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Targeted therapy for capillary-venous malformations

Signal Transduction and Targeted Therapy 2024年第7期9卷 3024-3039页

作者： Lola Zerbib Sophia Ladraa Antoine Fraissenon Charles Bayard Marina Firpion Quitterie Venot Sanela Protic Clément Hoguin Amandine Thomas Sylvie Fraitag Jean-Paul Duong Sophie Kaltenbach Estelle Balducci Coline Lefevre Patrick Villarese Vahid Asnafi Christine Broissand nicolas goudin Ivan Nemazanyy Gwennhael Autret Bertrand Tavitian Christophe Legendre Nadia Arzouk Veronique Minard-Colin Caroline Chopinet Michael Dussiot Denise MAdams Tristan Mirault Laurent Guibaud Paul Isenring Guillaume Canaud UniversitéParis Cité ParisFrance INSERM U1151 Institut Necker-Enfants MaladesParisFrance Service d’Imagerie Pédiatrique Hôpital Femme-Mère-EnfantHCLBronFrance CREATIS UMR 5220 Villeurbanne 69100France Service de Radiologie Mère-Enfant Hôpital NordSaint EtienneFrance Service d’Anatomie pathologique Hôpital Necker-Enfants MaladesAP-HPParisFrance Laboratoire d’Oncohématologie Hôpital Necker-Enfants MaladesAP-HPParisFrance Pharmacie Hôpital Necker-Enfants MaladesAP-HPParisFrance Necker Bio-Image Analysis INSERM US24/CNRS UMS 3633ParisFrance Platform for Metabolic Analyses Structure Fédérative de Recherche NeckerINSERM US24/CNRS UMS 3633ParisFrance Plateforme Imageries du Vivant Universitéde ParisPARCCINSERMParisFrance Service de Néphrologie Transplantation AdultesHôpital Necker-Enfants MaladesAP-HPParisFrance Service de Transplantation Hôpital La PitiéSalpétrièreAP-HPParisFrance Department of Pediatric and Adolescent Oncology INSERM 1015Gustave RoussyUniversitéParis-SaclayVillejuifFrance Service de Physiologie&Explorations Fonctionnelles Cardiovasculaires CHU de LilleLille 59000France INSERM U1163 Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutic ImplicationsLaboratoire d’Excellence GR-ExParisFrance Division of Oncology Comprehensive Vascular Anomalies ProgramChildren’s Hospital of PhiladelphiaPhiladelphiaPAUSA Service de Médecine Vasculaire hôpital Européen Georges-PompidouParisFrance Nephrology Research Group L’Hôtel-Dieu de Québec Research CenterDepartment of MedicineFaculty of MedicineLaval UniversityQuebecQC G1R2J6Canada Unitéde médecine translationnelle et thérapies ciblées Hôpital Necker-Enfants MaladesAP-HPParisFrance CNRS UMR8253 Institut Necker-Enfants MaladesParisFrance

Sporadic venous malformations are genetic conditions primarily caused by somatic gain-of-function mutation of PIK3CA or TEK,an endothelial transmembrane receptor signaling through *** malformations are associated with pain,bleedings,thrombosis,pulmonary embolism,esthetic deformities and,in severe cases,life-threatening *** authorized medical treatment exists for patients with venous ***,we created a genetic mouse model of PIK3CA-related capillary venous malformations that replicates patient *** showed that these malformations only partially signal through AKT *** compared the efficacy of different drugs,including rapamycin,a mTORC1 inhibitor,miransertib,an AKT inhibitor and alpelisib,a PI3Kαinhibitor at improving the lesions seen in the mouse *** demonstrated the effectiveness of alpelisib in preventing vascular malformations’occurrence,improving the already established ones,and prolonging *** these findings,we were authorized to treat 25 patients with alpelisib,including 7 children displaying PIK3CA(n=16)or TEK(n=9)-related capillary venous malformations resistant to usual therapies including sirolimus,debulking surgical procedures or percutaneous *** assessed the volume of vascular malformations using magnetic resonance imaging(MRI)for each *** demonstrated improvement in all 25 *** malformations previously considered intractable were reduced and clinical symptoms were *** showed a decrease of 33.4%and 27.8%in the median volume of PIK3CA and TEK malformations respectively,over 6 months on *** conclusion,this study supports PI3Kαinhibition as a promising therapeutic strategy in patients with PIK3CA or TEK-related capillary venous malformations.

