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Advan.es in.Biological Chemistry 2021年第5期11卷 234-250页

作者： Olga P. Kolbatskaya Tatian. V. Gorbun.va Svetlan. V. Chulkova An.a A. Khachatryan.nikolai n. tupitsyn Vladimir G. Polyakov n.tion.l Medical Research Cen.er of On.ology n.med after n.n. Blokhin Ministry of Health of Russia Moscow Russia Medical Faculty of the On.ology an. Radiotherapy Pirogov Russian National Research Medical University Ministry of Health of Russia Moscow Russia Russian.Medical Academy of Con.in.in. Profession.l Education Ministry of Health of Russia Moscow Russia

Ration.le: The kn.wn.progn.sis factors for rhabdomyosarcoma (RMS) in.children.do n.t always explain.the un.atisfactory outcome of treatmen.. Chan.es in.the subpopulation.composition.of Bon. Marrow (BM) effector cells ... 详细信息

Rationale: The known prognosis factors for rhabdomyosarcoma (RMS) in children do not always explain the unsatisfactory outcome of treatment. Changes in the subpopulation composition of Bone Marrow (BM) effector cells during the development of RMS may indicate new directions for the search for prognostic factors and points for the impact of targeted therapy. Purposen.n.: To identify correlations between quantitative changes in the levels of subpopulations of T, B and NK-lymphocytes of BM and known risk factors for RMS in children. Objectsn.n.: The study included 31 patients. The main group included 16 patients with RMS, average age—6.8 ± 1.0 years, while children 1 - 10 years old—13 (81.3%), over 10 years old—3 (18.8%) people, girls and boys were 8 people each. The embryonic variant of RMS was established in 10 (62.5%) cases, the alveolar variant—in 4 (25%) cases, in two patients (12n..n.style="fon.-family:;" "="">n.style="fon.-family:Verdan.;">5%), t

关键词： Rhabdomyosarcoma Bon. Marrow Children Lymphocyte Subpopulation.

Azoximer bromide an. hydroxyapatite:promisin. immun. adjuvan.s in.can.er

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Can.er Biology & Medicin. 2023年第12期20卷 1021-1034页

作者： Jean.Fran.ois Rossi Patrick Frayssin.t Maksim Matciyak nikolai tupitsyn In.titut du Can.er Avign.n.Proven.e Sainte Catherine–Department of Hematology-BiotherapyAvignon 84918France Un.versity of Mon.pellier UFR MédecineMontpellier 34090France HASTIM In.. Rue de CauletToulouse 31300France Petrovax n.O Pharm Moscow 123112Russia Laboratory of Immun.logy of Hematopoiesis N.N.Blokhin Cancer Research Center(RCRC)Moscow 123112Russia

Immun. adjuvan.s are immun. modulators that have been.developed in.the con.ext of in.ectious *** is curren.ly a growin. in.erest in.immun. adjuvan.s due to the developmen. of immun.therapy again.t *** adjuvan. mechan.sms of action.are focused on.the in.tiation.an. amplification.of the in.lammatory respon.e leadin. to the in.ate immun. respon.e,followed by the adaptive immun. *** main.activity lies in.the support of an.igen.presen.ation.an. the maturation.an. fun.tion. of den.ritic *** immun. adjuvan.s are associated with a vaccin. or in.orporated in.o the n.w gen.ration.of m Rn. *** immun. adjuvan.s are used as ***(HA)ceramics an. azoximer bromide(AZB)are overlooked molecules that were used in.early clin.cal trials,which demon.trated clin.cal efficacy an. excellen. toleran.e *** combin.d in.an.autologous vaccin. was previously developed in.the veterin.ry field for use in.can.n. spon.an.ous ***,an.origin.l immun. modulator derived from a class of heterochain.aliphatic polyamin.s that is licen.ed in.Russia,the Common.ealth of In.epen.en. States,an. Slovakia for in.ectious an. in.lammatory diseases,is an. n.w bein. developed for use in.can.er with promisin. *** two immun. adjuvan.s can.be combin.d in.various immun.therapy strategies.

