检索结果-南通市图书馆

Recurrent postmenopausal bleeding - just endometrial disease or ovarian sex cord-stromal tumor? A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第1期10卷 275-282页

作者： jiao Wang Qing Yang ning-ning Zhang Dan-Dan Wang Department of Obstetrics and Gynecology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

BACKGROUND Postmenopausal bleeding(PMB)is a common gynecologic complaint among elderly women,and endometrial hyperplasia is a common cause of this bleeding.Ovarian fibromas are the most common type of ovarian sex cord-stromal tumor(SCST).They arise from non-functioning stroma,rarely show estrogenic activity,and stimulate endometrial hyperplasia,causing abnormal vaginal bleeding.CASE SUMMARY We report herein the case of a 64-year-old Chinese woman who presented with recurrent PMB.A sex hormone test revealed that her estrogen level was significantly higher than normal,and other causes of hyperestrogenism had been excluded.The patient had undergone four curettage and hysteroscopy procedures in the past 7 years due to recurrent PMB and endometrial hyperplasia.The culprit behind the increase in estrogen level—an ovarian cellular fibroma with estrogenic activity—was eventually found during the fifth operation.CONCLUSION Ovarian cellular fibromas occur insidiously,and some may have endocrine functions.Postmenopausal patients with recurrent PMB and endometrial thickening observed on ultrasonography are recommended to undergo sex hormone testing while waiting for results regarding the pathology of the endometrium.If the estrogen level remains elevated,the clinician should consider the possibility of an ovarian SCST and follow-up the patient closely,even if the imaging results do not indicate ovarian tumors.Once the tumor is found,it should be removed as soon as possible no matter the size to avoid endometrial lesions due to long-term estrogen stimulation.More studies are needed to confirm whether preventive total hysterectomy with bilateral salpingo-oophorectomy should be recommended for women with recurrent PMB exhibiting elevated estrogen levels,despite the auxiliary examination results not indicating ovarian mass.The physical and psychological burden caused by repeated curettage could be prevented using this technique.

关键词： Postmenopausal bleeding Endometrial hyperplasia Estrogen excess Ovarian cellular fibroma Case report

基于联合方向梯度和均值对比度的红外弱小目标检测方法

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

红外与毫米波学报 2024年第1期43卷 106-115页

作者：李宁郭义放焦继超逄敏徐威北京邮电大学电子工程学院北京100876 中国电波传播研究所第三研究部山东青岛266108

针对小目标在整幅图像中占比很低,且目标周围存在大量杂波,提出了一种基于联合方向梯度(Associated Directional Gradient,ADG)和均值对比度(Mean Contrast,MC)的红外弱小目标检测算法。该算法由两个模块组成:ADG利用红外弱小目标的高... 详细信息

针对小目标在整幅图像中占比很低,且目标周围存在大量杂波,提出了一种基于联合方向梯度(Associated Directional Gradient,ADG)和均值对比度(Mean Contrast,MC)的红外弱小目标检测算法。该算法由两个模块组成:ADG利用红外弱小目标的高斯分布模型,将单一方向的梯度与一个相邻方向上的梯度相加组成新的联合梯度特征,增强真实目标、抑制背景杂波的同时能够消除高亮边缘对目标检测效果的影响;MC融入方向信息来计算目标的多方向对比度,选用多方向对比度的最小值抑制结构噪声,并将均值滤波的思想引入对比度的计算,抑制背景中的孤立噪声,进一步降低检测的虚警率。在实际红外图像上的实验结果表明,该算法在增强目标信噪比和抑制背景噪声方面,能够取得较好效果。

关键词：红外图像目标检测联合方向梯度均值对比度

银修饰硅胶复合材料对气态碘的捕集及其固化研究

在线全文

学校读者我要写书评

暂无评论

化工新型材料 2024年第4期52卷 172-177,183页

作者：黄双双雷浩唐娇邹浩潘宁王孝强西南科技大学国防科技学院绵阳621010 中国工程物理研究院绵阳621900 中国兵器装备集团自动化研究所有限公司绵阳621000

以硅胶为载体,采用水热浸渍法制备银修饰硅胶复合材料,对富碘后的复合材料进行低温玻璃固化处理,以期实现对气态放射性碘的长期安全处置。通过扫描电子显微镜和X射线衍射仪对复合材料的形貌和结构进行表征,考察了浸渍反应温度对银负载... 详细信息

