Interrogating the interplay of angiogenesis and immunity in metastatic colorectal cancer
作者机构：Hematology Oncology UnitThe Fourth Department of Internal MedicineSchool of MedicineNational and Kapodistrian University of AthensAttikon University HospitalHaidari 12462AthensGreece The Second Department of PathologySchool of MedicineNational and Kapodistrian University of AthensAttikon University HospitalHaidari 12462AthensGreece The Fourth Surgical ClinicSchool of MedicineNational and Kapodistrian University of AthensAttikon University HospitalHaidari 12462AthensGreece
出 版 物：《World Journal of Methodology》 (世界方法学杂志)
年 卷 期：2022年第12卷第1期
页 面：43-53页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Vascular endothelial growth factor Circulating tumor cells Colorectal cancer MicroRNAs Microvascular density Crosstalk Angiogenesis Immunity
摘 要：Colon cancer is the third most common malignancy and the fifth most frequent cause of death from neoplastic disease *** the time of diagnosis,more than 20%of patients already have metastatic *** the last 20 years,the natural course of the disease has changed due to major changes in the management of metastatic disease such as the advent of novel surgical and local therapy approaches as well as the introduction of novel chemotherapy drugs and targeted agents such as anti-epidermal growth factor receptor,anti-BRAF and *** is a complex biological process of new vessel formation from existing ones and is an integral component of tumor progression supporting cancer cells to grow,proliferate and *** molecules are involved in this proangiogenic process,such as vascular endothelial growth factor and its receptors on endothelial cells.A well-standardized methodology that is applied to assess angiogenesis in the tumor microenvironment is microvascular density by using immunohistochemistry with antibodies against endothelial CD31,CD34 and CD105 *** smaller molecules,such as the micro-RNAs,which are small non-coding RNAs,are being studied for their usefulness as surrogate biomarkers of angiogenesis and *** this review,we will discuss recent advances regarding the investigation of angiogenesis,the crosstalk between elements of the immune microenvironment and angiogenesis and how a disorganized tumor vessel network affects the trafficking of CD8+T cells in the tumor ***,we will present recent data from clinical trials that combine antiangiogenic therapies with immune checkpoint inhibitors in colorectal cancer.
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