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Ureteroscopy and stones:Current status and future expectations

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World journal of Nephrology 2014年第4期3卷 243-248页

作者： Anna E Wright nicholas j Rukin Bhaskar K Somani Department of Urology New Cross Hospital Department of Urology University Hospital Southampton NHS Trust

Urolithaisis is becoming an ever increasing urological,nephrological and primary care *** a lifetime prevalence approaching 10% and increasing morbidity due to stone disease,the role of ureteroscopy and stone removal is becoming more *** discuss the current status of stone disease and review the ever increasing role that ureteroscopy has to play in its *** discuss technological advances that have been made in stone management and give you an overview of when,how and why ureteroscopy is the most common treatment option for stone *** touch on the role of robotic ureteroscopy and the future of ureteroscopy in the next 10 years.

关键词： Ureteroscopy Techniques Ureteral stones Calculi Treatment Advances

Machine-learning-based head impact subtyping based on the spectral densities of the measurable head kinematics

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journal of Sport and Health Science 2023年第5期12卷 619-629,F0003页

作者： Xianghao Zhan Yiheng Li Yuzhe Liu nicholas j.Cecchi Samuel j.Raymond Zhou Zhou Hossein Vahid Alizadeh jesse Ruan Saeed Barbat Stephen Tiernan Olivier Gevaert Michael M.Zeineh Gerald A.Grant David B.Camarillo Department of Bioengineering Stanford UniversityStanfordCA 94305USA Department of Biomedical Data Science Stanford UniversityStanfordCA 94305USA Ford Motor Company 3001 Miller RdDearbornMI 48120USA Technological University Dublin DublinD07 EWV4Ireland Department of Radiology Stanford UniversityStanfordCA 94305USA Department of Neurosurgery Stanford UniversityStanfordCA 94305USA

Background:Traumatic brain injury can be caused by head impacts,but many brain injury risk estimation models are not equally accurate across the variety of impacts that patients may undergo,and the characteristics of different types of impacts are not well *** investigated the spectral characteristics of different head impact types with kinematics ***:Data were analyzed from 3262 head impacts from lab reconstruction,American football,mixed martial arts,and publicly available car crash data.A random forest classifier with spectral densities of linear acceleration and angular velocity was built to classify head impact types(e.g.,football,car crash,mixed martial arts).To test the classifier robustness,another 271 lab-reconstructed impacts were obtained from 5 other instrumented ***,with the classifier,type-specific,nearest-neighbor regression models were built for brain ***:The classifier reached a median accuracy of 96% over 1000 random partitions of training and test *** most important features in the classification included both low-and high-frequency features,both linear acceleration features and angular velocity *** head impact types had different distributions of spectral densities in low-and high-frequency ranges(e.g.,the spectral densities of mixed martial arts impacts were higher in the high-frequency range than in the low-frequency range).The type-specific regression showed a generally higher R2value than baseline models without ***:The machine-learning-based classifier enables a better understanding of the impact kinematics spectral density in different sports,and it can be applied to evaluate the quality of impact-simulation systems and on-field data augmentation.

关键词： Classification Contact sports Head impacts Impact kinematics Traumatic brain injuryTagedAPTARAEnd

Emerging mechanisms for exercise effects on muscle wasting and anabolic resistance

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Sports Medicine and Health Science 2020年第4期2卷 175-176页

作者： j.William Deaver nicholas P.Greene Cachexia Research Laboratory Exercise Science Research CenterDepartment of HealthHuman Performance and RecreationUniversity of ArkansasFayettevilleARUSA Muscle Biology Laboratory Department of Health and KinesiologyTexas A&M UniversityCollege StationTXUSA

Introduction At the 2018 Annual Meeting of the American College of Sports Medicine,presentations were given by *** ***,james ***,and james ***,at a symposium titled“Emerging Mechanisms for Exercise Effects on Muscle Wasting and Anabolic Resistance”.Inspired by the presentations at this symposium,the following reviews have been crafted to examine the current understanding of muscle diseases characterized by muscle wasting and anabolic resistance,particularly their identification,development,progression,and mitigation.

关键词： resistance mechanisms muscle

Development of a Portable Electro-Mechanical Educational Model for Variable Rate Center Pivot Irrigation Technology

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journal of Water Resource and Protection 2016年第4期8卷 449-458页

作者： Young j. Han Ahmad Khalilian jose Payero nicholas Rogers Department of Agricultural and Environmental Sciences Clemson University Clemson SC USA Edisto Research and Education Center Department of Agricultural and Environmental Sciences Clemson University Blackville SC USA

Center pivot irrigation systems usually apply a relatively uniform amount of water to fields that are often inherently variable, which could lead to significant waste of water and energy. To address this issue, our team is now developing an Intelligent Center Pivot (ICP) by integrating sensor-based irrigation scheduling with variable rate irrigation technology. However, before this technology can be applied in commercial production, it is necessary to educate growers about its practicality and potential benefits. The objective of this study was to develop a portable tabletop intelligent center pivot model (ICPDemo) to demonstrate and promote adoption of the ICP technology. This paper describes an ICPDemo constructed in 2014, including the design specifications, electro-mechanical design, control strategy, and performance. The ICPDemo has performed according to design specifications and is successfully being used to demonstrate the benefits and effectiveness of ICP technology for irrigation scheduling.

