检索结果-南通市图书馆

Emergence of taurine as a therapeutic agent for neurological disorders

Neural Regeneration Research 2024年第1期19卷 62-68页

作者： Ashok Jangra Priyanka Gola Jiten Singh Pooja Gond Swarnabha Ghosh Mahesh Rachamalla Abhijit Dey Danish Iqbal Mehnaz Kamal Punya Sachdeva Saurabh kumar jha Shreesh Ojha Dinesh kumar niraj kumar jha Hitesh Chopra Shing Cheng Tan Department of Pharmaceutical Sciences Central University of HaryanaMahendergarhHaryanaIndia Department of Biology University of SaskatchewanSaskatoonSKCanada Department of Life Sciences Presidency UniversityKolkataWest BengalIndia Department of Health Information Management College of Applied Medical SciencesBuraydah Private CollegesBuraydahSaudi Arabia Department of Pharmaceutical Chemistry College of PharmacyPrince Sattam Bin Abdulaziz UniversityAl-KharjSaudi Arabia GloNeuro Vishwakarma RoadNoidaIndia Department of Biotechnology School of Engineering&Technology(SET)Sharda UniversityGreater NoidaUttar PradeshIndia Department of Pharmacology and Therapeutics College of Medicine and Health SciencesUnited Arab Emirates UniversityAl AinUnited Arab Emirates School of Bioengineering&Biosciences Lovely Professional UniversityPhagwaraIndia Department of Biotechnology School of Applied&Life Sciences(SALS)Uttaranchal UniversityDehradunIndia Chitkara College of Pharmacy Chitkara UniversityPunjabIndia UKM Medical Molecular Biology Institute Universiti Kebangsaan MalaysiaKuala LumpurMalaysia

Taurine is a sulfur-containing,semi-essential amino acid that occurs naturally in the *** alternates between inflammation and oxidative stress-mediated injury in various disease *** part of its limiting functions,taurine also modulates endoplasmic reticulum stress,Ca^(2+)homeostasis,and neuronal activity at the molecular *** effectively protects against a number of neurological disorders,including stro ke,epilepsy,cerebral ischemia,memory dysfunction,and spinal cord *** various therapies are available,effective management of these disorders remains a global *** 30 million people are affected *** design of taurine fo rmation co uld lead to potential drugs/supplements for the health maintenance and treatment of central nervous system *** general neuroprotective effects of taurine and the various possible underlying mechanisms are discussed in this *** article is a good resource for understanding the general effects of taurine on various *** the strong evidence for the neuropharmacological efficacy of taurine in various experimental paradigms,it is concluded that this molecule should be considered and further investigated as a potential candidate for neurotherapeutics,with emphasis on mechanism and clinical studies to determine efficacy.

关键词： antioxidant epilepsy γ-amino butyric acid neurodegenerative disorders neuroprotection oxidative stress spinal cord injury taurine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Molecular basis of fluoride toxicities:Beyond benefits and implications in human disorders

引用

Genes & Diseases 2023年第4期10卷 1470-1493页

作者： Priyankar Pal niraj kumar jha Debankur Pal Saurabh kumar jha Uttpal Anand Abilash Valsala Gopalakrishnan Abhijit Dey Prabir kumar Mukhopadhyay Department of Life Sciences Presidency UniversityKolkataWest Bengal 700073India Department of Biotechnology School of Engineering and Technology(SET)Sharda UniversityGreater NoidaUttar Pradesh 201310India Department of Biotechnology School of Applied&Life Sciences(SALS)Uttaranchal UniversityDehradun 248007India Department of Biotechnology Engineering and Food Technology Chandigarh UniversityMohali 140413India Department of Life Sciences Ben-Gurion University of the NegevBeer-Sheva 84105Israel Department of Biomedical Sciences School of Bio Sciences and TechnologyVellore Institute of Technology(VIT)VelloreTamil Nadu 632014India

