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放射性药品的药物警戒

医药导报 2024年第10期43卷 1615-1619页

作者：孙悦郑雨璇张镇江张瑜娴张冉卢畅张丽李鼎涂家郴谢晶周焕宫建沈阳药科大学药物流行病与临床药物评价课题组沈阳110016 蚌埠医科大学第一附属医院临床试验研究中心蚌埠233000

放射性药品在医疗领域发挥着重要作用,但同时也存在一定的风险和安全隐患。医疗机构实行药物警戒,保障患者用药安全,包括放射性药品的药物使用安全。美国和欧盟药物警戒体系的运行及管理等方面较为成熟,中国可以借鉴其先进理念,建立适... 详细信息

放射性药品在医疗领域发挥着重要作用,但同时也存在一定的风险和安全隐患。医疗机构实行药物警戒,保障患者用药安全,包括放射性药品的药物使用安全。美国和欧盟药物警戒体系的运行及管理等方面较为成熟,中国可以借鉴其先进理念,建立适合自己的放射性药物警戒体系。

关键词：放射性药品药物警戒上市许可持有人药物安全性评价

Raman tensor of graphite:Symmetry of G,D and D′phonons

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Science China Materials 2022年第1期65卷 268-272页

作者： Mingge Jin lu Cheng Wei zheng Ying ding Yanming Zhu Lemin Jia Feng Huang State Key Laboratory of Optoelectronic Materials and Technologies School of MaterialsSun Yat-sen UniversityGuangzhou 510275China

Graphite is a natural highly-anisotropic layered material formed by stacking in the direction perpendicular to two-dimensional(2D)graphene *** an anisotropic material,graphite is characterized by its extraordinary optical response[1].For example,the Raman scattering effect of graphite is both complex and intriguing to be an important window for peeping through its physical properties[1].

关键词：实验证据声子偏振角拉曼共振机制对称性首次记录角分辨

Preparation of high-affinity rabbit monoclonal antibodies for ciprofloxacin and development of an indirect competitive ELISA for residues in milk

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第10期11卷 812-818页

作者： Bin HUANG Yun YIN Lei lu Hai ding Lin WANG Ting YU Jia-jin ZHU Xiao-dong zheng Yan-zhen ZHANG Department of Food Science and Nutrition Zhejiang University Hangzhou 310029 China Department of Stomatology the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China Yikang Biotechnology Company Hangzhou 310029 China

A convenient competitive enzyme-linked immunosorbent assay(ELISA) for ciprofloxacin(CPFX) was developed by using rabbit monoclonal antibodies(RabMAbs) against a hapten-protein conjugate of CPFX-bovine serum albumin(BSA).The indirect competitive ELISA of CPFX had a concentration at 50% inhibition(IC50) of 1.47 ng/ml and a limit of detection(LOD) of 0.095 ng/*** mAb exhibited some cross-reactivity,however,not so high with enrofloxacin(28.8%),ofloxacin(13.1%),norfloxacin(11.0%),fleroxacin(22.6%),and pefloxacin(20.4%).And it showed almost no cross-reactivity with other antibiotics or sulfonamides evaluated in this *** competitive ELISA kit developed here could be used as a screening tool to detect and control illegal addition of CPFX in food *** kit had been applied to milk detection and the recovery rates from samples spiked by CPFX were in a range of 63.02%-84.60%,with coefficients of variation of less than 12.2%.

关键词： Ciprofloxacin Competitive enzyme-linked immunosorbent assay (ELISA) Rabbit monoclonal antibody Residues Cross-reactivity

Sunway supercomputer architecture towards exascale computing: analysis and practice

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Science China(Information Sciences) 2021年第4期64卷 177-197页

作者： Jiangang GAO Fang zheng Fengbin QI Yajun ding Hongliang LI Hongsheng lu Wangquan HE Hongmei WEI Lifeng JIN Xin LIU Daoyong GONG Fei WANG Yan zheng Honghui SUN Zhou ZHOU Yong LIU Hongtao YOU National Research Center of Parallel Computer Engineering and Technology

