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Incorporation of hydroxyapatite in crosslinked gelatin/chitosan/poly(vinyl alcohol) hybrids utilizing as reinforced composite sponges, and their water absorption ability

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Progress in Natural Science:Materials International 2021年第5期31卷 664-671页

作者： Thi Sinh Vo Tran Thi Bich Chau Vo Truong Sinh Nguyen nhan duy pham School of Mechanical Engineering Sungkyunkwan University Department of Chemistry Memorial University of Newfoundland Department of Industrial Management Can Tho University

The crosslinked gelatin/chitosan/poly(vinyl alcohol)/hydroxyapatite(GEL/CTS/PVA/HAp, GCPH) sponges were fabricated by a freeze-drying method to yield the reinforced composite sponges with proper features. The porosity value and pore size of the crosslinked GCPH sponges reached ～80% and 50–100 μm, respectively, which can be an appropriate range to allow cells to migrate into the reinforced composite sponges in the tissue engineering technology. Besides, the proper bonding presence between HAp particles and the crosslinked polymeric matrix or the crosslinked network formation between the polymers were also proved through fourier-transform infrared spectroscopy(FTIR), X-ray diffraction(XRD) and thermal gravimetric(TG/DTG) analysis. Owing to incorporation of HAp particles and good distribution of HAp particles inside the crosslinked polymeric matrix, their mechanical properties were improved through the determination of compression tests. Concomitantly, their water absorption ability reached effectively in both the distilled water and Na Cl solution, and their recovery also maintained well for 10 absorbing–squeezing cycles to be considered as an effective reusability for the crosslinked sponge ***, the crosslinked GCPH sponge prepared in the present study can become a potential candidate to apply especially in the biomedical/medical applications and tissue engineering technology.

关键词： Reinforced composite sponge Gelatin Chitosan Poly(vinyl alcohol) Hydroxyapatite Water absorption ability Reusability

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Enhancement of water absorption capacity and compressibility of hydrogel sponges prepared from gelatin/chitosan matrix with different polyols

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Progress in Natural Science:Materials International 2022年第1期32卷 54-62页

作者： Thi Sinh Vo Tran Thi Bich Chau Vo Trung Tien Tran nhan duy pham School of Mechanical Engineering Sungkyunkwan University Department of Industrial Management Can Tho University Department of Chemistry Memorial University of Newfoundland

The hydrogel sponges have prepared successfully from gelatin/chitosan(GEL/CTS) matrix with different polyols basing on scanning electron microscopy(SEM) and Fourier-transform infrared spectroscopy(FTIR) analysis. The results indicate that the compressibility and thermal properties(thermal gravimetric analysis, TGA) were improved significantly with adding the different polyols [poly(vinyl alcohol)-PVA, and poly(ethylene glycol)-poly(propylene glycol)-poly(ethylene glycol) – PEPEG] into GEL/CTS matrix. Specially, the as-prepared hydrogel sponges with superabsorbent behavior were also investigated with the attained water absorption capacity to 605 g gand 585 g gfor GCV＿1/1/0.3 and GCE＿1/1/0.3 sponges, respectively, as well as the excellent water absorption capacity in a wide range of p H and salt concentration. Hence, these studies demonstrated that the hydrogel sponges are concerned as potential and promising candidates to apply especially in the fields of biomedicine and hygiene.

关键词： Hydrogel sponges Absorbent Chitosan Polyols Gelatin Water absorption capacity

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Effects of Serum Concentration, Synchronization Time and Confluence on the Cell-Cycle Synchronization Efficiency of Goat Fibroblasts

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Open Journal of Animal Sciences 2024年第3期14卷 194-203页

作者： Van Khanh Nguyen Huong Thu Thi Vu Au Thi Hoang Yen Kim Thi pham Giang Thi Thanh nhan Hung Phu Lai Lan Doan pham Key Laboratory of Animal Cell Biotechnology National Institute of Animal Science Hanoi Vietnam

This study aims to evaluate the effect of serum concentration, synchronization time, and confluence degree on the synchronisation efficiency of goat fibroblast cycle. The results indicated that there was no difference in the percentage of nucleated fibroblasts in the G0/G1 stage between serum concentrations of 0.3% and 0.4% (83.89% and 82.69%, respectively, P > 0.05) as well as between serum concentrations of 0.2% and 0.5% (76.95% and 75.46%, respectively, P > 0.05). The percentage of nucleated fibroblasts in the G0/G1 stage was highest at the concentration of 0.3% and lowest in the control group (83.89% vs. 62.67%, P 0.05). The beneficial effect of high confluence was confirmed by the large percentage of nucleated fibroblasts at the G0/G1 stage. The 60% confluency was significantly lower than the 80% and 100% confluency (73.44%, 86.63%, and 87.17%, respectively, P < 0.05). The results indicate that the goat fibroblast cycle synchronization is the most effective at the serum concentration of 0.3%, 72 hours of synchronization and 100% confluency.