Detrimental impacts of fluoride have become a global concern for several *** its beneficial role which is restricted only in skeletal tissues,deleterious effects are also observed in soft tissues and *** generation of enhanced oxidative stress is the commencement of excess fluoride exposure which may lead to cell *** causes cell death through autophagy via Beclin 1 and mTOR signaling *** these,several or-gan specific anomalies through different signaling pathways have been ***-drial dysfunction,DNA damage,autophagy and apoptosis are the damaging outcomes in case of hepatic *** concentration defects and cell cycle arrest have been reported in renal *** immune response has been characterized in the cardiac ***-tive dysfunction,neurodegenerative condition and learning impairment have also been *** steroidogenesis,gametogenic abnormalities,epigenetic alterations and birth defect are the major reprotoxic *** immune responses,altered immu-nogenic proliferation,differentiation as well as altered ratio of immune cells are well-defined anomalies in the immune *** the mechanistic approach of fluoride toxicity in phys-iological systems is common,it follows different signaling *** review emphasizes diverse signaling pathways which are the targets of overexposed fluoride.

关键词： Fluoride Autophagy Mitochondrial dysfunction Signaling cascades System disorders

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Application of Response Surface Methodology for Analysing and Optimizing the Finned Solar Air Heater

引用

Journal of Thermal Science 2024年第3期33卷 985-1009页

作者： Vineet SINGH Vinod Singh YADAV Vaibhav TRIVEDI Manoj kumar niraj kumar Department of Mechanical Engineering School of Engineering&TechnologyIFTM UniversityMoradabadUttar PradeshIndia Department of Mechanical Engineering NITUttarakhandPauriUttarakhandIndia Department of Electronics and Communication Engineering Jaypee Institute of Information TechnologyNoidaUttar Pradesh201309India

In this research paper,a solar air heater with triangular fins has been experimentally analysed and ***,an experimental set-up of a solar air heater having triangular fins has been developed at the location of 28.10°N,78.23°*** heat transfer rate through fins and fins efficiency has been determined by the Finite Difference Method model *** experimental data and modeled data of response parameters have been optimized in MINITAB-17 software by the Response Surface Methodology *** creating the response surface design,three input parameters have been selected namely solar intensity,Reynolds number,and fin base-to-height *** range of solar intensity,Reynolds number,and fin base-to-height ratio is 600 to 1000W/m^(2),4000 to 6000,and 0.4 to 0.8 *** response surface design has been analyzed by calculating the outlet temperature,friction factor,Nusselt number,fin efficiency,thermal performance factor,and exergy *** optimum settings of input parameters:solar intensity is 1000 W/m^(2);Reynolds number is 4969.7,and the fin base to height ratio is 0.6060,on which these response:namely outlet temperature of 92.531℃,friction factor of 0.2350,Nusselt number of 127.761,thermal efficiency of 50.836%,thermal performance factor of 1.4947,and exergy efficiency of 8.762%.

关键词： solar air heater optimization fins exergy response surface methodology air

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Novel Multi-objective Protection Coordination Scheme for a Microgrid with Optimal Deployment of Dual-setting ROCOV Based Relays

引用

Protection and Control of Modern Power Systems 2024年第4期9卷 23-38页

作者： Praveen kumar Gupta Priyanshul Niranjan niraj kumar Choudhary Nitin Singh Ravindra kumar Singh the Department of Electrical Engineering Motilal Nehru National Institute of Technology AllahabadPrayagraj 211004India

Relay coordination is crucial in electrical power systems to protect against malfunctions and damage caused by unexpected events like short *** address the challenge associated with the reverse direction of fault current,dual-setting(DS)directional over-current relays have evolved but failed to provide proper coordination during changes of load,generation,and *** the meantime,with the increasing number of DS relays,the total relay operating time tends to ***,this paper proposes a protection scheme based on the optimal deployment of conventional and dual-setting rate of change of voltage(DS-ROCOV)relays in distribution *** holds true for varying network topologies and is unaffected by variations in load and *** objective of the proposed scheme is to ensure reliable and efficient protection against faults in distribution systems by minimizing the overall operating time with the optimal number of DS-ROCOV *** proposed protection scheme’s performance is evaluated for different coordination time interval values as well as in different microgrid *** paper outlines the design and implementation of the proposed protection scheme which is validated on the modified IEEE 14-bus system using simulations in Matlab/Simulink.

