检索结果-南通市图书馆

Can intracellular Staphylococcus aureus in osteomyelitis be treated using current antibiotics?A systematic review and narrative synthesis

引用

Bone Research 2022年第4期10卷 661-678页

作者： Anja R.Zelmer Renjy nelson Katharina Richter Gerald J.Atkins Centre for Orthopaedic and Trauma Research Faculty of Health and Medical SciencesUniversity of AdelaideAdelaideSA 5000Australia Department of Infectious Diseases Central Adelaide Local Health NetworkAdelaideSA 5000Australia Royal Adelaide Hospital AdelaideSA 5000Australia Richter Lab Department of SurgeryBasil Hetzel Institute for Translational Health ResearchUniversity of AdelaideAdelaideSA 5011Australia

Approximately 40%of treatments of chronic and recurrent osteomyelitis fail in part due to bacterial *** aureus,the predominant pathogen in human osteomyelitis,is known to persist by phenotypic adaptation as small-colony variants(SCVs)and by formation of intracellular reservoirs,including those in major bone cell types,reducing susceptibility to *** infections with *** are difficult to treat;however,there are no evidence-based clinical guidelines addressing these infections in *** conducted a systematic review of the literature to determine the demonstrated efficacy of all antibiotics against intracellular *** relevant to osteomyelitis,including protein biosynthesis inhibitors(lincosamides,streptogramins,macrolides,oxazolidines,tetracyclines,fusidic acid,and aminoglycosides),enzyme inhibitors(fluoroquinolones and ansamycines),and cell wall inhibitors(beta-lactam inhibitors,glycopeptides,fosfomycin,and lipopeptides).The PubMed and Embase databases were screened for articles related to intracellular *** infections that compared the effectiveness of multiple antibiotics or a single antibiotic together with another treatment,which resulted in 34 full-text articles fitting the inclusion *** combined findings of these studies were largely inconclusive,most likely due to the plethora of methodologies ***,the reported findings in the context of the models employed and possible solutions for improved understanding are explored *** rifampicin,oritavancin,linezolid,moxifloxacin and oxacillin were identified as the most effective potential intracellular treatments,the scientific evidence for these is still relatively *** advocate for more standardized research on determining the intracellular effectiveness of antibiotics in *** osteomyelitis to improve treatments and patient outcomes.

关键词： treatment finding synthesis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Advances in Multi-Terabit, Long-Haul WDM Transmission for Terrestrial Networks

引用

光学学报 2003年第S1期23卷 546-547页

作者： Benyuan Zhu Lynn E. nelson OFS 791 Holmdel-Keyport Rd Holmdel NJ 07733OFS 791 Holmdel-Keyport Rd Holmdel NJ 07733

This paper reviews the recent advances in multi-terabit long-haul transmission technologies for terrestrial optical networks. The use of high performance new fibres, low-noise Raman amplification, optimised modulation... 详细信息

关键词： for on of WDM Advances in Multi-Terabit Long-Haul WDM Transmission for Terrestrial Networks in

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Medical use and misuse of psychoactive prescription medications among US youth and young adults

引用

Family Medicine and Community Health 2021年第1期9卷 1-17页

作者： Israel Agaku Satomi Odani Jantel nelson Oral Health Policy and Epidemiology Harvard School of Dental MedicineBostonMassachusettsUSA Department of Social Medicine University of CreteRethimnoCreteGreece Great Life Counseling Center AddisonTexasUSA