关键词： Goat Fibroblast Cycle Synchronisation Serum Concentration Synchronization Time Confluence

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Research on stability of laminated composite plate under nonlinear aerodynamic load

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Theoretical & Applied Mechanics Letters 2023年第4期13卷 320-328页

作者： The Van Tran Quoc Hoa pham nhan Thinh Hoang Faculty of Mechanical Engineering Industrial University of Ho Chi Minh CityHo Chi Minh City 700000Vietnam Tran Dai Nghia University Ho Chi Minh City700000Vietnam Faculty of Engineering and Technology Nguyen Tat Thanh UniversityHo Chi Minh City 700000Vietnam

In this paper,we propose an finite element approach based on classical plate theory to investigate the dynamic stability of a layered composite plate subject to nonlinear aerodynamic *** study considers the influence of temperature,nonlinear geometry,and nonlinear aerodynamic load on composite plate structures ***,the present work conduct comparison the results of the critical pressure value between the nonlinear aerodynamic load and the linear aerodynamic load,thereby pointing out some necessary cases which must consider the nonlinearity of aerodynamic load for calculating the aerospace *** determine the critical pressure value and vibrational amplitude response of the plate by means of *** outcomes of our calculations can be useful in designing and repairing body shells and wings of aircraft equipment.

关键词： Finite element approach Nonlinear aerodynamic load Composite plate

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The Influence of Social Desirability on Self-Reported Sexual Behavior in HIV Survey in Rural Ethiopia

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World Journal of AIDS 2013年第4期3卷 345-349页

作者： Alexander Vu Kiemanh pham nhan Tran Saifuddin Ahmed Department of Emergency Medicine The Johns Hopkins School of Medicine Baltimore USA Department of International Health The Johns Hopkins Bloomberg School of Public Health Baltimore USA Department of International Health The Johns Hopkins Bloomberg School of Public Health Baltimore USA Department of Population Family and Reproductive Health and Department of Biostatistics The Johns Hopkins Bloomberg School of Public Health Baltimore USA

Objective: It is in order to examine associations between social desirability (SD) and self-reports of abstinence among youths in rural Ethiopia. Methods: Youths of ages 15-24 (114 participants) were administered questionnaire to assess HIV knowledge and primary abstinence and a modified Marlowe-Crowne Social Desirability Scale to assess SD bias. The relationships between SD groups (dichotomized into high and low) and abstinence by various characteristics were assessed by using Fisher’s exact p-values. Results: The odds of individuals reporting abstinence were 13.2 times greater in the high SD group compared to the low SD group (p-value 0.002) when adjusted for education, gender, age group, and HIV knowledge. The differences in abstinence between the high and low SD score groups were also examined for selected variables. Conclusions: Individuals who exhibited more SD bias were more likely to report primary abstinence. SD bias should be considered when conducting self-reported surveys to measure the effectiveness of HIV prevention programs.

关键词： Social Desirability Bias Self-Reported Sexual Behaviors HIV Surveys

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Mobilization of Arsenic in Groundwater in the Southern Hanoi City (Vietnam) as Studied by Isotopic and Related Techniques

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Journal of Environmental Protection 2013年第7期4卷 68-74页

作者： Dang Duc nhan Doan Van Canh pham Quy nhan Nguyen Thi Thanh Thuy Dinh Thi Bich Lieu Vo Thi Anh Dang Anh Minh Center for Water Resources Management Hanoi Vietnam Hanoi University of Mining and Geology Hanoi Vietnam Institute for Nuclear Science and Technology Hanoi Vietnam Vietnam Association of Hydrogeology Hanoi Vietnam Vietnam Atomic Energy Institute Hanoi Vietnam