关键词： PIK3CA malformations venous

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Heterosis effect for larval performance of fall armyworm interstrain hybrids

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Insect Science 2024年第4期31卷 1296-1312页

作者： Laijiao Lan nicolas Nègre DGIMI University of MontpellierINRAEMontpellierFrance

Spodoptera frugiperda,also known as fall armyworm(FAW),is an invasive crop pest that can feed on a variety of host plants,posing a serious threat to food *** are two sympatric strains of FAW that are morphologically identical but described with different food preferences:the“rice strain”(SfR)and the“corn strain”(SfC).A few genetic loci exist to identify these two *** and Z-chromosome-linked haplotypes are the most used,but the biggest part of the genome displays little polymorphism between strains that could explain their adaptation to different *** have previously observed consistent transcription differences between the strains in both laboratory and natural ***,we wonder if there are effects from host-strain-associated loci,maternally or paternally inherited,on FAW performance that could explain the divergence between the two FAW *** test this hypothesis,we first produced two F1 hybrid generations(SfR♀×SfC♂,SfC♀×SfR♂).These reciprocal hybrids should be heterozygous for all chromosomes except for the maternally inherited mitochondrial and sexual W *** evaluate whether plant preference is determined by these genetic loci,we cultivated the two hybrids and the two parental strains in triplicate on an artificial diet and recorded several phenotypic traits such as weight over time,survival rate,emerging rate,developmental time,and sex ***,the same performance experiment was carried out on corn ***,on the artificial diet,the two hybrid genotypes were both more performant than the two parental strains in terms of survival rate,pupal emerging rate,and developmental time,whereas they were intermediate to the inbred parental strains in pupal *** the corn plant diet,both hybrid genotypes outperformed the two parental strains in larval *** these asymmetrical results revealed that mitochondrial or sex-linked haplotypes alone cannot explain the performance differences

关键词： fall armyworm Haldane's rule heterosis hybrid performance mitochondria

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Diabetes and pulmonary infection:how hyperglycaemia shapes the immune system

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1245-1246页

作者： Christian Herder Michael Roden nicolas Venteclef Institute for Clinical Diabetology German Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf40225DüsseldorfGermany German Center for Diabetes Research(DZD) Partner Düsseldorf85764München-NeuherbergGermany Department of Endocrinology and Diabetology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University Düsseldorf40225DüsseldorfGermany Institut Necker-Enfants Malades(INEM) UniversitéParis CitéINSERM UMR-S1151CNRS UMR-S8253ParisFrance

In a recent study published in Nature,Nobs and colleagues aimed to identify novel mechanisms that may explain why diabetes is associated with an increased susceptibility to viral respiratory *** analyses revealed a central role of lung dendritic cells(DC)which exhibited several functional defects induced by hyperglycaemia and consequently result in impaired antiviral immune responses.

关键词： impaired lung respiratory

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Estimating wood quality attributes from dense airborne LiDAR point clouds

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Forest Ecosystems 2024年第2期11卷 226-235页

作者： nicolas Cattaneo Stefano Puliti Carolin Fischer Rasmus Astrup Norwegian Institute of Bioeconomy Research(NIBIO) Division of Forest and Forest ResourcesHøgskoleveien 81433ÅsNorway

Mapping individual tree quality parameters from high-density LiDAR point clouds is an important step towards improved forest *** present a novel machine learning-based workflow that uses individual tree point clouds from drone laser scanning to predict wood quality indicators in standing *** object reconstruction methods,our approach is based on simple metrics computed on vertical slices that summarize information on point distances,angles,and geometric attributes of the space between and around the *** models use these slice metrics as predictors and achieve high accuracy for predicting the diameter of the largest branch per log (DLBs) and stem diameter at different heights (DS) from survey-grade drone laser *** show that our models are also robust and accurate when tested on suboptimal versions of the data generated by reductions in the number of points or emulations of suboptimal single-tree segmentation *** approach provides a simple,clear,and scalable solution that can be adapted to different situations both for research and more operational mapping.

关键词： UAV laser scanning Wood quality Machine learning Point cloud metrics

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Spectroscopic factors of resonance states with the Gamow shell model

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 38-45页

作者： Mengran Xie Jianguo Li nicolas Michel Honghui Li Wei Zuo CAS Key Laboratory of High Precision Nuclear Spectroscopy Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China