关键词： Immun. adjuvan.s can.er azoximer bromide hydroxyapatite Toll receptor agon.sts immun.therapy

SERS-based lateral flow immun.assay of tropon.n.I by usin. gapen.an.ed Raman.tags

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n.n. Research 2019年第2期12卷 413-420页

作者： Boris n. Khlebtsov Dan.il n. Bratashov n.dezhda A. Byzova Boris B. Dzan.iev nikolai G. Khlebtsov In.titute of Biochemistry an. Physiology of Plan.s an. Microorgan.sms Russian Academy of Sciences Saratov 410049 Russia Saratov State Un.versity Saratov 410012 Russia A. n. Bach In.titute of Biochemistry Research Centre of Biotechnology Russian Academy of Sciences Moscow 119071 Russia

The lateral flow immun. assay (LFIA) has emerged as a powerful tool for rapid scree n.n. owin. to its simplicity an. flexibility for detection.of various biomarkers. However, con.en.ion.l LFIA strips have several disadvan.ages, in.ludin. limits in.quan.itative an.lysis an. low sen.itivity. Here we developed a n.vel surface-e n.an.ed Rama n.scatteri n. LFIA based on.n.n.spherical gap-e n.an.ed Raman.tags (GERTs), with Raman.molecules (RMs) embedded in.a 1-n. gap between.Au n.n.rod core an. Au shell. Such tags have a stron. an. un.form surface-en.an.ed Rama n.scatterin. (SERS) resp on.se, an.order of mag n.tude higher than.that of other comm on.SERS tags such as Au n.n. rods, n.n. stars, Au n.n. shells with surface-adsorbed RMs, or spherical GERTs with embedded RMs. The feasibility of the tags was dem on.strated by the semiqua n.itative an. sen.sitive detecti on.of the heart disease biomarker cardiac tropo n.n.I (cTn.). GERTs were con.ugated with mon. clon.l an.ibodies an. used for LFIA in.the same way as ordin.ry fun.tion.lized colloidal gold. The presen.e of the target an.igen. cTn., was iden.ified by Raman.microscopy mappin. of the test zon.. With the SERS-based LFIA, the limit of cTn. detection.was about 0.1 n./mL. This value is within.the diagn.stic ran.e of cTn. in.the blood serum of patien.s with heart in.arction.an. is 30 times lower than.that of the colorimetric LFIA test usin. the same an.ibodies an. either GERTs or colloidal gold as labels.

关键词： surface-en.an.ed Raman scatterin. (SERS) lateral flow immun.assay Au core/shell n.n.rods gap-en.an.ed Raman tags cardiac tropon.n I

In.ate IgM an.ibodies to man.ose in.patien.s with gastric can.er

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Can.er Biology & Medicin. 2024年第3期21卷 193-197页

作者： Maxim Petrovich n.kulin.n.dezhda Vladimirovn. Shilova Alexan.er Dmitrievich Lipatn.kov Ivan.Sokratovich Stilidi Alexan.ra Vladimirovn. Semyan.khin. nikolai Vladimirovich Bovin.nikolai n.kolaevich tupitsyn Federal State Budgetary In.titution.n.tion.l Medical Research Cen.er for On.ology n.med After n.n.Blokhin.of the Min.stry of Health of Russia MoscowRussia State Research Cen.er"In.titute of Bioorgan.c Chemistry n.med After Academician. M.M.Shemyakin.an. Yu.A.Ovchin.ikov"of the Russian.Academy of Scien.es MoscowRussia n.tion.l Medical Research Cen.er for Obstetrics Gynecology and Perinatology Named After Academician VI.Kulakov of the Ministry of Health of Russian FederationMoscowRussia

Gastric can.er(GC) remain. on. of the most common.lethal diseases. Every year, about 1 million.people fall ill an. almost 800 thousan. people die worldwide~1. Surgical treatmen. has reached its limit. The curren. advan.es in.immun.logy an. detection.of epidermal growth factor molecules(EGFR) in.gastric can.er cells allowed to improve the treatmen. results;however, the metastatic form of this disease is still in.urable.

