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CB1 receptor localization in rat spinal cord and roots,dorsal root ganglion,and peripheral nerve

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中国药理学报 1999年第12期20卷 1115-1120页

作者： m Clara.SANUDO-PENA nicole m strangman Ken mACKIE J mchael WALKER TSOU Kang The Alan m Schrier Research Laboratory Departments of Psychology and NeuroscienceBrown University ProvidenceRhode Island 02912 Department of Anesthesiology University of Washington School of Medicine Seattle WA 98195-6540USA

AIm:The localization of CB1 receptors in the spinal cord,spinal roots,dorsal root ganglion(DRG),and peripheral nerve of the rat was ***:We studied the distribution of CB1 cannabinoid receptors by immunohistochemistry using an antibody raised against the N-terminal of the ***:The spinal cord showed numerous transverse fibers labelled for CB1 receptors throughout and concentrated in the dorsal ***-stained cells were observed throughout the spinal cord gray *** DRG also showed cells and fibers labelled for CB1 *** fibers were observed in both dorsal and ventral roots as well as in peripheral ***:The presence of CB1 receptors in the DRG,the dorsal root,and the dorsal horn is in accordance with the analgesic effects of *** presence of labelled cells and fibers in the ventral horn and ventral root provides a substrate for cannabinoid-induced muscle relaxant and antispastic effects.

关键词： cannabinoids cannabinoid receptors spinal ganglia spinal nerve roots peripheral nerves central muscle relaxants analgesia

大麻酚类受体-1在脊髓、背角、背根神经节和周围神经的分布(英文)

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Acta Pharmacologica Sinica 1999年第12期20卷 61-66页

作者： m Clara.SANUDO-PENA,nicole m strangman,Ken mACKIE,J mchael WALKER,TSOU Kang The Alan m Schrier Research Laboratory Departments of Psychology and Neuroscience Brown University Providence Rhode Island 02912 The Alan m Schrier Research Laboratory Departments of Psychology and Neuroscience Brown University Providence Rhode Island 02912 Department of Anesthesiology University of Washington School of medicine Seattle WA 98195-6540 USA The Alan m Schrier Research Laboratory Departments of Psychology and Neuroscience Brown University Providence Rhode Island 02912 The Alan m Schrier Research Laboratory Departments of Psychology and Neuroscience Brown University Providence Rhode Island 02912

关键词：大麻酚类大麻酚类受体脊神经节脊神经根周围神经中枢性肌松弛药镇痛

Controlling Heat Transfer for the manufacturing of High molecular Weight Polyisobutylene via Formation of micelles

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Chinese Journal of Polymer Science 2019年第9期37卷 898-902页

作者： Szilard Csihony nicole Janssen Klaus mühlbach Advanced materials & Systems

An alternative cationic polymerization method is developed to produce high molecular weight polyisobutylene (Hm-PIB) with molecular weights above 5×10^5g/mol. The method involves micelle formation via functionalized low molecular weight polyisobutylene (Lm-PIB) in non-polar solvent. One end of Lm-PIB is modified with an imidazolium-containing ionic group, which together with the anion (eg. Al2Cl7) works as Lewis acid. While the monomer isobutylene dissolves readily in non-polar solvent, polymerization can occur only within the micelle, which affords stable Hm-PIB particles. Hm-PIB with a molecular weight (mW) close to 1 × 10^6 g/mol was produced successfully with the described method.

