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高效液相色谱法测量青海湖浮游植物色素浓度

海洋技术 2005年第2期24卷 46-49,54页

作者：朱建华伍慧敏周虹丽汪小勇国家海洋技术中心天津300111 香港科技大学海岸与大气研究中心

2003年8月,我们利用高效液相色谱法(HPLC)对浮游植物色素进行分类定量分析。结果表明青海湖的叶绿素类以叶绿素a和b为主,叶绿素a浓度最高;光合作用类胡萝卜素种类极少,浓度很低;光保护色素种类较多,浓度较高,其中以Zea,Diadino,β.β-Ca... 详细信息

2003年8月,我们利用高效液相色谱法(HPLC)对浮游植物色素进行分类定量分析。结果表明青海湖的叶绿素类以叶绿素a和b为主,叶绿素a浓度最高;光合作用类胡萝卜素种类极少,浓度很低;光保护色素种类较多,浓度较高,其中以Zea,Diadino,β.β-Car和Viola为主。

关键词：高效液相色谱法青海湖色素浓度浮游植物 2003年8月测量叶绿素a浓度类胡萝卜素 β-Car 定量分析植物色素光合作用色素种类光保护

^(68)Gallium-labelled PSMA-PET/CT as a diagnostic and clinical decision-making tool in Asian prostate cancer patients following prostatectomy

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Cancer Biology & Medicine 2019年第1期16卷 157-165页

作者： Janice S.H.Tan charles X.Y.Goh Yen Sin Koh Youquan Li Jeffrey K.L.Tuan Eu Tiong Chua Terence W.K.Tan Michael L.C.wang Lui Shiong Lee Kae Jack Tay Ravindran Kanesvaran Chee Keong Toh Aaron K.T.Tong Winnie W.C.Lam Melvin L.K.Chua Division of Radiation Oncology National Cancer Centre Singapore Department of Nuclear Medicine and Molecular Imaging Singapore General Hospital Radiological Sciences Academic Clinical Programme Duke-NUS Medical School Oncology Academic Clinical Programme Duke-NUS Medical School Department of Urology Singapore General Hospital Department of Surgery Sengkang General Hospital Division of Medical Oncology National Cancer Centre Singapore Division of Medical Sciences National Cancer Centre Singapore

Objective: Prostate cancers(PCa) in Asian individuals are molecularly distinct from those found in their Caucasian *** is no risk stratification tool for Asian men with rapid biochemical recurrence(BCR) following radical prostatectomy(Rad P). This study aims to assess the detection rate of ^(68)Ga-prostate-specific membrane antigen-positron emission tomography/computed tomography(PSMA-PET/CT) for diagnosis of clinical recurrence and as a treatment decision making tool in Asian patients with BCR post-Rad ***: ^(68)Ga PSMA-PET and CT body with/without bone scan [conventional workup(CWU)] were performed in 55 Asian patients with BCR within 36 months post-Rad P. Two blinded reviewers assessed the images. Detection rates of ^(68)Ga PSMAPET/CT were evaluated, and impact on management was reviewed by comparison with ***: Median time to BCR post-Rad P was 8.1 months. Detection rate for ^(68)Ga PSMA-PET/CT was 80%(44/55). A positive scan was significantly associated with increasing prostate-specific antigen(PSA) level [odds ratio(OR) = 1.13(95% CI 1.05–1.30), P =0.017], but not with higher Gleason grade or shorter PSA doubling time. Compared to CWU, ^(68)Ga PSMA-PET/CT detected an additional 106 lesions in 33/44 patients with a positive scan, resulting in a change in management in 25/44(56.8%) patients: 10 to hormonal therapy(HT) and whole pelvis radiotherapy(RT) in addition to bed RT, and 15 to palliative HT ***: In the present report, we demonstrated the diagnostic and treatment decision utility of ^(68)Ga PSMA-PET/CT in Asian men with rapid BCR. Detection of small volume nodal and systemic recurrences at low PSA levels(ng/mL) highlights the role of the tool in assigning patients to treatment intensification with HT-RT or palliative HT in polymetastatic disease.