以硅胶为载体,采用水热浸渍法制备银修饰硅胶复合材料,对富碘后的复合材料进行低温玻璃固化处理,以期实现对气态放射性碘的长期安全处置。通过扫描电子显微镜和X射线衍射仪对复合材料的形貌和结构进行表征,考察了浸渍反应温度对银负载量、吸附时间和碘质量浓度对碘吸附量的影响,并对吸附动力学曲线和吸附等温线进行了拟合。结果表明:硝酸银负载在硅胶表面,银负载量达到17.8%;30min内复合材料对气体碘的吸附可达到平衡,吸附行为符合准二级动力学模型,为化学吸附;Langmuir等温吸附模型更适合描述复合材料对气态碘的吸附过程,复合材料吸附碘的过程为单层吸附行为,复合材料对碘的理论最大吸附量为169.5mg/g。固化结果表明,玻璃固化体主要以碘化银(AgI)和碘七氧化五铋(Bi_(5)O_(7)I)形式封存碘,碘元素浸出率为1.436×10^(-6) g/(m^(2)•day)。

关键词：银硅胶碘吸附低温玻璃固化

Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期 1541-1554页

作者： Jinmei Ye Cong Duan Jiaxin Han Jinrong Chen ning Sun Yuan Li Tifei Yuan Daihui Peng Division of Mood Disorder Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Department of Psychiatry First Hospital of Shanxi Medical University Shanghai Key Laboratory of Psychotic Disorders Brain Health Institute National Center for Mental Disorders Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Co-Innovation Center of Neuroregeneration Nantong University

In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation. This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder. Herein, we critically review the neuroinflammation theory in major depressive disorder, providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate, and that it constitutes the neuroinflammatory disease pathway. After its release, mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation. Detectable exosomes render encaged mitochondrial DNA relatively stable. This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice. These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder. This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers, to improve diagnostic precision in major depressive disorder.

关键词：

基于模块化思想的LCC-HVDC改进小信号建模及交互稳定性分析

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

电力系统保护与控制 2024年第10期52卷 84-94页

作者：王顺亮刘海军谢洋马俊鹏李永琪焦宁刘天琪四川大学电气工程学院四川成都610065

随着电网换相型高压直流输电(line commutated converter based high voltage direct current, LCC-HVDC)技术的广泛应用,交直流混联电力系统的交互稳定性问题日益突出。首先基于状态空间平均法建立了考虑非线性换相重叠动态过程的LCC... 详细信息

随着电网换相型高压直流输电(line commutated converter based high voltage direct current, LCC-HVDC)技术的广泛应用,交直流混联电力系统的交互稳定性问题日益突出。首先基于状态空间平均法建立了考虑非线性换相重叠动态过程的LCC换流器传递函数模型。为适应愈加复杂的直流输电系统建模,提出利用模块化思想分别建立LCC-HVDC各子系统小信号模型,并推导了能反映交直流系统和换流器之间电气耦合特性的接口矩阵实现子系统连接,从而模块化建立精确且易于扩展的计及控制链路延时和锁相环输出相位波动的双端LCC-HVDC系统改进小信号模型。最后分析了控制系统参数和控制链路延时对系统小干扰稳定性的影响以及失稳模态的主导因素,揭示了双端LCC-HVDC系统交直流混合谐振机理及送受端交互影响具体过程。研究结果可以为系统参数设计、谐振抑制措施提供理论基础。

关键词： LCC-HVDC 状态空间模型模块化控制链路延时谐振影响因素

High expression of protein phosphatase 2 regulatory subunit B''alpha predicts poor outcome in hepatocellular carcinoma patients after liver transplantation

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2021年第7期13卷 716-731页

作者： Jia-Jia He Lei Shang Qun-Wei Yu ning jiao Shuang Qiu Wei-Xiong Zhu Dong-Feng Wu Yun-Er Tian Qing Zhang Clinical College of General Hospital of Chinese People's Armed Police Force Anhui Medical UniversityHefei 230032AnhuiChina Department of Organ Transplantation The Third Medical Center of Chinese PLA General HospitalBeijing 100039China Department of Health Statistics Fourth Military Medical UniversityXi'an 710032Shanxi ProvinceChina Department of Ophthalmology The Third Medical Center of Chinese PLA General HospitalBeijing 100039China

BACKGROUND Protein phosphatase 2 regulatory subunit B''alpha(PPP2R3A)gene has been reported in other tumors,but the influence of PPP2R3A gene expression on the occurrence,development,and prognosis of hepatocellular carcinoma(HCC)remains unclear.AIM To investigate whether the PPP2R3A gene could be used to predict tumor recurrence and survival of HCC patients after liver transplantation(LT).METHODS Diseased liver tissues of HCC patients after LT were collected as well as their clinical data and follow-up information.The immunohistochemical method was used to detect the expression of PPP2R3A protein in the tissues of 108 patients with primary liver cancer.Theχ2 test was used to analyze the relationship between PPP2R3A protein expression levels and the clinicopathological features of tumors.The Kaplan-Meier method was used to analyze overall postoperative survival.The COX proportional hazard model was used to analyze adverse prognostic factors.RESULTS Immunohistochemistry showed that the PPP2R3A protein was mainly expressed in the cytoplasm of HCC cells.Compared to corresponding peritumoral tissues,expression was higher in HCC tissues(P≤0.001).Correlation analysis showed that high PPP2R3A expression was correlated with preoperative serum alphafetoprotein(AFP)levels(P=0.003),tumor-node-metastasis-t stage(P≤0.001),and envelope invasion(P=0.001).Univariate analysis showed that overall survival(P≤0.001)and recurrence-free survival(P=0.025)of patients with high PPP2R3A expression(≥4 points)were poor compared to those with low expression(<4 points).The overall survival rates or recurrence-free survival rates at 1,2,and 3 years with high PPP2R3A expression were 73%,38%,and 23%or 31%,23%,and 23%,respectively.Multivariate analysis showed that high PPP2R3A expression(hazard ratio=2.900,95%confidence interval:1.411–5.960,P=0.004)was an independent survival risk factor of HCC patients after LT,and it was also an independent predictor of postoperative tumor recurrence.This study also showed in patients with AFP≥400 ng/mL,the over