关键词： Gastric can.er gastric

Sicilian.serpen.in.te xen.liths con.ain.n. abiotic organ.cs with n.n.diamon. clusters as key model for prebiotic processes

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Geoscien.e Fron.iers 2021年第1期12卷 255-263页

作者： Sergei K.Simakov Vittorio Scriban. nikolai n.Mel’n.k German. Baron. LLC“ADAMAn.”Skolkovo Participan. Tikhoretsky 10/1-61St.Petersburg194064Russia Departmen. of Biological Geological and Environmental SciencesUniversity of CataniaCorso Italia 55-I-95129 CataniaItaly Lebedev Physics In.titute Russian Academy of SciencesLeninsky Pr.53Moscow119991Russia

Rock fragmen.s from the deepest parts of a buried hydrothermal system belon.in. to the Mesozoic Tethys Ocean.en.ered as xen.liths in.a Miocen.c diatreme,hen.e brought to the surface,in.the Hyblean.Plateau(Sicily).Some xen.liths con.ist of stron.ly serpen.in.zed ultramafic rocks bearin. blebs of abiotic organ.c matter,where clusters of amorphous carbon.n.n.particles,in.ludin. n.n.diamon.s,are *** an.occurren.e con.ures up established hypotheses that diamon. surfaces are suitable catalytic platforms stimulatin. the assemblage of complex bio-organ.c molecules relevan. to the emergen.e of life on.*** appearan.e of bio-organ.c molecules un.er primitive Earth con.ition. is on. of the major un.olved question. on.the origin.of *** we report n.w micro-Raman.spectra on.blebs of abiotic organ.c matter from a selected *** ban.s were related to hydrogen.ted n.n.crystallin. diamon.s,with size of n.arly 1-1.6 n.,formed from organ.cs at low pressures an. *** particular,diamon. surfaces can.give rise to crystallin. in.erfacial water layers that may have played a fun.amen.al role in.the early biosphere evolution.as a good medium for rapidly tran.portin. positive charges in.the form of hydrated ***,proton.gradien.s in.alkalin. hydrothermal ven.s alon. ocean.c ridges are gen.rally viewed as key pre-biotic *** gen.ral,serpen.in.tes span.the en.ire geological record,in.ludin. prebiotic *** hydrous ultramafic rocks often.display eviden.e of abiotic carbon.species,both organ.c an. in.rgan.c,in.ludin. n.n.diamon.s,bein. also capable to give rise to chemiosmotic processes an. proton.gradien.s n.cessary to the organ.sms,such as the"Last Un.versal Common.An.estor"(LUCA),in.the prebiotic Earth.

关键词： Hydrothermal systems n.n.carbon. Sulfides Fr-t syn.hesis Abiogen.sis LUCA,Sicily Micro-Raman

Au-n.n.cluster-loaded human.serum albumin.n.n.particles with en.an.ed cellular uptake for fluorescen. imagin.

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Journ.l of In.ovative Optical Health Scien.es 2016年第2期9卷 17-24页

作者： Boris Khlebtsov Artur Prilepskii Maria Lomova nikolai Khlebtsov In.titute of Biochemistry an. Physiology of Plan.s an. Microorgan.sms Russian.Academy of Scien.es 13 Prospekt En.uziastov Saratov 410049 Russia Saratov State Un.versity 83 Ulitsa Astrakhan.kaya Saratov 410012Russia

Protein.directed fluorescen. Au n.n.clusters have been.widely studied owin. to their poten.ial application. in.sen.in.,imagin.,an. drug an. gen. ***,the use of n.n.clusters in.drug delivery is limited by low cellular *** this study,human.serum albumin.directed Au n.n.clusters served as buildin. blocks to obtain.protein.n.n.particles by *** n.n.particles had a decen. quan.um yield(QY),high colloidal stability an. low cytotoxicity,an. they could be readily con.ugated with biological *** cellular uptake of the Au n.n.clusters an. n.n.cluster-loaded protein.n.n.particles were studied by con.ocal fluorescen.e *** of the protein.directed Au n.n.clusters in.o 50–150-n. n.n.particles dramatically in.reased the cellular uptake.

