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Associations between health-related fitness and patient-reported symptoms in newly diagnosed breast cancer patients

Journal of Sport and Health Science 2024年第6期13卷 851-862页

作者： Ki-Yong An Fernanda Z.Arthuso Myriam Filion Spencer J.Allen Stephanie M.Ntoukas Gordon J.Bell Jessica McNeil Qinggang Wang Margaret L.McNeely Jeff K.Vallance Lin Yang S.nicole Culos-Reed Leanne Dickau John R.Mackey Christine M.Friedenreich Kerry S.Courneya Faculty of Kinesiology Sportand RecreationCollege of Health SciencesUniversity of AlbertaEdmonton T6G 2H9Canada Department of Kinesiology School of Health and Human SciencesUniversity of North Carolina at GreensboroGreensboroNC 27412USA Department of Cancer Epidemiology and Prevention Research Cancer Care AlbertaAlberta Health ServicesCalgary T2S 3C3Canada Faculty of Rehabilitation Medicine University of AlbertaEdmonton T6G 2H9Canada Faculty of Health Disciplines Athabasca UniversityAthabasca T9S 3A3Canada Department of Oncology Cumming School of MedicineUniversity of CalgaryCalgary T2N 4N1Canada Faculty of Kinesiology University of CalgaryCalgary T2N 1N4Canada Faculty of Medicine and Dentistry University of AlbertaEdmonton T6G 2H9Canada

Background:Newly diagnosed breast cancer patients experience symptoms that may affect their quality of life,treatment outcomes,and *** and managing breast cancer-related symptoms soon after diagnosis is *** purpose of this study was to investigate the associations between health-related fitness(HRF)and patient-reported symptoms in newly diagnosed breast cancer ***:This study utilized baseline data from the Alberta Moving Beyond Breast Cancer Cohort Study that were collected within 90 days of *** measures included peak cardiopulmonary fitness(peak volume of oxygen consumption(VO_(2peak))),maximal muscular strength and endurance,flexibility,and body *** measures included depression,sleep quality,and *** multivariable logistic regression was performed for ***:Of 1458 participants,51.5%reported poor sleep quality,26.5%reported significant fatigue,and 10.4%reported moderate *** multivariable-adjusted models,lower relative VO_(2peak)was independently associated with a greater likelihood of all symptom measures,including moderate depression(p<0.001),poor sleep quality(p=0.009),significant fatigue(p=0.008),any symptom(p<0.001),and multiple symptoms(p<0.001).VO_(2peak)demonstrated threshold associations with all symptom measures such that all 3 lower quartiles exhibited similar elevated risk compared to the highest *** strength of the threshold associations varied by the symptom measure with odds ratios ranging from-1.5 for poor sleep quality to-3.0 for moderate depression and multiple ***,lower relative upper body muscular endurance was also independently associated with fatigue in a dose-response manner(p=0.001),and higher body weight was independently associated with poor sleep quality in an inverted U pattern(p=0.021).Conclusion:Relative VO_(2peak)appears to be a critical HRF component associated with multiple patient-reported symptoms in newly diag

关键词： Breast cancer Fatigue Depression Sleep quality Cardiorespiratory fitness

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煮字人生——林青霞、黄心村二人谈

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扬子江文学评论 2024年第4期 48-54页

作者：林青霞黄心村张真瑞(整理) 宋宝平(整理) 不详香港大学比较文学系

二○二三年二月十日,中国香港大学文学院和比较文学系合办的“煮字人生:林青霞、黄心村二人谈”讲座,在中国香港大学百周年校园李兆基会议中心大会堂(The Grand Hall)隆重举行,场内超过八百位的听众、坐满三个直播室的观众以及场外众多... 详细信息

二○二三年二月十日,中国香港大学文学院和比较文学系合办的“煮字人生:林青霞、黄心村二人谈”讲座,在中国香港大学百周年校园李兆基会议中心大会堂(The Grand Hall)隆重举行,场内超过八百位的听众、坐满三个直播室的观众以及场外众多的等候观众,将现场挤得水泄不通。对谈伊始,黄心村播放了一段珍贵录像,记录了1998年林青霞和张国荣走上港大比较文学系的讲堂,与当年比较文学系系主任阿巴斯(Ackbar Abbas)对谈的盛况。时隔25年之后,林青霞再次应黄心村之邀来到了港大的讲坛,所以黄心村说“青霞和港大文学院的因缘是前定的,25年前就定下的,然后我和她认识只是一个时间的问题,是命中注定要认识的”,由此开始了她们的对谈。

