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Traumatic lumbar hernia: A systematic review of the literature

Chinese Journal of Traumatology 2024年第1期27卷 53-57页

作者： Ioannis Tsouknidas nikolaos Tasis Maria Ioanna Antonopoulou Vasileios Acheimastos Dimitrios KManatakis Department of Surgery Stony Brook University HospitalStony BrookNew YorkUSA Department of Surgical Oncology St Savvas Cancer HospitalAthensGreece nd Department of Surgery Athens Naval and Veterans HospitalAthensGreece Department of Surgery Naval Hospital of CreteChaniaGreece

Purpose:Traumatic lumbar hernia(TLH)constitutes a protrusion of content through a defect in the posterior abdominal wall,as a result of *** rare entity has been described in limited number of ***:A systematic review of the literature was performed according to the meta-analysis of observational studies in epidemiology *** English literature from 1990 until 2021 was reviewed,using PubMed,EMBASE and Google Scholar bibliographic databases,to identify case reports and case series with patients that were diagnosed with *** each eligible study,demographics,clinical presentation,hernia characteristics,preoperative imaging investigations,operation details,and postoperative data were extracted for *** analysis was performed on SPSS,version ***:A total of 62 studies were included for review,with 164 patients with *** age was(42.6±14.3)years(47.6%males,31.1%females,gender not specified in 35 cases).Mean diameter of hernia neck was(6.3±3.1)cm,while the triangles of Petit and Grynfeltt were affected in 74.5%and 14.6%,*** diagnosed in the emergency setting account for 54.2%,with CT scan establishing diagnosis in all but one case(97.7%).A delayed diagnosis was made in 45.8%,at a mean 1 year following *** bulging(82.8%)and chronic back pain(34.3%)were the most frequent *** both delayed and acute group,open surgery(63.6%and 92.3%,respectively)was the preferred surgical *** complications were reported in 11.4%of acute and 15.0%of delayed *** recurrence was 7%.Conclusions:TLH is uncommon with 164 cases described since *** scan is the gold standard in *** surgery is generally the preferred approach,particularly in the emergency *** TLH can be treated either by primary suture repair or mesh,depending on the local conditions,whereas delayed cases usually require a mesh.

关键词： Lumbar hernia Petit Grynfeltt Traumatic lumbar hernia Trauma

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Trends of autoimmune liver disease inpatient hospitalization and mortality from 2011 to 2017:A United States nationwide analysis

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World Journal of Hepatology 2024年第7期16卷 1029-1038页

作者： Ali Wakil Yasameen Muzahim Mina Awadallah Vikash Kumar Natale Mazzaferro Patricia Greenberg nikolaos Pyrsopoulos Department of Gastroenterology and Hepatology The Brooklyn Hospital CenterBrooklynNY 11201United States Department of Gastroenterology and Hepatology University of Iowa Hospitals and ClinicsIowa CityIA 52242United States Department of Gastroenterology and Hepatology Rutgers the New Jersey Medical SchoolNewarkNJ 07103United States Department of Biostatistics and Epidemiology Rutgers School of Public HealthPiscatawayNJ 08854United States

BACKGROUND Autoimmune liver diseases(AiLD)encompass a variety of disorders that target either the liver cells(autoimmune hepatitis,AIH)or the bile ducts[primary biliary cholangitis(PBC),and primary sclerosing cholangitis(PSC)].These conditions can progress to chronic liver disease(CLD),which is characterized by fibrosis,cirrhosis,and hepatocellular *** studies have indicated a rise in hospitalizations and associated costs for CLD in the US,but information regarding inpatient admissions specifically for AiLD remains *** To examine the trends and mortality of inpatient hospitalization of AiLD from 2011 to *** This study is a retrospective analysis utilizing the National Inpatient Sample(NIS)*** subjects admitted between 2011 and 2017 with a diagnosis of AiLD(AIH,PBC,PSC)were identified using the International Classification of Diseases(ICD-9)and ICD-10 *** AiLD admission was defined if the first admission code was one of the AiLD *** AiLD admission was defined as having the AiLD diagnosis anywhere in the admission diagnosis(25 diagnoses).Subjects aged 21 years and older were *** national estimates of hospitalization were derived using sample weights provided by NIS.χ^(2)tests for categorical data were *** primary trend characteristics were in-hospital mortality,hospital charges,and length of *** From 2011 to 2017,hospitalization rates witnessed a significant decline,dropping from 83263 admissions to 74850 admissions(P65),mostly female(median 59%)(P<0.05),and primarily Caucasians(median 68%)(P<0.05).Medicare was the major insurance(median 56%),followed by private payer(median 27%)(P<0.05).The South was the top geographical distribution for these admissions(median 33%)(P<0.05),with most admissions taking place in big teaching institutions(median 63%)(P<0.05).Total charges for admissions rose from 66031 in 2011

