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Macular carotenoid supplementation improves disability glare performance and dynamics of photostress recovery

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Eye and Vision 2016年第1期3卷 231-238页

作者： James M.stringham Kevin J.O’Brien nicole t.stringha. Nutritional Neuroscience Laboratory Department of Physiology and PharmacologyUniversity of GeorgiaAthensGA 30602USA Vision Sciences Laboratory Department of PsychologyUniversity of GeorgiaAthensGA 30602USA Interdisciplinary Neuroscience Program Biomedical Health Sciences InstituteUniversity of GeorgiaAthensGA 30602USA

Background:the so-called macular carotenoids(MC)lutein(L),zeaxanthin(Z),and meso-zeaxanthin(MZ)comprise the diet-derived macular pigment(MP).the purpose of this study was to determine effects of MC supplementation on the optical density of MP(MPOD),repeated-exposure photostress recovery(PSR),and disability glare(DG)***:this was a double-blind,placebo-controlled ***-nine young(mean age=21.7),healthy volunteers participated in this *** supplemented their daily diet with either 10 mg L+2 mg total Z(1 mg Z+1 mg MZ;n=24),20 mg L+4 mg total Z(2 mg Z+2 mg MZ;n=25),or placebo(n=10)for 12 *** primary outcome was a composite measure of visual performance in glare,defined by change in DG and *** outcomes included MPOD and visual *** primary endpoint for outcomes was 12 *** was assessed with customized heterochromatic flicker *** times for an 8 cycle/degree,15%contrast Gabor patch target were determined after each of five successive exposures to intense LED *** threshold was defined as the intensity of a ring of lights through which subjects were able to maintain visibility of the aforementioned *** of all parameters were conducted at baseline,6 months,and 12 ***-measures ANOVA,and Pearson product-moment correlations were used to determine statistically significant correlations,and changes within and between ***:MPOD for subjects in both supplementation groups increased significantly versus placebo at both 6-and 12-month visits(ptionally,PSR times and DG thresholds improved significantly from baseline compared to placebo at 6-and 12-month visits(pt baseline,MPOD was significantly related to both DG thresholds(r=0.444;p=0.0021)and PSR times(r=-0.56;ption of MPOD,the repeated-exposure PSR curves became more asymptotic,as opposed to *** change in subjects’DG thresholds were significantly related to chang

关键词： Lutein Zeaxanthin Mesozeaxanthin Visual performance Photostress recovery Disability glare Macular pigment Visual cycle

Multi-point temperature measurements in packed beds using phosphor thermometry and ray tracing simulations

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Particuology 2024年第2期85卷 77-88页

作者： Guangtao Xuan Mirko Ebert Simson Julian Rodrigues nicole Vorhauer-Huget Christian Lessig Benoit Fond Institute of Fluid Dynamics and thermodynamics OVGU MagdeburgUniversitaetsplatz 2Magdeburg39106Saxony-AnhaltGermany Institute of Simulations and Graphics OVGU MagdeburgUniversitaetsplatz 2Magdeburg39106Saxony-AnhaltGermany Institute of Process Engineering OVGU MagdeburgUniversitaetsplatz 2Magdeburg39106Saxony-AnhaltGermany ONERA The French Aerospace LabDepartment of AerodynamicsAeroelasticity and Aeroacoustics(DAAA)Paris-Saclay University8rue des VertugadinsMeudon92190France

Packed bed reactors are commonly found in the process industry,for example in flame-assisted calci-nation for cement *** the heat transfer inside the bed is essential for process control,product quality and energy *** we propose a technique to determine the internal temperature distribution of packed beds based on a combination of lifetime-based phosphor ther-mometry,ray tracing simulations,and assimilation of temperature data using finite element heat transfer *** establish and validate the technique,we considered a reproducible regular packing of 6 mm diameter aluminum spheres,with one of the spheres in the top layer being electrically *** a sphere inside the packing is coated with thermographic phosphors and excitation light is directed to-wards the packing,luminescence from the coated sphere exits the packed bed after multiple reflection and the sphere's temperature can be *** measurements showed that the temper-ature obtained by phosphor thermometry is independent of the luminescent sphere *** imaging the luminescence on a camera,the luminescence distribution in recorded image depended,however,on the position of the ***,in setups with multiple phosphor-coated spheres,their signals can be separated using a least squares *** demonstrate the approach using a setup with three luminescent spheres and validated the temperature readings against thermocouple *** obtain the spatial signatures for individual sphere positions required for the least squares fit,ray tracing simulations were *** provide an efficient alternative to single sphere measurements that are only practical for regular spherical packed ***-point measurements were used as input to a finite element heat transfer simulations to determine parameters such as particle-to-particle air gap *** these,the full temperature distribution inside the bed could be assimilated from the meas