We provide an investigation of the spectroscopic factor of resonance states in A=5-8 nuclei,utilizing the Gamow shell model(GSM).Within the GSM,the configuration mixing is taken into account exactly with the shell model framework,and the continuum coupling is addressed via the complex-energy Berggren ensemble,which treats bound,resonance,and non-resonant continuum single-particle states on an equal *** a result,both the configuration mixing and continuum coupling are meticulously considered in the *** first calculate the low-lying states of helium isotopes and isotones with the GSM,and the results are compared with that of ab initio no-core shell model(NCSM)*** results indicate that GSM can reproduce the low-lying resonance states more accurately than the *** this,we delve into the spectroscopic factors of the resonance states as computed through both GSM and NCSM,concurrently conducting systematic calculations of overlap functions pertinent to these resonance ***,the calculated overlap function and spectroscopic factor of6He(01+)■νp3/2→^(7)He(3/2_(1)-)with GSM are compared with the results from ab initio NCSM,variational Monte Carlo,and Green’s function Monte Carlo calculations,as well as available experimental *** results assert that wave function asymptotes can only be reproduced in GSM,where resonance and continuum coupling are precisely addressed.

关键词： spectroscopic factor overlap function resonance states continuum coupling isospin symmetry breaking

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Trimming the fat myth: adipose tissue’s role in liver regeneration

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Hepatobiliary Surgery and Nutrition 2024年第4期13卷 727-731页

作者： Andrea Peloso nicolas Golse Hepato-Biliary Center Paul-Brousse HospitalAssistance Publique-Hôpitaux de ParisVillejuifFrance Division of Transplantation and Abdominal Surgery Department of SurgeryGeneva University Hospitals and Faculty of MedicineGenevaSwitzerland UMRS 1193 Paris-Saclay UniversityInsermPathogenesis and Treatment of Liver DiseasesFHU HepatinovVillejuifFrance

We read with great interest the paper from Jena(Germany)recently published in Hepatobiliary Surgery and Nutrition by Deeb et al.,which caught our attention,given its clinical *** fact,post-hepatectomy liver failure(PHLF)remains nowadays a significant clinical challenge,occasionally leading to death or potentially requiring,in highly selected cases,rescue liver transplantation(1).Within quaternary care centers,the incidence of PHLF fluctuates from 5%to 20%,depending on the criteria employed,the underlying liver parenchyma quality and the type of hepatectomy(2).Hence,liver regeneration(LR)holds paramount importance in hepatic surgery as it directly impacts post-operative outcomes(3):it is a strictly orchestrated phenomenon that entails the activation of hepatocytes and hepatic progenitor cells,as well as the regulation of cell-cycle genes and growth *** contributing to PHLF include pre-operative,intra-operative and post-operative elements,leading to careful patient selection(4).

关键词： Liver regeneration(LR) adipose tissue liver living-donor transplantation

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Influence of ambient water coloration on habitat and conspecific choice in the female Lake Malawi cichlid, Metriaclima zebra

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Current Zoology 2024年第2期70卷 214-224页

作者： Noori Choj nicolas Mathevon Eileen A.Hebets Marilyn Beauchaud School of Biological Sciences University of Nebraska-LincolnLincolnNEUSA ENES Bioacoustics Research Laboratory CRNLCNRSInsermUniversite de Saint-EtienneSaint-EtienneFrance Max Planck Institute of Animal Behavior KonstanzGerman

Female cichlid fish living in African great lakes are known to have sensory systems that are adapted to ambient light *** sen-sory system adaptations are hypothesized to have influenced the evolution of the diverse male nuptial *** rock-dwelling Lake Malawi mbuna cichlids,however,the extent to which ambient light environments influence female sensory systems and potentially associated male nuptial coloration remains ***,the ubiquitous blue flank coloration and UV reflection of male mbuna cichlids suggest the potential impacts of the blue-shifted ambient light environment on these cichlid's visual perception and male nuptial coloration in the shallow water depth in Lake *** the present study,we explored whether and how the sensory bias of females influences intersexual communication in the mbuna cichlid,Metriaclima zebra.A series of choice experiments in various light environments showed that *** females (1)have a pref-erence for the blue-shifted light environment,(2)prefer to interact with males in blue-shifted light environments,(3)do not show a preference between dominant and subordinate males in full-spectrum,long-wavelength filtered,and short-wavelength filtered light environments,and (4)show a"reversed"preference for subordinate males in the UV-filtered light *** results suggest that the visual perception of *** females may be biased to the ambient light spectra in their natural habitat by local adaptation and that this sensory bias may influence the evolution of blueand UV reflectivepatterns in male nuptial coloration.

关键词： ambient light environment Lake Malawi male coloration mbuna cichlids Metriaclima zebra sensory bias UV coloration UV perception visual communication.