关键词： Autoimmune hepatitis Autoimmune liver disease Epidemiology Cost-Effective care Admissions trend Mortality rate

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Upper extremity vascular injuries:Etiology,management and outcome

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World Journal of Critical Care Medicine 2024年第2期13卷 159-167页

作者： nikolaos Stefanou Theodoros Mylonas Fragkiskos A Angelis Christina Arnaoutoglou Sokratis E Varitimidis Zoe H Dailiana Department of Orthopaedic Surgery Faculty of MedicineSchool of Health SciencesUniversity of ThessalyUniversity Hospital of LarissaLarissa 41500Greece Department of Hand Upper Extremity and MicrosurgeryIASO ThessaliasLarissa 41500Greece

BACKGROUND Vascular injuries of the upper extremities are considered relatively rare injuries affecting mostly the young *** often are complex injuries accompanied by other musculoskeletal trauma or trauma in other anatomic *** management is challenging since they can lead to disabilities with major socioeconomic *** To analyze data about the mechanism of injury,the management algorithm and functional outcomes of vascular injuries of the upper *** One hundred and fifteen patients(96 males and 19 females)with arterial injuries of the upper extremity treated in a tertiary trauma center from January 2003 to December 2022 was *** patients’age was 33.7 years and the mean follow up time was 7.4 *** with Mangled Extremity Severity Score≥7 and Injury Severity Score≥20,previous upper limb surgery or major trauma and any neuromuscular or psychiatric disease were excluded,from the *** A penetrating trauma was the most common cause of *** radial artery was the artery injured in most of the cases(37.4%)followed by the ulnar(29.5%),the brachial(12.1%)and the axillary(6%).A simultaneous injury of both of the forearm’s arteries was in 15.6%of the *** 93%of the cases there were other concomitant musculoskeletal injuries of the *** lacerations were the most common,followed by nerve *** postoperative functional scores(full Disabilities of the Arm,Shoulder,and Hand and VAS)had very satisfactory *** Although vascular injuries of the upper extremity are rare,they may occur in the context of major combined musculoskeletal *** a multidisciplinary approach is essential to optimize outcome,the ability of trained hand surgeons to repair all injuries in combined vascular and musculoskeletal upper extremity trauma,excluding isolated vascular injuries,ensures shorter operative times and better functional outcomes.

关键词： Upper extremity Vascular injuries Complex injuries Musculoskeletal trauma Mangled extremity

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World Journal of Methodology 2024年第2期14卷 75-87页

作者： Maria Papaioannou Evdoxia Vagiana Serafeim-Chrysovalantis Kotoulas Maria Sileli Katerina Manika Alexandros Tsantos nikolaos Kapravelos 1^(st)Intensive Care Unit G Papanikolaou General HospitalExohiThessaloniki 57010Greece 2^(nd)Intensive Care Unit G Papanikolaou General HospitalExohiThessaloniki 57010Greece Intensive Care Unit Hippokration General HospitalThessaloniki 54642Greece Department of Pulmonary Medical SchoolAristotle University of ThessalonikiG.Papanikolaou General HospitalExohiThessaloniki 57010Greece 2^(nd)Department of Internal Medicine General Hospital of Thessaloniki“Ippokration”Thessaloniki 54642Greece

