Zbed3 participates in the subcortical maternal complex and regulates the distribution of organelles
Zbed3 participates in the subcortical maternal complex and regulates the distribution of organelles作者机构：State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China Key Laboratory of Urban Agriculture (North) of Ministry of Agriculture College of Biological Science and Engineering Beijing University of Agriculture Beijing 102206 China
出 版 物：《Journal of Molecular Cell Biology》 (分子细胞生物学报（英文版）)
年 卷 期：2018年第10卷第1期
页 面：74-88页
核心收录：
学科分类：0710[理学-生物学] 07[理学] 08[工学] 071009[理学-细胞生物学] 09[农学] 0813[工学-建筑学] 0901[农学-作物学] 0814[工学-土木工程] 090102[农学-作物遗传育种]
基 金：国家自然科学基金 the Strategic Priority Research Program of the Chinese Academy of Sciences
主 题：Zbed3 SCMC organelle distribution maternal effect gene cytoskeleton early embryogenesis cytoplasmic lattices
摘 要：We previously identified a subcortical maternal complex （SCMC） that is essential for early embryogenesis and female fertility in mice. However, the molecular mechanism by which the SCMC affects female fertility remains largely uncharacterized. Here, we report that a novel maternal protein, zinc finger BED-type containing 3 （Zbed3）, participates in the SCMC. Depletion of maternal Zbed3 results in reduced fecundity of females, because of the impaired and delayed development in a proportion of mutant embryos. The loss of maternal Zbed3 results in asymmetric zygotic division and abnormal distributions of organeUes in the affected oocytes and zygotes, similar to the phenotypes observed in females with disrupted core SCMC genes. Further investiga- tion revealed that these phenotypes are associated with disrupted dynamics of microtubules and/or formation of cytoplasmic lat- tices （CPLs）. The stability and localization of Zbed3 depend on, but are not required for, the formation of the SCMC. Thus, our data suggest Zbed3 as one of downstream proteins mediating SCMC functions and provide further insights into the roles of the SCMC and CPLs in female fertility.
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