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Non-alcoholic fatty liver disease and diabetes: From physiopathological interplay to diagnosis and treatment

World Journal of Gastroenterology 2014年第26期20卷 8377-8392页

作者： nathalie C Leite Cristiane A Villela-Nogueira Claudia R L Cardoso Gil F Salles Internal Medicine Department University Hospital Clementino Fraga FilhoSchool of MedicineUniversidade Federal do Rio de Janeiro

Non-alcoholic fatty liver disease(NAFLD)is highly prevalent in patients with diabetes mellitus and increasing evidence suggests that patients with type 2diabetes are at a particularly high risk for developing the progressive forms of NAFLD,non-alcoholic steatohepatitis and associated advanced liver ***,diabetes is an independent risk factor for NAFLD progression,and for hepatocellular carcinoma development and liver-related mortality in prospective ***,patients with NAFLD have an elevated prevalence of *** studies have shown that NAFLD presence predicts the development of type2 *** and NAFLD have mutual pathogenetic mechanisms and it is possible that genetic and environmental factors interact with metabolic derangements to accelerate NAFLD progression in diabetic *** diagnosis of the more advanced stages of NAFLD in diabetic patients shares the same challenges as in non-diabetic patients and it includes imaging and serological methods,although histopathological evaluation is still considered the gold standard diagnostic *** effective established treatment is not yet available for patients with steatohepatitis and fibrosis and randomized clinical trials including only diabetic patients are *** sought to outline the published data including epidemiology,pathogenesis,diagnosis and treatment of NAFLD in diabetic patients,in order to better understand the interplay between these two prevalent diseases and identify the gaps that still need to be fulfilled in the management of NAFLD in patients with diabetes mellitus.

关键词： Non-alcoholic fatty liver disease Diabetes mellitus Pathogenesis Diagnosis Treatment

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Rapid laser synthesis of surfactantless tantalum-based nanomaterials as bifunctional catalysts for direct peroxide–peroxide fuel cells

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SmartMat 2023年第6期4卷 84-97页

作者： Xiaoyong Mo Brigitte Bouchet Fabre nathalie Herlin-Boime Edmund C.M.Tse HKU-CAS Joint Laboratory on New Materials Department of ChemistryUniversity of Hong KongHong Kong SARChina NIMBE CEACNRSCEA SaclayUniversitéParis-SaclayGif-sur-YvetteFrance HKU Zhejiang Institute of Research and Innovation HangzhouChina

Efficient and durable electrocatalysts are instrumental in enabling next-generation fuel cell *** present,expensive precious metals are used as state-of-the-art *** this report,cost-effective nanosized tantalum-based alternatives are synthesized for the first time via a green and scalable laser pyrolysis method as bifunctional catalysts for direct peroxide–peroxide fuel *** rapid laser pyrolysis strategy allows for the production of nanoparticles at a laboratory scale of grams per hour,compatible with a detailed exploration of the functional properties of as-synthesized *** varying the precursor ratio between ammonia and tantalum ethanolate,five tantalum-based nanomaterials(TaNOC)are prepared with crystalline phases of Ta_(2)O_(5),Ta_(4)N_(5),Ta_(3)N_(5),and TaN in tunable *** studies in neutral and alkaline conditions demonstrate that Ta_(4)N_(5) is the active component for both H_(2)O_(2) oxidation and *** isotope effect studies show that protons are involved at or before the rate-determining ***-term stability studies indicate that Ta_(3)N_(5) grants surfactant-free TaNOC-enhanced longevity during electrocatalytic *** together,bifunctional TaNOC can act as active and robust electrocatalysts for H_(2)O_(2) reduction and *** pyrolysis is envisioned to produce refractory metal nanomaterials with boosted corrosion resistance for energy catalysis.

关键词： bifunctional catalysis laser pyrolysis peroxide fuel cells tantalum nanomaterials

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Ion Beam Figuring System for Synchrotron X-Ray Mirrors Achieving Sub-0.2-µrad and Sub-0.5-nm Root Mean Square

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Nanomanufacturing and Metrology 2023年第3期6卷 1-11页

作者： Tianyi Wang Lei Huang Yi Zhu Stefano Giorgio Philip Boccabella nathalie Bouet Mourad Idir Brookhaven National Laboratory National Synchrotron Light Source II(NSLS-II)PO Box 5000UptonNY11973USA

Optics with high-precision height and slope are increasingly desired in numerous industrial *** instance,Kirkpatrick-Baez(KB)mirrors play an important role in synchrotron X-ray applications.A KB system is composed of two aspherical,grazing-incidence mirrors used to focus an X-ray *** fabrication of KB mirrors is challenging due to the aspherical departure of the mirror surfaces from base geometries and the high-quality requirements for slope and height *** this paper,we present the process of manufacturing an elliptical cylinder KB mirror using our in-house-developed ion beam figuring(IBF)and metrology ***,the key aspects of figuring and finishing processes with IBF are illustrated in *** effect of positioning error on the convergence of the residual slope error is highlighted and ***,inspection and cross-validation using different metrology instruments are performed and used as the final validation of the *** confirm that relative to the requested off-axis ellipse,the mirror has achieved 0.15-μrad root mean square(RMS)and 0.36-nm RMS residual slope and height errors,respectively,while maintaining the initial 0.3-nm RMS microroughness.