In recent years, the improvements of system performance and energy efficiency for supercomputers have faced increasing challenges, which create more intensive demands on the architecture design for realizing exascale computing. This paper first analyzes the main requirements of exascale computing on the aspects of the parallel computing application and supercomputing center operation. Afterwards, a mapping scheme of "demands-challenges-architecture" is proposed. Then, the major challenges of exascale supercomputer, such as scalability, power consumption, data movement, programming and availability, are thoroughly analyzed, and the corresponding appropriate solutions are proposed. Moreover, this paper proposes the Sunway computer architecture towards exascale computing in which the many-core processor, network chipset and software system are all domestically-designed. The technology roadmap of Sunway supercomputer will hold the comprehensive design methods for the architecture, including the processor, interconnect network,assembly structure, power supply, cooling system, system software, parallel algorithm and application support, promising great advances for exascale supercomputing.

关键词： supercomputer exascale Sunway scalability power consumption data movement programming availability

Plasma-assisted fabrication of monolayer phosphorene and its Raman characterization

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Nano Research 2014年第6期7卷 853-859页

作者： Wanglin lu Haiyan Nan Jinhua Hong Yuming Chen Chen Zhu zheng liang Xiangyang Ma Zhenhua Ni Chuanhong Jin Ze Zhang State Key Laboratory of Silicon Materials Key Laboratory of Advanced Materials and Applications for Batteries of Zhejiang Province Department of Materials Science and Engineering Zhejiang University Hangzhou 310027 China Department of Physics Southeast University Nanjing 211189 China Graphene Research and Characterization Center Taizhou Sunano New Energy Co. Ltd. Taizhou 225300 China

There have been continuous efforts to seek novel functional two-dimensional semiconductors with high performance for future applications in nanoelectronics and optoelectronics. In this work, we introduce a successful experimental approach to fabricate monolayer phosphorene by mechanical cleavage and a subsequent Ar＊ plasma thinning process. The thickness of phosphorene is unambiguously determined by optical contrast spectra combined with atomic force microscopy （AFM）. Raman spectroscopy is used to characterize the pristine and plasma-treated samples. The Raman frequency of the A2g mode stiffens, and the intensity ratio of A2g to Alg modes shows a monotonic discrete increase with the decrease of phosphorene thickness down to a monolayer. All those phenomena can be used to identify the thickness of this novel two-dimensional semiconductor. This work on monolayer phosphorene fabrication and thickness determination will facilitate future research on phosphorene.

关键词： Mechanical cleavage monolayer phosphorene two-dimensionalsemiconductor plasma thinning optical contrast Raman spectroscopy

响应面法优化枯草芽孢杆菌发酵废渣超声辅助提取蛋白工艺

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生物化工 2024年第4期10卷 19-23,29页

作者：廖宽祺丁宁聂立璇姜振锟李林炜卢斌周康熙陈禹舟厦门烟草工业有限责任公司福建厦门361026 龙岩烟草工业有限责任公司福建龙岩364000 福建中烟工业有限责任公司福建厦门361021 厦门通仙实业有限公司福建厦门361021

从发酵废渣中提取蛋白是废弃物综合利用的有效途径之一。本研究在单因素试验的基础上,通过响应面法优化枯草芽孢杆菌发酵废渣的蛋白提取工艺。试验结果表明,在缓冲液pH 9.59、缓冲液体积35 mL(料液比1∶350,g∶mL)、超声温度80℃、超声... 详细信息

从发酵废渣中提取蛋白是废弃物综合利用的有效途径之一。本研究在单因素试验的基础上,通过响应面法优化枯草芽孢杆菌发酵废渣的蛋白提取工艺。试验结果表明,在缓冲液pH 9.59、缓冲液体积35 mL(料液比1∶350,g∶mL)、超声温度80℃、超声时间40 min的条件下,可提取蛋白量为(70.42±0.53)mg/g,相比优化前提高了197%。该工艺能为后续相关蛋白的研究及应用提供技术支撑和原料供给。

关键词：发酵废渣废物利用响应面优化蛋白提取

Improved Blending Attention Mechanism in Visual Question Answering

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Computer Systems Science & Engineering 2023年第10期47卷 1149-1161页