BACKGROUND Tracheostomy is commonly used in intensive care unit(ICU)patients who are expected to be on long-term mechanical ventilation or suffer from emergency upper airway ***,some studies have conflicting findings regarding the optimal technique and its timing and *** To provide evidence of practice,characteristics,and outcome concerning tracheostomy in an ICU of a tertiary care *** This was a retrospective cohort study including adult critical care patients in a single ICU for two consecutive ***’demographic characteristics,severity of illness(APACHE II score),level of consciousness[Glasgow Coma Scale(GCS)],comorbidities,timing and type of tracheostomy procedure performed and outcome were *** defined late as tracheostomy placement after 8 days or no *** Data of 660 patients were analyzed(median age of 60 years),median APACHE II score of 19 and median GCS score of 12 at *** was performed in 115 patients,of whom 63 had early and 52 late *** tracheostomy was mainly executed in case of altered level of consciousness and severe critical illness polyneuromyopathy,however there were no significant statistical results(47.6%vs 36.5%,P=0.23)and(23.8%vs 19.2%,P=0.55)*** the method selected,early surgical tracheostomy(ST)was conducted in patients with maxillofacial injuries(50.0%vs 0.0%,P=0.033),whereas late surgical tracheostomy was selected for patients with goiter(44.4%vs 0.0%P=0.033).Patients with early tracheostomy spent significantly fewer days on mechanical ventilation(15.3±8.5 vs 22.8±9.6,P<0.001)and in ICU in general(18.8±9.1 vs 25.4±11.5,P<0.001).Percutaneous dilatation tracheostomy(PDT)vs ST was preferable in older critical care patients in the case of Central Nervous System underlying cause of admission(62.5%vs 26.3%,P=0.004).ST was the method of choice in compromised airway(31.6%,vs 7.3%P=0.008).A large proportion of patients(88/115)with t

关键词： Tracheostomy Early tracheostomy Late tracheostomy Percutaneous dilatation tracheostomy Surgical tracheostomy Weaning Survival Mechanical ventilation

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Interdepartmental miscommunication regarding radiology:Addressing chronic challenges and exploring solutions

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World Journal of Radiology 2024年第5期16卷 109-114页

作者： nikolaos-Achilleas Arkoudis Emmanouil Karofylakis Ornella Moschovaki-Zeiger Spyridon Prountzos Evgenia Efthymiou George Samonis Christos Koutserimpas Research Unit of Radiology and Medical Imaging National and Kapodistrian University of AthensAthens 11528Greece The Second Department of Radiology General University Hospital“Attikon”National and Kapodistrian University of AthensChaidari 12462Greece Addenbrooke’s Hospital Cambridge University Hospitals NHS Foundation TrustCambridge CB20QQUnited Kingdom Department of Medicine University of CreteHeraklionCrete 71500Greece The First Department of Oncology Metropolitan HospitalNeon FalironAthens 18547Greece Orthopaedics Surgery and Sports Medicine Department FIFA Medical Centre of ExcellenceCroix-Rousse HospitalLyon University HospitalLyon 69004France Department of Anatomy National and Kapodistrian University of AthensAthens 11527Greece

Effective communication and collaboration among healthcare professionals are crucial for delivering high-quality patient *** miscommunication poses a significant challenge to healthcare systems,potentially undermining the quality of healthcare services *** the same manner,communication barriers between referring physicians and radiologists can specifically affect radiology services and patient *** article attempts to put the spotlight on the ever-present chronic challenges of this issue and prompt readers to recognize the relevant potential pitfalls in their daily clinical *** solutions are explored and proposed,which should be tailored to the specific needs and issues that each individual institution may face.

关键词： Radiology Miscommunication Collaboration Barriers Solutions Patient care Healthcare services Referring physician Challenges Medical

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Improving the operational stability of perovskite solar cells with cesium-doped graphene oxide interlayer

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Journal of Energy Chemistry 2024年第9期96卷 483-490页

作者： Masaud Almalki Katerina Anagnostou Konstantinos Rogdakis Felix T.Eickemeyer Mostafa Othman Minas M.Stylianakis Dimitris Tsikritzis Anwar Q.Alanazi nikolaos Tzoganakis Lukas Pfeifer Rita Therisod Xiaoliang Mo Christian M.Wolff Aïcha Hessler-Wyser Shaik M.Zakeeruddin Hong Zhang Emmanuel Kymakis Michael Grätzel Laboratory of Photonics and Interfaces École Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Department of Electrical and Computer Engineering Hellenic Mediterranean UniversityHeraklionCrete 71410Greece Institute of Electrical and Microengineering(IEM)Photovoltaics and Thin-Film Electronics Laboratory(PV-Lab) École Polytechnique Fédérale de Lausanne(EPFL)Neuchâtel 2000Switzerland Department of Nursing Faculty of Health SciencesHellenic Mediterranean UniversityCrete 71410Greece Centre Interdisciplinaire de Microscopie Electronique École Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Future Energy Technology Institute King Abdulaziz City for Science and Technology(KACST)P.O.Box 6086Riyadh 11442Saudi Arabia State Key Laboratory of Photovoltaic Science and Technology Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and PerceptionInstitute of OptoelectronicsDepartment of Materials ScienceFudan UniversityShanghai 200433China

Perovskite solar cells(PSCs)have made great advances in terms of power conversion efficiency(PCE),yet their subpar stability continues to hinder their *** interface between the perovskite layer and the charge-carrier transporting layers plays a crucial role in undermining the stability of *** this work,we propose a strategy to stabilize high-performance PSCs with PCE over 23%by introducing a cesium-doped graphene oxide(GO-Cs)as an interlayer between the perovskite and hole-transporting *** GO-Cs treated PSCs exhibit excellent operational stability with a projected T80(the time where the device PCE reduces to 80%of its initial value)of 2143 h of operation at the maximum powering point under one sun illumination.

