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Early osmotic adjustment responses in drought-resistant and drought-sensitive oilseed rape

Journal of Integrative Plant Biology 2014年第8期56卷 797-809页

作者： Sarah Hatzig L.Irina Zaharia Suzanne Abrams Marie Hohmann Laurie Legoahec Alain Bouchereau nathalie Nesi Rod J.Snowdon Department of Plant Breeding IFZ Research Centre for Biosystems Land Use and Nutrition Justus Liebig University National Research Council of Canada Aquatic and Crop Resource Development Department of Chemistry University of Saskatchewan UMR 1349 INRA-AgroCampus Ouest-Université de Rennes 1 Joint Laboratory for Genetics Environment and Plant Protection (IGEPP) Bat.301 BP 35327 35653 Le Rheu Cedex France

The impact of osmotic stress on growth, physiolo- gy, and metabolism of winter oilseed rape （Brassica napus L.） was investigated by detailed analysis of biomass traits, hormone metabolites and osmolytes in two genetically unrelated drought-tolerant genotypes and two unrelated drought-sensitive genotypes. Seedlings were grown in vitro under controlled conditions and osmotic stress was simulated by applying a gradual treatment with polyethylene glycol （PEG 6ooo）, followed by hypo-osmotic treatment of variants used for metabolite determination. The results provide a basis for the identification of reliable selection criteria for drought resistance in oilseed rape. The in vitro cultivation system established during this study enabled effective discrimination of early osmotic stress responses between drought-resistant and -susceptible oilseed rape genotypes that also show large differences in relative seed yield under drought conditions in the field. Clear physiological and metabolic differences wereobserved between the drought-resistant and drought-sensitive genotypes, suggesting that osmotic adjustment is a key component of drought response in oilseed rape. Unexpected- ly, however, the drought-resistant genotypes did not show typical hormonal adjustment and osmolyte accumulation, suggesting that they possess alternative physiological mech- anisms enabling avoidance of stress symptoms.

关键词： Abscisic acid Brassica napus drought hormones metabolites

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Adjuvant Treatment for High-Risk Operable Prostate Cancer

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Journal of Cancer Therapy 2010年第1期1卷 10-20页

作者： Bernard Paule nathalie Brion AP-HP Groupe Henri Mondor-Albert ChenevierService OncologieCreteilFrance Centre Hospitalier de Versailles Hopital Andre Mignotunite TherapeutiqueLe ChesnayFrance UFR de Medecine Paris Ile-de-France Ouest Universite Versailles Saint Quentin en YvelinesGuyancourtFrance.

Patients who have undergone a radical prostatectomy may have to face high risks of recurrence. The risk of recurrence is elevated due to probable occult metastatic disease at the time of diagnosis. A rationale for using multimodal approach in order to minimize the chance of disease recurrence and to improve the survival of high risk patients is emerging from preclinical and clinical studies. New molecular and genetics assays, may help to select patients most likely to benefit from these approaches. In this review, we will especially discuss the potential benefits of adjuvant therapy after radical prostatectomy. This paper presents the identification of these high-risk patients;the explanation of an adjuvant treatment of residual disease after a radical prostatectomy;the clinical studies with adjuvant androgen deprivation, radiotherapy and/or chemotherapy and the microarrays analysis. This review highlights the importance of these new adjuvant treatments that aims at targeting the factor which triggers metastatic disease following a radical

关键词： Adjuvant Treatment Radical Prostatectomy High-Risk Patients

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Relationship between Children’s Body Mass Index and Parents’ Obesity and Socioeconomic Status: A Multilevel Analysis Applied with Luxembourg Data

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Health 2014年第17期6卷 2322-2332页

作者： Anastase Tchicaya nathalie Lorentz Living Conditions/Health Research Team CEPS/INSTEAD Esch-sur-Alzette Luxembourg

