检索结果-南通市图书馆

Extrahepatic right portal vein ligation allows parenchyma-sparing en bloc resection of segments 7, 8 and 4a for liver tumors engaging the right and middle hepatic veins

引用

Hepatobiliary & Pancreatic Diseases International 2015年第5期14卷 539-542页

作者： Charalampos Farantos nikolaos arkadopoulos Pantelis Vassiliu Panagiotis Kokoropoulos nikolaos Economopoulos Aggeliki Pandazi Vassilis Smyrniotis Fourth Department of Surgery Athens University Medical School Attikon University Hospital Second Department of Radiology Athens University Medical School Attikon University Hospital Second Department of Anesthesiology Athens University Medical School Attikon University Hospital

Right trisectionectomy for posterior liver tumors engaging the right and middle hepatic veins may lead to post-hepatectomy liver failure if the anticipated liver remnant is small. In such patients we developed a parenchymasparing one-step approach, that includes extrahepatic right portal vein ligation accompanied by en bloc resection only of segments 7, 8 and 4a and resection of the right and middle hepatic veins. The technique was applied in 3 patients with normal liver function, where according to the preoperative computed tomography the volume of segments 1, 2 and 3 ranged between 17% and 20% of the total liver volume. In all patients liver biochemistry improved rapidly postoperatively and a doubling of volume of segments 1, 2 and 3 was achieved by the third postoperative week, as extrahepatic right portal vein ligation ameliorated reperfusion injury of the remaining segments 5 and 6 and induced hypertrophy of segments 1, 2, 3 and 4b. There was no mortality or long-term *** are alive and free of disease 74, 50 and 17 months after the operation, respectively. We propose that the term ＂extended upper right sectionectomy＂ may be considered for the en bloc resection of segments 7, 8 and 4a, in future revisions ofthe Brisbane 2000 terminology of hepatic anatomy and resections.

关键词： liver trisectionectomy extrahepatic right portal vein ligation parenchyma-sparing hepatectomy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Interrogating the interplay of angiogenesis and immunity in metastatic colorectal cancer

引用

World Journal of Methodology 2022年第1期12卷 43-53页

作者： Katerina Kampoli Periklis G Foukas Anastasios Ntavatzikos nikolaos arkadopoulos Anna Koumarianou Hematology Oncology Unit The Fourth Department of Internal MedicineSchool of MedicineNational and Kapodistrian University of AthensAttikon University HospitalHaidari 12462AthensGreece The Second Department of Pathology School of MedicineNational and Kapodistrian University of AthensAttikon University HospitalHaidari 12462AthensGreece The Fourth Surgical Clinic School of MedicineNational and Kapodistrian University of AthensAttikon University HospitalHaidari 12462AthensGreece

Colon cancer is the third most common malignancy and the fifth most frequent cause of death from neoplastic disease *** the time of diagnosis,more than 20%of patients already have metastatic *** the last 20 years,the natural course of the disease has changed due to major changes in the management of metastatic disease such as the advent of novel surgical and local therapy approaches as well as the introduction of novel chemotherapy drugs and targeted agents such as anti-epidermal growth factor receptor,anti-BRAF and *** is a complex biological process of new vessel formation from existing ones and is an integral component of tumor progression supporting cancer cells to grow,proliferate and *** molecules are involved in this proangiogenic process,such as vascular endothelial growth factor and its receptors on endothelial cells.A well-standardized methodology that is applied to assess angiogenesis in the tumor microenvironment is microvascular density by using immunohistochemistry with antibodies against endothelial CD31,CD34 and CD105 *** smaller molecules,such as the micro-RNAs,which are small non-coding RNAs,are being studied for their usefulness as surrogate biomarkers of angiogenesis and *** this review,we will discuss recent advances regarding the investigation of angiogenesis,the crosstalk between elements of the immune microenvironment and angiogenesis and how a disorganized tumor vessel network affects the trafficking of CD8+T cells in the tumor ***,we will present recent data from clinical trials that combine antiangiogenic therapies with immune checkpoint inhibitors in colorectal cancer.