Sixteen samples of surface and groundwater from the most southern part of the Hanoi city (Vietnam) has been taken and analyzed for the soluble major ions, namely Na+, K+, , Ca2+, Mg2+, Cl-, , and arsenic as well as molybdenum content along with isotopic composition of deuterium and oxygen (δ2H and δ18O), tritium activity, and δ13C in DIC. The stable isotopic composition of groundwater indicates the water in that area is recharged from the local meteoric and theRed River’s water sources. The mean residence time of the groundwater should be before 60-ies of the past century as its 3H activity ranged from LOD of the analytical technique (0.4 TU) to 2.1 TU only implying that As would not be related to its recent application. The concentrations of As in the water samples is weakly correlated with those of Fe2+ (R2 = 0.08) but it strongly did with the concentrations of bicarbonate (R2 = 0.80). Thus, bicarbonate seems to liberate As adsorbed on hydrous ferric oxides (Hfo) into water through the displacement mechanism. The surface adsorption-desorption of As could be proven by a strong correlation between As and Mo concentrations (R2 = 0.77). The bicarbonate formation in groundwater was thought to be, partly, due to the bio-mineralization of natural organic matter (NOM) by bacteria followed by the dissolution of calcite and/or dolomite present in the sediments. Evidence for the NOM bio-mineralization was found in the close relationship between δ13C and the concentration of bicarbonate in water. Therefore, the mobilization of As in groundwater of bicarbonate type in the southern part of Hanoi city seems to be not only due to the reductive dissolution of the Hfo but the bicarbonate displacement also should be considered.

关键词： Arsenic Mobilization Isotopic Technique Groundwater Nom Bio-Mineralization As-Bicarbonate Displacement

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Optimal culture conditions for the generation of natural killer cell-induced dendritic cells for cancer immunotherapy

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Cellular & Molecular Immunology 2012年第1期9卷 45-53页

作者： Thanh-nhan Nguyen-pham Deok-Hwan Yang Truc-Anh Thi Nguyen Mi-Seon Lim Cheol Yi Hong Mi-Hyun Kim Hyun Ju Lee Youn-Kyung Lee Duck Cho Soo-Young Bae Jae-Sook Ahn Yeo-Kyeoung Kim Ik-Joo Chung Hyeoung-Joon Kim Je-Jung Lee Research Center for Cancer Immunotherapy Chonnam National University Hwasun HospitalJeollanamdoKorea Department of Hematology-Oncology Chonnam National University Hwasun HospitalJeollanamdoKorea Vaxcell-Bio Therapeutics JeollanamdoKorea The Brain Korea 21 Project Center for Biomedical Human Resources at Chonnam National UniversityGwangjuKorea

Dendritic cell(DC)-based vaccines continue to be considered an attractive tool for cancer *** require an additional signal from the environment or other immune cells to polarize the development of immune responses toward T helper 1(Th1)or Th2 *** play a role in natural killer(NK)cell activation,and NK cells are also able to activate and induce the maturation of *** investigated the types of NK cells that can induce the maturation and enhanced function of DCs and the conditions under which these interactions *** that were activated by resting NK cells in the presence of inflammatory cytokines exhibited increased expression of several costimulatory molecules and an enhanced ability to produce *** cell-stimulated DCs potently induced Th1 polarization and exhibited the ability to generate tumor antigen-specific cytotoxic T lymphocyte *** data demonstrate that functional DCs can be generated by coculturing immature DCs with freshly isolated resting NK cells in the presence of Toll-like receptor agonists and proinflammatory cytokines and that the resulting DCs effectively present antigens to induce tumor-specific T-cell responses,which suggests that these cells may be useful for cancer immunotherapy.

关键词： cancer immunotherapy dendritic cells natural killer cells signal

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Type I and II interferons enhance dendritic cell maturation and migration capacity by regulating CD38 and CD74 that have synergistic effects with TLR agonists

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Cellular & Molecular Immunology 2011年第4期8卷 341-347页

作者： Thanh-nhan Nguyen-pham Mi-Seon Lim Truc Anh Thi Nguyen Youn-Kyung Lee Chun-Ji Jin Hyun Ju Lee Cheol Yi Hong Jae-Sook Ahn Deok-Hwan Yang Yeo-Kyeoung Kim Ik-Joo Chung Byoung Chul Park Hyeoung-Joon Kim Je-Jung Lee Research Center for Cancer Immunotherapy Chonnam National University Hwasun HospitalJeollanamdoKorea Department of Hematology-Oncology Chonnam National UniversityGwangjuKorea The Brain Korea 21 Project Center for Biomedical Human Resources at Chonnam National UniversityGwangjuKorea Vaxcell-Bio Therapeutics JeollanamdoKorea Korea Research Institute of Bioscience and Biotechnology(KRIBB) DaejeonKorea

