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An effective strategy for dendrite free Li metal anodes:Nickel foam decorated with high lattice-matching CoN and CoF_(2) nanosheets for dense deposition

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Nano Research 2024年第5期17卷 4069-4078页

作者： Wenlong liu Jianzong Man Xiaodong Sun ning Zhang Yehong Du kun liu Zhongsheng Wen Song Li Juncai Sun Institute of Materials and Technology Dalian Maritime UniversityDalian 116026China Shandong Provinvial Key Laboratory of Chemical Energy Storage and Novel Cell Technology and School of Chemistry and Chemical enginneringLiaocheng UniversityLiaocheng 252000China Department of Public Security Management Liaoning Police CollegeDalian 116036China

The notorious dendrite and infinite volume change seriously restrict the advancement of lithium metal anodes(LMAs),during the long-term process of stripping/***,the nanosheets of metal fluoride(CoF_(2))and metal nitride(CoN)with magnificent lithiophilicity on the nickel(Ni)foam are designed as the“regulator”to uniform the Li plating and build stronger solid electrolyte interface(SEI)layer for dendrite free *** Ni foam offers abundant space to receive deposited Li *** CoN nanosheets can guarantee the fast transfer of electrons,which provides a stable interface of Li^(+)***,the nanosheet structure with lithiophilicity would accelerate the move of Li+and decrease the nucleation barrier,due to the high lattice-matching of Li and ***,the CoF_(2) could increase the content of F(LiF)in the SEI layer,which enhances the strength and avoids the destruction of SEI *** the cooperation of CoN and CoF_(2),the composited anode(Li/NF@CNCF)exhibits ultra-long cycle performance(more than 1200 h)and fantastic structure stability at 1 mA·cm^(-2) with 1 mAh·cm^(-2).Based on the LiFePO_(4) and Li/NF@CNCF,the full cells deliver excellent specifical capacity and steady coulombic *** strategy contributes an effective approach to alleviate the issues of lithium metal anodes in the field of LMAs.

关键词： CoN and CoF_(2) lattice-matching nanosheet lithiophilicity lithium metal anodes

Major royal-jelly proteins intake modulates immune functions and gut microbiota in mice

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Food Science and Human Wellness 2024年第1期13卷 444-453页

作者： Hang Wu Shican Zhou Wenjuan ning Xiao Wu Xiaoxiao Xu Zejin liu Wenhua liu kun liu Lirong Shen Junpeng Wang Infection and Immunity Institute and Translational Medical Center of Huaihe Hospital Henan UniversityKaifeng 475000China College of Biology Science and Engineering Hebei University of Economics and BusinessShijiazhuang 050061China College of Biosystems Engineering and Food Science Zhejiang Key Laboratory for Agro-Food ProcessingZhejiang UniversityHangzhou 310058China

In this study,we investigated the effects of major royal jelly proteins(MRJPs)on the estrogen,gut microbiota,and immunological responses in *** given 250 or 500 mg/kg,not 125 mg/kg of MRJPs,enhanced the proliferation of splenocytes in response to *** splenocytes and mesenteric lymphocytes activated by T-cell mitogens(Con A and anti-CD3/CD28 antibodies)released high levels of IL-2 but low levels of IFN-γand *** release of IL-4 was unaffected by ***,splenocytes and mesenteric lymphocytes activated by LPS were prevented by MRJPs at the same dose as that required for producing IL-1βand IL-6,two pro-inflammatory *** production of IL-1β,IL-6,and IFN-γwas negatively associated with estrogen levels,which were higher in the MRJP-treated animals than in the control *** of the gut microbiota revealed that feeding mice 250 mg/kg of MRJPs maintained the stability of the natural intestinal microflora of ***,the LEf Se analysis identified biomarkers in the MRJP-treated mice,including Prevotella,Bacillales,Enterobacteriales,Gammaproteobacteria,Candidatus_Arthromitus,and *** results showed that MRJPs are important components of royal jelly that modulate host immunity and hormone levels and help maintain gut microbiota stability.

关键词： Major royal-jelly proteins Immunity Estrogen Gut microbiota Cytokines

Hippocampal dopamine as a key regulator for learning deficits in Parkinson's disease

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Neural Regeneration Research 2024年第6期19卷 1193-1194页

作者： kun Wu Shuai liu Shanghai Key Laboratory of Brain Functional Genomics(Ministry of Education) Affiliated Mental Health Center(ECNU)School of Psychology and Cognitive ScienceEast China Normal UniversityShanghaiChina Shanghai Changning Mental Health Center ShanghaiChina NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai ShanghaiChina

Parkinson's disease(PD)is a progressive neurodegenerative disorder with clinical symptoms of involuntary or uncontrollable movements such as tremors,rigidity,and *** learning deficit is largely overlooked in the past ... 详细信息

关键词： impaired dopamine clinical

Sub-nanosized vanadate hybrid clusters maintain glucose homeostasis and restore treatment response in inflammatory disease in obese mice