关键词： Vascular endothelial growth factor Circulating tumor cells Colorectal cancer MicroRNAs Microvascular density Crosstalk Angiogenesis Immunity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Does clamping during liver surgery predispose to thrombosis of the hepatic veins? Analysis of 210 cases

引用

World Journal of Gastroenterology 2009年第3期15卷 339-343页

作者： nikolaos arkadopoulos Vaia Stafyla Athanasios Marinis Vassilios Koutoulidis Kassiani Theodoraki Theodosios Theodosopoulos Ioannis Vassiliou nikolaos Dafnios Georgios Fragulidis Vassilios Smyrniotis Second Department of Surgery School of MedicineUniversity of AthensAretaieion University Hospital76 Vassilisis Sofia's Ave11528 AthensGreece First Department of Radiology School of MedicineUniversity of Athens Aretaieion University Hospital76 Vassilisis Sofi a's Ave11528 AthensGreece First Department of Anesthesiology School of MedicineUniversity of AthensAretaieion University Hospital76 Vassilisis Sofi a's Ave11528 AthensGreece

AIM:To test whether clamping during liver surgery predisposes to hepatic vein ***:We performed a retrospective analysis of 210 patients who underwent liver resection with simultaneous inflow and outflow ***,flow in the hepatic veins was assessed by Doppler ultrasonography during the reperfusion ***,patency of the hepatic veins was assessed by contrast-enhanced CT angiography,when necessary after 3-6 mo follow ***:Twelve patients(5.7%) developed intraoperative liver remnant ***,intraoperative ultrasonography did not reveal evidence of hepatic vein *** three of these patients a kinking of the common trunk of the middle and left hepatic veins hindering outflow was recognized and was managed successfully bysuturing the liver remnant to the *** three patients(10.9%) who developed signs of mild outflow obstruction postoperatively,had no evidence of thrombi in the hepatic veins or flow disturbances on ultrasonography and contrast-enhanced CT angiography,while *** term assessment of the patency of the hepatic veins over a 3-6 mo follow-up period did not reveal thrombi formation or clinical manifestations of out flow ***:Extrahepatic dissection and clamping of the hepatic veins does not predispose to clinically important thrombosis.

关键词： CT血管造影术多普勒超声检查肝切除术选择性肝动脉排除术

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Management of primary retroperitoneal synovial sarcoma: A case report and review of literature

引用

World Journal of Gastrointestinal Surgery 2019年第1期11卷 27-33页

作者： Aikaterini Mastoraki Dimitrios Schizas Ioannis S Papanikolaou George Bagias nikolaos Machairas George Agrogiannis Theodore Liakakos nikolaos arkadopoulos 4th Department of Surgery National and Kapodistrian University of Athens Attikon University Hospital 1st Department of Surgery National and Kapodistrian University of Athens Laikon Hospital Hannover Medical School Clinic for General Visceral and Transplant Surgery 3rd Department of Surgery National and Kapodistrian University of Athens Attikon University Hospital 1st Department of Pathology National and Kapodistrian University of Athens

BACKGROUND Synovial sarcoma(SS) is a rare type of soft tissue sarcoma that is usually developed from areas where synovial tissue exists, especially at the ***, several cases of retroperitoneal SS(RSS) have been described. We herein report a case of RSS presented in our *** SUMMARY A 69-year-old female patient was admitted with a large, palpable, firm mass in the right abdominal space SS. Computerized tomography scan depicted a concentric, sharply marinated retro-peritoneal lesion which was displacing the right kidney and the lower edge of the liver. Subsequently, the patient underwent surgical excision of the mass with additional right nephrectomy and resection of the right adrenal gland and a part of the diaphragm. The final histological diagnosis of the tumour was grade II monophasic *** RSS is encountered in the biphasic type, the monophasic fibrous, and the monophasic epithelial category as well. Relevant clinical manifestations are not always documented at early stages. Therefore, the final diagnosis is posed after complete histological examination taking into consideration the results of immunochemistry and genetic analysis. Therapeutic approach happens often late when metastases at the lungs and the liver are apparent. Thus, 5-year survival rates remain low.

