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“Active Feedback” Fitbit-Based Physical Activity and Sleep Hygiene Intervention for Memory Assessment Service (MAS) Patients with Cognitive Deficits: Feasibility, Acceptability, Sleep Quality, Stress, and Wellbeing Outcomes

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Advances in Aging Research 2024年第4期13卷 61-74页

作者： Chris Griffiths Farah Hina Chee Siang Ang Louise Birkett-Swan Casey Bonham Lauren Currell Emily Ward natasha Stace-Wood Jessica Plumbridge Northamptonshire Healthcare NHS Foundation Trust Northampton UK School of Computing University of Kent Canterbury UK

Research Background: Compared to the general population, people experiencing age-related cognitive decline are more likely to have low levels of physical activity and sleep problems. Sufficient physical activity and quality sleep are protective factors against cognitive decline and poor health and can improve coping with stressors. The “Active Feedback” intervention comprises a wearable activity and sleep tracker (Fitbit), access to Fitbit software healthy lifestyle software apps;one session with Memory Assessment Service (MAS) staff providing physical activity and sleep hygiene advice and two further engagement, discussion, and feedback sessions. Purpose/Aim: This study investigates the acceptability and feasibility of Active Feedback and the effect on stress, mental wellbeing, and sleep quality, and the links between these factors. Methods: An open-label patient cohort design with no control group was used. Pre-intervention, 4-week and 8-week intervention assessments were performed using participant self-report measures: Perceived Stress Scale (PSS), Warwick-Edinburgh Mental Wellbeing Scale (WEMWBS), and Sleep Conditioning Index (SCI). Twenty-five participants completed an eight-week three-session intervention (18 males and 7 females), with the age range of 66 - 84 years old, and average age of 73.8 years (SD = 5.09). Fifteen participants had a diagnosis of MCI, ten participants did not. Results: There were non-significant improvements in SCI scores from 21.0 (SD = 8.84) to 21.6 (SD = 6.20) at 8 weeks, PSS scores from 17.5 (SD = 5.89) to 17.0 (SD = 6.20) at 8 weeks, and WEMWBS scores from 46.9 (SD = 9.23) to 48.8 (SD = 9.69) at 8 weeks. There were negative correlations between WEMWBS and PSS. Conclusion: Active Feedback intervention was found to be feasible and acceptable. Active Feedback could be enhanced to include motivational interviewing and goal setting.

关键词： Fitbit Tracker MCI Exercise Insomnia Physical Activity Wearables Sleep

Antimony, Arsenic and Thallium Bioaccumulation in Asiatic Clam (Corbicula fluminea ) Transplanted along the Manadas Creek, Laredo, Texas

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Amalgamated gold-nanoalloys with enhanced catalytic activity for the detection of mercury ions(Hg^2+)in seawater samples

Journal of Environmental Protection（环境保护） 2024年第4期 379页

作者： natasha Garcia Vaughan Thomas Alfred Addo-Mensah

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博看期刊

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Nano Research 2020年第4期13卷 989-998页

作者： natasha Logan Claire McVey Christopher Elliott Cuong Cao Institute for Global Food Security School of Biological SciencesQueens University Belfast19 Chlorine GardensBelfastBT95DLUK Material and Advanced Technologies for Healthcare Queens University Belfast18-30 Malone RoadBelfastBT95BNUK

