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Polygonatum kingianum rhizome extract alleviates collagen antibody-induced arthritis by modulating proinflammatory cytokine production in mice

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Asian Pacific Journal of Tropical Biomedicine 2020年第11期10卷 490-495页

作者： Huyen Do thi Thanh Phuong Ngo thi Hien nguyen thi Thu Nga nguyen thi Hung Le Ngoc Thao Dothi Ha Le Minh Graduate University of Science and Technology Vietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam Institute of Natural Products Chemistry Vietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam Hanoi Open University101 nguyen Hien str Hai Ba Trung Dist.HanoiVietnam Laboratory of Bioassay Institute of BiotechnologyVietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam Chemistry Lab Project Center for Research and Technology transferVietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam

Objective: To evaluate the anti-arthritic effects of Polygonatum kingianum rhizome extract using both in vitro and in vivo ***: Lipopolysaccharide-induced RAW 264.7 macrophages were treated with an ethanol extract of Polygonatum kingianum rhizomes at different concentrations to determine nitric oxide and prostaglandin E2(PGE2) production. For in vivo study, Polygonatum kingianum ethanol extract was further investigated for its antiinflammatory effect in a mouse model with collagen antibodyinduced arthritis. Phytochemical study of Polygonatum kingianum ethanol extract was also ***: Saponins(142 mg/g total yield) was the main component in the Polygonatum kingianum ethanol extract. 5α,8α-ergosterol peroxide,(E,E)-9-oxooctadeca-10,12-dienoic acid and 3-(2?-hydroxy-4?-methoxy-benzyl)-5,7-dihydroxy-8-methyl-chroman-4-one were isolated from the extract. Polygonatum kingianum ethanol extract exhibited potential anti-inflammatory effects by inhibiting nitric oxide and PGE2 production in RAW 264.7 cells in a dosedependent manner. The level of arthritis in mice with collagen antibody-induced arthritis was significantly reduced(P<0.01) after treatment with Polygonatum kingianum ethanol extract, particularly at a dose of 1 000 mg/kg body weight. Besides, the extract demonstrated the regulatory effects on serum tumor necrosis factoralpha, interleukin-6, and interleukin-10 in treated ***: Polygonatum kingianum ethanol extract has beneficial effects on inflammatory cytokine regulation and PGE2 inhibition in an experimental mouse model with collagen antibody-induced arthritis. The phytochemical screening reveals that the saponin, as the main component, and sterols(daucosterol and 5α,8α-ergosterol peroxide) from Polygonatum kingianum ethanol extract may contribute to its promising in vitro and in vivo anti-inflammatory activities.

关键词： inflammatory cytokine PGE2

Marker-Assisted Selection of Xa21 Conferring Resistance to Bacterial Leaf Blight in indica Rice Cultivar LT2

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Rice science 2018年第1期25卷 52-56页

作者： Hue thi nguyen Quang Hong VU Tan Van MAI Thu thi nguyen Lam Duc VU Tung Thanh nguyen Long Viet nguyen Hien Thu thi VU Hue thi NONG Trung nguyen DINH Nakano TOSHITSUGU Liet Van VU Crop Research and Development Institute Vietnam National University of Agriculture Trau Qui Gia Lam Hanoi 10000 Vietnam Faculty of Agronomy Vietnam National University of Agriculture Trau Qui Gia Lam Hanoi 10000 Vietnam Faculty of Biotechnology Vietnam National University of Agriculture Trau Qui Gia Lam Hanoi 10000 Vietnam Faculty of Land Management Vietnam National University of Agriculture Trau Qui Gia Lam Hanoi 10000 Vietnam Japan International Cooperation Agency 16 Phan Chu Trinh Hoan Kiem Hanoi 10000 Vietnam

Bacterial leaf blight of rice (BLB), caused by Xanthomonas oryzae pv. oryzae, is one of the most destructive diseases in Asian rice fields. A high-quality rice variety, LT2, was used as the recipient ***21, which carries the Xa21 gene, was used as the donor parent. The resistance gene Xa21 was introduced into LT2 by marker-assisted backcrossing. Three Xoo races were used to inoculate the improved lines following the clipping method. Eleven BC_3F_3 lines carrying Xa21 were obtained based on molecular markers and agronomic performance. The 11 lines were then inoculated with the three Xoo races. All the 11 improved lines showed better resistance to BLB than the recipient parent LT2. Based on the level of resistance to BLB and their agronomic performance, five lines (BC_3F_3 5.***.5.1, BC_3F_3 5.***.5.12, BC_3F_3 8.***.6.44, BC_3F_3 9.***.4.1 and BC_3F_3 9.***.4.23) were selected as the most promising for commercial release. These improved lines could contribute to rice production in terms of food security.