关键词： Perovskite solar cells Doped graphene oxide Graphene related material Long-term operational stability

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Management of distal cholangiocarcinoma with arterial involvement: Systematic review and case series on the role of neoadjuvant therapy

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2689-2701页

作者： Lewis A Hall Duncan Loader Santiago Gouveia Marta Burak James Halle-Smith Peter Labib Moath Alarabiyat Ravi Marudanayagam Bobby V Dasari Keith J Roberts Syed S Raza Michail Papamichail David C Bartlett Robert P Sutcliffe nikolaos A Chatzizacharias Department of Hepatopancreatobiliary Surgery and Liver Transplantation University Hospitals Birmingham NHS Foundation TrustBirmingham B152GWUnited Kingdom Institute of Immunology and Immunotherapy University of BirminghamBirmingham B152TTUnited Kingdom College of Medical and Dental Sciences University of BirminghamBirmingham B152TTUnited Kingdom Institute of Clinical Sciences University of BirminghamBirmingham B152TTUnited Kingdom

BACKGROUND The use of neoadjuvant therapy(NAT)in distal cholangiocarcinoma(dCCA)with regional arterial or extensive venous involvement,is not widely accepted and evidence is *** To synthesise evidence on NAT for dCCA and present the experience of a highvolume tertiary-centre managing dCCA with arterial *** A systematic review was performed according to PRISMA guidance to identify all studies reporting outcomes of patients with dCCA who received *** patients from 2017 to 2022 who were referred for NAT for dCCA at our centre were retrospectively collected from a prospectively maintained *** characteristics,NAT type,progression to surgery and oncological outcomes were *** Twelve studies were *** definition of“unresectable”locally advanced dCCA was *** studies reported outcomes for 9 patients who received NAT for dCCA with extensive vascular involvement.R0 resection rate ranged between 0 and 100%but without survival benefit in most *** studies considered either NAT in resectable dCCA or inclusive with extrahepatic *** presented case series includes 9 patients(median age 67,IQR 56-74 years,male:female 5:4)referred for NAT for borderline resectable or locally advanced *** patients progressed to surgery and 2 were *** patient died at 14 months with evidence of recurrence at 6 months and the other died at 51 months following recurrence 6 months *** Evidence for benefit of NAT is *** on criteria for uniform definition of resectability for dCCA is *** propose using the established National-Comprehensive-Cancer-Network®criteria for pancreatic ductal adenocarcinoma.

关键词： Cholangiocarcinoma Neoadjuvant therapy Arterial involvement Locally advanced Systematic review

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COVID-19 in pregnancy:Perinatal outcomes and complications

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World Journal of Virology 2024年第4期13卷 62-73页

作者： Karolina Akinosoglou Georgios Schinas Evangelia Papageorgiou Theodoros Karampitsakos VasilikiDimakopoulou Eleni Polyzou Argyrios Tzouvelekis Markos Marangos Despoina Papageorgiou nikolaos Spernovasilis George Adonakis Department of Medicine University of PatrasPatras 26504Greece Department of Obstetrics and Gynecology University General Hospital of PatrasPatras 26504Greece Department of Pneumonology University General Hospital of PatrasPatras 26504Greece Department of Infectious Diseases German Oncology CenterLimassol 4108LimassolCyprus

