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Copper-cysteamine nanoparticle-mediated microwave dynamic therapy improves cancer treatment with induction of ferroptosis

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Bioactive Materials 2023年第6期24卷 322-330页

作者： Hui Zhou Zhongtao Liu Zijian Zhang nil kanatha pandey Eric Amador William Nguyen Lalit Chudal Li Xiong Wei Chen Yu Wen Department of General Surgery Second Xiangya HospitalCentral South UniversityChangsha410011China Department of Physics The University of Texas at ArlingtonArlingtonTX76019-0059USA

Photodynamic Therapy(PDT)holds a great promise for cancer patients,however,due to the hypoxic characteristics of most solid tumors and the limited penetration depth of light in tissues,the extensive clinical application of PDT is ***,we report microwave induced copper-cysteamine(Cu-Cy)nanoparticles-based PDT as a promising cancer treatment to overcome cancer resistance in combination with *** treatment efficiency of Cu-Cy-mediated microwave dynamic therapy(MWDT)tested on HCT15 colorectal cancer(CRC)cells via cell titer-blue cell viability assay and live/dead assay reveal that Cu-Cy upon MW irradiation can effectively destroy HCT15 CRC cells with average IC-50 values of 20μg/*** cytotoxicity of Cu-Cy to tumor cells after MW stimulation can be alleviated by ferroptosis ***,Cu-Cy mediated MWDT could deplete glutathione peroxide 4(GPX4)and enhance lipid peroxides(LPO)and malondialdehyde(MDA).Our findings demonstrate that MW-activated Cu-Cy killed CRC cells by inducing *** superior in vivo antitumor efficacy of the Cu-Cy was corroborated by a HCT15 tumor-bearing mice *** experiments showed that the GPX4 expression level in Cu-Cy+MW group was significantly lower than that in other ***,these findings demonstrate that Cu-Cy nanoparticles have a safe and promising clinical application prospect in MWDT for deep-seated tumors and effectively inhibit tumor cell proliferation by inducing ferroptosis,which provides a potential solution for cancer resistance.

关键词： Cu-Cy Microwave PDT Cell death Colorectal cancer Ferroptosis

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Study of copper-cysteamine based X-ray induced photodynamic therapy and its effects on cancer cell proliferation and migration in a clinical mimic setting

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Bioactive Materials 2022年第1期7卷 504-514页

作者： Xiangyu Chen Jiayi Liu Ya Li nil kanatha pandey Taili Chen Lingyun Wang Eric Horacio Amador Weijun Chen Feiyue Liu Enhua Xiao Wei Chen Department of Radiology The Second Xiangya Hospital of Central South UniversityChangshaHunanChina Department of Physics The University of Texas at ArlingtonArlingtonTX76019USA Department of Oncology Xiangya HospitalCentral South UniversityChangshaHunan Province410011China Department of Oncology The Second Xiangya Hospital of Central South UniversityChangshaHunanChina

Copper-cysteamine as a new generation of sensitizers can be activated by light,X-rays,microwaves,or ultrasound to produce reactive oxygen species.X-ray induced photodynamic therapy(X-PDT)has been studied extensively;however,most of the studies reported so far were conducted in the laboratory,which is not conducive to the clinical translation *** this contribution,for the first time,we investigated the treatment efficiency of copper-cysteamine(Cu-Cy)based X-PDT by mimicking the clinical conditions with a clinical linear accelerator and building deep-seated tumor models to study not only the effectiveness but also its effects on the cell migration and proliferation in the level of the cell,tissue,and *** results showed that,without X-ray irradiation,Cu-Cy nanoparticles(NPs)had a low toxicity in HepG2,SK-HEP-1,Li-7,and 4T1 cells at a concentration below 100 mg/***,for the first time,it was observed that Cu-Cy mediated X-PDT can inhibit the proliferation and migration of these cell lines in a dose-dependent *** markers of migration and cell proliferation,proliferating cell nuclear antigen(PCNA)and E-cadherin,from tumor tissue in the X-PDT group were remarkably different from that of the control ***,the MRI assessment showed that the Cu-Cy based X-PDT inhibited the growth of deeply located tumors in mice and rabbits(p<0.05)without any obvious toxicities in ***,these new findings demonstrate that Cu-Cy NPs have a safe and promising clinical application prospect in X-PDT to improve the efficiency of radiotherapy(RT)for deep-seated tumors and effectively inhibit tumor cell proliferation and migration.