关键词： ^68Ga PSMA PET/CT prostate cancer Asian diagnostic recurrence prostatectomy salvage radiotherapy

Genetic variants in the ADD1 and GNB3 genes and bloodpressure response to potassium supplementation

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Frontiers of Medicine 2010年第1期4卷 59-66页

作者： Dai-Hai YU De-Pei LIU Lai-Yuan wang Jing CHEN Cashell E.JAQUISH Dabeeru C.RAO James E.HIXSON Jian-Feng HUAng Chung-Shiuan CHEN charles GU Ji-Chun CHEN Jie CAO Shu-Feng CHEN Paul K.WHELTON Jiang HE Dong-Feng GU Department of Evidence-based Medicine and Population Genetics Cardiovascular Institute and Fu Wai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Chinese National Human Genome Center at Beijing Beijing 100176China Department of Epidemiology Tulane University School of Public Health and Tropical MedicineNew OrleansLA 70112USA Department of Medicine Tulane University School of MedicineNew OrleansLA 70112USA National Heart Lungand Blood InstituteNational Institute of HealthBethesdaMD 20892USA Washington University in St.Louis School of Medicine St.LouisMO 63110USA University of Texas School of Public Health HoustonTX 77030USA Loyola University Medical Center MaywoodIL 60153USA

Dietary potassium-supplementation has been associated with a decreased risk of hypertension and other cardiovascular ***,blood pressure(BP)responses to potassium supplementation vary among *** study was designed to examine the association between 12 single nucleotide polymorphisms(SNPs)in the adducin 1 alpha(ADD1)and guanine nucleotide binding protein(G protein)beta polypeptide 3(GNB3)genes and systolic BP(SBP),diastolic BP(DBP),and mean arterial pressure(MAP)responses to *** conducted a 7-day high-sodium intervention(307.8 mmol sodium/day)followed by a 7-day high-sodium with potassium-supplementation(60 mmol potassium/day)among 1906 Han Chinese participants from rural north *** measurements were obtained at the end of each intervention period using a random-zero *** identiﬁed signiﬁcant associations between ADD1 variant rs17833172 and SBP,DBP,and MAP responses to potassium-supplementation(all Png responses of 1.99(0.25,3.73),–0.65(–0.10,–0.21),and–0.23(–0.37,0.83),respectively,for those who were homozygous for A *** addition,participants with at least one copy of the G allele of rs12503220 of the ADD1 gene had significantly increased DBP and MAP response to potassium-supplementation(P=0.0041 and 0.01,respectively),which was also significant after correction for multiple *** and MAP responses to potassiumsupplementation were–1.36(–1.63,–1.10)and–2.07(–2.32,–1.82)for those with at least G allele compared to corresponding responses of 0.86(–0.68,2.40)and–0.45(–1.74,0.84)for those who were homozygous for A *** summary,our study identified novel associations between

关键词： blood pressure genetics polymorphism dietary potassium potassium sensitivity adducin 1 alpha(ADD1) guanine nucleotide binding protein beta polypeptide 3(GNB3)

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胃内水球治疗肥胖症患者的疗效与安全性评估

中华医学杂志 2007年第6期87卷 388-391页

作者：梅力文吴国伟曾玉珊王睿智郑婉姗香港中文大学内科及药物治疗学系邱燕萍林全庆周振中香港中文大学内科及药物治疗学系香港中文大学外科学系香港沙田威尔斯亲王医院营养部

目的评估以胃内水球方法治疗肥胖症患者的疗效与安全性。方法对48位中国香港特别行政区华裔[其中女35例,平均年龄(39±9)岁]自2004年11月开始接受并已完成胃内水球治疗的肥胖患者进行分析。患者的平均基础体重和体重指数分别为(106±26)... 详细信息