Mercury(Hg)is extremely toxic,and continues to cause major threats to aquatic life,human health and the ***^2+mainly derives from seawater as a product of atmospheric deposition,therefore there is great demand for sensing approaches that can detect Hg^2+in seawater ***,we demonstrate that the peroxidase-mimicking activity of gold nanoparticles(AuNPs)or so-called nanozymes,can be exploited for the detection of Hg^2+ions in various water *** a high electrolyte environment,the catalytic activity for the oxidation of 3,3’,5,5’-tetramethylbenzidine(TMB)was significantly diminished due to poor stability of the *** activity was reduced by-73.7%when the NaCl concentration was higher than 1.168%,which is much lower than that of seawater(-3.5%),thus presenting its unsuitability for detecting Hg^2+in harsh water *** overcome this limitation,AuNPs were first functionalized with oligo-ethylene glycol(OEG),of which their colloidal form presented high stability in NaCl concentrations up to 20%and across a wide range of pHs from ***,the catalytic activity of OEG-AuNPs for the oxidation of TMB was strongly suppressed by the coating,but enhanced upon formation of Au-Hg *** novel finding underlies a straightforward,sensitive,and highly selective detection platform for Hg^2+in water *** approach could detect the exposure limit level for Hg^2+in drinking water(i.e.,2 ppb for tap and bottled water)as set by the United States Environmental Protection Agency(EPA)and the World Health Organization(WHO).When Hg^2+was spiked into a 3.5%saline solution and a coastal seawater certified reference material(CRM),the detection limits were found to be 10 ancM 3 ppb,respectively,which exceed the Hg^2+concentrations commonly found within seawater(-60-80 ppb).The whole procedure takes less than 45 min to conduct,providing a highly innovative,rapid and low-cost approach for detecting Hg^2+in complex water matrices.

关键词： gold nanoparticles nanozyme peroxidase-like mercury detection w ater samples seawater

Trans-Golgi Network-An Intersection of Trafficking Cell Wall Components

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Journal of Integrative Plant Biology 2012年第11期54卷 875-886页

作者： natasha Worden Eunsook Park Georgia Drakakaki Department of Plant Sciences University of CaliforniaDavis 95616USA

The cell wall, a crucial cell compartment, is composed of a network of polysaccharides and proteins, providing structural support and protection from external stimuli.

关键词： Cell wall chemical genomics endomembrane trafficking trans-Golgi network vesicle proteomics.

Evidence for using a dual COX 1/2 and 5-LOX inhibitor in neurodegenerative diseases

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Neural Regeneration Research 2017年第7期12卷 1077-1078页

作者： natasha Irrera Alessandra Bitto Department of Clinical and Experimental Medicine University of Messina Messina Italy

A complex network of factors contributes to neuroinflammation,such as infections,brain injuries and accumulation of toxic metabolites（Gendelman,2002）.Eicosanoids and several cytokines are the main mediators of inflammatory process;in fact,when an inflammatory condition persists,it can be responsible for the progression of degenerative diseases,

关键词： COX LOX in Evidence for using a dual COX 1/2 and 5-LOX inhibitor in neurodegenerative diseases for

Pediatric ocular nanomedicines：Challenges and opportunities

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Chinese Chemical Letters 2017年第9期28卷 1817-1821页

作者： natasha D.Sheybani Hu Yang Department of Biomedical Engineering Virginia Commonwealth University Richmond VA 23284. United States Department of Chemical & Life Science Engineering. Virginia Commonwealth University Richmond VA 23219. United States Department of Pharmaceutics Virginia Commonwealth University Richmond VA 23298. United States Massey Cancer Center. Virginia Commonwealth University Richmond VA 23298. United States

The eye is a highly complex,yet readily accessible organ within the human *** such,the eye is an appealing candidate target for a vast array of drug *** advances in ocular drug therapy research,the focus on pediatric ocular drug delivery continues to be highly underrepresented due to the limited number of degenerative ocular diseases with childhood *** this review,we explore more deeply the reasons underlying the disparity between ocular therapies available for children and for adults by highlighting diseases that most commonly afflict children（with focus on the anterior eye） and existing prognoses,recent developments in ocular drug delivery systems and nanomedicines for children,and barriers to use for pediatric patients

关键词： Pediatric Ocular drug delivery Nanomedicine Drug administration Compliance

Biology and architecture:An ongoing hybridization of scientific knowledge and design practice by six architectural offices in France

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Frontiers of Architectural Research 2021年第2期10卷 240-262页

作者： natasha Chayaamor-Heil Louis Vitalis UMR MAP-MAACC CNRS National Architecture School of Paris La VilletteParisFrance