关键词： Retroperitoneal tumours Synovial sarcoma Case report Clinical presentation Diagnostic modalities Therapeutic management

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Inferior vena cava obstruction and collateral circulation as unusual manifestations of hepatobiliary cystadenocarcinoma

引用

Hepatobiliary & Pancreatic Diseases International 2013年第3期12卷 329-331页

作者： nikolaos arkadopoulos Anneza I Yiallourou Constantinos Palialexis Emmanouil Stamatakis Evi Kairi-Vassilatou Vassilis Smyrniotis 4th Department of Surgery Attikon University Hospital University of Athens 2nd Department of Surgery Aretaieion Hospital University of Athens Department of Radiology Aretaieion Hospital University of Athens Department of Anesthesiology Aretaieion Hospital University of Athens Department of Pathology Aretaieion Hospital University of Athens

BACKGROUND: Hepatobiliary cystadenocarcinoma represents a rare epithelial malignant tumor derived from the intrahepatic bile duct. METHODS: A 71-year-old woman, who had undergone laparoscopic drainage of a cystic lesion of the right hepatic lobe, was misdiagnosed as having hepatic echinococcal disease, and received intracystic infusion of 95% ethanol four years ago. She was admitted to our hospital for further treatment. RESULTS: Physical examination revealed dilated superficial veins across the right abdominal wall. After mapping the direction of blood flow in these vessels, we assumed that this was a sign of inferior vena cava obstruction. Abdominal ultrasound, computed tomography, magnetic resonance imaging combined with magnetic resonance angiography showed a large cystic mass in the right upper quadrant and epigastrium, displacing the adjacent structures, adherent to the inferior vena cava, which was not patent, resulting in dilation of superficial epigastric veins. The patient underwent an exploratory laparotomy. Total excision of the huge mass measuring 16×15 cm was possible under selective vascular exclusion of the liver. Removal of the tumor resulted in immediate restoration of flow in the inferior vena cava. On the basis of the pathology and findings of immunohistochemical analysis, a hepatobiliary cystadenocarcinoma was ***: In the present case, hepatobiliary cystadenocar-cinoma was accompanied by dilated superficial venous collaterals due to inferior vena cava obstruction. Selective vascular exclusion of the liver allowed a safe oncological resection of the tumor.

关键词： hepatobiliary cystadenocarcinoma inferior vena cava obstruction collateral circulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Facing the challenge of venous thromboembolism prevention in patients undergoing major abdominal surgical procedures for gastrointestinal cancer

引用

World Journal of Gastrointestinal Oncology 2018年第10期10卷 328-335页

作者： Aikaterini Mastoraki Sotiria Mastoraki Dimitrios Schizas Raphael Patras nikolaos Krinos Ioannis S Papanikolaou Andreas Lazaris Theodore Liakakos nikolaos arkadopoulos 4th Department of Surgery National and Kapodistrian University of AthensAttikon University HospitalAthens 12462Greece Department of Vascular Surgery National and Kapodistrian University of AthensAttikon University HospitalAthens 12462Greece 1st Department of Surgery National and Kapodistrian University of AthensLaikon HospitalAthens 11527Greece

Venous thromboembolism(VTE)refers to a hypercoa-gulable state that remains an important and preven-table factor in the surgical treatment of *** includes two identical entities with regards to deep vein thrombosis and pulmonary *** incidence of VTE after major abdominal interventions for gastro-intestinal,hepato-biliary and pancreatic neoplastic disor-ders is as high as 25%without *** use of classic or low-molecular-weight heparin,anti-Xa factors,antithrombotic stocking,intermittent pneumatic compression devices and early mobilization have been ***,thromboprophylaxis is often dis-continued after discharge,although a serious risk may persist long after the initial triggering event,as the coagu-lation system remains active for at least 14 d *** aim of this review is to evaluate the results of the current practice of VTE prevention in cancer patients undergoing major abdominal surgical operations,with special attention to adequately elucidated guidelinesand widely accepted *** addition,the recent literature is presented in order to provide an update on the current concepts concerning the surgical manage-ment of the disease.

关键词： Deep vein thrombosis Pulmonary embolism Gastro-intestinal cancer Thromboprophylaxis Venous thromboembolism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Successful management of adhesion related small bowel ischemia without intestinal resection: A case report and review of literature

引用

World Journal of Gastrointestinal Pathophysiology 2019年第2期10卷 29-35页

作者： Pantelis Vassiliu Vasiliki Ntella George Theodoroleas Zisis Mantanis Ioanna Pentara Eleni Papoutsi Aikaterini Mastoraki nikolaos arkadopoulos 4th Department of Surgery National and Kapodistrian University of Athens Attikon University Hospital

