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Differential mortality Outcomes in Real-world Patients with Lean,Nonobese,and Obese Nonalcoholic Fatty Liver Disease

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Journal of Clinical and Translational Hepatology 2023年第7期11卷 1448-1454页

作者： Vy H.Nguyen Audrey Ha nicholas Ajit Rouillard Richard Hieu Le Ashley Fong Surya Gudapati Jung Eun Park mayumi maeda Scott Barnett Ramsey Cheung mindie H.Nguyen Division of Gastroenterology and Hepatology Stanford University Medical CenterPalo AltoCAUSA Harvard medical School BostonMAUSA William Carey University College of Osteopathic medicine HattiesburgMSUSA Washington University St LouisMOUSA Division of Gastroenterology and Hepatology Palo Alto Veterans Affairs Medical CenterPalo AltoCAUSA Department of Epidemiology and Population Health Stanford University Medical CenterPalo AltoCAUSA

Background and Aims:Nonalcoholic fatty liver disease(NAFLD)is commonly associated with obesity but can de-velop in normal-weight people(lean NAFLD).We compared outcomes in lean,overweight,and obese ***:This retrospective chart review included patients at Stanford University medical Center with NAFLD confirmed by imaging between march 1995 and December ***,overweight,and obese patients had body mass index of25.0 andm2 for non-Asian and>23.0 and≥27.5 for overweight and obese Asian ***:A total of 9061 lean(10.2%),overweight(31.7%),and obese(58.1%)patients were *** patients were 5 years older than obese patients(53±17.4 VS.48.7±±15.1 years),more were female(59.6%vs.55.2%),white(49.1%vs.46.5%),had NASH(29.2%VS.22.5%),cirrhosis(25.3%.Vs.19.2%),or nonliver cancer(25.3%Vs.18.3%).Fewer had diabetes(21.7%Vs.35.8%)or metabolic comorbidi-ties(all pmortality similar to other groups but higher overall(p=0.01)and nonliver-related(p=0.02)*** multivariable model adjustment for covariates,differences between lean and obese NAFLD in liver-related,nonliver-related,and over-all mortality(adjusted hazard ratios of 1.34,1.00,and 1.32;p=0.66,0.99,and 0.20,respectively)were not ***:Lean NAFLD had fewer metabolic comorbidi-ties but similar adverse or worse outcomes,suggesting that it is not *** providers should provide the same level of care and intervention as for overweight and obese NAFLD.

关键词： Chronic liver disease Cirrhosis Lean NAFLD Liver-related mortality NAFLD NASH Nonliver cancer mortality

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1992年以来欧美《文选》学研究一瞥

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古代文学前沿与评论 2018年第2期 29-39页

作者：魏宁香港大学中文学院

欧美汉学界在《文选》研究方面取得的成果为数不多,尤其鲜有直接以《文选》为题的研究。但20世纪以来在《文选》翻译上的长足进展,推动了欧美汉学界的《文选》研究,康达维在《文选》翻译和研究上取得的成果是其中的代表。近年西方学者... 详细信息

欧美汉学界在《文选》研究方面取得的成果为数不多,尤其鲜有直接以《文选》为题的研究。但20世纪以来在《文选》翻译上的长足进展,推动了欧美汉学界的《文选》研究,康达维在《文选》翻译和研究上取得的成果是其中的代表。近年西方学者在《文选》研究维度上有所突破,不仅在《文选》翻译和细读,以及探讨文学作品的历史文化意义方面有新的成果,也开始关注过去欧美汉学界极少涉猎的《文选》编纂动机以及编者研究等问题。

关键词：欧美《文选》学研究翻译与细读历史文化背景研究编纂研究

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慢性原发性疼痛

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中国疼痛医学杂志 2021年第2期27卷 81-86页

作者：吕岩(译) 周华成(译) 林夏清(译) 吴莹(译) 宋学军(审校) 万有(审校) 樊碧发(审校) 韩济生(审校) nicholas m 空军军医大学西京医院疼痛科西安710100 哈尔滨医科大学附属第四医院疼痛科哈尔滨150001 南方科技大学疼痛医学中心南方科技大学围术期医学研究中心深圳518055 北京大学医学部疼痛医学中心北京100191 北京大学神经科学研究所北京100191 国家卫健委中日友好医院疼痛科北京100029 不详