关键词： rice backcrossing bacterial leaf blight marker-assisted selection

Investigation of Polymorphisms in Coding Region of OsHKT1in Relation to Salinity in Rice

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Rice science 2016年第6期23卷 334-338页

作者： pham quynh-hoa tran xuan-an nguyen thi-nha-trang tran thi-thuy-anh hoang hai-yen nguyen thi-hong-van tang thi-hanh do thi-phuc Faculty of Biology VNU University of ScienceHanoi334 Nguyen TraiThanh XuanHanoiVietnam Faculty of Agronomy Vietnam National University of AgricultureNgo Xuan Quang StreetTrau QuyGia LamHanoiVietnam

Rice （Oryza sativa） is sensitive to salinity, but the salt tolerance level differs among cultivars,which might result from natural variations in the genes that are responsible for salt tolerance. High-affinitypotassium transporter （HKTs） has been proven to be involved in salt tolerance in plants. Therefore, wescreened for natural nucleotide polymorphism in the coding sequence of OsHKT1, which encodes the HKTprotein in eight Vietnamese rice cultivars differing in salt tolerance level. In total, seven nucleotidesubstitutions in coding sequence of OsHKT1 were found, including two non-synonymous and five synonymoussubstitutions. Further analysis revealed that these two non-synonymous nucleotide substitutions （G50Tand T1209A） caused changes in amino acids （Gly17Val and Asp403Glu） at signal peptide and the loop ofthe sixth transmembrane domain, respectively. To assess the potential effect of these substitutions on theprotein function, the 3D structure of HKT protein variants was modelled by using PHYRE2 webserver. Theresults showed that no difference was observed when compared those predicted 3D structure of HKTprotein variants with each other. In addition, the codon bias of synonymous substitutions cannot clearlyshow correlation with salt tolerance level. It might be interesting to further investigate the functional roles ofdetected non-synonymous substitutions as it might correlate to salt tolerance in rice.

关键词： polymorphism salt stress OsHKT1 gene rice

In vivo anticancer activity of maesopsin 4—O— β—glucoside isolated from leaves of Artocarpus tonkinensis *** Gagnep

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Asian Pacific Journal of Tropical Medicine 2016年第4期9卷 343-348页

作者： Trinh thi Thuy Dao Duc thien Tran Quang Hung nguyen Thanh Tam nguyen thi Hoang Anh nguyen thi Nga nguyen thi Cuc Le Phuong Mai Tran Van Sung Domenico V.Delfino Do thi Thao Institute of Chemistry.Vietnam Academy of Science and Technology Institute of Biotechnology Vietnam Academy of Science and Technology National Research Council Canada Measurement Science and Standards1200 Montreal RoadBuilding M-12.Ottatca.Ontario KIA OR6 Department of Medicine University of PerugiaPiazzale Gambuli.S.Andrea delle Fratte

Objective:To investigate the antitumor effect of maesopsin 4-O-β-glucoside(TAT2) isolated from the leaves of Artocarpus tonkinensis(***) *** ***:The antitumor activity of TAT2 was evaluated in Lewis lung carcinoma(LLC) tumor-bearing ***/c mice had tumors induced by implantation with 2× 10~6 LLC cells into the subcutaneous right posterior ***-bearing mice were treated orally with a range of doses of TAT2 and a standard drug,*** were observed for tumor growth and mortality *** was collected to determine hematological and biochemical *** TAT2 was isolated from an ethanolic extract of *** *** structure was determined by MS and NMR spectroscopy,and identified as *** compound did not show acute toxicity at the highest dose tested(2 OIK) mg/kg body weight).TAT2 exhibited antitumor activity by decreasing tumor growth,increasing the survival rale,and ameliorating some hematological and biochemical parameters at doses of 100 and 200 mg/kg body weight(P<0.05).Conclusions:These results indicate that TAT2 possesses clear antitumor *** to its bioavailability and low toxicity,and the fact that it could be isolated in a large scale from *** leaves,the compound shows promise as a potential anticancer drug.