Objective To investigate prevalence and correlates of medical use and misuse of psychoactive prescription medications among US youth and young *** Cross-sectional,self-reported surveys from the 2015-2018 National Survey of Drug Use and *** was probabilistic and nationally *** The target population included individuals from households,non-institutional group quarters(eg,college dormitories)and civilians living on military *** were completed using computer-assisted self-interview *** Our analytical sample included youth and young adults aged 12-25 years(n=110556).Psychoactive prescription medication misuse was a report by the respondent that they had used psychoactive prescription medications in the past year in any way not directed or prescribed for *** use was defined as past-year use without a report of *** certain variables were assessed only among adults,our multivariable analysis to identify correlates of misuse was restricted to young adults aged 18-25 years(n=55690).Results Among US youth aged 12-17 years,25.0%reported use of any psychoactive prescription medication assessed,and 5.7%reported past-year use of at least two psychoactive prescription *** youth who used any psychoactive prescription medications,20.9%(1.3 million)reported misuse;3.4%were classified as having substance use ***-year use of each psychoactive prescription medication was:opioids(19.0%),stimulants(7.2%),tranquillisers(4.3%)and sedatives(2.2%).Among users of each psychoactive prescription medication,the estimated percentage reporting misuse was as follows:opioids(17.6%,0.8 million),stimulants(24.2%,0.4 million),tranquillisers(40.1%,0.4 million)and sedatives(14.2%,80000).Among users of each psychoactive prescription medication,the estimated percentage having substance use disorder was as follows:opioids 2.6%,stimulants 3.0%,tranquillisers 7.0%and sedatives 3.6%.Analyses amo

关键词： bases prescribed sectional

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Enhancement of THz generation in LiNbO_(3) waveguides via multi-bounce velocity matching

引用

Light(Science & Applications) 2022年第12期11卷 2994-3001页

作者： Blake S.Dastrup Eric R.Sung Frank Wulf Clara Saraceno Keith A.nelson Department of Chemistry Massachusetts Institute of TechnologyCambridgeMA 02139USA Faculty of Electrical Engineering and Information Technology Ruhr University BochumBochum 44801Germany

To realize the full promise of terahertz polaritonics(waveguide-based terahertz field generation,interaction,and readout)as a viable spectroscopy platform,much stronger terahertz fields are needed to enable nonlinear and even robust linear terahertz *** use a novel geometric approach in which the optical pump is totally internally reflected to increase the distance over which optical rectification *** matching is achieved by tuning the angle of internal *** doing this,we are able to enhance terahertz spectral amplitude by over 10x compared to conventional single-pass terahertz *** analysis of the depletion mechanisms reveals that 3-photon absorption and divergence of the pump beam are the primary limiters of further *** level of enhancement is promising for enabling routine spectroscopic measurements in an integrated fashion and is made more encouraging by the prospect of further enhancement by using longer pump wavelengths.

关键词： pump waveguide tuning

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Field ovipositional behavior and laboratory studies on development of Dacus punctatifrons （Diptera：Tephritidae） on tomato

引用

Insect Science 2005年第5期12卷 393-398页

作者： JUSTIN N.OKOLLE nelson N.NTONIFOR Department of Life Sciences University of Buea Buea Cameroon

The tomato fruit fly Dacus punctatifrons is a pest of tomato, Lycopersicon esculentum Mill in Cameroon. Oviposition behavior, developmental durations for the life stages, pupal and adult weights as well as adult longevities were investigated on tomato. The peak period of oviposition was recorded between the hours of 10：30-11：30 and 14：30-5：30. The number of eggs per clutch varied from 3-12. Although the development period was similar for both sexes, the pupal weights, adult weights as well as adult longevities were significantly different.

关键词： Cameroon Dacus punctatifrons development tephritidae tomato oviposition

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Awareness and adoption of land,soil and water conservation practices in the Chinyanja Triangle,Southern Africa

引用

International Soil and Water Conservation Research 2017年第2期5卷 122-129页

作者： nelson Mango Clifton Makate Lulseged Tamene Powell Mponela Gift Ndengu International Centre for Tropical Agriculture(CIAT) c/o Kawanda Research StationP.O.Box 6247KampalaUganda International Centre for Tropical Agriculture(CIAT) P.O.MP 228HarareZimbabwe International Centre for Tropical Agriculture(CIAT) c/o Chitedze Agricultural Research StationP.O.Box 158LilongweMalawi