关键词： Irrigation Center Pivot Irrigation Electro-Mechanical Model Sensors Control Variable Rate Irrigation

Trends in leadership at orthopaedic surgery sports medicine fellowships

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World journal of Orthopedics 2021年第6期12卷 412-422页

作者： nicholas C Schiller Andrew j Sama Amanda F Spielman Chester j Donnally III Benjamin I Schachner Dhanur M Damodar Christopher C Dodson Michael G Ciccotti Miller School of Medicine University of MiamiMiamiFL 33136United States Department of Orthopaedic Surgery Rothman Institute at Thomas Jefferson UniversityPhiladelphiaPA 19107United States Department of Orthopedic Surgery University of Miami HospitalMiamiFL 33316United States

BACKGROUND Fellowship directors(FDs)in sports medicine influence the future of trainees in the field of *** the characteristics these leaders share must be brought into *** all current sports medicine FDs,our group analyzed their demographic background,institutional training,and academic *** To serve as a framework for those aspiring to achieve this position in orthopaedics and also identify opportunities to improve the *** Fellowship programs were identified using both the American Orthopaedic Society for Sports Medicine and the Arthroscopy Association of North America Sports Medicine Fellowship *** demographic and educational background data for each FD was gathered via author review of current curriculum vitae(CVs).Any information that was unavailable on CV review was gathered from institutional biographies,Scopus Web of Science,and emailed *** ensure the collection of as many data points as possible,fellowship program coordinators,orthopaedic department offices and FDs were directly contacted via phone if there was no response via *** information of interest included:Age,gender,ethnicity,residency/fellowship training,residency/fellowship graduation year,year hired by current institution,time since training completion until FD appointment,length in FD role,status as a team physician and *** Information was gathered for 82 *** these,97.5%(n=80)of the leadership were male;84.15%(n=69)were Caucasian,7.32%(n=6)were Asian-American,2.44%(n=2)were Hispanic and 2.44%(n=2)were African American,and 3.66%(n=3)were of another race or *** mean age of current FDs was 56 years old(±9.00 years),and the mean Scopus H-index was 23.49(±16.57).The mean calendar years for completion of residency and fellowship training were 1996(±15 years)and 1997(±9.51 years),*** time since fellowship training completion until FD appointment was 9.77 years.17.07%(n=14)of

关键词： Sports medicine fellowship Medical education Orthopaedic surgery Orthopaedic fellowship Orthopaedic leadership

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偏倚一览:发表偏倚

英国医学杂志中文版 2022年第3期25卷 166-167页

作者： nicholas j DeVito Ben Goldacre 陈立敏(译) Nuffield Department of Primary Care Health Sciences University of OxfordOxfordUK 不详

背景Dickersin和Min将发表偏倚定义为“基于研究结果的方向或强度”而不发表研究。这种不发表会带来偏倚,妨碍人们确切理解和综合描述某一领域的证据影发表偏倚是报告偏倚的一种,与传播偏倚密切相关,不过通常传播偏倚适用于所有形式的... 详细信息

背景Dickersin和Min将发表偏倚定义为“基于研究结果的方向或强度”而不发表研究。这种不发表会带来偏倚,妨碍人们确切理解和综合描述某一领域的证据影发表偏倚是报告偏倚的一种,与传播偏倚密切相关,不过通常传播偏倚适用于所有形式的成果传播,而不仅限于期刊出版物。各种不同的偏倚常常被归入发表偏倚的总体定义中。

关键词：发表偏倚出版物传播定义

The practicality and sustainability of a community advisory board at a large medical research unit on the Thai-Myanmar border

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Health 2013年第2期5卷 229-236页

作者： Khin Maung Lwin Thomas j. Peto nicholas j. White nicholas P. j. Day Francois Nosten Michael Parker Phaik Yeong Cheah Mahidol Oxford Tropical Medicine Research Unit Faculty of Tropical Medicine Mahidol University Bangkok Thailand Shoklo Malaria Research Unit Mae Sot Thailand The Ethox Centre Department of Public Health and Primary Health Care University of Oxford Oxford UK

Community engagement is increasingly promoted to strengthen the ethics of medical research in low-income countries. One strategy is to use community advisory boards (CABs): semi-independent groups that can potentially safeguard the rights of study participants and help improve research. However, there is little published on the experience of operating and sustaining CABs. The Shoklo Malaria Research Unit (SMRU) has been conducting research and providing healthcare in a population of refugees, migrant workers, and displaced people on the Thai-Myanmar border for over 25 years. In 2009 SMRU facilitated the establishment of the Tak Province Community Ethics Advisory Board (T-CAB) in an effort to formally engage with the local communities both to obtain advice and to establish a participatory framework within which studies and the provision of health care can take place. In this paper, we draw on our experience of community engagement in this unique setting, and on our interactions with the past and present CAB members to critically reflect upon the CAB’s goals, structure and operations with a focus on the practicalities, what worked, what did not, and on its future directions.

