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Standardized Management of Acute Pulmonary Hemorrhage after Percutaneous Pulmonary Vein Intervention

Congenital Heart Disease 2024年第4期19卷 389-397页

作者： Catalina Vargas-Acevedo Gareth j.Morgan Rhynn Soderstrom Richard Ing nicholas Houska jenny E.Zablah Department of Pediatric Cardiology University of ColoradoThe Heart InstituteChildren’s Hospital ColoradoAuroraCO 80045USA Department of Pharmacology Children’s Hospital ColoradoAuroraCO 80045USA Department of Anesthesia University of ColoradoChildren’s Hospital ColoradoAuroraCO 80045USA

Introduction:Pulmonary hemorrhage(PHm)is a life-threatening complication that can occur after catheter-based interventions in patients with pulmonary vein stenosis(PVS).Inhaled racemic epinephrine(iRE)and tra-nexamic acid(iTXA)have been used in other conditions,but a standardized approach in PVS has not been *** aimed to describe the current management of PHm after PVS catheter-based ***:We present a retrospective review of episodes of PHm from july 2022 to February *** was deﬁned as frank blood suctioned from the endotracheal tube including blood-tinged secretions and>3%decrease in saturations and/or ventilatory changes with or without acute chest X-ray *** individual episode of PHm was considered a separate *** was calculated based on the total number of PVS interventions during the study ***:Eleven episodes of PHm were identiﬁed out of 108 PVS interventions,resulting in an incidence of 10.2%.Five(45.5%)had primary PVS,and seven(63.6%)had bilateral *** median age at PHm was 23 months(3-91 months).Four episodes were treated with iRE,ﬁve with both iRE and iTXA,and two with only iTXA due to a history of suprasystemic right ventricular *** time on mechanical ventila-tion after PHm was 24 h(15-72 h)and a median ICU stay of 2 days(1-8 days).Hemostasis was achieved in all *** were no adverse events after iTXA,however,transient hypertension was observed after iRE which was ***:The implementation of a standardized protocol for the treatment of PHm in PVS has the potential to improve procedural planning,has a wider availability of medications,and greater awareness by the providers involved,possibly leading to earlier detection of PHm and appropriate treatment.

关键词： Pulmonary vein stenosis congenital heart disease pulmonary hemorrhage inhaled tranexamic acid racemic epinephrine

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Heart healthy equals prostate healthy and statins, aspirin, and/or metformin （S.A.M.） are the ideal recommendations for prostate cancer prevention

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Asian journal of Andrology 2015年第5期17卷 783-791,I0008页

作者： Mark A Moyad nicholas j Vogelzang Department of Urology University of Michigan Medical Center Ann Arbor Michigan USA Developmental Therapeutics Committee and Genitourinary Committee for US Oncology Research Comprehensive Cancer Centers of Nevada Las Vegas Nevada USA

Cardiovascular disease （CVD） has been the number one cause of death in the U.S. for 114 of the last 115 years. Lifestyle factors that promote CVD also appear to increase prostate cancer risk and those that reduce CVD risk also appear to reduce the risk of prostate cancer. The largest randomized trials utilizing dietary supplements or pharmacologic agents for prostate cancer prevention （Selenium and Vitamin E Cancer Prevention Trial [SELECT]） have also shed light on the problems and future solutions in this area. Dietary supplements that have not been found to be CVD protective, such as selenium and Vitamin E have not been found to be prostate protective. In addition, over exposure to specific anti-oxidants in nutritionally replete populations may be encouraging cancer growth. Futuretrials of dietary supplements to prevent prostate cancer could be problematic because by the time a definitive trial is initiated the participants will no longer be ＂deficient＂ in the nutrient being tested, which arguably occurred in the SELECT trial. It is also interesting that statins, aspirin, and/or metformin （S.A.M.） are 3 generic, low-cost, heart healthy agents derived from natural sources with separate mechanism of actions, which all appear to have the best benefit to risk ratio compared to any other agent available for prostate cancer prevention, especially aggressive disease, or as an ancillary agent （s） to conventional cancer treatment. It is time to focus on the forest over the trees and recommend proven CVD protective measures for men concerned about their risk of prostate cancer.

关键词： aspirin diet lifestyle metformin prostate cancer statins

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Teleseismic waves reveal anisotropic poroelastic response of wastewater disposal reservoir

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Earth and Planetary Physics 2021年第6期5卷 547-558页

作者： Andrew j Barbour nicholas M Beeler u.s.geological survey earthquake science centerusa

Connecting earthquake nucleation in basement rock to fluid injection in basal,sedimentary reservoirs,depends heavily on choices related to the poroelastic properties of the fluid-rock system,thermo-chemical effects *** constraints on these parameters outside of laboratory settings are rare,and it is commonly assumed that the rock layers are *** the Arbuckle wastewater disposal reservoir in Osage County,Oklahoma,high-frequency formation pressure changes and collocated broadband ground velocities measured during the passing of large teleseismic waves show a poroelastic response of the reservoir that is both azimuthally variable and anisotropic;this includes evidence of static shifts in pressure that presumably relate to changes in local *** azimuthal dependence in both the static response and shear coupling appears related to tectonic stress and strain indicators such as the orientations of the maximum horizontal stress and faults and *** dynamic strains from a nearby borehole strainmeter,we show that the ratio of shear to volumetric strain coupling is~0.41 which implies a mean Skempton's coefficient of A=0.24 over the plausible range of the undrained Poisson's *** these observations are made at relatively low confining pressure and differential stress,we suggest that the hydraulically conductive fracture network is a primary control on the coupling between pore pressure diffusion and elastic stresses in response to natural or anthropogenic sources.