关键词：林青霞挤得水泄不通李兆基张国荣阿巴斯直播室香港大学比较文学系

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最狭长山脉造就最狭长国度散落在智利与秘鲁的异度空间之谜

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环球人文地理 2024年第5期 38-49页

作者：丸子 Mark.C 胡子捷森郭卓然徐霄宇惺辰 MitchellFrye nicole videobuzzing Nataliya atosan Leckerstudio

在安第斯山脉的中部，谜团伴随着文明散落在狭长的海岸线，似乎永远找不到答案……安第斯山脉从南到北分为三大部分，北安第斯包括厄瓜多尔、哥伦比亚和委内瑞拉；中安第斯包括智利和秘鲁科迪勒拉；南安第斯包括火地岛和巴塔哥尼亚科迪...

在安第斯山脉的中部，谜团伴随着文明散落在狭长的海岸线，似乎永远找不到答案……安第斯山脉从南到北分为三大部分，北安第斯包括厄瓜多尔、哥伦比亚和委内瑞拉；中安第斯包括智利和秘鲁科迪勒拉；南安第斯包括火地岛和巴塔哥尼亚科迪勒拉。其中最引人关注的是中安第斯，这里仿佛是被神明选中的圣地，狭长的智利拥有世界上最孤独的岛屿；神秘的秘鲁掌握着印加帝国古老的文明。

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The role of cellular and molecular neuroimmune crosstalk in gut immunity

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Cellular & Molecular Immunology 2023年第11期20卷 1259-1269页

作者： Daping Yang nicole Almanzar Isaac M.Chiu Department of Immunology Harvard Medical SchoolBostonMA02115USA

The gastrointestinal tract is densely innervated by the peripheral nervous system and populated by the immune *** two systems critically coordinate the sensations of and adaptations to dietary,microbial,and damaging stimuli from the external and internal microenvironment during tissue homeostasis and *** brain receives and integrates ascending sensory signals from the gut and transduces descending signals back to the gut via autonomic *** regulate intestinal immune responses through the action of local axon reflexes or through neuronal circuits via the gut-brain *** neuroimmune crosstalk is critical for gut homeostatic maintenance and disease *** this review,we discuss the roles of distinct types of gut-innervating neurons in the modulation of intestinal mucosal *** will focus on the molecular mechanisms governing how different immune cells respond to neural signals in host defense and *** also discuss the therapeutic potential of strategies targeting neuroimmune crosstalk for intestinal diseases.

关键词： Neuroimmunology Neuroimmune Host defense Gut Sensory

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Global geoepidemiology of gastrointestinal surgery rates in Crohn’s disease

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1835-1844页

作者： Simcha Weissman Muhammad Aziz Ayrton Bangolo Vignesh K Nagesh Htat Aung Midhun Mathew Lino Garcia Shiva A Chandar Praveena Karamthoti Harinder Bawa Aseel Alshimari Yabets Kejela Nazish Mehdi Chrishanti A Joseph Athri Kodali Rohan Kumar Priya Goyal Sanya Satheesha Fnu Nivedita nicole Tesoro Tanni Sethi Gurpreet Singh Areej Belal Alina Intisar Hirra Khalid Samuel Cornwell Suchith B Suresh Kareem Ahmed Karabo K Marole Om P Anand Rahat B Reshi Tej I Mehta Sameh Elias Joseph D Feuerstein Department of Medicine Hackensack Meridian Health Palisades Medical CenterNorth BergenNJ 07047United States Division of Gastroenterology and Hepatology University of Toledo Medical CenterToledoOH 43614United States Department of Medicine University of WashingtonSeattleWA 98195United States Department of Radiology Johns Hopkins University HospitalBaltimoreMD 21218United States Division of Gastroenterology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMA 02215United States

BACKGROUND Data regarding the worldwide gastrointestinal surgery rates in patients with Crohn’s disease(CD)remains *** To systematically review the global variation in the rates of surgery in *** A comprehensive search analysis was performed using multiple electronic databases from inception through July 1,2020,to identify all full text,randomized controlled trials and cohort studies pertaining to gastrointestinal surgery rates in adult patients with *** included continent based demographic data,CD surgery rates over time,as well as the geoepidemiologic variation in CD surgery *** analyses were conducted using *** Twenty-three studies spanning four continents were *** median proportion of persons with CD who underwent gastrointestinal surgery in studies from North America,Europe,Asia,and Oceania were 30%(range:1.7%-62.0%),40%(range:0.6%-74.0%),17%(range:16.0%-43.0%),and 38%*** clear association was found regarding the proportion of patients undergoing gastrointestinal surgery over time in North America(R^(2)=0.035)and Europe(R^(2)=0.100).A moderate,negative association was seen regarding the proportion of patients undergoing gastrointestinal surgery over time(R^(2)=0.520)in *** There appears to be significant inter-continental variation regarding surgery rates in *** evidencebased guidelines accounting for the geographic differences in managing patients with CD is ***,as a paucity of data on surgery rates in CD exists outside the North American and European continents,future studies,particularly in less studied locales,are warranted.

