High expression of protein phosphatase 2 regulatory subunit B''alpha predicts poor outcome in hepatocellular carcinoma patients after liver transplantation

作     者：Jia-Jia He Lei Shang Qun-Wei Yu Ning Jiao Shuang Qiu Wei-Xiong Zhu Dong-Feng Wu Yun-Er Tian Qing Zhang 

作者机构：Clinical College of General Hospital of Chinese People's Armed Police ForceAnhui Medical UniversityHefei 230032AnhuiChina Department of Organ TransplantationThe Third Medical Center of Chinese PLA General HospitalBeijing 100039China Department of Health StatisticsFourth Military Medical UniversityXi'an 710032Shanxi ProvinceChina Department of OphthalmologyThe Third Medical Center of Chinese PLA General HospitalBeijing 100039China 

出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)

年 卷 期：2021年第13卷第7期

页      面：716-731页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：National Natural Science Foundation of China No.81372595 

主　　题：Protein phosphatase 2 regulatory subunit B''α Hepatocellular carcinoma Liver transplantation Prognosis Alpha-fetoprotein 

摘      要：BACKGROUND Protein phosphatase 2 regulatory subunit B alpha(PPP2R3A)gene has been reported in other tumors,but the influence of PPP2R3A gene expression on the occurrence,development,and prognosis of hepatocellular carcinoma(HCC)remains *** To investigate whether the PPP2R3A gene could be used to predict tumor recurrence and survival of HCC patients after liver transplantation(LT).METHODS Diseased liver tissues of HCC patients after LT were collected as well as their clinical data and follow-up *** immunohistochemical method was used to detect the expression of PPP2R3A protein in the tissues of 108 patients with primary liver ***χ2 test was used to analyze the relationship between PPP2R3A protein expression levels and the clinicopathological features of *** Kaplan-Meier method was used to analyze overall postoperative *** COX proportional hazard model was used to analyze adverse prognostic *** Immunohistochemistry showed that the PPP2R3A protein was mainly expressed in the cytoplasm of HCC *** to corresponding peritumoral tissues,expression was higher in HCC tissues(P≤0.001).Correlation analysis showed that high PPP2R3A expression was correlated with preoperative serum alphafetoprotein(AFP)levels(P=0.003),tumor-node-metastasis-t stage(P≤0.001),and envelope invasion(P=0.001).Univariate analysis showed that overall survival(P≤0.001)and recurrence-free survival(P=0.025)of patients with high PPP2R3A expression(≥4 points)were poor compared to those with low expression(4 points).The overall survival rates or recurrence-free survival rates at 1,2,and 3 years with high PPP2R3A expression were 73%,38%,and 23%or 31%,23%,and 23%,*** analysis showed that high PPP2R3A expression(hazard ratio=2.900,95%confidence interval:1.411–5.960,P=0.004)was an independent survival risk factor of HCC patients after LT,and it was also an independent predictor of postoperative tumor *** study als