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Heat shock protein 20 promotes sirtuin 1-dependent cell proliferation in induced pluripotent stem cells

World Journal of Stem Cells 2021年第6期13卷 659-669页

作者： Mujib Ullah nicole Pek Min Qian Gustavo Yannarelli Asma Akbar Institute for Immunity and Transplantation Stem Cell Biology and Regenerative MedicineSchool of MedicineStanford UniversityStanfordCA 94304United States Immunology and School of Medicine Stanford UniversityStanfordCA 94304United States Laboratorio de Regulación Génica y Células Madre Instituto de Medicina TraslacionalTrasplante y Bioingeniería(IMeTTyB)Universidad Favaloro-CONICETBuenos Aires 1078Argentina Institute for Molecular Medicine School of MedicineStanford UniversityStanfordCA 94304United States

BACKGROUND Heat shock proteins(HSPs)are molecular chaperones that protect cells against cellular stresses or ***,it has been increasingly recognized that they also play crucial roles in regulating fundamental cellular ***20 has been implicated in cell proliferation,but conflicting studies have shown that it can either promote or suppress *** underlying mechanisms by which HSP20 regulates cell proliferation and pluripotency remain *** the effect of HSP20 on cell proliferation has been recognized,its role in inducing pluripotency in human-induced pluripotent stem cells(iPSCs)has not been *** To evaluate the efficacy of HSP20 overexpression in human iPSCs and evaluate the ability to promote cell *** purpose of this study was to investigate whether overexpression of HSP20 in iPSCs can increase pluripotency and *** We used iPSCs,which retain their potential for cell ***20 overexpression effectively enhanced cell proliferation and *** of HSP20 in iPSCs was characterized by immunocytochemistry staining and realtime polymerase chain *** also used cell culture,cell counting,western blotting,and flow cytometry analyses to validate HSP20 overexpression and its *** This study demonstrated that overexpression of HSP20 can increase the pluripotency in ***,by overexpressing HSP20 in iPSCs,we showed that HSP20 upregulated proliferation markers,induced pluripotent genes,and drove cell proliferation in a sirtuin 1(SIRT1)-dependent *** data have practical applications in the field of stem cell-based therapies where the mass expansion of cells is needed to generate large quantities of stem cell-derived cells for transplantation *** We found that the overexpression of HSP20 enhanced the proliferation of iPSCs in a SIRT1-dependent ***,we established the distinct crosstalk between HSP20 and SIR

关键词： Heat shock proteins Stem cells Proliferation Induced pluripotent stem cells Sirtuin-1 Heat shock protein 20 Pluripotency

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The emerging role and targetability of the TCA cycle in cancer metabolism

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Protein & Cell 2018年第2期9卷 216-237页

作者： nicole M. Anderson Patrick Mucka Joseph G. Kern Hui Feng Abramson Family Cancer Research Institute University of Pennsylvania Philadelphia PA 19104-6160 USA Perelman School of Medicine at the University of Pennsylvania Philadelphia PA 19104 USA Departments of Pharmacology and Medicine The Center for Cancer Research Section of Hematology and Medical Oncology Boston University School of Medicine Boston MA 02118 USA Program in Biomedical Sciences Boston University School of Medicine Boston MA 02118 USA

The tricarboxylic acid （TCA） cycle is a central route for oxidative phosphorylation in cells, and fulfills their bioenergetic, biosynthetic, and redox balance require- ments. Despite early dogma that cancer cells bypass the TCA cycle and primarily utilize aerobic glycolysis, emerging evidence demonstrates that certain cancer cells, especially those with deregulated oncogene and tumor suppressor expression, rely heavily on the TCA cycle for energy production and macromolecule synthesis. As the field progresses, the importance of aberrant TCA cycle function in tumorigenesis and the potentials of applying small molecule inhibitors to perturb the enhanced cycle function for cancer treatment start to evolve. In this review, we summarize current knowledge about the fuels feeding the cycle, effects of oncogenes and tumor suppressors on fuel and cycle usage, common genetic alterations and deregulation of cycle enzymes, and potential therapeutic opportunities for targeting the TCA cycle in cancer cells. With the application of advanced technology and in vivo model organism studies, it is our hope that studies of this previously overlooked biochemical hub will provide fresh insights into cancer metabolism and tumorigenesis, subsequently revealing vulnerabilities for thera- peutic interventions in various cancer types.