关键词： Coordination time interval DS-ROCOV relay multi-objective optimization optimal-deployment protection coordination

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Massless Dirac perturbations of black holes in f(Q)gravity:quasinormal modes and a weak deflection angle

引用

Communications in Theoretical Physics 2024年第9期76卷 73-82页

作者： Ahmad Al-Badawi Sohan kumar jha Department of Physics Al-Hussein Bin Talal UniversityPO Box 2071111Ma'anJordan Department of Physics Chandernagore CollegeChandernagoreHooghlyWest BengalIndia

This article considers a static and spherical black hole(BH)in f(Q)gravity.f(Q)gravity is the extension of symmetric teleparallel general relativity,where both curvature and torsion are vanishing and gravity is described by *** this study,we investigate the possible implications of quasinormal mode(QNM)modified Hawking spectra and deflection angles generated by the *** Wentzel–Kramers–Brillouin method is used to solve the equations of motion for massless Dirac perturbation fields and explore the impact of the nonmetricity parameter(Q_(0)).Based on the QNM computation,we can ensure that the BH is stable against massless Dirac perturbations and as Q_(0)increases the oscillatory frequency of the mode *** then discuss the weak deflection angle in the weak field limit *** compute the deflection angle up to the fourth order of approximation and show how the nonmetricity parameter affects *** find that the Q_(0)parameter reduces the deflection angle.

关键词： black holes in f(Q)gravity massless Dirac perturbations quasinormal modes deflection angle

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Proposed numerical and machine learning models for fiber-reinforced polymer concrete-steel hollow and solid elliptical columns

引用

Frontiers of Structural and Civil Engineering 2024年第8期18卷 1169-1194页

作者： Tang QIONG Ishan jha Alireza BAHRAMI Haytham F.ISLEEM Rakesh kumar Pijush SAMUI School of Applied Technologies Qujing Normal UniversityQujing 655011China Department of Civil Engineering Indian Institute of Technology-BHUVaranasi 221005India Department of Building Engineering Energy Systems and Sustainability ScienceFaculty of Engineering and Sustainable DevelopmentUniversity of GävleGävle 80176Sweden Department of Civil Engineering National Institute of Technology-PatnaPatna 800005India

This study employs a hybrid approach,integrating finite element method(FEM)simulations with machine learning(ML)techniques to investigate the structural performance of double-skin tubular columns(DSTCs)reinforced with glass fiber-reinforced polymer(GFRP).The investigation involves a comprehensive examination of critical parameters,including aspect ratio,concrete strength,number of GFRP confinement layers,and dimensions of steel tubes used in DSTCs,through comparative analyses and parametric *** ensure the credibility of the findings,the results are rigorously validated against experimental data,establishing the precision and trustworthiness of the *** present research work examines the use of the columns with elliptical cross-sections and contributes valuable insights into the application of FEM and ML in the design and evaluation of structural systems within the field of structural engineering.

关键词： elliptical column fiber-reinforced polymer machine learning finite element method ABAQUS

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Helicobacter pylori isolated from gastric juice have higher pathogenic potential than biopsy isolates

引用

Genes & Diseases 2024年第1期11卷 34-37页

作者： Budhadev Baral Dharmendra Kashyap Nidhi Varshney Tarun Prakash Verma Ajay kumar Jain Debi Chatterji Vinod kumar Amit Mishra Awanish kumar Hem Chandra jha Infection Bioengineering Group Department of Biosciences and Biomedical EngineeringIndian Institute of Technology IndoreSimrolIndoreMadhya Pradesh 453552India Choithram Hospital and Research Center IndoreMadhya Pradesh452014India Department of Metallurgy Engineering and Materials Science Indian Institute of Technology IndoreSimrolIndoreMadhya Pradesh 453552India Department of Bioscience&Bioengineering Indian Institute of Technology JodhpurNH 65 Nagaur RoadJodhpur DistrictKarwarRajasthan 342037India Department of Biotechnology National Institute of Technology RaipurGE RoadRaipurChhattisgarh 492010India

Persistent gastritis induced by Helicobacter pylori(***)is the strongest known risk factor for gastric cancer(GC).*** is prevalent in about 50%world's population,while it causes cancer in less than 2%of exposed individuals.1 Our studies found that *** infection can induce oncogenic properties in AGS cells by deregulating multiple factors associated with the cell cycle,apoptosis,and other important events associated with cancer progression.