关键词： Copper-cysteamine Nanoparticle Photodynamic therapy X-ray Cell migration Proliferation

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Aggregation-induced emission luminogens for highly effective microwave dynamic therapy

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Bioactive Materials 2022年第1期7卷 112-125页

作者： nil kanatha pandey Wei Xiong Lingyun Wang Wei Chen Brian Bui Jian Yang Eric Amador Mingli Chen Christina Xing Aseem Atul Athavale Yaowu Hao Wirya Feizi Lloyd Lumata Department of Physics The University of Texas at ArlingtonArlingtonTX 76019USA Key Laboratory of Functional Molecular Engineering of Guangdong Province School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou510640China Department of Biomedical Engineering The Pennsylvania State UniversityUniversity ParkPA16802USA Department of Chemistry College of SciencesNortheastern UniversityBox 332Shenyang 110819China Department of Materials Science and Engineering The University of Texas at ArlingtonArlingtonTX 76019USA Department of Physics The University of Texas at Dallas800 West Campbell RoadRichardsonTX 75080USA

Aggregation-induced emission luminogens(AIEgens)exhibit efficient cytotoxic reactive oxygen species(ROS)generation capability and unique light-up features in the aggregated state,which have been well explored in image-guided photodynamic therapy(PDT).However,the limited penetration depth of light in tissue severely hinders AIEgens as a candidate for primary or adjunctive therapy for clinical ***,microwaves(MWs)show a distinct advantage for deeper penetration depth in tissues than ***,for the first time,we report AIEgen-mediated microwave dynamic therapy(MWDT)for cancer *** found that two AIEgens(TPEPy-I and TPEPy-PF6)served as a new type of microwave(MW)sensitizers to produce ROS,including singlet oxygen(1O2),resulting in efficient destructions of cancer *** results of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)and live/dead assays reveal that the two AIEgens when activated by MW irradiation can effectively kill cancer cells with average IC-50 values of 2.73 and 3.22μM,***,the ability of the two AIEgens to be activated by MW not only overcomes the limitations of conventional PDT,but also helps to improve existing MW ablation therapy by reducing the MW dose required to achieve the same therapeutic outcome,thus reducing the occurrence of side-effects of MW radiation.

关键词： AIEgens Microwaves Photodynamic therapy Reactive oxygen species Microwave ablation Cancer treatment Singlet oxygen

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Use of copper-cysteamine nanoparticles to simultaneously enable radiotherapy,oxidative therapy and immunotherapy for melanoma treatment

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1852-1854页

作者： Qi Zhang Xiangdong Guo Yingnan Cheng Lalit Chudal nil kanatha pandey Jieyou Zhang Lun Ma Qing Xi Guangze Yang Ying Chen Xin Ran Chengzhi Wang Jingyi Zhao Yan Li Li Liu Zhi Yao Wei Chen Yuping Ran Rongxin Zhang Department of Immunology and Research Center of Basic Medical Sciences Key Laboratory of Immune Microenvironment and Diseases of Educational Ministry of ChinaTianjin Key Laboratory of Cellular and Molecular ImmunologyTianjin Medical University300070 TianjinChina Institute of Integrative Medicines for Acute Abdominal Diseases Tianjin Nankai Hospital300100 TianjinChina Department of Physics The University of Texas at ArlingtonArlingtonTX 76019-0059USA Guangdong Province Key Laboratory for Biotechnology Drug Candidates Institute of Basic Medical SciencesSchool of Life Sciences and BiopharmaceuticsGuangdong Pharmaceutical UniversityGuangzhouChina Department of Dermatovenereology West China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Radiology The University of Texas Southwestern Medical CenterDallasTXUSA

Dear Editor,Melanoma,squamous cell carcinoma(SCC),and basal cell carcinoma(BCC)are three major types of skin *** them,melanoma is the most severe form and accounts for~4%of all newly diagnosed cancers annually in the United *** is estimated that approximately 9500 people are diagnosed with skin cancer every day,and more than 1 million Americans are living with *** treatment is still a major challenge in the *** therapy(PDT)is composed of targeted ablation and immune activation,is less invasive than other therapies and has been widely used in the treatment of various cancers.