关键词： Packed beds Phosphor thermometry Ray tracing Heat transfer simulation Data assimilation

Intracellular Metabolite transporters in Plants

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Molecular Plant 2010年第1期3卷 21-53页

作者： nicole Linka Andreas RM. Weber Institute of Plant Biochemistry Heinrich-Heine Universit~t D0sseldorf Geb. 26.03.01 Universitsstsstrasse 1 40225 Dasseldorf Germany

Due to the presence of plastids, eukaryotic photosynthetic cells represent the most highly compartmentalized eukaryotic cells. this high degree of compartmentation requires the transport of solutes across intracellular membrane systems by specific membrane transporters. In this review, we summarize the recent progress on functionally characterized intracellular plant membrane transporters and we link transporter functions to Arabidopsis gene identifiers and to the transporter classification system. In addition, we outline challenges in further elucidating the plant membrane permeome and we provide an outline of novel approaches for the functional characterization of membrane transporters.

关键词： Membrane biochemistry molecular transport transporters membrane proteins.

Mouse modelling of the MDM2/MDMX-p53 signalling axis

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Journal of Molecular Cell Biology 2017年第1期9卷 34-44页

作者： nicole R. tackmann Yanping Zhang Department of Radiation Oncology Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill Chapel Hill NC 27514 USA Curriculum in Genetics and MoLecular Biology School of Medicine University of North Carolina at Chapel HiLl Chapel HILL NC 27514 USA Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy Cancer Institute Xuzhou Medical College Xuzhou 221002 China

It is evident that p53 activity is critical for tumour prevention and stress response through its transcriptional activation of genes affecting cellular senescence, apoptosis, cellular metabolism, and DNA repair. the regulation of p53 is highly complex, and MDM2 and MDMX are thought to be critical for deciding the fate of p53, both through inhibitory binding and post-translational modification. Many mouse models have been generated to study the regulation of p53 in vivo, and they have altered our inter- pretations of how p53 is regulated by MDM2 and MDMX. Although MDM2 is absolutely required for p53 regulation, certain func- tions are dispensable under unstressed conditions, including the ability of MDM2 to degrade p53. MDMX, on the other hand, may only be required in select situations, like embryogenesis. these models have also clarified how cellular stress signals modify the p53-inhibiting activities of MDM2 and MDMX in vivo. It is clear that more work will need to be performed to further understand the contexts for each of these signals and the requirements of various MDM2 and MDMX functions. Here, we will discuss what we have learned from mouse modelling of MDM2 and MDMX and underscore the ways in which these models could inform future therapies.

关键词： p53 MDM2 MDMX E3 ubiquitin ligase cancer

Systematic review with meta-analysis on transplantation for alcohol-related liver disease:Very low evidence of improved outcomes

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World Journal of Gastroenterology 2019年第13期25卷 1628-1639页

作者： nicole t Shen Cristina Londono Stephanie Gold Ashley Wu Keith C Mages Robert S Jr Brown Department of Medicine Division of Gastroenterology and Hepatology Weill Cornell Medicine New York Department of Medicine Weill Cornell Medical College New York Department of Medicine Division of Internal Medicine Weill Cornell Medicine New York Department of Medicine Weill Cornell Medical College Samuel J. Wood Library and C.V. Starr Biomedical Information Center New York