BACKGROUND The risk of severe coronavirus disease 2019(COVID-19)in pregnant women is *** To examine the outcomes of pregnant women with COVID-19 and report perinatal outcomes and complications,while providing a brief review of current *** The study included pregnant women presenting from April 2020 to February 2022 to the emergency department(ED)of a tertiary *** retrospectively recorded the maternal and perinatal files,including patient epidemiological and clinical characteristics,laboratory values,outcomes,treatment modalities and associations were *** Among the 60 pregnant women,25%required hospitalization,all of whom were *** delivery occurred in 30%of *** percent of neonates required admission to the neonatal intensive care unit,and 5%were classified as small for their gestational *** mothers survived COVID-19 and pregnancy,with 6.6%requiring invasive mechanical *** delivery rates did not differ between hospitalized and non-hospitalized pregnant women;composite unfavorable perinatal outcomes,including stillbirth,small for gestational age,or neonatal intensive care unit(ICU)admission,did not significantly increase in the cases hospitalized for COVID-19(P=0.09).The odds of hospitalization increased 2.3-fold for each day of delayed ED presentation[***(95%CI:1.46-3.624),P<0.001].Comorbidity status was an independent predictor of hospitalization,albeit with marginal significance[***=16.13(95%CI:1.021-255.146),P=0.048].No independent predictors of adverse fetal outcome(composite)were identified,and eventual hospitalization failed to reach statistical significance by a slight margin(P=0.054).CONCLUSION Delayed ED presentation and comorbidities increase hospitalization *** study highlights the importance of continuous and specific guidance for managing pregnant COVID-19 patients,including timely and appropriate interventions to minimize maternal and perinatal morbidity an

关键词： SARS-CoV-2 COVID-19 Pregnancy Maternal outcomes Preterm delivery

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Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood

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四川生理科学杂志 2024年第5期46卷 1111-1111页

作者： nikolaos P Daskalakis 不详

The molecular pathology of stress-related disorders remains *** brain multiregion,multiomic study of posttraumatic stress disorder(PTSD)and major depressive disorder(MDD)included the central nucleus of the amygdala,hippocampal dentate gyrus,and medial prefrontal cortex(mPFC).Genes and exons within the mPFC carried most disease signals replicated across two independent *** pointed to immune function,neuronal and synaptic regulation,and stress *** factor and gene network analyses provided the underlying genomic structure.

关键词： structure. cortex medial

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Hepatocellular carcinoma national burden across different geographical regions in the United States between 2001 and 2020

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World Journal of Methodology 2024年第4期14卷 110-120页

作者： Yazan Abboud Raj Malhotra Muhammad Hassaan Arif Maan Anna Mathew Ibrahim Abboud Chun-Wei Pan Saqr Alsakarneh Fouad Jaber Islam Mohamed David Kim nikolaos T Pyrsopoulos Department of Internal Medicine Rutgers New Jersey Medical SchoolNewarkNJ 07103United States University of California Riverside School of Medicine RiversideCA 92521United States Department of Internal Medicine John H Stroger Hospital of Cook CountyChicagoIL 60612United States Department of Internal Medicine University of Missouri-Kansas CityKansasMO 64108United States Division of Gastroenterology and Hepatology Rutgers New Jersey Medical SchoolNewarkNJ 07101United States

BACKGROUND While prior data showed an increasing incidence of hepatocellular carcinoma(HCC)in the United States,there are limited comprehensive and comparative data on the geographical variations of HCC trends in different demographicspecific *** To evaluate sex and age-specific incidence rates and time trends in different geographical regions in the United *** Age-adjusted HCC incidence rates were collected from the United States Cancer Statistics(USCS)database which covers approximately 98%of the population in the United *** rates were stratified by sex,age,and geographical *** percentage change(APC)and average APC(AAPC)were estimated using Joinpoint Regression.A pairwise comparison was conducted between sex-specific *** There were 467344 patients diagnosed with HCC in the United States in the USCS database between 2001 and *** rates and trends varied by geographical *** looking at the West region(115336 patients),incidence rates of HCC were overall increasing and also increasing in older ***,when evaluating younger adults,HCC incidence rates decreased in men but not in women with a sex-specific absolute AAPC-difference of 2.15(P=0.005).When evaluating the Midwest region(84612 patients),similar results were *** incidence rates were increasing in the overall population and in older adults as well,they were decreasing in younger men but not in women with a sex-specific absolute AAPC-difference of 1.61(P<0.001).For the Northeast region(87259 patients),the analysis showed similar results with decreasing HCC incidence rates in younger men but not counterpart women(Sex-specific AAPC-difference=3.26,P<0.001).Lastly,when evaluating the south(180137 patients),the results were also decreasing in younger men but not in women(Sex-specific AAPC-difference=2.55,P<0.001).CONCLUSION Nationwide analysis covering around 98%of the United States population shows an increasing incidence of HCC across all

关键词： Hepatocellular carcinoma Incidence Epidemiology Health disparity Geography

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