关键词： melanoma treatment radiotherapy

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ANALYSIS OF DYNAMIC PRICING SCENARIOS FOR MULTIPLE-GENERATION PRODUCT LINES

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Journal of Systems Science and Systems Engineering 2015年第1期24卷 107-129页

作者： nil Kilicay-Ergin Chun-yuLin Gul E.Okudan Great Valley School of Graduate Professional Studies Penn State University Department of Industrial and Manufacturing Engineering Penn State UniversityUniversity Park School of Engineering Design Department of Industrial and Manufacturing EngineeringPenn State UniversityUniversity Park

In technology-intensive markets, it is a common strategy for companies to develop long-term multiple generation product lines instead of releasing consecutive single products. Even though this strategy is more profitable than sequentially introducing single product generations, it can also result in inter-product line cannibalization. Cannibalization of multiple-generation product lines is a complex problem that needs to be taken into account at the early product line planning stage in order to sustain long-term profitability. In this paper, we propose an agent-based model that can simulate the potential cannibalization scenarios within a multiple-generation product line. We view a multiple-generation product line （MGPL） as complex adaptive system where each product generation in the MGPL adjusts its sales price over time based on the shifts in the market demand. The proposed model provides insights into how various pricing strategies impact the overall lifecycle profitability of MGPL and can be used to assist companies in developing appropriate dynamic pricing strategies at the early product line planning stages.

关键词： Multiple-generation product lines cannibalization agent-based modeling dynamic pricingscenarios

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Epididymal changes associated with cryptorchidism in rats

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Asian Journal of Andrology 2001年第4期3卷 277-280页

作者： Izzet Kocak Mehmet Dundar nil Culhaci Department of Urology Department of UrologyDepartment of Pathology Adnan Menderes University School of Medicine Aydin 09100 Turkey

Aim: To investigate the effect of a new mechanically induced cryptorchidism model on rat epididymal ***: Eighteen 21-day-old Sprague Dawley rats were randomly divided into 3 groups of 6 animals each. Ani-mals of Groups 1 and 2 were made unilaterally cryptorchid by closing the left inguinal canal, while Group 3 (controls),sham operated. At Day 60 (Group 1) and Day 90 (Group 2 and 3), the rats were sacrificed. The epididymides of bothsides were weighed, and the diameter of the epididymal tubules, the height of the tubular epithelium and the presenceof fibrosis of the caput epididymides were examined under a light-microscope. Results: The cryptorchid epididymishad a significantly lower weight increase than the contralateral ones and the controls, but the epithelial height and diam-eter of caput epididymal tubules were not significantly different. Fibrosis was not observed. Conclusion; The au-thors proposed that this new model is a convenient method to evaluate the epididymal changes associated with experi-mental cryptorchidism. (Asian J Androl 2001 Dec; 3: 277 - 280)

关键词： cryptrorchidism epididymis histology rats

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Geodynamic significance and genesis of chromitites from the Islahiye ophiolite(Gaziantep,SE Anatolia)as constrained by platinum group element(PGE)compositions and mineral chemistry characteristics

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Acta Geochimica 2022年第5期41卷 741-752页

作者： nil Yapici Gael Calo sinda Ngbangandimbo Nusret Nurlu Department of Mining Engineering University ofÇukurovaAdanaTurkey Department of Geological Engineering University ofÇukurovaAdanaTurkey Mühendislik Fakültesi Jeoloji Mühendisliği BölümüÇukurovaÜniversitesi01330 BalcalıAdanaTurkey