BACKGROUND Alcohol-related liver disease(ALD) is a leading cause of liver failure and indication for liver transplantation that arises in the setting of alcohol use disorder(AUD). Previous reviews of transplantation for ALD are limited in scope of outcomes and type of ALD studied. A comprehensive systematic review could improve use of transplantation in ALD and improve future research. We hypothesize that while transplanting ALD may improve mortality and relapse,findings will be limited by pre-specified causes of heterogeneity-assessment and treatment of AUD, definition of ALD, spectrum of ALD studied, assessment and rates of relapse, and study quality and *** to optimize liver transplantation for ALD, understanding existing research to guide future research, we conducted a systematic review with *** We conducted a systematic review, comparing liver transplant to no-transplant in patients with ALD, with a primary outcome of both short-and long-term mortality and relapse. We performed a comprehensive search of MEDLINE,EMBASE, Web of Science, and the Cochrane Library databases for peer-reviewed journal articles comparing use of liver transplant in ALD to no-transplant. two reviewers independently conducted screening, full text review, and data extraction according to the PRISMA guidelines. We report the quality of the evidence according to the GRADE *** We analyzed data from 10 studies. Of 1332 participants, 34.2%(456/1332) had undergone liver transplantation, while 65.8%(876/1332) had not. While random effects meta-analysis suggested transplant in comparison to no-transplant had an association of reduced mortality that did not reach statistical significance, relative risk(RR) = 0.51(0.25-1.05), but not relapse risk, RR = 0.52(0.18-1.53), significant heterogeneity limited these findings. When restricted to prospective data,transplant compared to no-transplant significantly reduced mortality, RR = 0.25(0.13-0.46, P < 0.01), and relap

关键词： Alcohol-related hepatitis Alcohol-related cirrhosis Alcohol use disorder Liver transplantation Standardization

Forecasting the development of boreal paludified forests in response to climate change: a case study using Ontario ecosite classification

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Forest Ecosystems 2015年第1期2卷 45-55页

作者： Benoit Lafleur nicole J Fenton Yves Bergeron Institut de recherche sur les forêts Université du Québec en Abitibi-Témiscamingue 445 boul. de l’Université Rouyn-Noranda QC J9X 5E4 Canada Centre d’étude de la forêt Université du Québec à Montréal 141 Avenue du Président-Kennedy Montréal QC H2X 1Y4 Canada

Background：Successional paludification,a dynamic process that leads to the formation of peatlands,is influenced by climatic factors and site features such as surficial deposits and soil *** boreal regions,projected climate change and corresponding modifications in natural fire regimes are expected to influence the paludification process and forest *** objective of this study was to forecast the development of boreal paludified forests in northeastern North America in relation to climate change and modifications in the natural fire regime for the period 2011–***：A paludification index was built using static（*** deposits and soil texture）and dynamic（*** regime and soil organic layer thickness）stand scale factors available from forest *** index considered the effects of three temperature increase scenarios（i.e.＋1°C,＋3°C and＋6°C）and progressively decreasing fire cycle（from 300 years for 2011–2041,to 200 years for 2071–2100）on peat accumulation rate and soil organic layer（SOL）thickness at the stand level,and paludification at the landscape ***：Our index show that in the context where in the absence of fire the landscape continues to paludify,the negative effect of climate change on peat accumulation resulted in little modification to SOL thickness at the stand level,and no change in the paludification level of the study area between 2011 and ***,including decreasing fire cycle to the index resulted in declines in paludified ***,the index predicts a slight to moderate decrease in the area covered by paludified forests in 2100,with slower rates of ***：Slower paludification rates imply greater forest productivity and a greater potential for forest harvest,but also a gradual loss of open paludified stands,which could impact the carbon balance in paludified ***,as the thick Sphagnum layer typical of paludified forests may protect soil organic layer from dr

关键词： Boreal forest Canada Carbon sequestration Paludification Peat forests Forest harvest

Helper t cell differentiation

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Cellular & Molecular Immunology 2019年第7期16卷 634-643页

作者： Jordy Saravia nicole M.Chapman Hongbo Chi Department of Immunology St.Jude Children’s Research HospitalMemphisTNUSA

CD4^(+)t helper cells are key regulators of host health and *** the original model,specialized subsets of t helper cells are generated following activation through lineage-specifying cytokines and transcriptional programs,but recent studies have revealed increasing complexities for CD4^(+)t-cell ***,we first discuss CD4^(+)t-cell differentiation from a historical perspective by highlighting the major studies that defined the distinct subsets of t helper *** next describe the mechanisms underlying CD4^(+)t-cell differentiation,including cytokine-induced signaling and transcriptional *** then review current and emerging topics of differentiation,including the plasticity and heterogeneity of t cells,the tissue-specific effects,and the influence of cellular metabolism on cell fate ***,recent advances in cutting-edge approaches,especially systems biology tools,have contributed to new concepts and mechanisms underlying t-cell differentiation and will likely continue to advance this important research area of adaptive immunity.