Obesity in children is a health crisis because the problem is increasing in most developed countries. This study measures the relationship between body mass index (BMI) of children aged 7 - 12 years residing in Luxembourg and the weight and socioeconomic status of their parents. The data used are from the 2007 Socio-Economic Panel Liewen zu L?tzebuerg/European Union-Statistics on Income and Living Conditions survey, which covers a population of approximately 10,000 people. The study sample includes 775 children whose weight and height were recorded to calculate their BMI. The descriptive analysis with the socioeconomic distribution of the children’s BMI and the multilevel logistic regression of the probability to be in overweight or obese were performed. The mean BMI of children was 17.4 kg/m2 for boys and girls. The prevalence of overweight was 21.2% (including 3% who were obese). Weight status, educational level, physical activity, and eating habits of parents were associated with BMI in children. Furthermore, children of foreign nationality had 2.9 times more risk to be overweight or obese than other children of Luxembourg nationality (OR = 2.90, 95%CI: 1.38 - 6.10). Children living in household with at least one parent who was obese were 6.51 times more likely to be in overweight or obese compared to those in household with both parents normal (OR = 6.51, 95%CI: 2.48 - 17.08). Overall, nationality and weight status of parents were the main determinants of children’s weight status. Promoting healthy diets and regular physical activity and educating parents on the consequences of overweight and obesity on children’s health in adulthood are effective strategies to control overweight and obesity.

关键词： BMI Obesity Children Socioeconomic Status Luxembourg

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Encoding of local and global cues in domestic dogs’ spatial working memory

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Open Journal of Animal Sciences 2013年第3期3卷 1-11页

作者： Sylvain Fiset nathalie Malenfant Université de Moncton Campus d’Edmundston Edmundston Canada

The current study investigated whether domestic dogs encode local and/or global cues in spatial working memory. Seven dogs were trained to use a source of allocentric information (local and/or global cues) to locate an attractive object they saw move and disappear behind one of the three opaque boxes arrayed in front of them. To do so, after the disappearance of the target object and out of the dogs’ knowledge, all sources of allocentric information were simultaneously shifted to a new spatial position and the dogs were forced to follow a U-shaped pathway leading to the hiding box. Out of the seven dogs that were trained in the detour problem, only three dogs learned to use the cues that were moved from trial to trial. On tests, local (boxes and experimenter) and/or global cues (walls of the room) were systematically and drastically shifted to a new position in the testing chamber. Although they easily succeeded the control trials, the three dogs failed to use a specific source of allocentric information when local and global cues were put in conflict. In discussion, we explore several hypotheses to explain why dogs have difficulties to use allocentric cues to locate a hidden object in a detour problem and why they do not differentiate the local and global cues in this particular experimental setting.

关键词： Local and Global Cues Spatial Working Memory Domestic Dogs Allocentric and Egocentric Cues Object Permanence

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Therapeutic MUC1-Based Cancer Vaccine Expressed in Flagella-Efficacy in an Aggressive Model of Breast Cancer

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World Journal of Vaccines 2012年第3期2卷 109-120页

作者： nathalie Machluf Ruth Arnon Department of Immunology The Weizmann Institute of Science Rehovot Israel

MUC1, a tumor-associated antigen overexpressed in many carcinomas, represents a candidate of choice for cancer immunotherapy. Flagella-based MUC1 vaccines were tested in therapeutic setting in two aggressive breast cancer models, comprising the implantation of the 4T1-MUC1 cell line in either Balb/c, or Human MUC1 transgenic mice in which spontaneous metastases occurs. Recombinant flagella carrying only 7 amino acid of MUC1 elicited therapeutic activity, affecting both the growth of established growing tumors and the number of metastases. Higher therapeutic activity was achieved with an additional recombinant flagella designed with the SYFPEITHI algorithm. The vaccines triggered a Th1 response against MUC1 with no evident autoimmune response towards healthy MUC1-expressing tissues. Recombinant flagella carrying a 25-residue fragment of MUC1, induced the most effective response, as evidenced by a significant reduction of both the size and growth rate of the tumor as well as by the lower number of metastases, and expanding life span of vaccinated mice.