关键词： Ion beam figuring Kirkpatrick-Baez Synchrotron X-ray mirrors Stitching interferometry Optical fabrication Optical metrology

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Constructing and Cleaning Identity Graphs in the LOD Cloud

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Data Intelligence 2020年第3期2卷 323-352页

作者： Joe Raad Wouter Beek Frank van Harmelen Jan Wielemaker nathalie Pernelle Fatiha Saïs Deptartment of Computer Science Vrije UniversityAmsterdamThe Netherlands Computer Science Research Laboratory(LRI)of the University Paris Sud French National Centre for Scientific ResearchParis Saclay UniversityOrsayFrance

In the absence of a central naming authority on the Semantic Web,it is common for different data sets to refer to the same thing by different *** multiple names are used to denote the same thing,owl:sameAs statements are needed in order to link the data and foster *** that date back as far as 2009,observed that the owl:sameAs property is sometimes used *** our previous work,we presented an identity graph containing over 500 million explicit and 35 billion implied owl:sameAs statements,and presented a scalable approach for automatically calculating an error degree for each identity *** this paper,we generate subgraphs of the overall identity graph that correspond to certain error *** show that even though the Semantic Web contains many erroneous owl:sameAs statements,it is still possible to use Semantic Web data while at the same time minimising the adverse effects of misusing owl:sameAs.

关键词： Linked Open Data Identity Quality Reasoning

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Neurostimulation for fecal incontinence after correction of repair of imperforate anus

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World Journal of Clinical Cases 2017年第3期5卷 124-127页

作者： Alexandre Bougie nathalie McFadden Sandeep Mayer Michel Lebel Ghislain Devroede Surgery Department Centre Hospitalier Universitaire de SherbrookeFaculté de MédecineUniversité de Sherbrooke Medicine Department NeurologyCentre Hospitalier Universitaire de SherbrookeFaculté de MédecineUniversité de Sherbrooke

We are reporting the case of a 32-year-old female who had suffered from fecal incontinence(FI). She was born with an imperforate anus and a recto-vaginal fistula; she underwent repair at 6 mo of age. At 29 years of age, she was still fecally incontinent despite extensive pelvic floor reeducation. A magnetic resonance imaging and an anal electromyography were performed. Because her symptoms were considered to be probably due to extra-sphincteric implantation of the neo-anus, a redo was performed of the recto-neo-anal intra-sphincteric anastomosis. A neurostimulator device was subsequently implanted for persistent incontinence. Solid and liquid FI resolved, and her quality of life improved markedly. Combining surgery to correct the position of the neo-anus within the anal sphincter complex and neurostimulation could thus become a new approach in cases of refractory FI for patients with imperforate anus as a newborn. Follow-up into adulthood after pediatric imperforate anus surgery should be recommended for adult patients with persistent FI.

关键词： Fecal incontinence Congenital malformation Neuromodulation Neurostimulation Imperforate anus

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用于大肠杆菌消毒的负载型和悬浮型TiO_2催化剂的动力学和催化效率（英文）

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催化学报 2014年第9期35卷 1571-1577页

作者： Majdi Kacem Gael Plantard nathalie Wery Vincent Goetz National Center for Scientific Research UPR 8521 Laboratory of PROcess Materials and Solar Energy Tecnosud Rambla de la thermodynamique 66100 Perpignan France University of Perpignan Via Domitia 52 Paul Alduy 66100 Perpignan France National Institute for Agricultural Research UR0050 Laboratory of Environmental Biotechnology Avenue des Etangs 11100 Narbonne France

TiO2‐mediated photocatalysis is widely used in a variety of applications and products in the envi‐ronmental and energy fields, including photoelectrochemical conversion, self‐cleaning surfaces, and especially water purification systems. The dimensionality of the structure of a TiO2 material can affect its properties, functions, and more specifically, its photocatalytic performance. In this work, the photocatalytic inactivation of Gram‐negative Escherichia coli using three photocatalysts, differ‐ing in their structure and other characteristics, was studied in a batch reactor under UVA light. The aim was to establish the disinfection efficiency of solid TiO2 compared with that of suspended cata‐lysts, widely considered as reference cases for photocatalytic water disinfection. The bacterial inac‐tivation profiles obtained showed that: (1) the photoinactivation was exclusively related to the quantity of photons retained per unit of treated volume, irrespective of the characteristics of the photocatalyst and the emitted light flux densities;(2) across the whole UV light range studied, each of the photocatalytic solids was able to achieve more than 2 log bacterial inactivation with less than 2 h UV irradiation;(3) none of the used catalysts achieved a total bacterial disinfection during the treatment time. For each of the catalysts the quantum yield has been assessed in terms of disinfec‐tion efficiency, the 2D material showed almost the same performance as those of suspended cata‐lysts. This catalyst is promising for supported photocatalysis applications.