关键词： glutaminolysis the TCA cycle cancer metabolism glycolysis

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Leaf/shoot level ecophysiology in two broadleaf and two needle-leaf species under representative cloud regimes at alpine treeline

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Journal of Plant Ecology 2016年第6期9卷 762-772页

作者： Adriana Sanchez nicole M.Hughes William K.Smith Programa de Biología Universidad del RosarioCarrera 24 No.63C-69BogotáDC 110011Colombia Department of Biology Wake Forest University136 Winston HallWinston-SalemNC 27106USA Department of Biology High Point UniversityUniversity Station 3591High PointNC 27262USA

Aims The effects of clouds are now recognized as critically important to the understanding of climate change impacts on ***,few studies have focused specifically on the ecophysiological responses of plants to *** continental mountain ranges are characterized by common convective cloud formation in the afternoons,yet little is known regarding this influence on plant water and carbon *** we compare the ecophysiology of two contrasting,yet ubiquitous growth forms,needle-leaf and broadleaf,under representative cloud regimes of the Snowy Range,Medicine Bow Mountains,southeastern Wyoming,*** Photosynthetic gas exchange,water use efficiency,xylem water potentials and micrometeorological data were measured on representative clear,overcast and partly cloudy days during the summers of 2012 and 2013 for two indigenous broadleaf(Caltha leptosepala and Arnica parryi)and two needle-leaf species(Picea engelmannii and Abies lasiocarpa)that co-occur *** Findings Reductions in sunlight with cloud cover resulted in more dramatic declines in photosynthesis for the two broadleaf species(ca.50-70%reduction)versus the two conifers(no significant difference).In addition,the presence of clouds corresponded with lower leaf conductance,transpiration and plant water status in all ***,the more constant photosynthesis in conifers under all cloud conditions,coupled with reduced transpiration,resulted in greater water use efficiency(ca.25%higher)than the broadleaf *** differences appear to implicate the potential importance of natural cloud patterns in the adaptive ecophysiology of these two contrasting,but common,plant growth forms.

关键词： gas exchange light response curves water use efficiency xylem water potential

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Orexins:A promising target to digestive cancers,inflammation,obesity and metabolism dysfunctions

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World Journal of Gastroenterology 2021年第44期27卷 7582-7596页

作者： Alain Couvineau Thierry Voisin Pascal nicole Valerie Gratio Anne Blais INSERM UMR1149/Inflammation Research Center Team“From inflammation to cancer in digestive diseases”labeled by“la Ligue Nationale contre le Cancer”University of ParisDHU UNITYParis 75018France UMR PNCA AgroParisTechINRAUniversitéParis-SaclayParis 75005France

Hypothalamic neuropeptides named hypocretin/orexins which were identified in 1998 regulate critical functions such as wakefulness in the central nervous *** past 20 years had revealed that orexins/receptors system was also present in the peripheral nervous system where they participated to the regulation of multiple functions including blood pressure regulation,intestinal motility,hormone secretion,lipolyze and reproduction *** to these peripheral functions,it was found that orexins and their receptors were involved in various diseases such as acute/chronic inflammation,metabolic syndrome and *** present review suggests that orexins or the orexin neural circuitry represent potential therapeutic targets for the treatment of multiple pathologies related to inflammation including intestinal bowel disease,multiple sclerosis and septic shock,obesity and digestive cancers.

关键词： Orexin Neuropeptide G-protein coupled receptor superfamily Inflammation Metabolic syndrome Cancer

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Magnetic systems for cancer immunotherapy

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Acta Pharmaceutica Sinica B 2021年第8期11卷 2172-2196页

作者： nicole B.Day William C.Wixson C.Wyatt Shields IV Department of Chemical&Biological Engineering University of ColoradoBoulderCO 80303USA

Immunotherapy is a rapidly developing area of cancer treatment due to its higher specificity and potential for greater efficacy than traditional *** cell modulation through the administration of drugs,proteins,and cells can enhance antitumoral responses through pathways that may be otherwise inhibited in the presence of immunosuppressive *** systems offer several advantages for improving the performance of immunotherapies,including increased spatiotemporal control over transport,release,and dosing of immunomodulatory drugs within the body,resulting in reduced off-target effects and improved *** to alternative methods for stimulating drug release such as light and pH,magnetic systems enable several distinct methods for programming immune ***,we discuss how magnetic hyperthermia can stimulate immune cells and trigger thermoresponsive drug ***,we summarize how magnetically targeted delivery of drug carriers can increase the accumulation of drugs in target ***,we review how biomaterials can undergo magnetically driven structural changes to enable remote release of encapsulated ***,we describe the use of magnetic particles for targeted interactions with cellular receptors for promoting antitumor ***,we discuss translational considerations of these systems,such as toxicity,clinical compatibility,and future opportunities for improving cancer treatment.