Chromitites associated with intensely altered dunites and harzburgites from fourteen dif ferent localities in the Islahiye ophiolites(SE Anatolia)is reported here for the first *** chromitites were observed as lenticular and banded bodies with disseminated and massive textures and containing magnesiochromite grains with the following composition:CrO=58.91–59.74 wt%,Al_(2)O_(3)=10.85–11.20 wt%,and TiO=0.09–0.13 wt%.The Mg#[Mg/(Mg+Fe)]values of magnesiochromite from the Islahiye ophiolite range between 0.52 and 0.60 and their Cr#[Cr/(Cr+Al)]values vary from 0.7802 to *** contents vary with a constant pattern,coincident with the estimated parental liquids that have originated from the derivative of a single bulk of boninitic magma together with Al,Ti-poor,and Cr-rich initial *** chromitites are serpentinised in almost all parts of the study area,and harzburgite and dunite can be observed in different *** the overall composition of platinum group elements(PGE)in most examined chromitites varies between 97 and 191 ppb,three chromitites from the Islahiye region present enrichments in overall PGE(up to 214 ppb).The mineralogical and geochemical features of chromitites from the Islahiye region exhibit a robust similarity to podiform chromitites in the mantle fragment of supra–subduction zone type ophiolitic *** estimated parental magmas of the investigated chromites are consistent with the diff erentiation of arcrelated melts and do not suggest an oceanic spreading centre tectonic *** Islahiye chromites are enriched in IPGE(Ir,Os,Ru),with the occasional presence of Ru and Ir and higher Os contents in ***,we did not find any platinum group minerals(PGM)associated with the serpentine silicate sample matrix,which would have stated a secondary enrichment in *** chromitites in the investigated region have high Cr and low Ti values,are defined as magnesiochromite and were crystallised from a characte

关键词： Chromite Platinum group element Platinum group mineral Ophiolite Mineral chemistry

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New statistical results on the optical IDV data of BL Lac S5 0716+714

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Research in Astronomy and Astrophysics 2015年第3期15卷 327-332页

作者： Bogdan Dǎnilǎ Alexandru Marcu Gabriela Raluca Mocanu Faculty of Physics Babes-Bolyai University Romanian Academy Astronomical Institute Astronomical Observatory Cluj-Napoca

This paper reports on the statistical behavior of the optical Intraday Variability of BL Lac S5 0716＋714. Available Intraday Variability data in the opti- cal are tested to see whether or not the magnitude is lognormally distributed. Our results consistently indicate that this is not the case. This is in agreement with a previ- ous discussion about data for the same object but in a different observational period. Simultaneously, the spectral slope of the light curves is calculated. The implications of these findings on models that describe both the location and source of Intraday Variability are presented.

关键词： radiation mechanisms non-thermal -- BL Lacertae objects individual:S5 0716+714

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Production and characterization of hydrophobic zinc borate by using palm oil

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International Journal of Minerals,Metallurgy and Materials 2013年第11期20卷 1081-1088页

作者： nil Baran Acarali Nurcan Tugrul Emek Moroydor Derun Sabriye Piskin Department of Chemical Engineering Yildiz Technical University

Zinc borate （ZB） was synthesized using zinc oxide, boric acid synthesized from colemanite, and reference ZB as seed. The effects of reaction parameters such as reaction time, reactant ratio, and seed ratio on its yield were examined. Then, the effects of palm oil with solvents （isopropyl alcohol （IPA）, ethanol, and methanol） added to the reaction on its hydrophobicity were explored. Reactions were carried out under determined reaction conditions with magnetically and mechanically stirred systems. The produced ZB was characterized by X-ray diffraction （XRD）, Fourier transform infrared spectroscopy （FT-IR）, scanning electron microscopy （SEM）, and measurements of contact angle identified hydrophobicity. The results showed that hydrophobic ZB was successfully produced under determined reaction conditions. The change of process parameters influenced its yield and the usage of palm oil provided hydrophobicity.

关键词： zinc borate hydrophobicity seed contact angle palm oil

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Hollow dimension of modules

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2005年第10期6卷 1055-1057页

作者： ORHAN nil KESKiN TüTüNCü Derya Department of Mathematics University of HacettepeBeytepe 06532 AnkaraTurkeyDepartment of Mathematics University of Hacettepe Beytepe 06532 AnkaraTurkey

In this paper, we are interested in the following general question： Given a module Mwhich has finite hollow dimension and which has a finite collection of submodules Ki （ 1≤i≤n） such that M=K1 ＋... ＋Kn can we find an expression for the hollow dimension of Min terms of hollow dimensions of modules built up in some way from Kt… ,Kn？ We prove the following theorem： Let Mbe an amply supplemented module having finite hollow dimension and let Ki （ 1 ≤i≤n） be a finite collection of submodules of M such that M=K1 ＋... ＋Kn. Then the hollow dimension h（M） of M is the sum of the hollow dimensions of Ki （1≤i≤n） if and only if Ki is a supplement of K1＋...＋K（i-1）＋K（i＋1）＋...＋Kn in M for each 1≤i≤n.

关键词： Hollow dimension Supplement submodule

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