本文介绍ICD-11(国际疾病分类-11)中有关慢性原发性疼痛(Chronic primary pain,CPP)的诊断标准。疼痛持续或反复发作超过3个月,伴有显著的情绪情感异常或功能障碍,且排除其他慢性疼痛性疾病时,可诊断为慢性原发性疼痛。与所有疼痛一样,... 详细信息

本文介绍ICD-11(国际疾病分类-11)中有关慢性原发性疼痛(Chronic primary pain,CPP)的诊断标准。疼痛持续或反复发作超过3个月,伴有显著的情绪情感异常或功能障碍,且排除其他慢性疼痛性疾病时,可诊断为慢性原发性疼痛。与所有疼痛一样,本文为理解慢性原发性疼痛设定了一个生物、心理和社会环境整合模式,认为慢性原发性疼痛的各亚型都是由生物、心理和社会因素的相互作用诱导产生。与DSm-5和ICD-10的观点不同,ICD-11对慢性原发性疼痛的诊断不具有确定的生物或心理诱因,但需排除其他诊断。若有明确的原发疾病,并且疼痛是该疾病的继发症状,则诊断为慢性继发性疼痛。本文的目的是创建一个对全科医疗和专业疼痛管理皆适用的诊断分类,以便改进个体化治疗计划,同时对每个诊断分类提供更加准确的描述,为临床医师和研究人员提供帮助。

关键词： ICD-11 分类慢性疼痛慢性原发性疼痛复杂性区域疼痛综合征慢性弥漫性疼痛纤维肌痛头痛口面部疼痛内脏痛肌肉骨骼疼痛特发性疼痛(Idiopathic pain) 功能性疼痛

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Global land mapping of satellite-observed CO_(2)total columns using spatio-temporal geostatistics

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International Journal of Digital Earth 2017年第4期10卷 426-456页

作者： Zhao-Cheng Zeng Liping Lei Kimberly Strong Dylan B.A.Jones Lijie Guo min Liu Feng Deng nicholas m.Deutscher manvendra K.Dubey David W.T.Griffith Frank Hase Bradley Henderson Rigel Kivi Rodica Lindenmaier Isamu morino Hirofumi Ohyama Christof Petri Ralf Sussmann Voltaire A.Velazco Paul O.Wennberg Hui Lin Institute of Space and Earth Information Science The Chinese University of Hong KongHong KongPeople’s Republic of China Key Laboratory of Digital Earth Science Institute of Remote Sensing and Digital EarthChinese Academy of SciencesBeijingPeople’s Republic of China Department of Physics University of TorontoTorontoOntarioCanada Institute of Environmental Physics(IUP) University of BremenBremenGermany School of Chemistry University of WollongongWollongongAustralia Los Alamos National Laboratory Los AlamosNMUSA Karlsruhe Institute of Technology Institute for Meteorology and Climate Research(IMK-ASF)Germany FmI Arctic Research Center SodankyläFinland National Institute for Environmental Studies(NIES) TsukubaIbarakiJapan Earth Observation Research Center Japan Aerospace Exploration Agency(JAXA)Tsukuba-cityIbarakiJapan Karlsruhe Institute of Technology IMK-IFUGarmisch-PartenkirchenGermany California Institute of Technology PasadenaCAUSA Department of Geography and Resource management The Chinese University of Hong KongHong KongPeople’s Republic of China PNNL RichmondWA 99352USA. The Solar-Terrestrial Environment Laboratory Nagoya UniversityJapan

This study presents an approach for generating a global land mapping dataset of the satellite measurements of CO_(2)total column(XCO_(2))using spatio-temporal geostatistics,which makes full use of the joint spatial and temporal dependencies between *** mapping approach considers the latitude-zonal seasonal cycles and spatio-temporal correlation structure of XCO_(2),and obtains global land maps of XCO_(2),with a spatial grid resolution of 1°latitude by 1°longitude and temporal resolution of 3 *** evaluate the accuracy and uncertainty of the mapping dataset in the following three ways:(1)in cross-validation,the mapping approach results in a high correlation coefficient of 0.94 between the predictions and observations,(2)in comparison with ground truth provided by the Total Carbon Column Observing Network(TCCON),the predicted XCO_(2)time series and those from TCCON sites are in good agreement,with an overall bias of 0.01 ppm and a standard deviation of the difference of 1.22 ppm and(3)in comparison with model simulations,the spatio-temporal variability of XCO_(2)between the mapping dataset and simulations from the CT2013 and GEOS-Chem are generally *** generated mapping XCO_(2)data in this study provides a new global geospatial dataset in global understanding of greenhouse gases dynamics and global warming.