关键词： Protein phosphatase 2 regulatory subunit B''α Hepatocellular carcinoma Liver transplantation Prognosis Alpha-fetoprotein

Advanced nano drug delivery systems for neuroprotection against ischemic stroke

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第2期35卷 151-162页

作者： Chenchen Xie Jun Liao ning Zhang Yuhan Sun Yi Li Liyan Xiong Yingnan Zhang Xiaoyan Liu Wei Su Heming Chen Ping Zeng Xiaoqing Zhang Ying Lu Tingfang Wang Chuan Zhang Shanghai Engineering Research Center of Organ Repair School of MedicineShanghai UniversityShanghai 200444China Department of Pharmaceutical Science School of PharmacyNaval Medical UniversityShanghai 200433China Department of pharmacy the International Peace Maternity and Child Health HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200030China School of Pharmacy Shanghai Jiao Tong UniversityShanghai 200040China

Ischemic stroke(IS)represents a significant threat to brain health due to its elevated mortality and disability rates.The efficacy of small-molecule neuroprotective agents has been impeded by challenges associated with traversing the blood-brain barrier(BBB)and limited bioavailability.Conversely,advanced nano drug delivery systems hold promise for overcoming these obstacles by facilitating efficient transportation across the BBB and maintaining optimal drug concentrations.This review aims to explore advanced neuroprotective nano drug delivery systems as a means of effectively administering neuroprotective agents to the brain using pharmaceutical approaches in the treatment of IS.By examining these systems,researchers and clinicians can gain valuable insights and innovative concepts,illuminating the potential of advanced neuroprotective nano drug delivery systems.Leveraging these advancements can drive the progress of pioneering and efficacious therapeutic interventions for IS.

关键词： Target Blood-brain barrier Ischemic stroke Nano drug delivery Neuroprotection

Nitromethane-Enabled Fluorination of Styrenes and Arenes

在线全文

学校读者我要写书评

暂无评论

CCS Chemistry 2020年第6期2卷 566-575页

作者： Weijin Wang Tongyu Huo Xinyi Zhao Qixue Qin Yujie Liang Song Song Guosheng Liu ning jiao State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191 State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing 210023Jiangsu State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032

The electrophilic fluorination of unsaturated compounds provides a reliable approach to the generation of organofluorides,which are used widely in agrochemicals,pharmaceuticals,and other materials.Numerous active electrophilic fluorine reagents,such as the fluorine molecule(F_(2))or xenon difluoride(XeF_(2)),have been applied in fluorination.However,these reagents suffer from their hazardous,toxic,corrosive,and poor selective properties,and the relatively weak electrophilicity of Selectfluor or N-fluorobenzenesulfonimide(NFSI)usually limits their broad applications.Herein,we disclose nitromethane(MeNO_(2))as an efficient activator of Selectfluor and NFSI,as well as a stabilizer of carbocations.Therefore,the fluoro-azidation,fluoroamination,fluoroesterification of styrenes,and C–H fluorination of(hetero)arenes were well realized just by the facilitation of MeNO_(2).The mild reaction conditions and practicability made our current method a versatile protocol for accessing organofluorides.

关键词： fluoroazidation fluoroamination fluoroesterification electrophilic fluorination nitromethane

Development of innovative tripartite partnership for China’s engagement in global health: recommendations from China-Tanzania Cooperation Project on Malaria Control

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

贫困所致传染病(英文) 2024年第2期13卷 1-3页

作者： Ma Xuejiao Lu Shenning Ding Wei Deng Shanying Wang Duoquan Xiao ning Mlacha Yeromin Husain Lewis Zhou Xiaonong National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research) NHC Key Laboratory of Parasite and Vector Biology WHO Collaborating Center for Tropical Diseases National Center for International Research On Tropical Diseases Shanghai China University of Hong Kong Hong Kong China School of Global Health Chinese Center for Tropical Diseases Research Shanghai Jiao Tong University School of Medicine Shanghai China Ifakara Health Institute Dar-es-Salaam Tanzania Institute of Development Studies Brighton UK