关键词： Breast Cancer Flagella Vaccine Immunization Prophylactic MUC 1 Transgenic Mice Tumor Growth

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Lab-Scale Performance Evaluation of Vertical Flow Reed Beds for the Treatment of Chlorobenzene Contaminated Groundwater

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Journal of Environmental Protection 2012年第8期3卷 847-855页

作者： Gerard Merlin nathalie Cottin Laboratoire LCME Université de Savoie 73376 Le Bourget du Lac France Laboratoire LOCIE CNRS UMR5271- Université de Savoie73376 Le Bourget du Lac France

Chlorinated Benzenes (CBs) that were released into the environment contaminate groundwater at many existing and former industrial sites. A research program was initiated to investigate the ecoremediation of CBs contaminated groundwater using subsurface flow constructed wetlands. Four lab-scale experiments were performed to evaluate re- moval efficiency with different operation conditions. The first experiment was achieved with two different solid-state materials: a peat and a lava stone (pozzolana). In order to stimulate biological activity, organic matter coming from an aged Vertical Flow Constructed Wetlands (VFCW) was added to the media. Mass balance was determined to assess the fate of these pollutants in this system. The biofiltres of the second experiment were constructed with the same materials but bioaugmentation was realized by adding organic matter of VFCW or by bacteria inoculums. Peat and pozzolana biofiltres planted with Phragmites australis constituted the third experiment to evaluate the effect of plants. Bioaugmen- tation was constituted by the addition of OM coming from aged VFCW. Compost mixed with pozzolana was the solid-state material of the fourth experiment. Columns were made of two stages. The first stage was unplanted and the second stage was planted with Phragmites. Peat has been replaced by compost, a renewable material. Lab-scale biofil- tres remove CBs with an efficiency of 70% - 99%, depending on studied media and conditions. Greater efficiency was observed with bioaugmented media. Volatilization was very low (<0.2%) and the detection of chlorides in water indi- cated the occurrence of biodegradation. The experiments have shown that organic solid-state materials (compost or peat) are useful for groundwater remediation, with higher treatment efficiency than pozzolana material. Bioaugmentation increased biological activity. Clogging of biofiltres have been observed and can be reduced by the presence of plants or by a resting period of 14 -

关键词： Organochlorine Constructed Wetlands Phytoremediation Bioaugmentation Micropollutants

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Mec1-Dependent Phosphorylation of the Scc3 Subunit of Cohesin during Mitosis in Budding Yeast

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Advances in Bioscience and Biotechnology 2015年第3期6卷 153-163页

作者： nathalie Grandin Michel Charbonneau Université François-Rabelais de Tours CNRS GICC UMR 7292 Tours France

Cohesin is an evolutionary conserved complex that controls chromosome segregation during mitosis. Here we show that, in response to DNA damage, Saccharomyces cerevisiae Scc3, one of the major regulatory subunits of the Smc1-Smc3-Scc1 cohesin ring, is phosphorylated on S/T-Q residues. This event depended on the Mec1 checkpoint kinase as well as on cell cycle arrest triggered by the DNA damage checkpoint network. This phosphorylation event also took place during mitosis of an unperturbed cell cycle. The present finding that S. cerevisiae Scc3 is phosphorylated during mitosis represents a potentially important new regulatory step in cohesin’s mitotic functions.