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Nano Research 2024年第3期17卷 1818-1826页

作者： kun Chen Shengqiu liu Yujun Wei South China Advanced Institute for Soft Matter Science and Technology School of Emergent Soft MatterSouth China University of TechnologyGuangzhou 510641China Guangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing South China University of TechnologyGuangzhou 510641China Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices South China University of TechnologyGuangzhou 510641China

Obesity is closely related with insulin resistance and chronic ***,we report that unsaturated lipid-modified polyoxovanadates(ULPOVs)can restrict weight gain of diet-induced obese mice and improve their glycemic control and obesity-associated *** administration of the sub-nanosized ULPOVs at a low dosage for 7 weeks reduces the body weight and almost normalizes the blood glucose levels of obese mice fed on a high-fat *** treatment increases the activity of the nuclear receptor peroxisome proliferator-activated receptorγ(PPARγ)and reduces intestinal caloric intake,which may be the main reason for blood sugar and body weight *** addition to insulin-sensitizing,PPARγactivation induced by ULPOV treatment in obese mice with atopic dermatitis(AD)promotes the type 2 T helper(TH_(2))cell selective responses and therapeutic effects on immune dysregulation caused by *** data suggest sub-nanosized polyoxovanadate clusters as a class of potential candidates to relieve symptoms accompanied by diet-induced obesity.

关键词： polyoxovanadates lipid modification glucose homeostasis obesity inflammatory disease peroxisome proliferator-activated receptorγ(PPARγ)

Sensitivity of ghost imaging compared to conventional imaging [Invited]

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Chinese Optics Letters 2024年第6期22卷 15-32页

作者： Long-kun Du Shuai Sun Yao-kun Xu Hui-Zu Lin ning-Yi Leng Wei-Tao liu Institute for Quantum Science and Technology College of ScienceNational University of Defense TechnologyChangsha 410073China Interdisciplinary Center of Quantum Information National University of Defense TechnologyChangsha 410073China Hunan Key Laboratory of Mechanism and Technology of Quantum Information Changsha 410073China College of Electronic Science and Technology National University of Defense TechnologyChangsha 410073China Department of Mathematics College of ScienceNational University of Defense TechnologyChangsha 410073China

Ghost imaging has been attracting more and more attention, which provides a way to obtain images of objects with only a single-pixel detector. Considering possible applications, it becomes urgent to clarify the sensitivity of ghost imaging. Due to the unique characteristics of single-pixel detectors, which collect photons without distributing them to multiple pixels,often outperforming array sensors, ghost imaging is believed to be more sensitive than conventional imaging. However,a systematic analysis on the sensitivity of ghost imaging is yet to be completed. In this paper, we present a method for quantitatively assessing the sensitivity of ghost imaging. A detailed comparison is provided between ghost imaging and conventional imaging, taking into account the particle nature of photons and the noise of detection. With the settings of the two imaging methods being the same to the most extent, the minimal required number of detected photons for images of a certain quality is considered. For the thermal source version, ghost imaging demonstrates enhanced sensitivity under practical situations, with noise *** an entangled source, ghost imaging surpasses conventional imaging techniques in terms of sensitivity obviously. In one word, ghost imaging promises higher sensitivity at low photon flux and noisy situations.

关键词： sensitivity ghost imaging conventional imaging

Molecular glue triggers degradation of PHGDH by enhancing the interaction between DDB1 and PHGDH

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4001-4013页

作者： Ziqi Huang kun Zhang Yurui Jiang Mengmeng Wang Mei Li Yuda Guo Ruolin Gao ning Li Chenyang Wang Jia Chen Jiefu Wang ning liu Xiang liu Shuangwei liu Mingming Wei Cheng Yang Guang Yang The State Key Laboratory of Medicinal Chemical Biology College of Life SciencesCollege of PharmacyNankai UniversityTianjin 300071China Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for CancerTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300060China

Cancer stem cells(CSCs)play a pivotal role in tumor initiation,proliferation,metastasis,drug resistance,and ***,targeting CSCs has emerged as a promising avenue for cancer ***,3-phosphoglycerate dehydrogenase(PHGDH)has been identified as being intricately associated with the regulation of numerous cancer stem ***,reports detailing the functional regulators of PHGDH that can mitigate the stemness across cancer types are *** this study,the novel“molecular glue”LXH-3-71 was identified,and it robustly induced degradation of PHGDH,thereby modulating the stemness of colorectal cancer cells(CRCs)both in vitro and in ***,LXH-3-71 was observed to form a dynamic chimera,between PHGDH and the DDB1-CRL E3 *** insights not only elucidate the anti-CSCs mechanism of the lead compound but also suggest that degradation of PHGDH may be a more viable therapeutic strategy than the development of PHGDH ***,compound LXH-3-71 was leveraged as a novel ligand for the DDB1-CRL E3 ligase,facilitating the development of new PROTAC molecules targeting EGFR and CDK4 degradation.