关键词： XCO_(2) ACOS-GOSAT Spatio-temporal geostatistics global mapping geospatial dataset

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中国经济改革及中期增长展望

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新金融评论 2018年第3期 112-121页

作者： nicholas Lardy PIIE Anthony m.Solomon

中国经济在过去40年的增长主要归因于市场力量崛起和私营企业扩张。国际金融危机之后的增长减速并非是伴随经济发展而不可避免的结果。贸易顺差占中国GDP的比重从2007年的8.7%缩减到2016年的2.2%,是中国经济增速放缓最重要的原因之一。... 详细信息

中国经济在过去40年的增长主要归因于市场力量崛起和私营企业扩张。国际金融危机之后的增长减速并非是伴随经济发展而不可避免的结果。贸易顺差占中国GDP的比重从2007年的8.7%缩减到2016年的2.2%,是中国经济增速放缓最重要的原因之一。其他因素还包括国有工业和服务业企业的资产回报率下降。如果未来不能实现比近几年更为深远的国有企业改革,中国可能很难保持6%~7%的增长水平。

关键词：经济改革增长展望

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Projection micro stereolithography based 3D printing and its applications

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International Journal of Extreme manufacturing 2020年第2期2卷 68-86页

作者： Qi Ge Zhiqin Li Zhaolong Wang Kavin Kowsari Wang Zhang Xiangnan He Jianlin Zhou nicholas X Fang Department of mechanical and Energy Engineering Southern University of Science and TechnologyShenzhen 518055GuangdongPeople’s Republic of China BmF material Technology Inc. Shenzhen 518110ShenzhenPeople’s Republic of China State-Key Laboratory of Advanced Design and manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082HunanPeople’s Republic of China Department of mechanical Engineering Massachusetts Institute of TechnologyCambridgeMA 02139-4307United States of America Digital manufacturing and Design Centre Singapore University of Technology and Design487372Singapore

Projection micro stereolithography(PμSL)is a high-resolution(up to 0.6μm)3D printing technology based on area projection triggered photopolymerization,and capable of fabricating complex 3D architectures covering multiple scales and with multiple *** paper reviews the recent development of the PμSL based 3D printing technologies,together with the related *** introduces the working principle,the commercialized products,and the recent multiscale,multimaterial printing capability of PμSL as well as some functional photopolymers that are suitable to Pμ*** review paper also summarizes a few typical applications of PμSL including mechanical metamaterials,optical components,4D printing,bioinspired materials and biomedical applications,and offers perspectives on the directions of the further development of PμSL based 3D printing technology.

关键词： projection microstereolithography multiscale 3D printing multimaterial 3D printing

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Pedicle screw accuracy assessment in ExcelsiusGPS?robotic spine surgery:evaluation of deviation from pre-planned trajectory

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Chinese Neurosurgical Journal 2018年第3期4卷 118-123页

作者： Bowen Jiang A.Karim Ahmed Corinna C.Zygourakis Samuel Kalb Alex m.Zhu Jakub Godzik Camilo A.molina Ari m.Blitz Ali Bydon Neil Crawford nicholas Theodore Department of Neurosurgery The Johns Hopkins School of MedicineThe Johns Hopkins Hospital600 N.Wolfe StreetMeyer 7-113BaltimoreMD 21287USA Department of Neurosurgery Barrow Neurological InstituteSt.Joseph’s Hospital and Medical CenterPhoenixAZUSA Department of Neuroradiology Johns Hopkins School of MedicineThe Johns Hopkins Hospital600 N Wolfe StBaltimoreMD 21287USA Department of Neurosurgery Johns Hopkins University School of Medicine1800 Orleans StreetZayed Tower Mailstop 6007Baltimore 21287MDUSA Globus medical Inc 2560 General Armistead AveAudubon 19403PAUSA