目的评估以胃内水球方法治疗肥胖症患者的疗效与安全性。方法对48位中国香港特别行政区华裔[其中女35例,平均年龄(39±9)岁]自2004年11月开始接受并已完成胃内水球治疗的肥胖患者进行分析。患者的平均基础体重和体重指数分别为(106±26)kg 和(40±9)kg/m^2,其中34(70.8%)例患有肥胖相关性疾病。此研究的治疗方法是运用胃内水球系统(bioEntericsintragastric balloon,BIB~)在静脉注射镇静药物下进行,并运用内镜进行水球的放置和取出操作。水球放置后患者需配合有限制性的平衡饮食(低于1200 kcal/d,1 cal=4.184 J)和适度的有氧运动(150 min/周)。结果患者住院和治疗时间中位数分别为1 d 和174 d;胃内水球治疗后平均体重下降(13±7)kg;平均体重指数下降(5±3)kg/m^2;平均超标体重下降(45±36)%;平均腰围减少(12±8)cm;以上所有指标均明显低于治疗前(均 P<0.01)。32(66.7%)例患者对此种减肥方法的疗效感到满意;未发现与胃内水球相关的严重并发症发生。结论胃内水球是一项安全的减肥装置,能让华裔肥胖症患者达至适量减重效果。

关键词：肥胖症减肥药胃内水球

Establishment of a Predictive Diagnostic Model for Acute Mycoplasma Pneumoniae Infection in Elderly Patients with Community-acquired Pneumonia

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Biomedical and Environmental Sciences 2017年第7期30卷 540-544页

作者： XiAO Hong Li XIN De Li wang Yan CUI Li Jian LIU Xiao Ya LIU Song SOng Li Hong LIU Chun Ling YIN Cheng Hong Department of Emergency Medicine Beijing Friendship Hospital Capital Medical University Beijing 100050 China Beijing Institute of Clinical Medicine Beijing Friendship Hospital Capital Medical University Beijing 100050 China Department of Infectious Disease and Critical Care Medicine Beijing Friendship Hospital Capital Medical University Beijing 100050 China Department of Internal Medicine Beijing Obstetrics and Gynaecology Hospital Capital Medical University Beijing 100026 China Respiratory Department Beijing Friendship Hospital Capital Medical University Beijing 100050 China Department of Emergency Medicine Beijing Guang Wai Hospital Beijing 100080 China Department of Infectious Disease Air Force General Hospital PLA Beijing 100142 China

We established a diagnostic model to predict acute Mycoplasma pneumoniae （M. pneumonia） infection in elderly Community-acquired pneumonia （CAP） patients. We divided 456 patients into acute and non-acute M. pneumoniae infection groups. Binary logistic regression and receiver operating characteristic （ROC） curves were used to establish a predictive model. The following independent factors were identified： age 〉 70 years; serum cTNT level 〉 0.0S ng/mL; lobar consolidation; mediastinal lymphadenopathy; and antibody titer in the acute phase 〉 1：40. The area under the ROC curve of the model was 0.923 and a score of 2 7 score predicted acute M. pneumoniae infection in elderly patients with CAP. The predictive model developed in this study has high diagnostic accuracy for the identification of elderly acute M. pneumoniae infection.

关键词： in as of were Establishment of a Predictive Diagnostic Model for Acute Mycoplasma Pneumoniae Infection in Elderly Patients with Community-acquired Pneumonia for with

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宮腔鏡術後急性肺水腫1例

镜湖医学 2016年第1期16卷 81-81页

作者：高永儉張靜嫻鄺炳宏潘慧吳朝興劉京平廖自偉曹麗勤澳門鏡湖醫院麻醉科中國

患者女性,55歲,診斷“黏膜下子宮肌瘤”於靜脈麻醉下行“宮腔鏡下子宮肌瘤電切術”。術前心肺檢查及實驗室檢查正常,心功能Ⅱ級、ASAⅡ級。患者入手術室後予開放靜脈通路,心電監護:SpO298%、RR 20次/分、P 86次/分、BP 134/86mmHg。患... 详细信息

患者女性,55歲,診斷“黏膜下子宮肌瘤”於靜脈麻醉下行“宮腔鏡下子宮肌瘤電切術”。術前心肺檢查及實驗室檢查正常,心功能Ⅱ級、ASAⅡ級。患者入手術室後予開放靜脈通路,心電監護:SpO298%、RR 20次/分、P 86次/分、BP 134/86mmHg。患者取截石位,常規消毒鋪巾,予鼻氧管吸氧氣,予fentanyl 50μg及propofol100mg靜脈誘導患者入睡後行手術,先在子宮加壓器予100mmHg壓力下,注入生理鹽水擴張子宮腔,行宮腔鏡檢查,術中發現子宮腔肌瘤予行電切,遂加大加壓器壓力至150mmhg,約10分鐘後患者出現血氧飽和度下降,心率加快,血壓稍低.