BACKGROUND Intraabdominal adhesions develop spontaneously or after an inflammatory process or surgical procedure in the *** are the most common cause of small bowel obstruction(SBO).SBO occasionally leads to intestinal ischemia(In Is)which can be a life-threatening condition that requires management as soon as *** herein report a case of SBO with In Is presented in our institution and treated without intestinal *** SUMMARY A 34-year-old man presented at the emergency department after a 12-h-onset diffuse abdominal pain,bloating and *** had a history of traumatic right hepatectomy 11 years ago as well as adhesiolysis and resection of a long part of small bowel 2 years *** abdominal computed tomography(CT)showed dilated loops that led to the diagnosis of *** to deteriorating lactic acidosis,the patient was *** of the small bowel around an adhesion led to2.30 m of ischemic *** the application of N/S 40°C for 20 min,the intestine showed signs of improvement and it was decided to avoid resection and instead temporary close the abdomen with vacuum-pack *** the second-look laparotomy 48 h later,the intestine appeared *** patient was discharged on the 8 th post-op day in excellent *** In case of SBO caused by adhesions,extreme caution is needed if In Is is present,as the clinical signs are mild and you should rely for diagnosis in CT findings and lactate *** surgical approach could reverse the effects of In Is,if performed quickly,so that intestinal resection is avoided and should be used even when minimum signs of viability are present.

关键词： Intraabdominal adhesions Intestinal ischemia Small bowel obstruction Vacuum-pack technique Case report Conservative surgical approach

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recurrent aggressive mesenteric desmoid tumor successfully treated with sorafenib: A case report and literature review

引用

World Journal of Clinical Oncology 2019年第4期10卷 183-191页

作者： Aikaterini Mastoraki Dimitrios Schizas Chrysovalantis Vergadis Leon Naar Alexios Strimpakos Michail G Vailas Natasha Hasemaki George Agrogiannis Theodore Liakakos nikolaos arkadopoulos 4th Department of Surgery National and Kapodistrian University of Athens Attikon University Hospital 1st Department ofSurgery National and Kapodistrian University of Athens Laikon Hospital Department of Radiology National and Kapodistrian University of Athens Laikon Hospital 1st Department of Pathology National and Kapodistrian University of Athens

BACKGROUND Desmoid tumors(DT) are locally advanced but histologically benign monoclonal neoplasms that can occur from any musculoaponeurotic structure. The aim of this report is to analyze a rare clinical case of an aggressive intra-abdominal DT successfully treated with *** SUMMARY A 36-year-old man presented with increasing colicky abdominal pain and a selfpalpable mass in his left abdomen. Fourteen years earlier he was diagnosed with a large intra-abdominal tumor, which adhered to the left colonic flexure, part of the major gastric curvature and the spleen. Subsequent exploratory laparotomy revealed a voluminous mass in the epigastrium, arising from the posterior surface of the stomach and invading the superior mesenteric vessels, transverse mesocolon and the small bowel mesentery. As the tumor was unresectable, a jejunojejunal bypass was performed. Traditional therapeutic interventions proved insufficient, and the patient was started on sorafenib with a subsequent fulldisease ***'s pathogenesis has been associated with mutations in the adenomatous polyposis coli(APC) gene or beta-catenin gene CTNNB1, sex steroids or previous surgical trauma. Local treatment modalities, such as surgery or radiotherapy, are implemented in aggressively progressing or symptomatic patients. Sorafenib is a hopeful therapeutic option against DTs, while several pharmacological agents have been successfully used.

关键词： Desmoid tumor Aggressive fibromatosis Case report Pathogenesis Therapeutic approach Sorafenib treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mesenteric ischemia:Pathogenesis and challengingdiagnostic and therapeutic modalities

引用

World Journal of Gastrointestinal Pathophysiology 2016年第1期7卷 125-130页

作者： Aikaterini Mastoraki Sotiria Mastoraki Evgenia Tziava Stavroula Touloumi nikolaos Krinos nikolaos Danias Andreas Lazaris nikolaos arkadopoulos 4th Department of Surgery Athens UniversityMedical SchoolATTIKON University Hospital12462 ChaidariAthensGreece Department of Vascular Surgery Athens UniversityMedical SchoolATTIKON University Hospital12462 ChaidariAthensGreece