关键词： Cationic polymerization High molecular weight polyisobutylene micelle

The role of cellular and molecular neuroimmune crosstalk in gut immunity

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Cellular & molecular Immunology 2023年第11期20卷 1259-1269页

作者： Daping Yang nicole Almanzar Isaac m.Chiu Department of Immunology Harvard Medical SchoolBostonMA02115USA

The gastrointestinal tract is densely innervated by the peripheral nervous system and populated by the immune *** two systems critically coordinate the sensations of and adaptations to dietary,microbial,and damaging stimuli from the external and internal microenvironment during tissue homeostasis and *** brain receives and integrates ascending sensory signals from the gut and transduces descending signals back to the gut via autonomic *** regulate intestinal immune responses through the action of local axon reflexes or through neuronal circuits via the gut-brain *** neuroimmune crosstalk is critical for gut homeostatic maintenance and disease *** this review,we discuss the roles of distinct types of gut-innervating neurons in the modulation of intestinal mucosal *** will focus on the molecular mechanisms governing how different immune cells respond to neural signals in host defense and *** also discuss the therapeutic potential of strategies targeting neuroimmune crosstalk for intestinal diseases.

关键词： Neuroimmunology Neuroimmune Host defense Gut Sensory

Helper T cell differentiation

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Cellular & molecular Immunology 2019年第7期16卷 634-643页

作者： Jordy Saravia nicole m.Chapman Hongbo Chi Department of Immunology St.Jude Children’s Research HospitalMemphisTNUSA

CD4^(+)T helper cells are key regulators of host health and *** the original model,specialized subsets of T helper cells are generated following activation through lineage-specifying cytokines and transcriptional programs,but recent studies have revealed increasing complexities for CD4^(+)T-cell ***,we first discuss CD4^(+)T-cell differentiation from a historical perspective by highlighting the major studies that defined the distinct subsets of T helper *** next describe the mechanisms underlying CD4^(+)T-cell differentiation,including cytokine-induced signaling and transcriptional *** then review current and emerging topics of differentiation,including the plasticity and heterogeneity of T cells,the tissue-specific effects,and the influence of cellular metabolism on cell fate ***,recent advances in cutting-edge approaches,especially systems biology tools,have contributed to new concepts and mechanisms underlying T-cell differentiation and will likely continue to advance this important research area of adaptive immunity.

关键词： T cells Treg differentiation plasticity immunometabolism

Pre-mRNA modifications and their role in nuclear processing

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Frontiers of Electrical and Electronic Engineering in China 2018年第3期6卷 210-227页

作者： nicole m martinez Wendy V Gilbert Department of molecular Biophysics ＆ Biochemistry Yale UniversityNew HavenCT 06520USA

Background： Cellular non-coding RNAs are extensively modified post-transcriptionally, with more than 100 chemically distinct nucleotides identified to date. In the past five years, new sequencing based methods have revealed widespread decoration of eukaryotic messenger RNA with diverse RNA modifications whose functions in mRNA metabolism are only beginning to be known. Results： Since most of the identified mRNA modifying enzymes are present in the nucleus, these modifications have the potential to function in nuclear pre-mRNA processing including alternative splicing. Here we review recent progress towards illuminating the role of pre-mRNA modifications in splicing and highlight key areas for future investigation in this rapidly growing field. Conclusions： Future studies to identify which modifications are added to nascent pre-mRNA and to interrogate the direct effects of individual modifications are likely to reveal new mechanisms by which nuclear pre-mRNA processing is regulated.

关键词： mRNA modification pre-mRNA modification splicing RNA-modifying enzymes

Borderline resectable pancreatic cancer: Definitions and management

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World Journal of Gastroenterology 2014年第31期20卷 10740-10751页

作者： nicole E Lopez Cristina Prendergast Andrew m Lowy Division of Surgical Oncology Department of Surgery Moores Cancer Center University of California San Diego

Pancreatic cancer is the fourth leading cause of cancer death in the United States. While surgical resection remains the only curative option, more than 80% of patients present with unresectable disease. Unfortunately, even among those who undergo resection, the reported median survival is 15-23 mo, with a 5-year survival of approximately 20%. Disappointingly, over the past several decades, despite improvements in diagnostic imaging, surgical technique and chemotherapeutic options, only modest improvements in survival have been realized. Nevertheless, it remains clear that surgical resection is a prerequisite for achieving longterm survival and cure. There is now emerging consensus that a subgroup of patients, previously considered poor candidates for resection because of the relationship of their primary tumor to surrounding vasculature, may benefit from resection, particularly when preceded by neoadjuvant therapy. This stage of disease, termed borderline resectable pancreatic cancer, has become of increasing interest and is now the focus of a multiinstitutional clinical trial. Here we outline the history, progress, current treatment recommendations, and future directions for research in borderline resectable pancreatic cancer.