关键词：二氧化钛催化剂大肠杆菌杀菌效率悬浮动力学光催化性能显示间歇式反应器

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Impact of ribavirin dose on retreatment of chronic hepatitis C patients

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World Journal of Gastroenterology 2012年第23期18卷 2966-2972页

作者： Christiane Stern Michelle Martinot-Peignoux Marie Pierre Ripault nathalie Boyer Corinne Castelnau Dominique Valla Patrick Marcellin Service d'Hépatologie and INSERM U773-CRB3 H pital Beaujon University Paris-Diderot

AIM: To study the efficacy and factors associated with a sustained virological response (SVR) in chronic hepatitis C (CHC) relapsing patients. METHODS: Out of 1228 CHC patients treated with pegylated interferon (PEG-IFN) and ribavirin (RBV), 165 (13%) had a relapse. Among these, 62 patients were retreated with PEG-IFN-2a or-2b and RBV. Clinical, biological, virological and histological data were collected. Initial doses and treatment modifications were recorded. The efficacy of retreatment and predictive factors for SVR were analyzed. RESULTS: An SVR was achieved in 42% of patients. SVR was higher in young ( 15.2 mg/kg per day (70% vs 35%, P = 0.04). In logistic regression, predictors of a response were age (P = 0.018), genotype (P = 0.048) and initial RBV dose/body weight (P = 0.022). None of the patients without a complete early virological response achieved an SVR (negative predictive value = 100%). CONCLUSION: Retreatment with PEG-IFN/RBV is effective in genotype 2 or 3 relapsers, especially in young patients. A high dose of RBV seems to be important for the retreatment response.

关键词： Chronic hepatitis C Relapse Retreatment Ribavirin Pegylated interferon

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Species and endosymbiont diversity of Bemisia tabaci （Homoptera： Aleyrodidae） on vegetable crops in Senegal

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Insect Science 2015年第3期22卷 386-398页

作者： Delatte Helene Baudin Remy Becker nathalie Girard Anne-Laure Ramatoulaye Sidebe Traore Lett Jean-Michel Reynaud Bernard CIRAD UMR PVBMT F-97410 Saint-Pierre La Reunion France Museum National d'Histoire Naturelle Institut de Systematique Evolution Biodiversite ISYEB UMR 7205 CNRS UPMC EPHE 75005 Paris France TECHNISEM Zone d'activite Anjou Actiparc de Jumelles 49160 Longue-Jumelles France

Bemisia tabaci-transmitted geminiviruses are one of the major threats on cassava and vegetable crops in Africa. However, to date, few studies are available on the diversity orB. tabaci and their associated endosymbionts in Africa. More than 28 species have been described in the complex ofB. tabaci cryptic species; among them, 2 are invasive pests worldwide： MED and MEAM1. In order to assess the species diversity orB. tabaci in vegetable crops in Senegal, several samplings in different localities, hosts and seasons were collected and analyzed with nuclear （microsatellite） and mitochondrial （COI） markers. The bacterial endosymbiont community was also studied for each sample. Two species were detected： MED Q1 and MEAM1 B. Patterns of MED Q1 （dominance on most of the samples and sites, highest nuclear and mitochondrial diversity and broader secondary endosymbiont community： Hamiltonella, Cardinium, Wolbachia and Rickettsia）, point toward a predominant resident begomovirus vector group for MED Q 1 on market gardening crops. Furthermore, the lower prevalence of the second species MEAM1 B, its lower nuclear and mitochondrial diversity and a narrower secondary endosymbiont community （Hamiltonella/Rickettsia）, indicate that this genetic group is exotic and results from a recent invasion in this area.

关键词： begomovirus vectors endosymbionts diversity MED and MEAM 1 species microsatellites mtCOI phylogeny whitefly

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Simone de Beauvoir on the Situation and Rights of French Women Colonizer

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Journal of Philosophy Study 2014年第7期4卷 465-472页

作者： nathalie Nya Pennsylvania State University

The goal of this paper is to establish from Simone de Beauvoir＇s perspective what happens when the situation and rights of French women are examined from the purview of their position as colonial subjects--as women colonizer. Following the analysis of Beauvoir as featured in The Ethics of Ambiguity and The Second Sex, the author first begins by examining the situation and rights of French women colonizer as it relates to the situation of the colonized. And then, the author examines the situation and rights of these women from their own stands as women and in relationships to the situation and rights of white French men. The paper concludes that while French women may have experienced white privilege, they suffered from gender oppression deriving from their second-class status as French colonial subjects.

关键词： gender colonialism women colonizer colonized voting rights oppression freedom

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The Question of Influence： Sartre and Beauvoir

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Journal of Literature and Art Studies 2016年第11期6卷 1304-1309页

作者： nathalie Nya John Carroll University University Heights Ohio United States

This paper examines the relationship of Simone Beauvoir to the field of philosophy; her work and her subject position as an author. In addition, this paper examines the relation of Sartre to Beauvoir as an author. I conclude that while Beauvoir may have defined herself as a writer, her training in and her position to, Philosophy should not be negated. Also, 1 add that Sartre＇s influence on the content of her body of work should be rejoiced and rather not criticized.

关键词： Beauvoir Sartre philosophy author existentialism feminism

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