关键词： Artocarpus tonkinensis BALB/c Hematological parameters Lewis lung carcinoma Maesopsin 4-0-β-glucoside

Effects of low energy (160 keV) X-ray on microbial inactivation,sprouting inhibition and genetic variation in potato

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Food Bioscience 2022年第3期47卷 262-270页

作者： nguyen An Son nguyen thi Nguyet Ha nguyen thi Minh Sang Le Doan Dinh Duc Le Ngoc Trieu Faculty of Physic and Nuclear Engineering Da Lat UniversityViet Nam Dalat Vocational Training College Viet Nam Faculty of Biology Da Lat UniversityViet Nam

The effects of low energy X-ray irradiation on microbial inactivation,sprouting inhibition and genetic variation were *** was an inverse correlation between the exposure dose in range of 0 Gy–5000 Gy and the survival rate of *** dose of 1000 Gy seemed to be suitable for inactivation of microorganisms because the respective survival rate is relatively low (0.59%).Dose rate of 13.87 Gy/min was the most appropriate to inactivate the microorganisms,with the survival rate of 0.37%.Applying the irradiation dose of 1000 Gy and dose rate of 13.87 Gy/min,there was a significant sprouting inhibition of irradiated potatoes compared to the control for six months *** effect of irradiation dose (100–1200 Gy) and dose rate (8.63–19.62 Gy/min) on genetic variation of the irradiated samples was assessed by DNA fingerprints induced from using three molecular techniques including Random Amplified Polymorphic DNA (RAPD),Start Codon Targeted Polymorphism (SCoT) and CAAT box – derived polymorphism (CBDP).At the irradiation dose of 1000 Gy and dose rate of 13.87 Gy/min,the level of genetic variation was relatively low (4.85%).Thus,this treatment is a suitable condition of irradiation for potato treatment with the purpose of preservation.

关键词： Dose Dose rate Low energy X-ray Microbial inactivation Potato

Combining Entropy Optimization and Sobel Operator for Medical Image Fusion

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Computer Systems Science & Engineering 2023年第1期44卷 535-544页

作者： nguyen Tu Trung Tran thi Ngan Tran Manh Tuan To Huu nguyen Faculty of Computer Science and Engineering Thuyloi University175 Tay SonDong DaHanoi010000Vietnam University of Information and Communication Technology Thai Nguyen UniversityThai Nguyen240000Vietnam

Fusing medical images is a topic of interest in processing medical *** is achieved to through fusing information from multimodality images for the purpose of increasing the clinical diagnosis *** fusion aims to improve the image quality and preserve the specific *** methods of medical image fusion generally use knowledge in many differentfields such as clinical medicine,computer vision,digital imaging,machine learning,pattern recognition to fuse different medical *** are two main approaches in fusing image,including spatial domain approach and transform domain *** paper proposes a new algorithm to fusion multimodal *** algorithm is based on Entropy optimization and the Sobel *** transform is used to split the input images into components over the low and high frequency ***,two fusion rules are used for obtaining the fusing *** rule,based on the Sobel operator,is used for high frequency *** second rule,based on Entropy optimization by using Particle Swarm Optimization(PSO)algorithm,is used for low frequency *** algorithm is implemented on the images related to central nervous system *** experimental results of the paper show that the proposed algorithm is better than some recent methods in term of brightness level,the contrast,the entropy,the gradient and visual informationfidelity for fusion(VIFF),Feature Mutual Information(FMI)indices.