Background: The ExcelsiusGPS?(Globus medical, Inc., Audubon, PA) is a next-generation spine surgery robotic system recently approved for use in the United States. The objective of the current study is to assess pedicle screw accuracy and clinical outcomes among two of the first operative cases utilizing the ExcelsiusGPS?robotic system and describe a novel metric to quantify screw deviation. methods: Two patients who underwent lumbar fusion at a single institution with the ExcelsiusGPS?surgical robot were included. Pre-operative trajectory planning was performed from an intra-operative CT scan using the O-arm (medtronic, Inc., minneapolis, mN). After robotic-assisted screw implantation, a post-operative CT scan was obtained to confirm ideal screw placement and accuracy with the planned trajectory. A novel pedicle screw accuracy algorithm was devised to measure screw tip/tail deviation distance and angular offset on axial and sagittal planes. Screw accuracy was concurrently determined by a blinded neuroradiologist using the traditional Gertzbein-Robbins method. Clinical variables such as symptomatology, operative data, and post-operative follow-up were also collected. Results: Eight pedicle screws were placed in two L4-L5 fusion cases. mean screw tip deviation was 2.1 mm (range 0.8-5.2 mm), mean tail deviation was 3.2 mm (range 0.9-5.4 mm), and mean angular offset was 2.4 degrees (range 0.7-3.8 degrees). All eight screws were accurately placed based on the Gertzbein-Robbins scale (88% Grade A and 12% Grade B). There were no cases of screw revision or new post-operative deficit. Both patients experienced improvement in Frankel grade and Karnofsky Performance Status (KPS) score by 6 weeks post-op. Conclusion: The ExcelsiusGPS? robot allows for precise execution of an intended pre-planned trajectory and accurate screw placement in the first patients to undergo robotic-assisted fusion with this technology.

关键词： Robotic spine surgery Robot-assisted surgery Excelsius GPS® Gertzbein-Robbins Pedicle screw accuracy

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上皮生长因子对鼠肺细胞动力学的调节及其对放射保护的意义(Ⅰ)

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癌症 2003年第11期22卷 1127-1134页

作者：马骏 Andrew J.Doig Nalinin Patel 崔念基 nicholas H.A.Terry 中山大学肿瘤防治中心放射治疗科 Department of Exp Radiation Oncology M.D.Anderson Cancer CenterUniversity of TexasHoustonTexas77030-4095USA

背景与目的:上皮生长因子(keratinocyte growth factor,KGF)引起肺Ⅱ型细胞增殖,并保护肺免受外界多种刺激。以往,对慢反应正常肺组织的动力学参数难以测定,然而,近年来发展的技术使得准确测定正常组织细胞动力学指标成为可能。BrdUrd... 详细信息

背景与目的:上皮生长因子(keratinocyte growth factor,KGF)引起肺Ⅱ型细胞增殖,并保护肺免受外界多种刺激。以往,对慢反应正常肺组织的动力学参数难以测定,然而,近年来发展的技术使得准确测定正常组织细胞动力学指标成为可能。BrdUrd掺入DNA后,用流式细胞仪分析可测定组织中细胞的增殖状况,本研究的目的是采用上皮生长因子刺激后,探讨鼠肺正常组织细胞增殖动力学改变的情况。方法:采用KGF(5 mg/kg)或生理盐水C_3Hf/Kam小鼠气管内注射,并分别在0,1,2,3,4,5,及7天予以处死,处死前20分钟或6小时,腹腔内给予BrdUrd(60 mg/kg),肺组织切下后,固定于60％酒精,经消化处理形成单个细胞核,在流式细胞仪分析前行BrdUrd及总DNA含量标记染色,计算出标记指数(LI),细胞S期时间(Ts)及倍增时间(T_(pot))等细胞动力学参数;免疫荧光染色技术用于鉴定增殖细胞的类型。结果:(1)建立了上皮生长因子(5 mg/kg)刺激肺Ⅱ型细胞增殖的方法及气管内给药的途径;(2)肺组织LI由正常值0.5％升至给药后第三天的5.5％,第七天回至正常;(3)细胞T_(pot)由75.5天降至4.7天;生理盐水治疗组增殖参数没有变化。结论:上皮生长因子可引起肺Ⅱ型细胞的增殖,主要表现为LI的升高及T_(pot)降低。这种增殖效应短暂,第七天回至正常。

关键词：上皮生长因子鼠肺细胞动力学放射治疗保护作用气管内给药

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Ultrafast imaging of terahertz electric waveforms using quantum dots

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Light(Science & Applications) 2022年第1期11卷 63-68页