As a highly interdisciplinary field,architecture is being influenced by many subjects of natural and social *** despite being apparently distant from architecture is currently a scientific field blending into design practices,which have evolved and shifted towards a new hybrid *** this article,we present an emerging design field of what we categorize as biomimetic architecture pioneering by six architectural offices in *** observe the impact of scientific researches on design processes and practices through six case studies led by these offices,which can be seen through the actors who involved in various types of interdisciplinary collaborations,through the competencies of the architect himself,and through new sources of ideas coming from biological sciences and related *** propose to use a classification of theoretical uses in modeling practice to better understand the role that biological knowledge plays in architectural design ***,the result of this analysis shows that the use of biology taking place in a design space has external purposes,which transform it to produce engineering devices or urban schemes rather than architectural *** also shows that biology in architectural design induces other kinds of non-biological knowledge,is not strictly theoretical and could be obsolete or *** findings lead to an epistemological discussion concerning the confusion between biological,knowledge,and architectural design‘know-how’.

关键词： Biology Biomimetic architecture Architectural design Hybridization Design epistemology Research-practice

Forcing biological sciences into architectural design: On conceptual confusions in the field of biomimetic architecture

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Frontiers of Architectural Research 2022年第2期11卷 179-190页

作者： Louis Vitalis natasha Chayaamor-Heil UMR MAP-MAACC CNRS National Architecture School of Paris La VilletteParisFrance

Certain confusion may be observed in the field of biomimetic architecture,as it emerges at the crossroad of two disciplinary domains:architectural design and biological *** biomimetics is defined as a science,once it is applied to architecture,biomimetic architecture should logically be defined as a science *** assertion collides with the nature of architectural design,which may rather be defined as a technology:its aim is to transform the world,not to explain *** the one hand,there is no obvious relationship between architecture and life *** the other hand,the biomimetic approach tends to redefine the concept of science itself by seeking to avoid the excesses of ***,existing applications of biomimetic design show that it is difficult to observe a genuine biomimetic architecture;most cases are closer to engineering component or urban planning and sometimes they involve little or no life *** aim of this paper is to describe this conceptual confusion through two movements called“forcings”,occurring between design and *** forcings are conceptualised as shifts between constructed scientific objects and given empirical ***,used in biology as in architecture,allow these shifts by virtue of their double *** are both tools for knowledge and for design,thus they may be conceptually forced into what they are not supposed to be,particularly in the field of biomimetic architecture where design process and scientific knowledge are said to meet.

关键词： Biomimetic architecture Architectural design Epistemology Design with biology Modeling theory

Hygiene hypothesis in inflammatory bowel disease: A criticalreview of the literature

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World Journal of Gastroenterology 2008年第2期14卷 165-173页

作者： natasha A Koloski Laurel Bret Graham Radford-Smith Department of Gastroenterology Royal Brisbane & Women'sHospital Herston Queensland 4072Australia Department of Gastroenterology Royal Brisbane & Women’sHospitalHerston Queensland 4072Australia

The hygiene hypothesis is thought to be a significant contributor to the growing incidence of inflammatory bowel disease (IBD) around the world, although the evidence for specific factors that underlie the hygiene hypothesis in IBD is unclear. We aimed to systematically review the literature to determine which hygiene-related factors are associated with the development of IBD. Publications identified from a broad based MEDLINE and Current Contents search between 1966 and 2007 on key terms relevant to the 'hygiene hypothesis' and IBD including H pylori exposure, helminths, cold chain hypothesis, measles infection and vaccination, antibiotic use, breastfeeding, family size, sibship, urban upbringing, day care attendance and domestic hygiene were reviewed. The literature suggests that the hygiene hypothesis and its association with decreased microbial exposure in childhood probably plays an important role in the development of IBD, although the strength of the supporting data for each of the factors varies considerably. The most promising factors that may potentially be associated with development of IBD include H pylori exposure, helminths, breastfeeding and sibship. However, the vast majority of studies in this area are plagued by serious methodological shortcomings, particularly the reliance on retrospective recall of information making it difficult to truly ascertain the importance of a 'hygiene hypothesis' in IBD. The 'hygiene hypothesis' in IBD is an important area of research that may give clues to the aetiology of this disease. Directions for future research are recommended.

关键词： Inflammatory bowel disease Hygiene hypothesis Microbial exposure Cold chain hypothesis H pylori Helminths Measles Antibiotic Breastfeeding Child care