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Development of NK cell-based cancer immunotherapies through receptor engineering

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Cellular & Molecular Immunology 2024年第4期21卷 315-331页

作者： Audrey Page nicolas Chuvin Jenny Valladeau-Guilemond Stéphane Depil Centre de Recherche en Cancérologie de Lyon UMR INSERM U1052 CNRS 5286Centre Léon BérardLyonFrance ErVimmune LyonFrance Centre Léon Bérard LyonFrance UniversitéClaude Bernard Lyon 1 LyonFrance

Natural killer(NK)cell-based immunotherapies are attracting increasing interest in the field of cancer *** clinical trials have shown promising outcomes,alongside satisfactory product efficacy and *** developments have greatly increased the therapeutic potential of NK cells by endowing them with enhanced recognition and cytotoxic *** review focuses on surface receptor engineering in NK cell therapy and discusses its impact,challenges,and future *** approaches are based on engineering with chimeric antigen receptors to allow NK cells to target specific tumor antigens independent of human leukocyte antigen *** approach has increased the precision and potency of NK-mediated recognition and elimination of cancer *** addition,engineering NK cells with T-cell receptors also mediates the recognition of intracellular epitopes,which broadens the range of target *** tumor peptide recognition by NK cells has also been improved by optimizing immunoglobulin constant fragment receptor expression and ***,engineered NK cells have an improved ability to recognize and destroy target cells coated with specific antibodies,thereby increasing their antibodydependent cellular *** ability of NK cell receptor engineering to promote the expansion,persistence,and infiltration of transferred cells in the tumor microenvironment has also been ***-based strategies for sustained NK cell functionality within the tumor environment have also been discussed,and these strategies providing perspectives to counteract tumor-induced ***,receptor engineering has led to significant advances in NK cell-based cancer *** technical challenges are addressed,these innovative treatments will likely reshape cancer immunotherapy.

关键词： NK cells Cell therapy Receptor engineering CAR

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Erratum to:Tribological behaviour of Ti_(3)C_(2)T_(x)nano-sheets:Substrate-dependent tribo-chemical reactions

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Friction 2024年第7期12卷 1618-1619页

作者： Alberto ROTA nicolas BELLINA Bo WANG Andreas ROSENKRANZ Dipartimento di Scienze Fisiche Informatiche e MatematicheUniversitàdi Modena e Reggio EmiliaModena 41125Italy CNR-Istituto di Nanoscienze Centro S3Modena 41125Italy Centro Interdipartimentale per la Ricerca Applicata e i Servizi nel settore della Meccanica Avanzata e della Motoristica Universitàdi Modena e Reggio EmiliaModena 41125Italy Key Laboratory of Marine New Materials and Related Technology Zhejiang Key Laboratory of Marine Materials and Protection TechnologyNingbo Institute of Material Technology&EngineeringChinese Academy of SciencesNingbo 315201China Department of Chemical Engineering Biotechnology and MaterialsUniversity of ChileSantiago 8370456Chile

Erratum to Alberto Rota,nicolas Bellina,Bo Wang&Andreas *** behaviour of Ti_(3)C_(2)T_(x)nano-sheets:Substratedependent tribo-chemical *** 11(8):1522–1533(2023).

关键词： Friction behaviour chemical

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The effects of data aggregation on long-term projections of forest stands development

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Forest Ecosystems 2024年第3期11卷 381-389页

作者： Kobra Maleki Rasmus Astrup nicolas Cattaneo Wilson Lara Henao Clara Anton-Fernandez Norwegian Institute of Bioeconomy Research Division of Forestry and Forest ResourcesP.O.Box 115ÅsNO-1431Norway

Forest management planning often relies on Airborne Laser Scanning(ALS)-based Forest Management Inventories(FMIs)for sustainable and efficient *** the area-based(ABA)approach,these inventories estimate forest characteristics for grid cell areas(pixels),which are then usually summarized at the stand *** the ALS-based high-resolution Norwegian Forest Resource Maps(16 m×16 m pixel resolution)alongside with stand-level growth and yield models,this study explores the impact of three levels of pixel aggregation(standlevel,stand-level with species strata,and pixel-level)on projected stand *** results indicate significant differences in the projected outputs based on the aggregation ***,the most substantial difference in estimated volume occurred between stand-level and pixel-level aggregation,ranging from-301 to+253 m^(3)·ha^(-1)for single *** differences were,on average,higher for broadleaves than for spruce and pine dominated stands,and for mixed stands and stands with higher variability than for pure and homogenous *** conclusion,this research underscores the critical role of input data resolution in forest planning and management,emphasizing the need for improved data collection practices to ensure sustainable forest management.

关键词： Growth and yield models Dominant species Norway spruce Scots pine Broadleaves Forest resource map Stand variability

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