作者： Siyu lu Yueming ding zhengtong Yin Mingzhe Liu Xuan Liu Wenfeng zheng Lirong Yin School of Automation University of Electronic Science and Technology of ChinaChengdu610054China College of Resource and Environment Engineering Guizhou UniversityGuiyang550025China School of Data Science and Artificial Intelligence Wenzhou University of TechnologyWenzhou325000China School of Public Affairs and Administration University of Electronic Science and Technology of ChinaChengdu611731China Department of Geography and Anthropology Louisiana State UniversityBaton Rouge70803LAUSA

Visual question answering(VQA)has attracted more and more attention in computer vision and natural language *** are committed to studying how to better integrate image features and text features to achieve better results in VQA *** of all features may cause information redundancy and heavy computational *** mechanism is a wise way to solve this ***,using single attention mechanism may cause incomplete concern of *** paper improves the attention mechanism method and proposes a hybrid attention mechanism that combines the spatial attention mechanism method and the channel attention mechanism *** the case that the attention mechanism will cause the loss of the original features,a small portion of image features were added as *** the attention mechanism of text features,a selfattention mechanism was introduced,and the internal structural features of sentences were strengthened to improve the overall *** results show that attention mechanism and feature compensation add 6.1%accuracy to multimodal low-rank bilinear pooling network.

关键词： Visual question answering spatial attention mechanism channel attention mechanism image feature processing text feature extraction

Is the evolution in tumors Darwinian or non-Darwinian?

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National Science Review 2018年第1期5卷 15-17页

作者： Hurng-Yi Wang Yuxin Chen ding Tong Shaoping Ling zheng Hu Yong Tao Xuemei lu Chung-I Wu Graduate Institute of Clinical Medicine Taiwan University State Key Laboratory of Biocontrol School of Life SciencesSun Yat-Sen University Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences Stanford Cancer Institute Stanford University School of Medicine

Although Darwinian selection driving the genetic diversity within tumors has been widely assumed by the field of cancer biology,recent studies that employ the rigorous tests of population genetics have increasingly suggested *** these new studies[1-5],the non-Darwinian,or neutral,model of evolution can adequately explain the documented diversities in tumors without invoking natural ***,the half-century-old debate of selectionism ***[6-8]on the role of natural selection in populations is being

关键词： Is the evolution in tumors Darwinian or non-Darwinian

Charactering protein fraction concentrations as influenced by nitrogen application in low-glutelin rice cultivars

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Journal of Integrative Agriculture 2016年第3期15卷 537-544页

作者： LI Gang-hua CHEN Yi-lu ding Yan-feng GENG Chun-miao LI Quan LIU zheng-hui WANG Shao-hua TANG She Jiangsu Collaborative Innovation Center for Modern Crop Production/Jiangsu Key Laboratory for Information Agriculture/National Engineering and Technology Center for Information Agriculture/Key Laboratory of Crop Physiology and Ecology in Southern China Nanjing Agricultural University Nanjing 210095 P.R.China

To optimize both grain yield and quality of low-glutelin rice cultivars under N-fertilizer strategies, two-year field experiments involving three low-glutelin rice cultivars（W1240, W1721, W025） and an ordinary rice cultivar（H9405） with five N treatments were carried out to determine the effects of N application rate and genotype on protein fractions contents and Glutelin/Prolamin ratio（Glu/Pro）. The difference of protein fraction concentrations affected by N application rate existed in genotypes. Ordinary rice cultivar had a larger increase in glutlein concentration affected by N application rate than low-glutelin rice cultivars did. Glutelin in H9405 had a increase of 30.6 and 41.0% under the N4 treatment（360 kg N ha^（–1）） when compared with N0 treatment（no fertilizer N） in 2010 and 2011 respectively, while all the low-glutelin rice cultivars showed relatively smaller increases for two years. Variance analysis showed no significant effect of N application rate on glutelin in W1240 and W025 while the effects on albumin, globulin and prolamin were significant in low-glutelin rice. What＇s more, N treatment had no significant i nfluence on Glu/Pro ratios in low-glutelin rice cultivars while a significant increase in Glu/Pro ratio was observed in ordinary rice cultivar. So low-gultelin rice cultivars showed a different pattern from ordinary rice cultivars when influenced by N application rate.

关键词： low-glutelin rice nitrogen protein fractions Glu/Pro