关键词： Gastrointestinal surgery Crohn’s disease Geoepidemiology Inflammatory bowel disease Prevalence

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Phenotypical statin-associated immune-mediated necrotizing myositis with histological features of inclusion body myositis

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Rheumatology & Autoimmunity 2023年第1期3卷 50-55页

作者： nicole Daver Sara Tonini Overlook Medical Center Institute for Rheumatic and Autoimmune DiseasesAtlantic Health SystemsSummitNew JerseyUSA

Introduction:Statin-associated immune-mediated necrotizing myositis(IMNM)is a rare but distinct idiopathic inflammatory myopathy(IIM)that requires early recognition and intervention to prevent irreversible muscle *** is typically characterized by active statin use,elevated creatinine kinase(CK)levels,proximal muscle weakness,and at times,a positive 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase(HMGCR)*** includes immediate discontinuation of the statin and may include corticosteroids,intravenous immunoglobulin(IVIG),and/or immunosuppressive *** body myositis(IBM),another distinct IIM,also presents with elevated CK levels but with insidious onset of distal upper and proximal lower extremity weakness and is typically refractory to *** Description:A 64-year-old female patient presented with proximal muscle weakness,elevated CK levels,and a positive HMGCR antibody in the setting of statin use with muscle pathology suggestive of both statinassociated IMNM and *** responded to subcutaneous methotrexate and a slow prednisone taper over several months,however,will require close monitoring for symptoms associated with either ***:In conclusion,we report a case of muscle weakness with muscle pathology demonstrating both statin-associated IMNM and *** case highlights the importance of understanding the clinical and pathological features of statin-associated IMNM and IBM.

关键词： 3-hydroxy-3-methyl-glutaryl-coenzympe A reductase antibody idiopathic inflammatory myopathy immune-mediated necrotizing myositis inclusion body myositis statin-associated myositis

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Comparison of Cardiovascular Parameters and Internal Training Load of Different 1-h Training Sessions in Non-elite CrossFit^(®)Athletes

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Journal of Science in Sport and Exercise 2023年第2期5卷 130-141页

作者： nicole Meier Danien Sietmann Annette Schmidt Institut Für Sportwissenschaft Fakultät Für HumanwissenschaftenUniversität Der Bundeswehr MünchenWerner‑Heisenberg‑Weg 3985577 NeubibergGermany

Purpose The fact that CrossFit^(®)is the best-known and rapidly growing concept for high-intensity interval training(HIIT)and high-intensity functional training(HIFT)results in a continuous increase of athletes performing CrossFit^(®).In the more than 15,000 CrossFit^(®)Affiliates worldwide,the training concept is usually offered in 1-h training sessions containing the CrossFit^(®)-related workout of the day(WOD),as well as a general warm-up,movement demonstrations,and skill ***,we report how physiological parameters measured by heart rate(HR)values vary during four different 1-h CrossFit^(®)training sessions of non-elite athletes(n=27)in a local affiliated training center and what influencing factors may *** The duration of the 1-h training sessions were divided into a warm-up part(WU-part),a skill development part combined with strength exercises(A-part),followed by the WOD part(B-part).Results Analysis of HR values shows high training intensity(≥91%HR_(max))not throughout the duration of each training session,only during *** mean HR values in B-part differ significantly compared to the remaining training parts(P<0.001)for all four training *** of different CrossFit^(®)experience levels revealed no significant differ-ence in acute physiological demands and training load between beginner and experienced CrossFit^(®)*** Our results may suggest that practicing CrossFit^(®)in 1-h training sessions combined anaerobic and aerobic exercise intensities,with the training concept allows beginners and experienced athletes to be trained with the same cardio-vascular responses and training intensities.