关键词： Pancreatic cancer Borderline resectable pancreatic cancer Neoadjuvant Vascular resection Pancreaticoduodenectomy Whipple

Patterns of fossil distributions within their environmental context from the middle Triassic in South Canyon,Central Nevada,USA

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Journal of Palaeogeography 2014年第1期3卷 74-89页

作者： Pedro m.monarrez nicole Bonuso Department of Geological Sciences California State University

The middle Triassic records the return of diverse marine communities after the severe effects of the end-Permian mass *** diversification leads to the mesozoic/modern adaptive radiation resulting in substantial changes in marine communities in comparison to their Paleozoic *** analysis focuses on the faunal abundance,ecological patterns,and environmental interpretation of a middle Triassic section in Central *** bulk samples were *** fossils were identified and tallied from hand samples and thin-sections were used to aid in environmental *** in the Late Anisian,we observed an ammonoid dominated to flat-clam,epifaunal dominated benthic community within a muddy,quiet,inner shelf depositional *** time,epifaunal bivalves dominate within a middle shelf environment followed by an increase in infaunalization and *** this time the presence of oncoids and the reported finding of corals suggest the middle shelf environment gave way to a higher energy patch reef shelf edge ***,we observe epifaunal brachiopods communities at the top of our section deposited in a middle shelf *** sum,we observe the dominance of modern taxa(i.e.,bivalves)with Paleozoic ecologies(i.e.,epifaunal),followed by the dominance of modern taxa with modern ecologies(i.e.,infaunal,thick shells)and then a return to Paleozoic taxa(i.e.,brachiopods)and Paleozoic ecologies within an overall transgressive environment.

关键词： biotic recovery middle Triassic Star Peak Group Favret Formation Augusta mountain Formation

RNA binding proteins in spermatogenesis： an in depth focus on the musashi family

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Asian Journal of Andrology 2015年第4期17卷 529-536页

作者： Jessie m Sutherland nicole A Siddall Gary R Hime Eileen A mcLaughlin School of Environmental and Life Sciences University of Newcastle Callaghan NSW 2308 Australia Anatomy and Neuroscience University of Melbourne ParkvilleVIC 3010 Australia

Controlled gene regulation during gamete development is vital for maintaining reproductive potential. During the complex process of mammalian spermatogenesis, male germ cells experience extended periods of the inactive transcription despite heavy translational requirements for continued growth and differentiation. Hence, spermatogenesis is highly reliant on mechanisms of posttranscriptional regulation of gene expression, facilitated by RNA binding proteins （RBPs）, which remain abundantly expressed throughout this process. One such group of proteins is the musashi family, previously identified as critical regulators of testis germ cell development and meiosis in Drosophila, and also shown to be vital to sperm development and reproductive potential in the mouse. This review describes the role and function of RBPs our recent knowledge of the musashi proteins in spermatogenesis. within the scope of male germ cell development, focusing on The functional mechanisms utilized by RBPs within the cell are outlined in depth, and the significance of sub-cellular localization and stage-specific expression in relation to the mode and impact of posttranscriptional regulation is also highlighted. We emphasize the historical role of the musashi family of RBPs in stem cell function and cell fate determination, as originally characterized in Drosophila and Xenopus, and conclude with our current understanding of the differential roles and functions of the mammalian musashi proteins, musashi-1 and musashi-2, with a primary focus on our findings in spermatogenesis. This review highlights both the essential contribution of RBPs to posttranscriptional regulation and the importance of the musashi family as master regulators of male gamete development.

关键词： gene regulation musashi musashi-1 musashi-2 posttranscriptional control RNA binding proteins spermatogenesis splicing testis translation