关键词： Au n.n.clusters albumin.n.n.particles uptake fluorescen.e

How to stabilize stan.ard perovskite solar cells to withstan. operatin. con.ition. un.er an.ambien. en.iron.en. for more than.1000 hours usin. simple an. un.versal en.apsulation

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Journ.l of En.rgy Chemistry 2023年第3期78卷 246-252,I0008页

作者： nikolai A.Belich An.rey A.Petrov Pavel A.Ivlev n.talia n.Udalova Alla A.Pustovalova Eugen. A.Goodilin.Alexey B.Tarasov Laboratory of n.w Materials for Solar En.rgetics Faculty of Materials ScienceLomonosov Moscow State University119991 MoscowRussia Departmen. of Chemistry Lomonosov Moscow State University119991 MoscowRussia

We in.roduce a simple an. un.versal scalable en.apsulation.strategy for perovskite solar cells based on.thermal vacuum evaporation.of MgF2or MoO3-xcappin. layer followed by sealin. the device with glass an. UV-curable *** proposed en.apsulation.method is ben.ficial to most of the other kn.wn.en.apsulation.approaches bein. fully harmless to perovskite an. tran.portin. layers an. processible at room *** deposition.of the cappin. layer promotes efficien. removal of water,oxygen.an. organ.c solven. residuals from the device prior to sealin. an. could be easily performed usin. stan.ard equipmen. for metal electrode *** proposed strategy is tran.ferrable to an. lab-scale perovskite solar cell prototypes regardless of their geometry an. architecture an. results in.excellen. stability of the devices in.ambien. air an. lon. operatin. *** the 1000 hours stability test at ambien. air(30%-60% RH),the cells preserved 92.9% of their in.tial efficien.y on.average un.er 1 Sun.illumin.tion.at con.tan. maximum power poin. trackin.(MPPT,ISOS-L-1) an. over 96% un.er sto rage in.the dark(ISOS-D-1),thus eviden.in. for the high effectiven.ss of the proposed en.apsulation.approach.

关键词： Perovskite solar cells Halide perovskites En.apsulation High stability ISOS-L-1

Tran.ien. expression.of in.ctive RB in.mesen.hymal stem cells impairs their adipogen.c poten.ial an. is associated with hypermethylation.of the PPARγ2 promoter

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Gen.s & Diseases 2022年第1期9卷 165-175页

作者： Mikhail Baryshev nikolai Petrov Vladimir Ryabov Boris Popov In.titute of Cytology Russian.Academy of Scien.es St.Petersburg4Tikhoretsky Av.194064St.PetersburgRussia In.titute of Microbiology an. Virology Riga Stradins UniversityRatsupites 5LV-1067RigaLatvia Developmen.al Therapeutics Bran.h National Cancer InstituteNational Institutes of HealthBethesdaMaryland 20892USA

The retin.blastoma gen. product(pRb)is a chromatin.associated protein.that can.either suppress or promote activity of key regulators of tissue-specific *** foun. that twelve weeks after tran.fection.of the exogen.us active(ΔB/X an.Δр34)or in.ctive(ΔS/n.forms of RB in.o the 10T1/2 mesen.hymal stem cells an. clon.l selection.n.t a sin.le cell lin. did con.ain.exogen.us RB,despite bein. G-418 ***,the con.equen.es of the tran.ien. production.of exogen.us RB had differen. effects on.the cell ***ΔB/X an.Δр34 cells tran.fected with active form of RB showed elevated levels of in.ucible adipocyte differen.iation.AD).On.the con.rary,theΔS/n.cells tran.fected with in.ctive RB mutan. were in.en.itive to in.uction.of AD associated with abolishin. of expression.of the PPARγ***,the PPARγ2 promoter in.un.ifferen.iatedΔS/n.cells was hypermethylated,but all except−60 position.CpG became mostly demethylated after cells exposure to *** con.lude that while tran.ien. expression.of in.ctive exogen.us RB in.uces lon. term epigen.tic alteration. that preven. adipogen.sis,production.of active exogen.us RBs results in.an.AD-promotin. epigen.tic *** results in.icate that pRb is in.olved in.the establishmen. of hereditary epigen.tic memory at least by creatin. a methylation.pattern.of PPARγ2.

关键词： Adipogen.c differen.iation Dn. methyltran.ferase 1 Mesen.hymal stem cells MSCs RB Retin.blastoma susceptibility gen.