关键词： Cohesin S/T-Q Phosphorylation Mec1 and Tel1 DNA Damage Cell Cycle Budding Yeast

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Antiviral effect of polyphenol rich plant extracts on herpes simplex virus type 1

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Food Science and Human Wellness 2018年第1期7卷 91-101页

作者： Sayed A.El-Toumy Josline Y.Salib Walaa A.El-Kashak Christel Marty Gilles Bedoux nathalie Bourgougnon Chemistry of Tannins Department National Research CentreDokki12622 CairoEgypt Chemistry of Natural Compounds Department National Research CentreDokki12622 CairoEgypt Centre de Rechercheet d’enseignement Yves Coppens Campus de TohannicBP 57356017 VannesFrance

Evaluation of the anti-herpetic activity of 25 Egyptian plants extracts was investigated in vitro in this *** antiviral activity against Herpes Simplex Virus type 1(HSV-1)was done on Vero cell lines by cell *** two plants extracts;namely Euphorbia coopire(Euphorbiaceae)and Morus alba(Moraceae)showed potent anti-herpetic activity and six other extracts showed moderate *** contrast,a bioassay monitored phytochemical exploration of these two plants led to the isolation of pure flavonoid *** antiviral activity of the isolated compounds was also examined,among which seven pure compounds namely;7-galloyl catechin,gallic acid,kaempferol 3-O-β-(6″-O-galloyl)-glucopyranoside,quercetin 3-O-β-(6″-O-galloyl)-glucopyranoside,curcumin,quercetin and kaempferol exhibited significant inhibition.

关键词： Egyptian plants Anti-HSV-1 Polyphenols Vero cell

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An integrated approach for modeling and solving the scheduling problem of container handling systems

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第2期7卷 234-239页

作者：陈璐奚立峰蔡建国 BOSTEL nathalie DEJAX Pierre School of Mechanical Engineering Shanghai Jiao Tong University IRCCyN–Nantes Cybernetic and Communication Research Institute BP 92 101 44321 Nantes Cedex 03 France Department of Automatic Control and Industrial Engineering Ecole des Mines de Nantes The Chantrerie F-44070 Nantes Cedex 03 France IUT of Saint Nazaire of Nantes University GLT Department 58 Michel Ange 44606 Saint Nazaire Cedex France

An integrated model is presented to schedule the container handling system. The objective is to improve the coop- eration between different types of equipments, and to increase the productivity of the terminal. The problem is formulated as a Hybrid Flow Shop Scheduling problem with precedence constraint, setup times and blocking (HFSS-B). A tabu search algorithm is proposed to solve this problem. The quality and efficiency of the proposed algorithm is analyzed from the computational point of view.

关键词： Container terminal Scheduling Tabu search Hybrid flow shop Makespan

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Vasarely painting at the nanoscale on sapphire crystals

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Nano Research 2020年第9期13卷 2512-2516页

作者： Caroline Matringe Elsa Thune Rémy Cavalotti Ahmad Fakih Stephan Amaud Nils Blanc nathalie Boudet Alessandro Coati Yves Garreau David Babonneau René Guinebretière IRCER UMR CNRS 7315Centre Europeen de la CeramiqueUniversite de Limoges12 rue Atlantis87068 LimogesFrance Institut Neel UPR CNRS 2940 CRG D2AM BeamlineESRFUniversite Grenoble Alpes38042 GrenobleFrance SixS Beamline Synchrotron SOLEILBP4891192 Gifsur YvetteFrance Laboratoire Materiaux et Phenomenes Quantiques UMR CNRS 7162Universite de Paris75013 ParisFrance Institut Pprime Departement Physique et Mecanique des Materiauxf UPR CNRS 3346Universite de PoitiersSP2MITSA 4112386073 Poitiers Cedex 9France

We demonstrate that convenient thermal treatment of a specific sapphire vicinal surface can induce the formation of a fully two-dimensional(2D)ordered surface made of a periodic assembly of(006)*** simiarity between the resuting surface topography and pattemns represented in the hexagon series"of paintings by Vasarely is really striking!We thus propose to call these surfaces as"nanoscaled Vasarely surfaces".We also show that the self-organization process,which is driven by the minimization of the free energy of a closed system,results in a quasi-linear isothermal growth of the facets'surface area over time.

关键词： nanoscaled Vasarely surfaces two-dimensional(2D)-self-organization sapphire vicinal surfaces

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