关键词： Ethics Community Engagement Community Advisory Boards Developing Countries Thailand Myanmar Global Health International Research

用IREFINDER算法在非翻译区搜索人和小鼠的铁反应元件

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Acta Biochimica et Biophysica Sinica 2002年第6期34卷 743-747页

作者：陈新,王鲁泉,黄弋,邱平,MURGOLO nicholas j.,GREENE jonathan R.,吴才宏,姜颖北京大学生命科学学院生物信息中心 Schering Plough研究所北京大学生命科学学院生物信息中心 Schering Plough研究所 Schering Plough研究所 Schering Plough研究所北京大学膜及膜的工程国家重点实验室北京大学生命科学学院生物信息中心北京100871 Nj07033 北京100871 Nj07033 Nj07033 Nj07033 北京100871 北京100871

铁反应元件 (IRE)具有的高度保守的RNA茎环结构 ,是胞质中IRE结合铁调控蛋白 (IRP)的位点。IRP与IRE的结合受细胞内铁含量的调控 ,与铁代谢有着密切的关系。许多与铁代谢有关的基因在 5′UTR或 3′UTR都存在IRE。当铁离子缺乏时 ,IRE与... 详细信息

铁反应元件 (IRE)具有的高度保守的RNA茎环结构 ,是胞质中IRE结合铁调控蛋白 (IRP)的位点。IRP与IRE的结合受细胞内铁含量的调控 ,与铁代谢有着密切的关系。许多与铁代谢有关的基因在 5′UTR或 3′UTR都存在IRE。当铁离子缺乏时 ,IRE与IRP结合 ,使核糖体的翻译进程受阻 ,抑制mRNA的翻译 ;而当铁离子浓度较高时 ,IRP就释放IRE ,促进翻译。因此 ,IRE在 5′UTR调节着翻译的起始[1] 。如果IRE位于 3′UTR ,IRE与IRP的结合可以稳定mRNA并预防其被降解。所有已知的IRE均为C1G5型 ,即环的 1号和 5号碱基位置分别是保守的C和G ;另外还存在一类体外合成的U1A5型IRE ,即环的 1号和 5号碱基位置分别是保守的U和A ,能够在体外有效地结合IRP。由于IRE与铁代谢、氧化性损伤 (oxidativestress)和衰老等过程都有密切的关系 ,因此在临床及新药研制等方面都很受重视。通过改进搜索IRE的算法 ,用计算机程序对人与鼠的mRNA非编码区(UTR)序列数据库进行全面的搜索 ,期望找出可能存在的C1G5或U1A5类型的IRE ,或包含这两种类型IRE的基因。

关键词：铁反应元件铁调控蛋白茎环结构非翻译区

Chronic Marijuana Smoking Does Not Negatively Impact Select Blood Oxidative Stress Biomarkers in Young, Physically Active Men and Women

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Health 2018年第7期10卷 960-970页

作者： Richard j. Bloomer Matthew Butawan nicholas j. G. Smith School of Health Studies University of Memphis Memphis TN USA

Background: The smoking of Cannabis sativa, the marijuana plant, is increasing in popularity among young adults, even those who may be engaged in regular exercise (i.e., athletes). Research has shown the plant to have antioxidant and analgesic properties, but the effects on oxidative stress are conflicting. The purpose of this study was to measure blood oxidative stress and cardio-metabolic parameters in physically active men and women who regularly smoke marijuana. Methods: A total of 43 marijuana smokers (23 ± 4 years) and 22 non-smokers (24 ± 7 years), who did not smoke tobacco products, participated in this study. Both smokers and non-smokers engaged in regularly exercise, totaling several hours per week (6.4 ± 4.0 and 6.8 ± 4.4, respectively). Smokers reported using marijuana frequently during the week (4.5 ± 2.3 sessions) for a minimum of three consecutive months prior to participating in the study. Blood samples were collected from participants following a 12-hour fast (all food, drink [except water] and smoking) and analyzed for malondialdehyde, advanced oxidation protein products, glucose, cholesterol, and triglycerides. Heart rate and blood pressure was also measured and recorded. Results: No differences of statistical significance were noted for any variable (p > 0.05), with very similar values noted between smokers and non-smokers. Conclusions: In a sample of young, physically active men and women, regular marijuana smoking is not associated with untoward effects on select biomarkers of oxidative stress and cardio-metabolic health. These findings do not suggest that marijuana smoking can be done without harm, as limitations of this study need to be considered.

关键词： Marijuana Cannabis Oxidative Stress Lipid Peroxidation Protein Oxidative