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Neuropsychopharmacological profile of Astragalus membranaceous ***

Journal of Traditional Chinese Medical Sciences 2019年第3期6卷 254-262页

作者： Aldarmaa Jalsrai Avijit Biswas nikolai i.suslov.joseph v.martin institute of Traditional Medicine and Technology 495 Ulaanbaatar-36Mongolia Biology Department Rutgers University315 Penn St.CamdenNJ 08102USA Research institute of Pharmacology and Regenerative Medicine 3 Lenin Ave.Tomsk 634028Russia Center for Computational and integrative Biology Rutgers UniversityCamdenNJ 08102USA

Objective:To clarify the neuropharmacological profile of the Mongolian vetch,Astragalus mongholicus(Astragalus membranaceous ***;synonym:***),extracts were evaluated for behavioral effects in rats and ***:An aqueous extract of *** was made by boiling roots from freshlycollected plants in 2.5 volumes(w/v)of water for 60 *** ethanol extract was made by incubating in 70%ethanol for 5 days at 25*** of the aqueous extracts were evaluated in a forced swimming assessment of antidepressant effects,a hole-board test of exploratory behavior,an analysis of inhibition of aggression following electrical stimulation and influences on amnesia resulting from ***,effects of ethanol extracts of *** were assessed on L-tryptophan induced twitches(indicating serotonin-mediated effects)and on hypothermia induced by apomorphine(indicating dopamine-mediated interactions)in ***:Per os(PO)administration of the aqueous decoction of the vetch to rats increased the response in a forced swimming test as reflected in wheel ***,the decoction had no significant effect on the exploratory behavior of rats in the hole-board *** PO administration of the aqueous extract of *** decreased the threshold for aggressive behavior and this effect persisted with subchronic *** administration of the plant extract suppressed aggression of *** ethanol extract of *** showed an antiserotoninergic action and had a significant influence on the hypothermia induced by ***:*** has a variety of potent psychotropic actions,suggesting influences on diverse neurotransmitter systems.

关键词： Antidepressant Anxiolytic Mongolian vetch Nootropic Psychotropic effect

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