关键词： Molecular glue Targeted protein degradation PHGDH Cancer stem cells PROTACs

PPB structure elimination,DRX nucleation mechanisms and grain growth behavior of the3rd-generation PM superalloy for manufacturing aviation components

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Chinese Journal of Aeronautics 2024年第1期37卷 325-344页

作者： Baoyun ZHANG Yongquan ning Zhaotian WANG Qiaomu liu School of Materials Science and Engineering Northwestern Polytechnical UniversityXi’an 710072China AECC Sichuan Gas Turbine Establishment Chengdu 610500China

Previous Particle Boundary(PPB),as the detrimental structure in Powder Metallurgy(PM)components,should be eliminated by subsequent hot process to improve the mechanical *** objective is to investigate the Dynamic Recrystallization(DRX)nucleation mechanisms and grain growth behavior of the 3rd-generation PM superalloy with PPB *** observation reveals that PPB decorated with(Ti,Ta,Nb)C carbides belongs to the discontinuous chain-like *** elimination of PPB networks can be achieved effectively via hot deformation due to the occurrence of *** different DRX nucleation mechanisms were proposed and discussed in detail according to the special microstructure characteristics of the PM ***,local lattice rotations can be detected in the vicinity of(Ti,Ta,Nb)C carbides during hot deformation and thus PPB structure serves as the preferential nucleation sites for DRX grains via Particle-Stimulated Nucleation(PSN).Then,Discontinuous-DRX(DDRX)characterized by grain boundary bulging dominates the microstructure refinement and Continuous-DRX(CDRX)operated by subgrain rotation can be regarded as an important assistant *** last,the initial Σ3 boundaries would lose their twin characteristics owing to the crystal rotation and then transform into the general High Angle Grain Boundaries(HAGBs).The distorted twins provide additional DRX nucleation sites,viz.,twin-assisted *** attention was focused on the grain growth behavior of the PM superalloy in subsequent annealing *** recrystallization temperature was determined to be about 1110.C and 1140.C can be considered as the critical temperature for grain *** findings would provide theoretical support for microstructure refinement of the 3rd-generation PM superalloy,which is of pivotal significance for improving the mechanical properties of aviation components.

关键词： PM superalloy Previous Particle Boundary(PPB) DRX nucleation Grain growth Microstructure refinement

Energy harvesting technology for AC overhead insulated transmission line based on electric field induction

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High Voltage 2024年第4期9卷 816-825页

作者： Le Zhou Hongwei liu kun Zuo Kuo Shang School of Electrical and Electronic Engineering North China Electric Power UniversityBeijingChina Electric Power Company of Sichuan Province Tianfu Power Supply Company ChengduSichuanChina Changde Power Supply Branch State Grid Hunan Electric Power Company LimitedChangdeHunanChina

To solve the problem of the energy harvesting(EEH)effect of the condition monitoring devices power supply on the transmission line is not *** authors designed three kinds of EEH schemes based on AC electric field induction,which can effectively improve the output power of load power *** EEH principle of each scheme was analysed in detail,and the influence factors such as the shape of outer energy harvester,capacitance compensation and impedance matching characteristics were ***,the experiment showed that 140.9 mW of power was obtained in direct-mode field EEH when the line voltage level was 10 *** high-potential field EEH mode obtained 4.1 mW of *** harvesting effect of the inner energy harvester with the same potential as the aluminium wire was obviously better,and 30.7 mW of power was ***,based on the third mode,when the load resistance was 2200Ω,the rectifier received 23.7 mW DC *** experimental results are in agreement with the theoretical analysis,which verifies the effectiveness of the electric field induction power supply technology.

关键词： field harvesting mode

Effects of orientation on the fatigue crack growth behaviors of the ZK60 magnesium alloy in air and PBS

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Journal of Magnesium and Alloys 2024年第1期12卷 281-294页

作者： Jiaqi Hu Zheng liu Zuoliang ning Hong Gao School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China Tianjin Key Laboratory of Chemical Process Safety and Equipment Technology Tianjin 300072China

Strong anisotropic corrosion and mechanical properties caused by specimen orientations greatly limit the applications of wrought magnesium *** investigate the influences of specimen orientation,the corrosion tests and(corrosion)fatigue crack growth tests were *** rolled and transverse surfaces of the materials show distinct corrosion rate differences in the stable corrosion stage,but the truth is the opposite for the initial stage of *** air,specimen orientations have a significant influence on the plastic deformation mechanisms near the crack tip,which results in different fatigue fracture surfaces and cracking *** with R-T specimens,N-T specimens show a slower fatigue crack growth(FCG)rate in air,which can be attributed to crack closure effects and deformation twinning near the crack *** corrosion environment will not significantly change the main plastic deformation mechanisms for the same type of ***,the FCG rate in phosphate buffer saline(PBS)is one order of magnitude higher than that in air,which is caused by the combined effects of hydrogen-induced cracking and anodic *** to the similar corrosion rates at crack tips,the specimens with different orientations display close FCG rates in PBS.

关键词： Magnesium alloy Orientation Corrosion Fatigue crack growth