The major limitation for the maturation of dendritic cells(DCs)using Toll-like receptor(TLR)agonists is their decreased ability to migrate into lymph nodes compared with conventional ***38 can be used as a multifunctional marker to modulate migration,survival and Th1 responses of ***74 has been shown to negatively regulate DC *** goal of this study was to investigate the combinations of TLR agonists and interferons(IFNs)that most effectively regulate CD38 and CD74 expression on *** TLR agonist stimulation in combination with IFN-a and IFN-c was the best method for regulating CD38 and CD74 expression and inducing the highest secretion of *** in vitro migration assay showed that DCs treated with this combination had significantly enhanced migratory ability,similar to that observed in cells expressing CD38,CD74 and *** results of this study suggest that an alternative maturation protocol in which two TLR ligands are combined with type I and II IFNs generates potent DCs that have both a high migratory capacity and high IL-12p70 production.

关键词： CD38 CD74 dendritic cells interferon Toll-like receptor

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Identification of novel HLA-A 0201-restricted epitopes from anterior gradient-2 as a tumor-associated antigen against colorectal cancer

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Cellular & Molecular Immunology 2012年第2期9卷 175-183页

作者： Hyun Ju Lee Cheol Yi Hong Chun-Ji Jin Mi-Hyun Kim Youn-Kyung Lee Thanh-nhan Nguyen-pham Hyunah Lee Byoung Chul Park Ik-Joo Chung Hyeoung-Joon Kim Je-Jung Lee Research Center for Cancer Immunotherapy Chonnam National University Hwasun Hospital Hwasun Jeollanamdo Korea Department of Hematology-Oncology Chonnam National University Gwangju Korea VaxcelI-Bio Therapeutics Hwasun Jeollanamdo Korea Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea Korea Research Institute of Bioscience and Biotechnology （KRIBB） Daejeon Korea The Brain Korea 21 Project Center for Biomedical Human Resources at Chonnam National University Gwangiu Korea

Anterior gradient-2 （AGR2） promotes tumor growth, cell migration and cellular transformation and its enhanced expression is almost completely restricted to malignant tissues, thus making AGR2 an interesting target for the development of immunotherapeutic strategies. We investigated whether the AGR2 molecule comprises human leukocyte antigen （HLA）-A 0201-binding epitopes recognized by human cytotoxic T lymphocytes （CTLs）, which could be targeted in dendritic cell （DC）-based cancer immunotherapy against colorectal cancer （CRC）. We reviewed the sequence of AGR2 for peptides that could potentially bind to HLA-A 0201 with the aid of a computer-based program. Five candidate peptides with different binding scores were synthesized and tested. These peptides were then assessed for their immunogenicity to elicit specific immune responses mediated by CTLs in vitro by means of enzyme-linked immunospot assays and CTL assays. AGR2 was highly expressed in several CRC cell lines, including DK01, DLD1, KM 12C, HCT-8 and HT-29. DCs pulsed with AGR2-P2 （aa 11-19; LLVALSYTL） or AGR2-P4 （aa 127-135; RIMFVDPSL） generated potent CTLs that could lyse T2 cells pulsed with AGR2-P2 or AGR2-P4 and HLA-A0201＋ AGR2-positive CRC cell lines in a strong dose-dependent and HLA-A 0201-restricted manner. In conclusion, these novel epitopes derived from AGR2 protein may be attractive candidates for DC-based immunotherapy for CRC.

关键词： AGR2 colorectal cancer dendritic cell tumor-associated antigen

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锦鲤咖啡馆

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现代装饰 2018年第4期 68-75页

作者： An Viet Dung An Thanh nhan pham Ngoc Linh Nguyen Thai Thach 彭佳 Farming Architects

项目旨在建造一个与锦鲤池相结合的咖啡馆空间。建筑共有三层,加上前院,面积约88平方米。业主希望设计师设计一个易于安装和移除的钢结构,此外,从天花板到家具,整个室内空间都由业主提供的回收的木板制作而成。咖啡馆使用了传统的Batran... 详细信息

项目旨在建造一个与锦鲤池相结合的咖啡馆空间。建筑共有三层,加上前院,面积约88平方米。业主希望设计师设计一个易于安装和移除的钢结构,此外,从天花板到家具,整个室内空间都由业主提供的回收的木板制作而成。咖啡馆使用了传统的Batrang双层瓦片作为建筑立面材料,给来客留下独特的第一印象。屋顶则像一层薄膜覆盖整个立面,使其在周围的建筑中显得格外醒目。

关键词：咖啡馆锦鲤建筑立面室内空间薄膜覆盖设计师钢结构天花板

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