关键词： H.pylori pylori Helicobacter

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Improved neurological diagnoses and treatment strategies via automated human brain tissue segmentation from clinical magnetic resonance imaging

引用

Intelligent Medicine 2024年第3期4卷 161-169页

作者： Puranam Revanth kumar Rajesh kumar jha P Akhendra kumar B Deevena Raju Department of Electronics and Communication Engineering Faculty of Science and TechnologyICFAI Foundation for Higher EducationHyderabadIndia Department of Data Science&AI Faculty of Science and TechnologyICFAI Foundation for Higher EducationHyderabadIndia

Objective Segmentation of medical images is a crucial process in various image analysis *** segmentation methods excel in accuracy when compared to manual segmentation in the context of medical image *** of the essential phases in the quantitative analysis of the brain is automated brain tissue segmentation using clinically obtained magnetic resonance imaging(MRI)*** allows for precise quantitative examination of the brain,which aids in diagnosis,identification,and classification of ***,the efficacy of the segmentation approach is crucial to disease diagnosis and treatment *** This study presented a hybrid optimization method for segmenting brain tissue in clinical MRI scans us-ing a fractional Henry horse herd gas optimization-based Shepard convolutional neural network(FrHHGO-based ShCNN).To segment the clinical brain MRI images into white matter(WM),grey matter(GM),and cerebrospinal fluid(CSF)tissues,the proposed framework was evaluated on the Lifespan Human Connectome Projects(HCP)*** hybrid optimization algorithm,FrHHGO,integrates the fractional Henry gas optimization(FHGO)and horse herd optimization(HHO)*** required 30 min,whereas testing and segmentation of brain tissues from an unseen image required an average of 12 *** Compared to the results obtained with no refinements,the Skull stripping refinement showed significant *** the method included a preprocessing stage,it was flexible enough to enhance image quality,allowing for better results even with low-resolution *** precision of 93.2%,recall of 91.5%,Dice score of 91.1%,and F1-score of 90.5% were achieved using the proposed FrHHGO-based ShCNN,which was superior to all other approaches.

关键词： Brain tissue segmentation Deep learning Magnetic resonance imaging Optimization technique Shepard convolutional neural network

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Higher Grain-Filling Rate in Inferior Spikelets of Tolerant Rice Genotype Offset Grain Yield Loss under Post-Anthesis High Night Temperatures

引用

Rice science 2024年第5期31卷 572-586,I0059-I0061页

作者： Nitin SHARMA Bhupinder SINGH Subbaiyan Gopala KRISHNAN Haritha BOLLINEDI Pranab kumar MANDAL Milan kumar LAL Prakash kumar jha P.V.Vara PRASAD Anjali ANAND Division of Plant Physiology Indian Council of Agricultural Research(ICAR)-Indian Agricultural Research Institute(IARI)New Delhi 110012India Division of Environment Science ICAR-IARINew Delhi 110012India Division of Genetics ICAR-IARINew Delhi 110012India ICAR-National Institute for Plant Biotechnology New Delhi 110012India Division of Crop Physiology and Biochemistry ICAR-National Rice Research InstituteCuttack 753006India Department of Plant and Soil Sciences Mississippi State UniversityStarkvilleMS 39762USA Feed the Future Innovation Lab for Collaborative Research on Sustainable Intensification Kansas State UniversityManhattanKS 66506USA Department of Agronomy Kansas State UniversityManhattanKS 66506USA

