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Cancer Biology & Medicine 2018年第2期15卷 178-181页

作者： Ling Zhang Yunxia Li Shaohong Zhang Chen Gao keke nie Youxin Ji Department of Oncology Qingdao Cancer Hospital Department of Medicine Laixi Meihuashan Hospital Department of Oncology Affiliated Qingdao Central Hospital of Qingdao University

Crizotinib,a small molecular tyrosine kinase inhibitor,manifests dramatic responses in patients with non-small cell lung cancer with echinoderm microtubule associated protein like 4-anaplastic lymphoma kinase(EML4-ALK)*** gene point mutation is the primary mechanism of acquired crizotinib resistance;however,the intrinsic mechanism is not fully ***,we report a patient with a low mutant allele fraction(MAF)of EML4-ALK rearrangement,who experienced primary resistance to crizotinib *** patient was a 66-year-old Chinese man,who had a history of metastatic lung cancer and was treated with first-and third-generation epidermal growth factor receptor tyrosine kinase inhibitors(EGFR TKIs).After 14 months of osimertinib treatment,his disease progressed,and next-generation sequencing was performed from a liquid biopsy of the patient’s *** EML4-ALK rearrangement was found and crizotinib was *** patient’s lung lesions continued to progress after one month of crizotinib treatment,and pemetrexed-bevacizumab was *** two cycles of chemotherapy,the metastatic cancers shrunk,and the patient maintained stable disease at his last ***4-ALK rearrangements can happen in patients with EGFR-positive NSCLC,after acquired resistance to EGFR TKI *** EGFR T790M and C797G mutations occur in cis is a critical mechanism of resistance to osimertinib *** MAF of EML4-ALK rearrangements in cancer cells might be a predictive factor for crizotinib treatment.

关键词： Non-small cell lung cancer EML4-ALK target therapy crizotinib

Milk fat globule epithelial growth factorⅧ(MFG-E8)sustains survival of cancer cells by prompting tumor angiogenesis and suppressing host immunities

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Oncology and Translational Medicine 2017年第1期3卷 31-37页

作者： keke nie Shichao Liu Ling Zhang Zhongfa Zhang Xiao Zou Youxin Ji Oncology Department Qingdao Cancer HospitalQingdao 266042China Oncology Department Qingdao Central HospitalThe 2nd Affiliated Hospital of Qingdao UniversityQingdao 266042China

Milk fat globule epithelial growth factor VIII(MFG-E8) is a novel adhesion protein mainly produced by macrophages and dendritic cells; it is expressed in most of the human tissues and functions to prompt cancer progression and survival. MFG-E8 contains a signal sequence for secretion, two epidermal growth factor(EGF)-like domains at the NH2 terminus and two discoidin domains with blood-clotting factor V/factor Ⅷ(C1 and C2) at the COOH terminus. The second EGF domain contains an arginine-glycine-aspartic(RGD) integrin-binding motif that engages α_vβ_5 integrins to facilitate cell adhesion and induce integrinmediated signal transduction. Integrin α_vβ_3 associates with VEGF receptor 2, engagement of integrins can promote angiogenesis, which plays key roles in growth, proliferation, and survival of cancer cells. VEGF stimulates the expression of α_vβ_3 and α_vβ_5 integrins on angiogenic vasculature, thereby potentiating effects of VEGF receptor engagement. Mice expressing a mutant form of α_vβ_3 integrin are unable to undergo tyrosine phosphorylation, confirming the important role that this integrin plays in pathological angiogenesis and providing important mechanistic insights. The C-terminus discoidin-like domains promote binding to membrane phospholipids, functioning close to VEGF like angiogenesis. MFG-E8 is an opsonin for apoptotic cells, and it acts as a bridging protein between apoptotic cells and phagocytes. It also influences cell immunities by altering CD4^+ and/or CD8^+ cells. Antibody or small peptide works with MFG-E8 at different functional sites or interacts with EGF-like domains and/or discoidin-like domains may play an important role in anti-angiogenesis or immune restoration. Altering the structures and/or functions of MFG-E8 and/or its domains is promising for development of novel anti-cancer strategies.