The promotion of land,soil and water conservation measures has been a widespread development in sub-Saharan Africa in a bid to tackle degradation and improve *** a result,several gov-ernments have launched various campaigns on soil,land and water conservation *** aim of this study is to determine some of the factors that influence farmers'awareness(knowledge)and adoption of land,soil and water conservation *** for this study was collected from 312 households using a questionnaire survey in the Chinyanja Triangle of Southern *** study *** sampled from Tete province of Mozambique,central and southern regions of Malawi and eastern Province of *** used t-tests to classify adopters and non-adopters of soil,land and water con-servation measures and binomial logit models to identify the factors that infuence farmers'knowledge of conservation measures and adoption of land productivity *** results show that the household head's age,education,agricultural advice reception and farmer group membership are critical in raising *** the household head's age,education,agricultural advice reception,farmer group membership,pieces of land owned or used in production and land-to-man ratio influenced adoption *** study,therefore,concludes that in order to improve land productivity in the Chinyanja Triangle,there is a need to consider farmers'heterogeneity in terms of household head's age,level of education,extension services outreach,and socio-economic char *** suggests that governments'policies in the region should be aimed at improving farmers'level of education,extension delivery that will target the elderly and the youth,land ownership,credit access,and social capital such as group formation.

关键词： Conservation Agriculture Awareness Adoption Chinyanja Triangle

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cloud computing for integrated stochastic groundwater uncertainty analysis

引用

International Journal of Digital Earth 2013年第4期6卷 313-337页

作者： Yong Liu Alexander Y.Sun Keith nelson Wesley E.Hipke National Center for Supercomputing Applications University of Illinois at Urbana-ChampaignUrbanaILUSA Bureau of Economic Geology University of Texas at AustinAustinTXUSA Arizona Department of Water Resources PhoenixAZUSA

One of the major scientific challenges and societal concerns is to make informed decisions to ensure sustainable groundwater availability when facing deep uncertainties.A major computational requirement associated with this is on-demand computing for risk analysis to support timely *** paper presents a scientific modeling service called‘ModflowOnAzure’which enables large-scale ensemble runs of groundwater flow models to be easily executed in parallel in the Windows Azure *** technical issues were addressed,including the conjunctive use of desktop tools in MATLAB to avoid license issues in the cloud,integration of Dropbox with Azure for improved usability and‘Drop-and-Compute,’and automated file exchanges between desktop and the *** scientific use cases are presented in this paper using this service with significant computational *** case is from Arizona,where six plausible alternative conceptual models and a streamflow stochastic model are used to evaluate the impacts of different groundwater pumping *** case is from Texas,where a global sensitivity analysis is performed on a regional groundwater availability *** of both cases show informed uncertainty analysis results that can be used to assist the groundwater planning and sustainability study.

关键词： MODFLOW groundwatersustainability uncertaintyanalysis global sensitivity analysis cloudcomputing WindowsAzure Dropbox alternative conceptual model cyberinfrastructure eScience

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Immune stress and diet influence reproductive fitness in male tuatara (Sphenodon punctatus)

引用

Current Zoology 2024年第6期70卷 786-794页

作者： Sarah K.Lamar Diane K.Ormsby Nicola J.nelson School of Biological Sciences Level 2Te Toki a Rata BuildingVictoria University of WellingtonWellington 6012New Zealand Centre for Biodiversity and Restoration Ecology Level 2Te Toki a Rata BuildingVictoria University of WellingtonWellington 6012New Zealand

The theoretical trade-off between immune and endocrine investment in mating animals has received mixed empirical support,particularly in *** investigated the relationship between male sexual characteristics,diet,and immune response to stress in an island population of tuatara(Sphenodon punctatus)across two mating *** are promiscuous,with a highly skewed mating system where males face significant competition for access to mates and postcopulatory competition for fertilization *** found that tuatara sperm viability and swim speed were negatively associated with male body condition and the ratio of heterophils to ***,sperm swim speed was negatively associated with spine area,mite load,and the total number of circulating white blood cells,but was positively associated with tick *** is likely a function of social dynamics in this system where larger male size predicts greater spatial overlap with potential rivals and increased tick *** the production of sexual characteristics may be costly,we also investigated the effect of diet on sperm *** did not identify an association between diet and sperm ***,sperm swim speed was negatively associated with carbon-13 and positively associated with *** suspect that these results reflect the influence of seabird-based nutrients in this island ecosystem,particularly polyunsaturated fatty acid,and antioxidant damage on tuatara *** total,these results provide evidence of a trade-off between pre-and post-copulatory sexual characteristics and the immune and endocrine systems in male tuatara.