关键词： Medical image fusion wavelet entropy optimization PSO Sobel operator

Some Mean Convergence Theorems for the Maximum of Normed Double Sums of Banach Space Valued Random Elements

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Acta Mathematica Sinica,English Series 2024年第7期40卷 1727-1740页

作者： Andrew ROSALSKY Le Van THANH nguyen thi THUY Department of Statistics University of FloridaGainesvilleFL 32611-8545USA Department of Mathematics Vinh UniversityVinhNghe AnViet Nam High School for Gifted Students Vinh UniversityVinhNghe AnViet Nam

In this correspondence,we establish mean convergence theorems for the maximum of normed double sums of Banach space valued random *** of the results pertain to random elements which are *** expand and improve a number of particular cases in the literature on mean convergence of random elements in Banach *** of the main contributions of the paper is to simplify and improve a recent result of Li,Presnell,and Rosalsky[Journal of Mathematical Inequalities,16,117–126(2022)].A new maximal inequality for double sums of M-dependent random elements is proved which may be of independent *** sharpness of the results is illustrated by four examples.

关键词： Double sum mean convergence Rademacher type p Banach space Banach space valued random element M-dependent random elements

ALMA observations of the circumstellar envelope around EP Aqr

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Research in Astronomy and Astrophysics 2019年第3期19卷 97-110页

作者： Pham thi Tuyet Nhung Do thi Hoai Pham Tuan-Anh thibaut Le Bertre Pierre Darriulat Pham Ngoc Diep nguyen thi Phuong nguyen thi Thao Jan Martin Winters Department of Astrophysics Vietnam National Space CenterVAST LERMA UMR 8112 CNRS and Observatoire de Paris PSL Research University Graduate University of Science and Technology VAST IRAM 300 rue de la Piscine Domaine Universitaire

Atacama Large Millimetre/sub-millimetre Array(ALMA) observations of CO(1–0) and CO(2–1) emissions from the circumstellar envelope of the asymptotic giant branch(AGB) star EP Aqr have been made with four times better spatial resolution than previously available. They are analysed with emphasis on the de-projection in space of the effective emissivity and flux of matter using as input a prescribed configuration of the velocity field, assumed to be radial. The data are found to display an intrinsic axisymmetry with respect to an axis making a small angle with respect to the line of sight. A broad range of wind configurations, from prolate(bipolar) to oblate(equatorial) has been studied and found to be accompanied by significant equatorial emission. Qualitatively, the effective emissivity is enhanced near the equator to produce the central narrow component observed in the Doppler velocity spectra and its dependence on star latitude generally follows that of the wind velocity with the exception of an omni-present depression near the poles. In particular, large equatorial expansion velocities produce a flared disc or a ring of effective emissivity and mass loss. The effect on the determination of the orientation of the star axis of radial velocity gradients, and possibly competing rotation and expansion in the equatorial disc, is discussed. In general,the flux of matter is found to reach a broad maximum at distances of the order of 500 AU from the *** are given that may be used to favour one wind velocity distribution over another. As a result of the improved quality of the data, a deeper understanding of the constraints imposed on morphology and kinematics has been obtained.

关键词： stars: AGB and post-AGB (stars:) circumstellar matter stars: individual: EP Aqr stars:mass-loss radio lines: stars

On the Laws of Large Numbers for Double Arrays of Independent Random Elements in Banach Spaces

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Acta Mathematica Sinica,English Series 2014年第8期30卷 1353-1364页

作者： Andrew ROSALSKY Le Van THANH nguyen thi THUY Department of Statistics University of FloridaGainesville Department of Mathematics Vinh University

For a double array of independent random elements {Vmn,m ≥ 1,n ≥ 1} in a real separable Banach space,conditions are provided under which the weak and strong laws of large numbers for the double sums mi=1 nj=1Vij,m ≥ 1,n ≥ 1 are *** the identically distributed and the nonidentically distributed cases are *** the main theorems,no assumptions are made concerning the geometry of the underlying Banach *** theorems are applied to obtain Kolmogorov,Brunk–Chung,and Marcinkiewicz–Zygmund type strong laws of large numbers for double sums in Rademacher type p（1 ≤ p ≤ 2） Banach spaces.

关键词： Real separable Banach space double array of independent random elements strong and weak laws of large numbers almost sure convergence convergence in probability Rademacher type p Banach space