关键词：截石位肺水黏膜下心功能 propofol mmHg

基于外源性脂联素探讨巨噬细胞移动抑制因子调控自噬在心肌缺血再灌注损伤的作用

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广西医科大学学报 2022年第10期39卷 1563-1570页

作者：王书君谭慧琼袁杰海南医学院第一附属医院老年医学科海口570102 中国医学科学院阜外医院心血管内科北京100037 新疆维吾尔自治区人民医院心内科乌鲁木齐830000

目的:基于外源性脂联素(Apn)探讨巨噬细胞移动抑制因子(MIF)在大鼠心肌缺血再灌注(MI/R)损伤后的作用及机制。方法:将50只SD大鼠随机分为假手术组(Sham组)、心肌缺血再灌注组(MI/R组)、Apn预处理组(Apn组)、MIF组和Apn预处理+MIF组(Apn+... 详细信息

目的:基于外源性脂联素(Apn)探讨巨噬细胞移动抑制因子(MIF)在大鼠心肌缺血再灌注(MI/R)损伤后的作用及机制。方法:将50只SD大鼠随机分为假手术组(Sham组)、心肌缺血再灌注组(MI/R组)、Apn预处理组(Apn组)、MIF组和Apn预处理+MIF组(Apn+MIF组),每组10只。除Sham组外,其余4组均建立MI/R模型,其中,Apn组和Apn+MIF组在缺血前15 min时腹腔注射重组Apn(5.0μg/g),MIF组和Apn+MIF组在再灌注120 min后腹腔注射rh-MIF(100 ng/kg);处理结束后,检测各组大鼠心功能指标:射血分数(EF)、缩短分数(FS)、左心室收缩期内径(LVIDs)以及左心室舒张期内径(LVIDd),ELISA法检测大鼠血清肌酸激酶同工酶(CK-MB)和乳酸脱氢酶(LDH)含量,HE染色检测各组大鼠心肌组织病理学形态,实时荧光定量聚合酶链式反应(RT-qPCR)检测各组大鼠心肌组织内MIF表达;免疫荧光染色检测各组大鼠心肌组织内自噬标记物LC3B表达;Western blotting检测各组大鼠心肌组织内自噬相关蛋白表达。结果:与MI/R组比较,Apn组和MIF组大鼠FS和EF升高,LVIDs和LVIDd减小(P<0.05),血清CK-MB和LDH含量下降(P<0.05),心肌组织内细胞和纤维损伤减小。此外,MIF组大鼠心肌组织内MIF mRNA及其蛋白相对表达量均升高(P<0.05),LC3B荧光染色强度减弱(P<0.05),Beclin-1蛋白相对表达量下调,p62蛋白相对表达量上调,LC3-Ⅱ/LC3-Ⅰ比值下降(P<0.05);与Apn组比较,Apn+MIF组大鼠FS和EF均进一步升高,LVIDs和LVIDd均减少(P<0.05),血清CK-MB和LDH含量下降(P<0.05),心肌组织损伤程度更小,大鼠心肌组织内MIF mRNA相对表达量和蛋白相对表达量均升高(P<0.05),同时,LC3B荧光染色强度减弱(P<0.05),Beclin-1蛋白相对表达量下调,p62蛋白相对表达量上调,LC3-Ⅱ/LC3-Ⅰ比值下降(P<0.05)。结论:基于Apn预处理对大鼠MI/R损伤的保护作用,再灌注后提高MIF能进一步抑制MI/R大鼠心肌组织内过度自噬并减少心肌组织损伤,对MI/R大鼠心功能起到保护作用。

关键词：心肌缺血再灌注脂联素巨噬细胞移动抑制因子自噬