关键词： t cells treg differentiation plasticity immunometabolism

Plant physiological changes along an encroachment gradient: an assessment of US Mid-Atlantic serpentine barrens

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Journal of Plant Ecology 2018年第6期11卷 853-865页

作者： nicole A.Havrilchak Jessica L.Schedlbauer Department of Biology West Chester University750 S.Church StreetWest ChesterPA 19383USA

Aims Serpentine barrens of the Mid-Atlantic United States are globally rare,grass-dominated ecosystems thought to exclude C3 spe-cies and characterized by unique soil ***,like many grassland ecosystems globally,these sites are presently facing encroachment by surrounding *** this ecosystem,the tendril climbing vine,Smilax rotundifolia,forms dense thickets around bar-rens that typically precede forest *** numerous factors speculatively initiate and promote encroachment in these systems,few studies have examined photosynthetic responses of serpentine grasses to changes in resource availability initiated by encroachers or physiological ability of encroaching *** to colonize high-light barren *** sought to under-stand both environmental and physiological dynamics of encroach-ment along an irradiance gradient in these *** At three serpentine barren sites in southeastern Pennsylvania,physiological responses of the native grasses Sorghastrum nutans and Schizachyrium scoparium to increased shading by ***-folia were ***,the physiological performance of *** in the forest understory was compared to that in sunlit barrens ***-saturated photosynthesis(A_(sat)),stomatal conductance(g_(s)),instantaneous transpiration efficiency(ItE),maximum efficiency of photosystem II(F_(v)/F_(m)),midday leaf water potential(ψ_(leaf))and specific leaf area(SLA)were measured for all species over the course of the 2014 growing ***-way analyses of variance were used to assess changes in these param-eters across growing environments,as well as seasonally for each *** regression analyses were also performed to inves-tigate the influence of vapor pressure deficit(D)and leaf tempera-ture(t_(leaf))on A_(sat) and *** Findings Light-saturated photosynthesis was significantly greater in ***-difolia growing in sun than in the shade(Pth

关键词： encroachment photosynthesis serpentine barren Schizachyrium scoparium Smilax rotundifolia Sorghastrum nutans

Comparison of Cardiovascular Parameters and Internal training Load of Different 1-h training Sessions in Non-elite CrossFit^(®)Athletes

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Journal of Science in Sport and Exercise 2023年第2期5卷 130-141页

作者： nicole Meier Danien Sietmann Annette Schmidt Institut Für Sportwissenschaft Fakultät Für HumanwissenschaftenUniversität Der Bundeswehr MünchenWerner‑Heisenberg‑Weg 3985577 NeubibergGermany

Purpose the fact that CrossFit^(®)is the best-known and rapidly growing concept for high-intensity interval training(HIIt)and high-intensity functional training(HIFt)results in a continuous increase of athletes performing CrossFit^(®).In the more than 15,000 CrossFit^(®)Affiliates worldwide,the training concept is usually offered in 1-h training sessions containing the CrossFit^(®)-related workout of the day(WOD),as well as a general warm-up,movement demonstrations,and skill ***,we report how physiological parameters measured by heart rate(HR)values vary during four different 1-h CrossFit^(®)training sessions of non-elite athletes(n=27)in a local affiliated training center and what influencing factors may *** the duration of the 1-h training sessions were divided into a warm-up part(WU-part),a skill development part combined with strength exercises(A-part),followed by the WOD part(B-part).Results Analysis of HR values shows high training intensity(≥91%HR_(max))not throughout the duration of each training session,only during *** mean HR values in B-part differ significantly compared to the remaining training parts(Ptraining *** of different CrossFit^(®)experience levels revealed no significant differ-ence in acute physiological demands and training load between beginner and experienced CrossFit^(®)*** Our results may suggest that practicing CrossFit^(®)in 1-h training sessions combined anaerobic and aerobic exercise intensities,with the training concept allows beginners and experienced athletes to be trained with the same cardio-vascular responses and training intensities.

关键词： CrossFit^(®)performance training load Exercise intensity Cardiovascular response High-intensity functional training