bacillus sonorensis NAM5 under optimized conditions in a *** was done in a fermenter under optimized conditions(72 h of incubation at 50℃temperature and 7 pH)to enhance the accumulation of *** bacterial strain was able to produce 5.28±0.11 gL^(-1)after 72 h of growth without any carbon and nitrogen source supplementation to the industrial *** culture accumulated 66%PHB of cell dry weight(CDW).The produced polymer was characterized through FTIR,NMR and ***,bacteria-treated industrial wastewater was used for phytotoxicity assay on agriculturally important crops such as wheat,maize and mung,which exhibited considerable difference in growth parameters.

关键词： Polyhydroxybutyrate Pulp and paper waste Fermentation Bacillus sonorensis Phytotoxicity assay

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Protease inhibitors:recent advancement in its usage as a potential biocontrol agent for insect pest management

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Insect Science 2020年第2期27卷 186-201页

作者： Sujata Singh Archana Singh Sumit kumar Pooja mittal Indrakant k.Singh Molecular Biology Research Laboratory Department of ZoologyDeshbandhu CollegeUniversity of DelhiKalkajiNew DelhiIndia Department of Botany Hans Raj CollegeUniversity of DelhiDelhiIndia

Plant derived protease inhibitors(PIs)are a promising defensin for crop im-provement and insect pest *** agronomist made significant efforts in utilizing PIs for managing insect *** potentials of PIs are still *** ability to compensate nutrient starvation induced by dietary PI feeding using different strategies,that is,overexpression of PI-sensitive protease,expression of PI-insensitive proteases,degradation of PI,has made this innumerable collection of PIs worthless.A practical challenge for agronomist is to identify potent PI candidates,to limit insect compensatory responses and to elucidate insect compensatory and resistance mechanisms activated upon *** knowledge could be further efficiently utilized to identify potential targets for RNAi-mediated pest *** vital genes of insects could be functionally anno-tated using the advanced gene-editing technique,CRISPR/*** research is exploiting different in silico and modern molecular biology techniques to utilize PIs in controlling insect pests *** review is structured to update recent advancements in this field,along with is chronological background.

关键词： gene stacking insect pest management PI transgenic proteases protease inhibitors transplastomic

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如何防止透平机械磁化

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化工装备技术 1986年第3期 37-38页

作者： Ashok k.mittal ,严培德

透平机的压缩机在运转中由于强的轴电流作用,有时会象发电机那样产生电能,结果导致设备的机械部件损坏,失去生产能力。在这种情况下,技术人员往往单纯地将磨损部件替换下来,装上新的,但结果发现使用一段时期后,新换上的部件又发生磨损,... 详细信息

透平机的压缩机在运转中由于强的轴电流作用,有时会象发电机那样产生电能,结果导致设备的机械部件损坏,失去生产能力。在这种情况下,技术人员往往单纯地将磨损部件替换下来,装上新的,但结果发现使用一段时期后,新换上的部件又发生磨损,这说明这些技术人员对部件损坏的真正原因

关键词：电刷密封件转轴碳刷集电装置透平机械轴电流剩磁强度机械部件轴承剩余磁场地磁场

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Role of Cholesterol Crystals During Acute Myocardial Infarction and Cerebrovascular Accident

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Cardiovascular Innovations and Applications 2017年第B5期2卷 347-362页

作者： Jagadeesh k.kalavakunta,MD Mayank k.mittal,MD Abed Janoudi,PhD Oliver G.Abela,MD Fadi Alreefi,MD George S.Abela,MSc,MD Department of Cardiology Michigan State University/Borgess Medical CenterKalamazooMIUSA Department of Medicine/Cardiology Michigan State UniversityEast LansingMIUSA Department of Medicine/Cardiology University of NevadaLas VegasUSA

Cholesterol crystals have long been recognized as part of atherosclerotic *** have been visualized by light microscopy as empty spaces or imprints where crystals were once present and then dissolved by tissue ***,until now,their role in atherosclerosis and plaque rupture had been considered to be ***,by the processing of tissue without ethanol it was possible to visualize their extensiveness and potential role in tissue ***,it was demonstrated that cholesterol expands in volume when crystallizing from the liquid to the solid state,which is the presumed cause of plaque rupture by sharp-tipped crystals growing out of the plaque's necrotic *** cally,in patients who died of myocardial infarction,all culprit coronary lesions had extensive cholesterol crystals perforating the fibrous cap and intima,while those patients who died of other causes and had plaques did not have crystals perforating the cap and ***,cholesterol crystals traveling downstream from the plaque rupture site can scrape the endothelium and promote ***,cholesterol crystals lodging into the muscle can trigger an inflammation with necrosis independent of circulatory compromise or *** findings suggest that cholesterol crystals could play a critical role in plaque rupture,as well as vascular and myocardial injury.

关键词： cholesterol crystals myocardial infarction stroke

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