关键词： milk fat globule epithelial growth factor Ⅷ(MFG-E8) carcinoma target therapy angiogenesis apoptosis

Treatment of Skin Reaction Induced by Nivolumab Combined with Radiotherapy in Non-small Cell Lung Cancer:A Case Report

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Chinese Medical Sciences Journal 2018年第3期33卷 183-187页

作者： Zhimei Zhao Shichao Liu Xiajuan Xu Zhongfa Zhang keke nie Youxin Ji Department of Oncology Affiliated Qingdao Central Hospital of Qingdao UniversityQingdaoShandong 266042China Department of Oncology Qingdao Cancer HospitalQingdaoShandong 266042China

Skin reaction or dermatological toxicities induced by immunotherapy is *** usually manifests skin rash or erythema and can be cured by skin lotion or ***,a human IgG4 programmed cell death protein 1(PD-1)inhibitor,blocks T cells activation preventing signal and allows the immune system to clear cancer *** was approved in the second-line therapy in squamous cell lung cancer by FDA,with less than 10%unusual skin reaction,like sensory neuropathy,peeling skin,erythema multiforme,vitiligo,and *** could aggravate this skin reaction through inflammatory response and promotion of *** combined treatment of anti-PD-1 and radiotherapy represented a new promising therapeutic approach in many studies,but the risk of side effects may be *** reported a patient with advanced squamous cell lung cancer who suffered from serious skin immune-related adverse events when he was treated with nivolumab and *** immune overreaction of the treatment of anti-PD-1 treatment and radiotherapy might cause these serious skin adverse *** report warranted careful workup to reduce the risk of side effects by combinative therapy with anti-PD-1 and radiotherapy.

关键词： skin reaction nivolumab immunotherapy radiotherapy non-small cell lung cancer

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渤南洼陷古近系高岭石发育特征及转化机理

石油勘探与开发 2009年第4期36卷 456-462页

作者：陈鑫钟建华袁静聂可可杨玉平中国石油大学(华东)地球资源与信息学院中国石油化工股份有限公司胜利油田分公司

砂岩储集层中高岭石的发育程度与储集层物性和油气聚集关系密切。通过对渤南洼陷古近系沙三段和沙四段的岩心观察、薄片鉴定、扫描电镜、黏土矿物X-衍射、岩心物性和含油级别分析测试,研究深层碎屑岩中高岭石的发育特征及形成机理。深... 详细信息

砂岩储集层中高岭石的发育程度与储集层物性和油气聚集关系密切。通过对渤南洼陷古近系沙三段和沙四段的岩心观察、薄片鉴定、扫描电镜、黏土矿物X-衍射、岩心物性和含油级别分析测试,研究深层碎屑岩中高岭石的发育特征及形成机理。深部碎屑岩储集层中的高岭石主要是由长石的溶蚀产生的,高岭石的发育是良好储集层和饱和油层出现的重要标志,高岭石含量出现相对高值的储集层与工业油层有很好的对应关系。研究区高岭石形成分为4个阶段:沉积高岭石向伊利石转化阶段、自生高岭石大量产生阶段、油层中的高岭石被油气包围阶段及油层中高岭石出现异常高值阶段。深部碎屑岩储集层中的高岭石形成于酸性流体和长石相互作用的酸性成岩场中,保存在油气充注形成的惰性成岩场中,在弱碱性成岩场中迅速向伊利石和绿泥石转化。

关键词：古近系高岭石发育特征转化机理研究意义渤南洼陷

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路基高边坡中锚杆支护系统的分析及应用

黑龙江交通科技 2024年第3期47卷 51-53页

作者：聂珂珂中国有色金属工业第六冶金建设有限公司河南郑州450006

基于弥勒至玉溪高速公路项目实例,建立了边坡锚杆支护计算模型,研究了不同的锚杆的竖向位置、横向间距以及锚杆锚固倾角等参数对于边坡支护安全系数的影响。结果表明:锚杆位置越靠近坡底,其边坡安全系数越高,可有效避免土体因剪切破坏... 详细信息

基于弥勒至玉溪高速公路项目实例,建立了边坡锚杆支护计算模型,研究了不同的锚杆的竖向位置、横向间距以及锚杆锚固倾角等参数对于边坡支护安全系数的影响。结果表明:锚杆位置越靠近坡底,其边坡安全系数越高,可有效避免土体因剪切破坏产生的滑移;锚杆间距越小,杆间有效支护区域重叠增大,间距2 m内支护效果波动较小;锚杆长度在一定范围内可以有效地提高边坡稳定性,但是超过一定长度后,其边坡稳定性没有进一步提高;锚固倾角小于30°时支护效果与角度呈正比,在40°时有所下降,说明存在最佳锚固角。

关键词：高边坡锚杆支护排布形式锚杆倾角

Severe acute interstitial lung disease induced by crizotinib therapy in a patient with c-Met amplification non-small cell lung cancer

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Chinese Medical Journal 2014年第8期127卷 1600-1600页

作者： Ji Youxin Zhang Zhongfa nie keke Lan Ketao Geng Chuanxin Liu Shichao Zhang Ling Zhang Zongchun Sun Lei Zou Xiao Qingdao Univ Dept Oncol Qingdao Cent Hosp Affiliated Hosp 2 Qingdao 266042 Shandong Peoples R China

To the editor： Severe acute interstitial lung disease is not uncommon during and after irradiation of the lung, but is very rare during crizotinib treatment. We reported here one case of severe acute interstitial lun...