关键词： CrossFit^(®)performance Training load Exercise intensity Cardiovascular response High-intensity functional training

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Methodology in coronary artery bypass surgery quality assessment

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Journal of Geriatric Cardiology 2022年第11期19卷 867-875页

作者： Zhongmin Li nicole Shirakawa Amy Chen Fu-Hai Ji Hong Liu Department of Anesthesiology and Pain Medicine University of California Davis HealthSacramentoUSA Department of Anesthesiology First Affiliated Hospital of Soochow UniversitySuzhouChina

Coronary artery bypass graft(CABG)is associated with a high risk of mortality and morbidity;thus,assessment of surgery quality is *** this perspective,we will focus on the structure,process,and outcomes measured as quality assessment.A set of 21 evidence-based structure,process,and outcome measures were selected as National Quality *** these,the Society of Thoracic Surgeons ultimately chose 11 individual quality measures grouped them into four domains used to assess the quality of *** four domains consisted of perioperative medical care,operative care,risk-adjusted operative mortality and postoperative risk-adjusted major *** measures have been useful as quality improvement tools in assessing the quality of CABG surgery.

关键词： bypass surgery mortality

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OTX2 stimulates adult retinal ganglion cell regeneration

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Neural Regeneration Research 2022年第3期17卷 690-696页

作者： Raoul Torero Ibad nicole Quenech’du Alain Prochiantz Kenneth L.Moya Centre for Interdisciplinary Research in Biology(CIRB) Collége de FranceCNRS UMR 7241INSERM U1050Labex MemoLifeParis Sciences et Lettres Research UniversityParisFrance

Retinal ganglion cell(RGC) axons provide the only link between the light sensitive and photon transducing neural retina and visual centers of the *** axon degeneration occurs in a number of blinding diseases and the ability to stimulate axon regeneration from surviving ganglion cells could provide the anatomic substrate for restoration of ***2 is a homeoprotein transcription factor expressed in the retina and previous studies showed that,in response to stress,exogenous OTX2 increases the in vitro and in vivo survival of *** we examined and quantified the effects of OTX2 on adult RGC axon regeneration in vitro and in *** results show that exogenous OTX2 stimulates the regrowth of axons from RGCs in cultures of dissociated adult retinal cells and from explants of adult retinal tissue and that RGCs respond directly to OTX2 as regrowth is observed in cultures of purified adult rat ***,after nerve crush in vivo,we observed a positive effect of OTX2 on the number of regenerating axons up to the optic chiasm within 14 days post crush and a very modest level of acuity absent in control *** effect of OTX2 on RGC survival and regeneration is of potential interest for degenerative diseases affecting this cell *** animal procedures were approved by the local "Comié d'éιthique en expérimentation animale n°59" and authorization n° 00702.01 delivered March 28,2014 by the French "Ministére de l'enseignement supérieur et de la recherche".

关键词： axon regeneration dissociated retinal culture GAP-43 homeoprotein optic nerve crush OTX2 retinal explants retinal ganglion cell

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Verteporfin synergizes the efflcacy of anti-PD-1 in cholangiocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2022年第5期21卷 485-492页

作者： Jianyang Fu nicole A McGrath Jihye Lee Xin Wang Gagandeep Brar Changqing Xie Thoracic and Gastrointestinal Malignancies Branch Center for Cancer ResearchNational Cancer InstituteNational Institutes of HealthBethesdaMD 20892USA Sandra and Edward Meyer Cancer Center Weill Cornell MedicineNew YorkNY 10065USA

Background:Cholangiocarcinoma(CCA)is one of the primary hepatobiliary malignant neoplasms with only 10%of 5-year survival *** immunotherapy with the blockade of immune checkpoints has no clear benefit in *** inhibition of YAP1 signaling by verteporfin has shown encouraging results by inhibiting cell proliferation and inducing *** study aimed to evaluate the potential benefit of the combination of verteporfin and anti-programmed cell death 1(PD-1)in CCA mouse ***:We assessed the cytotoxicity of verteporfin in human CCA cell lines in vitro,including both intrahepatic CCA and extrahepatic CCA *** examined the in vitro effect of verteporfin on cell proliferation,apoptosis,and *** evaluated the in vivo efflcacy of verteporfin,anti-PD-1,and a combination of both in subcutaneous CCA mouse ***:Our study showed that verteporfin reduced tumor cell growth and enhanced apoptosis of human CCA tumor cells in vitro in a dose-dependent ***,verteporfin impaired stemness evidenced by reduced spheroid formation and colony formation,decreased numbers of cells with aldehyde dehydrogenase activity and positive cancer stem cell markers(all P<0.05).The combination of verteporfin and anti-PD-1 reduced tumor burden in CCA subcutaneous SB1 tumor model compared to either agent ***:Verteporfin exhibits antitumor effects in both intrahepatic and extrahepatic CCA cell lines and the combination with anti-PD-1 inhibited tumor growth.

关键词： Verteporfin YAP1 Anti-programmed cell death-1 Immunotherapy Cholangiocarcinoma

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