Mesenteric ischemia(MI) is an uncommon medical condition with high mortality rates. ΜΙ includes inadequate blood supply, inflammatory injury and eventually necrosis of the bowel wall. The disease can be divided into acute and chronic MI(CMI), with the first being subdivided into four categories. Therefore, acute MI(AMI) can occur as a result of arterial embolism, arterial thrombosis, mesenteric venous thrombosis and nonocclusive causes. Bowel damage is in proportion to the mesenteric blood flow decrease and may vary from minimum lesions, due to reversible ischemia, to transmural injury, with subsequent necrosis and perforation. CMI is associated to diffuse atherosclerotic disease in more than 95% of cases, with all major mesenteric arteries presenting stenosis or occlusion. Because of a lack of specific signs or due to its sometime quiet presentation, this condition is frequently diagnosed only at an advanced stage. Computed tomography(CT) imaging and CT angiography contribute to differential diagnosis and management of AMI. Angiography is also the criterion standard for CMI, with mesenteric duplex ultrasonography and magnetic resonance angiography also being of great importance. Therapeutic approach of MI includes both medical and surgical treatment. Surgical procedures include restoration of the blood flow with arteriotomy, endarterectomy or anterograde bypass, while resection of necrotic bowel is always implemented. The aim of this review was to evaluate the results of surgical treatment for MI and to present the recent literature in order to provide an update on the current concepts of surgical management of the disease. Mesh words selected include MI, diagnostic approach and therapeutic management.

关键词： Acute mesenteric ischemia Mesentericischemia Chronic diagnostic approach Therapeuticmanagement Surgical strategy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Adjuvant chemotherapy and acute toxicity in hypofractionated radiotherapy for early breast cancer

引用

World Journal of Clinical Cases 2014年第11期2卷 705-710页

作者： Vassilis Kouloulias Anna Zygogianni Efrosini Kypraiou John Georgakopoulos Zoi Thrapsanioti Ivelina Beli Eftychia Mosa Amanta Psyrri Christos Antypas Christina Armbilia Maria Tolia Kalliopi Platoni Christos Papadimitriou nikolaos arkadopoulos Costas Gennatas George Zografos George Kyrgias Maria Dilvoi George Patatoucas nikolaos Kelekis John Kouvaris 2nd Department of Radiology Radiotherapy Unit Attikon University Hospital 12462 Athens Greece 1st Department of Radiology Radiotherapy Unit Aretaieion University Hospital 12462 Athens Greece Radiotherapy Department Larisa University Hospital 12462 Athens Greece Medical Oncology Unit Attikon University Hospital 12462 Athens Greece Department of Clinical Therapeutics Alexandra Hospital 12462 Athens Greece 4th Surgical Clinic Attikon University Hospital 12462 Athens Greece 1st Propaedeutic Surgical Clinic Medical School Ippokration Hospital 12462 Athens Greece

AIM: To evaluate the effect of chemotherapy to the acute toxicity of a hypofractionated radiotherapy(HFRT) schedule for breast cancer. METHODS: We retrospectively analyzed 116 breast cancer patients with T1, 2N0 Mx. The patients received3-D conformal radiotherapy with a total physical dose of 50.54 Gy or 53.2 Gy in 19 or 20 fractions according to stage, over 23-24 d. The last three to four fractions were delivered as a sequential tumor boost. All patients were monitored for acute skin toxicity according to the European Organization for Research and Treatment of Cancer/Radiation Therapy Oncology Group criteria. The maximum monitored value was taken as the final grading score. Multivariate analysis was performed for the contribution of age, chemotherapy and 19 vs 20 fractions to the radiation acute skin ***: The acute radiation induced skin toxicity was as following: grade Ⅰ 27.6%, grade Ⅱ 7.8% and grade Ⅲ 2.6%. No significant correlation was noted between toxicity grading and chemotherapy(P = 0.154, χ2 test). The mean values of acute toxicity score in terms of chemotherapy or not, were 0.64 and 0.46 respectively(P = 0.109, Mann Whitney test). No significant correlation was also noted between acute skin toxicity and radiotherapy fractions(P = 0.47, χ2test). According to univariate analysis, only chemotherapy contributed significantly to the development of acute skin toxicity but with a critical value of P = 0.05. However, in multivariate analysis, chemotherapy lost its statistical significance. None of the patients during the 2-years of follow-up presented any locoregional ***: There is no clear evidence that chemotherapy has an impact to acute skin toxicity after an HFRT schedule. A randomized trial is needed for definite conclusions.

关键词： Hypofractionated radiotherapy Breast cancer Acute toxicity Chemotherapy Retrospective analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：