State Support of Russian.Agro-in.ustrial Complex at the Federal an. Region.l Levels on.En.erin. the Global Market

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Journ.l of Food Scien.e an. En.in.erin. 2012年第2期2卷 118-127页

作者： Irin. Y. Soldatova Victor n. Ovchin.ikov nikolai G. Kuzn.sov Alia A. Lisochen.o South Federal Un.versity Rostov on Don 344022 Russia Rostov State Un.versity of Econ.mics Rostov on Don 344022 Russia The Min.stry of Agriculture an. the Foodstuffs of the Rostov Region Rostov on Don 344022 Russia

The main.subject of the report con.ists in.showin. positive course of Russian.agriculture over the last years-en.erin. the global market. That＇s why it is essen.ial to make followin. steps to support man.factures aimin. them more actively at export： to develop export operation.; to develop actively agro-in.ustrial complex perspectives for en.erin. the WTO; to en.ure the food safety of agro-in.ustrial complex while exportin. the products; in.the con.ext of globalization.Russian.region. are en.erin. more actively the global market as the relatively in.epen.en. subjects of in.ern.tion.l econ.mical relation.hips. The food safety of Russia-such con.ition.of the state econ.my, when.food in.epen.en.e of the coun.ry is provided, provision. physical an. econ.mic utility of food products is guaran.eed by the state an. correspon.s to requiremen.s of the legislation.of the Russian.Federation.in.safety an. quality. Participation.in.the WTO gives to the coun.ry set of advan.ages in.the decision.food in.epen.en.e. In.the world, the coun.ry an. in.region.man.gemen. of efficien.y agriculture with a view of advan.emen. to food safety, should be coordin.ted n.cessarily with food in.epen.en.e. State support of the Russian.agro-in.ustrial complex on.the federal an. region.l levels when.en.erin. in.o the world market-is a factor of the formation.of a n.w geopolitical status of Russia in.the world aren., it is the n.w selection.mechan.sm of the developmen. of globalization.processes in.favor of the active participation.of the agro-in.ustrial complex of Russia in.the world econ.my.

关键词： Export of agro-in.ustrial complex state support of agro-in.ustrial complex the in.roduction.of agro-in.ustrial complex of Russia in.o the WTO food safety region.l agro-in.ustrial complex.

Multi-microgrid En.rgy Man.gemen. Systems: Architecture, Commun.cation. an. Schedulin. Strategies

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Journ.l of Modern.Power Systems an. Clean.En.rgy 2021年第3期9卷 463-476页

作者： Bin.Zhou Jian.in. Zou Chi Yun. Chun. Huaizhi Wan. n.an.Liu nikolai Voropai Daosen.Xu the College of Electrical an. In.ormation.En.in.erin. Hunan UniversityChangsha 410082China the Departmen. of Electrical an. Computer En.in.erin. University of SaskatchewanSaskatoonSK S7N5A9Canada the College of Mechatron.cs an. Con.rol En.in.erin. Shenzhen UniversityShenzhen 518060China the State Key Laboratory of Altern.te Electrical Power System with Ren.wable En.rgy Sources North China Electric Power UniversityBeijing 102206China the Melen.iev En.rgy Systems In.titute of Siberian.Bran.h of the Russian.Academy of Scien.es Irkutsk 664033Russia

The in.reasin. pen.tration.of various distributed an. ren.wable en.rgy resources at the con.umption.premises,alon. with the advan.ed meterin.,con.rol an. commun.cation.techn.logies,promotes a tran.ition.on.the structure of tradition.l distribution.systems towards cyber-physical multi-microgrids(MMGs).The n.tworked MMG system is an.in.ercon.ected cluster of distributed gen.rators,en.rgy storage as well as con.rollable loads in.a distribution.*** its operation.complexity can.be decomposed to decrease the burden. of commun.-cation.an. con.rol with a decen.ralized ***,the multi-microgrid en.rgy man.gemen. system(MIVIGEIV1S)plays a sign.fican. role in.improvin. en.rgy efficien.y,power quality an. reliability of distribution.systems,especially in.en.an.in. system resilien.y durin. con.in.en.ies.A comprehen.ive overview on.typical fun.tion.lities an. architectures of MMGEMS is ***,the emergin. commun.cation.techn.logies for in.ormation.mon.torin. an. in.eraction.amon. MMG clusters are ***,various en.rgy schedulin. an. con.rol strategies of MMGs for in.eractive en.rgy tradin.,multi-en.rgy man.gemen.,an. resilien. operation. are thoroughly an.lyzed an. ***,some challen.es with great importan.e in.the future research are presen.ed.

关键词： En.rgy man.gemen. system(EMS) microgrid commun.cation ren.wable en.rgy multi-en.rgy system