关键词： poroelasticity dynamic strain anisotropy wastewater disposal Oklahoma induced seismicity

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Electrospun fibers:a guiding scaffold for research and regeneration of the spinal cord

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Neural Regeneration Research 2016年第11期11卷 1764-1765页

作者： nicholas j.Schaub National Institute of Standards & Technology Biosystems and Biomaterials Division

The challenge to regenerating the nervous system compared to other tissues in the body is the complexity of the tissue. For example, a small amount of scar tissue formation after an injury to the skin may have few negative side effects, but any scar tissue in the central nervous system is a major physical and chemical barrier to nerve regeneration （Sofroniew, 2009）.

关键词： Electrospun fibers

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Breaking the biotrophic interfacial complex:How genome editing can lead to rice blast resistance

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Molecular Plant 2023年第8期16卷 1243-1245页

作者： Vincent Were nicholas j.Talbot The Sainsbury Laboratory University of East AngliaNorwich Research ParkNorwich NR47UHUK

Genome editing is a transformational technology—by precisely altering the coding or regulatory sequence of a specific gene,it is now possible to change specific traits within a wide variety of *** a consequence,plant breeding can be taken to a new level of precision,and many countries are moving rapidly to adopt new legislation to permit genome editing(Greenwood et al.,2023).However,genome editing has so far seldom been used to develop disease-resistant *** is because plant immunity often depends on single dominant resistance genes,which encode immune receptors that recognize secreted effectors deployed by plant pathogens(jones and Dangl,2006).In this context,genetic modification has proven to be a much more powerful technology so far to introduce these genes from distinct varieties,or even different species,to develop disease resistant crop species(Greenwood et al.,2023),especially when multiple disease-resistance loci can be introduced together to provide more durable resistance(Luo et al.,2021).Genome editing can be used in an innovative way to resurrect previously effective resistance genes(Contreras et al.,2023),but it has been less effective at introducing new forms of disease resistance to crops.

关键词： breeding resistance editing

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Integrating volunteered smartphone data with multispectral remote sensing to estimate forest fuels

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International journal of Digital Earth 2016年第2期9卷 171-196页

作者： Colin j.Ferster nicholas C.Coops Department of Forest Resources Management University of British ColumbiaVancouverBCCanada

Volunteered data sources are readily available due to advances in electronic communications *** example,smartphones provide tools to collect ground-based observations over broad areas from a diverse set of data collectors,including people with,and without,extensive *** this study,volunteers used a smartphone application to collect ground-based *** structural components were then estimated over a broader area using high spatial resolution RapidEye remote sensing imagery(5 spectral bands 440–850 nm,5 m spatial resolution)and a digital elevation model following a three nearest neighbor approach(K-NN).Participants with professional forestry experience on average chose highpriority fuel load locations near buildings,while nonprofessional participants chose a broader range of conditions over a larger *** used together,the professional and nonprofessional observations provided a more complete assessment of forest conditions.A generalized framework is presented that utilizes K-NN imputation tools for estimating the distribution of forest fuels using remote sensing and topography variables,ensuring spatial representation,checking attribute accuracy,and evaluating predictor *** to integrate volunteered data from smartphone platforms with remote sensing may contribute toward more complete Earth observation for Digital Earth.

关键词： citizen science public participation in scientific research mobile RapidEye red edge WUI

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Thalidomide ameliorates portal hypertension via nitric oxide synthase independent reduced systolic blood pressure

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World journal of Gastroenterology 2015年第14期21卷 4126-4135页

作者： nicholas G Theodorakis Yining N Wang Vyacheslav A Korshunov Mary A Maluccio nicholas j Skill Division of Transplant Surgery Department of SurgerySchool of MedicineIndiana University School of Medicine University of Rochester

