Major royal-jelly proteins intake modulates immune functions and gut microbiota in mice

作     者：Hang Wu Shican Zhou Wenjuan Ning Xiao Wu Xiaoxiao Xu Zejin Liu Wenhua Liu Kun Liu Lirong Shen Junpeng Wang Hang Wu;Shican Zhou;Wenjuan Ning;Xiao Wu;Xiaoxiao Xu;Zejin Liu;Wenhua Liu;Kun Liu;Lirong Shen;Junpeng Wang

作者机构：Infection and Immunity Institute and Translational Medical Center of Huaihe HospitalHenan UniversityKaifeng 475000China College of Biology Science and EngineeringHebei University of Economics and BusinessShijiazhuang 050061China College of Biosystems Engineering and Food ScienceZhejiang Key Laboratory for Agro-Food ProcessingZhejiang UniversityHangzhou 310058China 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2024年第13卷第1期

页      面：444-453页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 08[工学] 083201[工学-食品科学] 

基　　金：financially supported by the National Natural Science Foundation of China(U2004104) the Natural Science Foundation of Henan Province(202300410080) the Key Project of Henan Education Committee(21A310005) the Internal Fund of Hebei University of Economics and Business(2020ZD10) the Postgraduate“Talent Program”of Henan University(SYL20060187 and SYL20060189) 

主　　题：Major royal-jelly proteins Immunity Estrogen Gut microbiota Cytokines 

摘      要：In this study,we investigated the effects of major royal jelly proteins(MRJPs)on the estrogen,gut microbiota,and immunological responses in *** given 250 or 500 mg/kg,not 125 mg/kg of MRJPs,enhanced the proliferation of splenocytes in response to *** splenocytes and mesenteric lymphocytes activated by T-cell mitogens(Con A and anti-CD3/CD28 antibodies)released high levels of IL-2 but low levels of IFN-γand *** release of IL-4 was unaffected by ***,splenocytes and mesenteric lymphocytes activated by LPS were prevented by MRJPs at the same dose as that required for producing IL-1βand IL-6,two pro-inflammatory *** production of IL-1β,IL-6,and IFN-γwas negatively associated with estrogen levels,which were higher in the MRJP-treated animals than in the control *** of the gut microbiota revealed that feeding mice 250 mg/kg of MRJPs maintained the stability of the natural intestinal microflora of ***,the LEf Se analysis identified biomarkers in the MRJP-treated mice,including Prevotella,Bacillales,Enterobacteriales,Gammaproteobacteria,Candidatus_Arthromitus,and *** results showed that MRJPs are important components of royal jelly that modulate host immunity and hormone levels and help maintain gut microbiota stability.