作者： moritz B.Heindl nicholas Kirkwood Tobias Lauster Julia A.Lang markus Retsch Paul mulvaney Georg Herink Experimental Physics VIII-Ultrafast Dynamics University of BayreuthBayreuthGermany ARC Centre of Excellence in Exciton Science School of ChemistryUniversity of MelbourneMelbourneAustralia Physical Chemistry I University of BayreuthBayreuthGermany

microscopic electric fields govern the majority of elementary excitations in condensed matter and drive electronics at frequencies approaching the Terahertz(THz)***,only few imaging schemes are able to resolve sub-wavelength fields in the THz range,such as scanning-probe techniques,electro-optic sampling,and ultrafast electron ***,intrinsic constraints on sample geometry,acquisition speed and field strength limit their ***,we harness the quantum-confined Stark-effect to encode ultrafast electric near-fields into colloidal quantum dot *** approach,termed Quantum-probe Field microscopy(QFIm),combines far-field imaging of visible photons with phase-resolved sampling of electric *** capturing ultrafast movies,we spatio-temporally resolve a Terahertz resonance inside a bowtie antenna and unveil the propagation of a Terahertz waveguide excitation deeply in the sub-wavelength *** demonstrated QFIm approach is compatible with strong-field excitation and sub-micrometer resolution—introducing a direct route towards ultrafast field imaging of complex nanodevices inoperando.

关键词： antenna waveguide quantum

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New frontiers for the materials genome initiative

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npj Computational materials 2019年第1期4卷 776-798页

作者： Juan J.de Pablo nicholas E.Jackson michael A.Webb Long-Qing Chen Joel E.moore Dane morgan Ryan Jacobs Tresa Pollock Darrell G.Schlom Eric S.Toberer James Analytis Ismaila Dabo Dean m.DeLongchamp Gregory A.Fiete Gregory m.Grason Geoffroy Hautier Yifei mo Krishna Rajan Evan J.Reed Efrain Rodriguez Vladan Stevanovic Jin Suntivich Katsuyo Thornton Ji-Cheng Zhao Institute for molecular Engineering University of ChicagoChicagoIL 60615USA Department of materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Physics University of CaliforniaBerkeleyBerkeleyCA 94720USA Department of materials Science and Engineering University of Wisconsin-MadisonMadisonWI 53706USA materials Department and materials Research Laboratory University of CaliforniaSanta BarbaraCA 93106USA Department of materials Science and Engineering Cornell UniversityIthacaNY 14853USA Department of Physics Colorado School of MinesGoldenCO 80401USA materials measurement Laboratory National Institute of Standards and TechnologyGaithersburgMD 20899USA Department of Physics University of Texas at AustinAustinTX 78712USA Department of Polymer Science and Engineering University of MassachusettsAmherstMA 01003USA Institute of Condensed matter and Nanosciences UniversitéCatholique de Louvain1348 Louvain-la-NeuveBelgium Department of materials Science and Engineering University of MarylandCollege ParkMD 20742USA Department of materials Design and Innovation University of Buffalo–The State University of New YorkBuffaloNY 14260-5030USA Department of materials Science and Engineering Stanford UniversityStanfordCA 94305USA Department of Chemistry and Biochemistry University of MarylandCollege ParkMD 20742USA Department of metallurgical and materials Engineering Colorado School of MinesGoldenCO 80401USA Department of materials Science and Engineering University of MichiganAnn ArborMI 48109USA Department of materials Science and Engineering The Ohio State UniversityColumbusOH 43210USA

The materials Genome Initiative(mGI)advanced a new paradigm for materials discovery and design,namely that the pace of new materials deployment could be accelerated through complementary efforts in theory,computation,and *** with numerous successes,new challenges are inviting researchers to refocus the efforts and approaches that were originally inspired by the *** may 2017,the National Science Foundation sponsored the workshop“Advancing and Accelerating materials Innovation Through the Synergistic Interaction among Computation,Experiment,and Theory:Opening New Frontiers”to review accomplishments that emerged from investments in science and infrastructure under the mGI,identify scientific opportunities in this new environment,examine how to effectively utilize new materials innovation infrastructure,and discuss challenges in achieving accelerated materials research through the seamless integration of experiment,computation,and *** article summarizes key findings from the workshop and provides perspectives that aim to guide the direction of future materials research and its translation into societal impacts.

关键词： utilize frontier accomplishment

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