关键词： reproductive ftness reptiles sexual selection sperm characteristics tuatara

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plant cytochrome P450 plasticity and evolution

引用

Molecular Plant 2021年第10期14卷 1244-1265页

作者： Cecilie Cetti Hansen David R.nelson Birger Lindberg Moller Daniele Werck-Reichhart Plant Biochemistry Laboratory Department of Plant and Environ mental ScienceUniversity of CopenhagenCopenhage nDenmark VILLUM Research Center for Plant Plasticity University of CopenhagenCopenhagenDenmark Department of Microbiology Immunology and BiochemistryUniversity of Tennessee Health Science CenterMemphisTNUSA Institute of Plant Molecular Biology Centre National de la Recherche Scientifique(CNRS)University of StrasbourgStrasbourgFrance

The superfamily of cytochrome P450(CYP)enzymes plays key roles in plant evolution and metabolic *** review provides a status on the CYP Iandscape within green algae and land *** 11 conserved CYP clans known from vascular plants are all present in green algae and several green algaespecific clans are *** 71,72,and 85 remain the largest CYP clans and include many taxaspecific CYP(sub)families reflecting emergence of linage-specific *** features and dynamics of CYP plasticity and evolution are discussed and exemplified by selected biosynthetic *** substrate promiscuity is commonly observed for CYPs from large families,favoring retention of gene duplicates and neofunctionalization,thus seeding acquisition of new *** of biosynthetic pathways producing metabolites with sporadic distribution across plant phylogeny reveals multiple exampies of convergent evolution where CYPs have been independently recruited from the same or different CYP families,to adapt to similar environmental challenges or ecological *** only a single or a few mutations are required for functional interconversion.A compilation of functionally characterized plant CYPs is provided online through the Plant P450 Database(***/public/vgrid/PlantP450/).

关键词： land plants green algae diversificati on promiscuity neofunctionalization convergent evolution functionalities plant metabolism

来源：

维普期刊数据库

维普期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Adaptive Computation Offloading and Resource Allocation Based on Deep Reinforcement Learning in Dynamic Mobile Edge Computing Environments

Adaptive Computation Offloading and Resource Allocation Base...

引用

作者： Empilo Eynthon Guillaume nelson 西南大学

学位级别：硕士

Evolving as a promising paradigm in wireless communications,mobile edge computing（MEC）deploys edge servers with endowed cloud computing services at a network access point such as a base *** through a well-known technique referred to as computation offloading,MEC connects a user terminal to a mobile base station（BS）to offload computationally intensive and delay sensitive mobile applications,to an edge server attached to the dedicated BS for remote *** edge computation offloading,mobile terminals and internet of things（Io T）devices can benefit from cloud computing resources one-hop away from the users’ ***,high energy consumption is still factor of a major challenge in MEC systems due to long communication *** cloud servers,MEC servers are resource-limited and can’t handle an escalating number of offloading tasks at given *** works of computation offloading in MEC generally focus on addressing this drawback issue by leveraging computation offloading among MEC servers and ignored the fact that,advances in Io T and artificial intelligence（AI）are enabling smart applications resulting in tremendous demand of computing resources which therefore with the growing number of users will cause edge cooperative offloading among base stations to be inefficient to manage these evolving *** on the above-mentioned aspect,this paper proposed an adaptive edge computation offloading and resource allocation that jointly leverages computation offloading among edge servers and between MEC and cloud ***,the main contributions of this paper are summarized as follows.（1）To reduce the channel pathloss and communication overhead factor of long transmission latency,a server path selection method based on channel frequency strength is considered in this paper.（2）To maintain low interference among contending offloading tasks,this paper adopts a timeslot-based system（TSBS）to efficiently exploit the MEC and

关键词：

来源：

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：