关键词： Drug delivery Immunotherapy Magnetic hyperthermia Magnetic nanoparticles Microrobotics Biomaterials

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Participatory Mapping and Visualization of Local Knowledge:An Example from Eberbach, Germany

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International Journal of Disaster Risk Science 2021年第1期12卷 56-71页

作者： Carolin Klonner Tomás J.Usón nicole Aeschbach Bernhard Höfle Institute of Geography Heidelberg University69120 HeidelbergGermany Institute of European Ethnology and IRI THESys(Integrative Research Institute on Transformations of Human-Environment Systems) Humboldt University of Berlin10117 BerlinGermany

A rise in the number of flood-affected people and areas has increased the interest in new methods and concepts that account for this *** are integrated into disaster risk reduction processes through participatory approaches and can provide valuable up-to-date local *** a field study in Eberbach(Baden–Wuerttemberg,Germany)sketch maps and questionnaires were used to capture local knowledge about *** on a previous study on urban flooding in Santiago de Chile,the tools were adapted and applied to river flooding in the city of Eberbach,which is regularly flooded by the Neckar River,a major river in southwest *** empirical database of the study comprises 40 participants in the study area and 40 in a control *** of the participants in each group are residents and half are *** sampling was used,and the questionnaires aimed to gather demographic information and explore what factors,such as property,influence the risk perception of the study *** results show that residents identify a larger spatial area as at risk than pedestrians,and owning property leads to higher risk *** flood type influenced the choice of the base maps for the sketch *** river flooding,one map with an overview of the area was sufficient,while for urban flooding a second map with more details of the area also enables the marking of small *** information gathered can complement authoritative data such as from flood *** participatory approach also increases the communication and trust between local governments,researchers,and citizens.

关键词： Disaster risk reduction Flooding Local knowledge Participatory approach Sketch maps Volunteered geographic information

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Characterisation of Human-Wildlife Conflicts around the Kahuzi-Biega National Park, Eastern Democratic Republic of Congo

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Journal of Environmental Protection（环境保护） 2024年第3期 343页

作者： Basubi Muke Matthieu Vwima Stany Ayagirwe Basengere Rodrigue Mushagalusa Freddy Benjamin-Fink nicole Bobo Kadiri Serge

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Floristic Diversity and Conservation Status of Guineo-Congolese Species in Southeastern Cameroon: The Case of the Gari-Gombo Communal Forest

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Open Journal of Forestry（林学期刊） 2024年第1期

作者： Boris Nyeck Valery Noiha Noumi nicole Maffo Maffo Victor Awe Djongmo Cedric Djomo Chimi Louis Zapfack

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A Qualitative Study on the Challenges Faced in Family-School-Community Partnership for A More Successful Education System in Suva,Fiji.

A Qualitative Study on the Challenges Faced in Family-School...

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作者： Shaniah nicole Sauca Olssson 浙江师范大学

学位级别：硕士

Despite current laws in place,Fiji is facing a major concern where many children are found not utilizing the government grant for free education and complying with current laws on compulsory ***,these children have been identified in urban and semi-urban *** study looks at Epstein’s six types of involvement and how it is being implemented in an urban school in *** study explores the difficulties faced in creating good family-school-community partnerships and what can be done to overcome these issues to build long lasting relationships between various stakeholders namely heads of school,teachers,parents,members of the community such as volunteers from organizations linked to the school,and *** two research questions guiding this qualitative study were 1.)What are some challenges building successful family-community-school partnership? and 2.)How can the challenges schools face with involving family members and community be overcome?Based on the interviews conducted with the various stakeholders,it was found that the main challenges faced in building successful FSC partnership had to do with the need to understand the different roles various stakeholders *** to lack of understanding and misunderstanding,divisions can be caused within the school *** study also identifies current methods used in the school to build and maintain their FSC partnerships and further suggestions were given based on other research papers on how to better the partnership.

关键词：家庭-学校-社区伙伴关系教育系统

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Loss of CD103^+ intestinal dendritic cells during colonic inflammation

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World Journal of Gastroenterology 2010年第1期16卷 21-29页

作者： Ulrike G Strauch nicole Grunwald Florian Obermeier Sonja Gürster Heiko C Rath Department of Internal Medicine I University of Regensburg

AIM:To investigate possible differences in dendritic cells(DC)within intestinal tissue of mice before and after induction of colitis. METHODS:Mucosal DC derived from intestinal tissue,as well as from mesenteric lymph nodes and spleen,were analyzed by fluorescence activated cell sorting(FACS) *** of these cells were analyzed for secretion of different pro-and anti-inflammatory cytokines. Immunohistochemistry and immunofluorescence were performed on cryosections of mucosal tissue derived from animals with colitis as well as from healthy mice. RESULTS:It was shown that DC derived from healthy intestinal lamina propria(LP)represented an immature phenotype as characterized by low-level expression of costimulatory *** contrast to DC from spleen and mesenteric lymph nodes(MLN)that secreted proinflammatory cytokines,LP-DC produced high levels of the anti-inflammatory cytokine *** induction of mu-rine colitis in a CD4 + CD62L + transfer model or in chronic Dextran sulfate sodium-colitis,a marked increase of activated CD80 + DC could be observed within the inflamed colonic ***,in contrast to splenic DC,a significant population of DC within MLN and colonic LP expressed the mucosal integrin CD103 which was lost during colitis. CONCLUSION:The constitutive secretion of antiinflammatory cytokines by immature DC within the intestinal LP might regulate the homeostatic balance between mucosal immunity and ***103 + DC could mediate this important function.

关键词： Dendritic cell Colitis Cytokines Integrin CD103

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