AIM: Portal hypertension is a common complication of liver cirrhosis and significantly increases mortality and *** reports have suggested that the compound thalidomide attenuates portal hypertension(PHT).However, the mechanism for this action is not fully *** hypothesis is that thalidomide destabilizes tumor necrosis factor α(TNFα) mR NA and therefore diminishes TNFα induction of nitric oxide synthase(NOS) and the production of nitric oxide(NO).To examine this hypothesis, we utilized the murine partial portal vein ligation(PVL) PHT model in combination with endothelial or inducible NOS isoform gene knockout ***: Wild type, inducible nitric oxide synthase(i NOS)-/- and endothelial nitric oxide synthase(e NOS)-/-mice received either PVL or sham surgery and were given either thalidomide or *** nitrate(total nitrate, NOx) was measured daily for 7 d as a surrogate of NO *** TNFα level was quantified by enzyme-linked immunosorbent ***α m RNA was quantified in liver and aorta tissue by reverse transcription-polymerase chain *** was determined by recording splenic pulp pressure(SPP) and abdominal aortic flow after 0-7 *** to thalidomide was determined by measurement of SPP and mean arterial pressure(MAP).RESULTS: SPP, abdominal aortic flow(Qao) and plasma NOx were increased in wild type and i NOS-/-PVL mice when compared to sham operated control *** contrast, SPP, Qao and plasma NOx were not increased in e NOS-/- PVL mice when compared to sham *** TNFα level in both sham and PVL mice was below the detection limit of the commercial ELISA ***, the effect of thalidomide on serum TNFα levels was undetermined in wild type, e NOS-/-or i NOS-/- *** acutely increased plasma NOx in wild type and e NOS-/- mice but not i NOS-/-***, thalidomide temporarily(0-90 min) decreased mean arterial pressure, SPP and Qao in wild type, e NOS-/- and i NOS-/- PVL mice, aft

关键词： Portal hypertension Thalidomide Nitric oxide Knock

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Putting PLX5622 into perspective:microglia in central nervous system viral infection

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Neural Regeneration Research 2023年第6期18卷 1269-1270页

作者： Alanna G.Spiteri nicholas j.C.King Viral Immunopathology Laboratory InfectionImmunity and Inflammation Research ThemeSchool of Medical SciencesFaculty of Medicine and HealthThe University of SydneySydneyNSWAustralia Sydney Cytometry The University of Sydney and Centenary InstituteSydneyNSWAustralia Ramaciotti Facility for Human Systems Biology The University of Sydney and Centenary InstituteSydneyNSWAustralia Charles Perkins Centre The University of SydneyAustralia The University of Sydney Institute for Infectious Diseases The University of SydneySydneyNSWAustralia The University of Sydney Nano Institute the University of SydneySydneyNSWAustralia

Elucidating the exact contribution of microglia to central nervous system(CNS)pathology has historically been extremely *** resident parenchymal myeloid cells are considered to have critical roles as frontline responders during pathogen invasion and CNS ***,understanding the precise temporal kinetics of microglial function is central to the evolution of novel therapeutics for disease intervention and/or resolution(Spiteri et al.,2022a).The development of PLX5622,a colony-stimulating factor 1 receptor(CSF-1R)inhibitor typically formulated into a rodent chow for simple oral administration has facilitated exploration of microglial functions in disease(Spangenberg et al.,2019).

关键词： invasion system precise

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Biomarkers in renal cell carcinoma:Are we there yet?

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Asian journal of Urology 2021年第4期8卷 362-375页

作者： Shuchi Gulati nicholas j.Vogelzang Division of Hematology and Oncology University of CincinnatiCincinnatiOhUSA Nevada Cancer Research Foundation Las VegasNVUSA

Management of kidney cancer has undergone a paradigm shift with the approval of new therapies over the last two *** these drugs have improved clinical outcomes in patients with kidney cancer,there are still a large number of patients who do not show objective responses.A multitude of investigators,including those for The Cancer Genome Atlas have biologically characterized and sub-classified kidney ***,we have not been able to identify molecular targets to effectively treat patients with kidney *** we familiarize ourselves with newer drugs for patients with kidney cancer,it is important to understand that these drugs may not work in every patient and instead may expose patients to unnecessary toxic effects along with burdening society with the financial *** we head toward the era of“precision medicine”,validated biomarkers are being utilized to guide treatment choices and help identify pathways of resistance in other tumor *** current review aims at evaluating the progress made so far in this realm for patients with kidney cancer.

关键词： Kidney cancer Clear cell Non-clear cell Immunotherapy Biomarkers

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A polarizing situation： Taking an in-plane perspective for next-generation near-field studies

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Frontiers of physics 2016年第2期11卷 1-17页

作者： P. james Schuck Wel Bao nicholas j. Borys Molecular Foundry Lawrence Berkeley National Laboratory Berkeley CA 94720 USA Department of Materials Science and Engineering University of California Berkeley CA 94720-1760 USA

By enabling the probing of light-matter interactions at the functionally relevant length scales of most materials, near-field optical imaging and spectroscopy accesses information that is unobtainable with other methods. The advent of apertureless techniques, which exploit the ultralocalized and enhanced near-fields created by sharp metallic tips or plasmonic nanoparticles, has resulted in rapid adoption of near-field approaches for studying novel materials and phenomena, with spatial resolution approaching sub-molecular levels. However, these approaches are generally limited by the dominant out-of-plane polarization response of apertureless tips, restricting the exploration and discovery of many material properties. This has led to recent design and fabrication breakthroughs in near-field tips engineered specifically for enhancing in-plane interactions with near-field light components. This mini-review provides a perspective on recent progress and emerging directions aimed at utilizing and controlling in-plane optical polarization, highlighting key application spaces where in-plane near-field tip responses have enabled recent advancements in the understanding and development of new nanostructured materials and devices.

关键词： near-field optical microscopy nano-optics TERS plasmonics optical antenna 2D materials

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