Increased nighttime respiratory losses decrease the amount of photoassimilates available for plant growth and yield. We hypothesized that the increased respiratory carbon loss under high night temperatures(HNT) could be compensated for by increased photosynthesis during the day following HNT exposure. Two rice genotypes, Vandana(HNT-sensitive) and Nagina 22(HNT-tolerant), were exposed to HNT(4 ℃ above the control) from flowering to physiological maturity. They were assessed for alterations in the carbon balance of the source(flag leaf) and its subsequent impact on grain filling dynamics and the quality of spatially differentiated sinks(superior and inferior spikelets). Both genotypes exhibited significantly higher night respiration rates. However, only Nagina 22 compensated for the high respiration rates with an increased photosynthetic rate, resulting in a steady production of total dry matter under HNT. Nagina 22 also recorded a higher grain-filling rate, particularly at 5 and 10 d after flowering, with 1.5- and 4.0-fold increases in the translocation of ^(14)C sugars to the superior and inferior spikelets, respectively. The ratio of photosynthetic rate to respiratory rate on a leaf area basis was negatively correlated with spikelet sterility, resulting in a higher filled spikelet number and grain weight per plant, particularly for inferior grains in Nagina 22. Grain quality parameters such as head rice recovery, high-density grains, and gelatinization temperature were maintained in Nagina 22. An increase in the rheological properties of rice flour starch in Nagina 22 under HNT indicated the stability of starch and its ability to reorganize during the cooling process of product formation. Thus, our study showed that sink adjustments between superior and inferior spikelets favored the growth of inferior spikelets, which helped to offset the reduction in grain weight under HNT in the tolerant genotype Nagina 22.

关键词： high night temperature inferior grain pasting property radiolabeled sugar superior grain

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Efficacy of stromal vascular fraction for knee osteoarthritis:A prospective,single-centre,non-randomized study with 2 years follow-up

引用

World Journal of Orthopedics 2024年第5期15卷 457-468页

作者： Madhan Jeyaraman Naveen Jeyaraman Tarun Jayakumar Swaminathan Ramasubramanian Rajni Ranjan Saurabh kumar jha Ashim Gupta Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennaiTamil Nadu 600077India Department of Biotechnology School of Engineering and TechnologySharda UniversityGreater NoidaUttar Pradesh 201310India Department of Orthopaedics and Regenerative Medicine South Texas Orthopaedic Research InstituteLaredoTX 78045United States Department of Orthopaedics KIMS-Sunshine HospitalHyderabadTelangana 500032India Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennaiTamil Nadu 600002India Department of Orthopaedics School of Medical Sciences and ResearchSharda UniversityGreater NoidaUttar Pradesh 201306India Department of Zoology Kalindi CollegeUniversity of DelhiNew Delhi 110008India Department of Orthopaedics and Regenerative Medicine Regenerative OrthopaedicsNoida 201301Uttar PradeshIndia Department of Orthopaedics and Regenerative Medicine Future BiologicsLawrencevilleGA 30043United States Department of Orthopaedics and Regenerative Medicine BioIntegrateLawrencevilleGA 30043United States

BACKGROUND Current osteoarthritis(OA)treatments focus on symptom relief without addressing the underlying disease *** regenerative medicine,current treatments have *** regenerative medicine,more research is needed for intra-articular stromal vascular fraction(SVF)injections in OA,including dosage optimization,long-term efficacy,safety,comparisons with other treatments,and mechanism *** To compare the efficacy of intra-articular SVF with corticosteroid(ICS)injections in patients with primary knee *** The study included 50 patients with Kellgren-Lawrence grades II and III *** were randomly assigned(1:1)to receive either a single intra-articular SVF injection(group A)or a single intra-articular ICS(triamcinolone)(group B)*** were followed up at 1,3,6,12,and 24 *** analog score(VAS)and International Knee Documentation Committee(IKDC)scores were administered before the procedure and at all *** safety of SVF in terms of adverse and severe adverse events was *** analysis was performed with SPSS Version 26.0,IBM Corp,Chicago,IL,United *** Both groups had similar demographics and baseline clinical ***-up showed minor patient loss,resulting in 23 and 24 in groups A and B *** A experienced a notable reduction in pain,with VAS scores decreasing from 7.7 to 2.4 over 24 months,compared to a minor reduction from 7.8 to 6.2 in Group *** difference in pain reduction in group A was statistically significant from the third month ***,Group A showed significant improvements in knee functionality,with IKDC scores rising from 33.4 to 83.10,whereas Group B saw a modest increase from 36.7 to *** improvement in Group A was statistically significant from 6 months and maintained through 24 *** Our study demonstrated that intra-articular administration of SVF can lead to reduced pain and improved knee function in pa

关键词： Knee osteoarthritis Adipose tissue Stromal vascular fraction Regenerative medicine Orthobiologics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：