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顺北油田分支断裂及断控储层的识别与描述研究

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工程地球物理学报 2024年第4期21卷 663-671页

作者：王鹏龚伟吴金才聂可可中国石化西北油田分公司勘探开发研究院新疆乌鲁木齐830011 吉奥科思(北京)能源科技有限公司北京102200

顺北油气田是断裂控制的断控油气田,其中不少断层发育有分支断裂。分支断裂在常规地震资料上难以发现,属于断距小或者说是比较隐蔽的断裂。因这些断裂带形态与分布不清,断控储集体特征也不清楚,从而使得储层预测与目标优选困难。如何对... 详细信息

顺北油气田是断裂控制的断控油气田,其中不少断层发育有分支断裂。分支断裂在常规地震资料上难以发现,属于断距小或者说是比较隐蔽的断裂。因这些断裂带形态与分布不清,断控储集体特征也不清楚,从而使得储层预测与目标优选困难。如何对这类断裂开展识别和描述,进而开展储层预测和目标评价,本次研究尝试从多种方法的组合使用入手,通过反复试验发现,把时频谱蓝化提高地震分辨率处理与方向性边界保持断层增强处理组合使用,能有效提高地震资料分支断裂的识别能力;把梯度结构张量断裂检测处理与最大似然属性断裂检测处理组合使用能很好地对分支断裂进行描述与刻画;把结构张量属性分析与缝洞增强处理组合使用能很好地对洞穴型储层进行有效刻画;GST(Gradient Structural Tensor)相干属性与不连续性属性联合使用实现了对孔洞型储层的预测;体曲率+最大似然属性组合使用实现了对裂缝型储层预测与描述;在不同类型储层预测基础上,通过不同类型储层的叠合得到的总储层预测。

关键词：分支断裂提高分辨率处理断层增强处理断裂检测断控储集体预测

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融入超像素分割的高分辨率影像面向对象分类

测绘通报 2021年第6期 44-49页

作者：聂倩七珂珂赵艳福宁波市测绘和遥感技术研究院浙江宁波315000 宁波市阿拉图数字科技有限公司浙江宁波315000

针对高分辨率遥感影像面向对象分类中容易受分割参数的影响、分类精度不稳定的问题,本文提出了一种融入超像素分割的高分辨率影像面向对象分类方法。该方法通过简单线性迭代聚类(SLIC)算法对原始影像进行聚类生成超像素影像,并在此基础... 详细信息

针对高分辨率遥感影像面向对象分类中容易受分割参数的影响、分类精度不稳定的问题,本文提出了一种融入超像素分割的高分辨率影像面向对象分类方法。该方法通过简单线性迭代聚类(SLIC)算法对原始影像进行聚类生成超像素影像,并在此基础上采用分形网络演化方法(FNEA)进行多尺度分割生成同质性对象,最后利用最邻近分类方法进行地物分类。试验结果表明,该方法不易受多尺度分割参数的影响,分类效果稳定,而且分类精度明显高于传统的面向对象分类方法,对于高分辨率遥感影像的广泛应用具有重要意义。

关键词：高分辨率遥感影像简单线性迭代聚类超像素分形网络演化方法多尺度分割面向对象分类

生成式人工智能绘画侵权的样态分析与规制路径

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行政与法 2023年第12期 86-98页

作者：聂洪涛马可可西安财经大学法学院

生成式人工智能绘画的出现为人工智能行业带来了巨大的发展机遇,但也带来了一系列挑战,如侵权行为的普遍存在、造假行为的猖獗以及生成式人工智能绘画的售卖牟利和侵犯隐私等。这些问题都成为阻碍生成式人工智能绘画产业健康可持续发展... 详细信息

生成式人工智能绘画的出现为人工智能行业带来了巨大的发展机遇,但也带来了一系列挑战,如侵权行为的普遍存在、造假行为的猖獗以及生成式人工智能绘画的售卖牟利和侵犯隐私等。这些问题都成为阻碍生成式人工智能绘画产业健康可持续发展的主要因素。生成式人工智能绘画侵权保护是一个包括政策、法律、科技、产业等多个领域和方面的系统性工程,要汇集多种力量共同推进。为了有效地防止生成式人工智能绘画侵权行为,应从生成式人工智能绘画的发展历程出发,系统分析生成式人工智能绘画侵权模式,深入探究生成式人工智能绘画的规制路径,从机制、主体、创新等多方面提出有效的优化策略,以期达到更好的法律规制效果。

关键词：生成式人工智能绘画侵权行为版权保护

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我国水资源法规体系现状浅析

四川水利 2010年第5期31卷 66-68页

作者：聂青周科科刘晓辉西华大学能源与环境学院成都610039

通过对我国水资源法规体系现状分析,指出现行法规体系存在的不足,并提出几种解决和完善法律法规体系的方法,以实现水资源保护的目的。

关键词：水资源法律法规问题解决方案