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Transmission of cryptococcosis by liver transplantation:A case report and review of literature

World Journal of Hepatology 2020年第5期12卷 253-261页

作者： Gustavo de Sousa Arantes Ferreira Andre Luis Conde Watanabe natalia de carvalho trevizoli Fernando Marcus Felippe Jorge Carolina de Fatima Couto Priscila Brizolla de Campos Gabriel Oliveira Nunes Caja department of Liver Transplantation Instituto de Cardiologia do Distrito FederalBrasilia 70673900Brazil

BACKGROUND Cryptococcosis is a fungal infection caused by the yeast-like encapsulated basidiomycetous fungus of the Cryptococcus neoformans(***)species *** fungi are ubiquitous in soil and bird droppings,and infection by them is an important global health concern,particularly in immunosuppressed patients,such as organ transplant recipients and those infected by the human immunodeficiency *** fungus usually enters the body through the respiratory tract,but extremely rare cases of infection acquired by transplantation of solid organs have been *** SUMMARY We report a case of disseminated cryptococcosis in a liver transplant recipient,diagnosed 2 wk after the *** patient initially presented with fever,hyponatremia and elevated transaminase levels,manifesting intense headache after a few *** cultures were positive for *** biopsy showed numerous fungal elements surrounded by gelatinous matrix and sparse granulomatous *** resonance imaging of the brain showed multiple small lesions with low signal in T2,peripheric enhancement and edematous halo,diffuse through the parenchyma but more concentrated in the subcortical *** with amphotericin B for 3 wk,followed by maintenance therapy with fluconazole,led to complete resolution of the *** recipients of both kidneys from the same donor also developed disseminated cryptococcosis,confirming the transplant as the source of *** organ donor lived in a rural area,surrounded by tropical rainforest,and had negative blood cultures prior to organ *** This case highlights the risk of transmission of fungal diseases,specifically of ***,through liver graft during liver transplantation.

关键词： Cryptococcosis Liver transplantation Cryptococcus neoformans Case report Immunosuppression Fungal infection

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Leukocytoclastic vasculitis caused by hepatitis C virus in a liver transplant recipient: A case report

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World Journal of Hepatology 2019年第4期11卷 402-408页

作者： Gustavo de Sousa Arantes Ferreira Andre Luis Conde Watanabe natalia de carvalho trevizoli Fernando Marcus Felippe Jorge Luiz Gustavo Guedes Diaz Milla Carolina Costa Lafeta Araujo Gabriela de Campos Araujo Amanda de Castro Machado department of Liver Transplantation Instituto de Cardiologia do Distrito Federal Curso de Medicina Universidade Catolica de Brasilia

BACKGROUND Infection by the hepatitis C virus(HCV) is currently considered to be a global health issue, with a high worldwide prevalence and causing chronic disease in afflicted individuals. The disease largely involves the liver but it can affect other organs, including the skin. While leukocytoclastic vasculitis has been reported as one of the dermatologic manifestations of HCV infection, there are no reports of this condition as the first symptom of HCV recurrence after liver *** SUMMARY We report here a case of leukocytoclastic vasculitis in a liver transplant recipient on maintenance immunosuppression. The condition presented as a palpable purpura in both lower extremities. Blood and urine cultures were negative and all biochemical tests were normal, excepting evidence of anemia and hypocomplementemia. Imaging examination by computed tomography showed a small volume of ascites, diffuse thickening of bowel walls, and a small bilateral pleural effusion. Skin biopsy showed leukocytoclasia and fibrinoid *** biopsy was suggestive of HCV recurrence in the graft, and HCV polymerase chain reaction yielded 11460 copies/mL and identified the genotype as 1 A. Treatment of the virus with a 12-wk direct-acting antiviral regimen of ribavirin, sofosbuvir and daclatasvir led to regression of the symptoms within the first 10 d and subsequent complete resolution of the *** This case highlights the difficulties of diagnosing skin lesions caused by HCVinfection in immunosuppressed patients.

关键词： Hepatitis C Liver transplantation Leukocytoclastic vasculitis Immunosuppression Direct-acting antivirals Case report

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Antioxidants Enzymes Activities and NO Levels in Hemodialysis and Continuous Ambulatory Peritoneal Dialysis—A Comparative Study

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Journal of Biosciences and Medicines 2024年第2期12卷 50-59页

作者： natalia Cristina Aparecida Ribeiro e Ribeiro Anderson Martins Tavares Jaslana Hainfellner da Silva João Paulo Lima Daher Salim Kanaan Luciene de carvalho Cardoso-Weide Laboratory of Neuroplasticity Neurobiology Department Biology Institute Federal Fluminense University Rio de Janeiro Brazil Postgraduate Program in Medical Sciences School of Medicine Federal Fluminense University Rio de Janeiro Brazil School of Biology UNIVERSO—Salgado de Oliveira University Rio de Janeiro Brazil department of Pathology Faculty of Medicine Federal Fluminense University Rio de Janeiro Brazil

It consists of a retrospective study with twenty-two individuals diagnosed with DRC: fourteen HD and eight CAPD, followed up in the dialysis center of Antonio Pedro University Hospital (HUAP) of Fluminense Federal University (UFF), between 2015 and 2017. Fifteen healthy control (HC) subjects were included, without diagnosed CKD. Patients with HIV positive, hepatitis A, B, and C, pregnant, cancer, smokers, alcoholics and those exposed to X-rays in the last 3 months, were excluded. Objectives: As oxidative stress and endothelial dysfunction may be linked to the higher prevalence of CVD in CKD patients, we measured the activities of the antioxidants enzymes: SOD and GPx and total NO levels in the plasma and serum of end-stage CKD patients undergoing dialysis therapy, comparing with the HC group. Methods: Quantification of NO levels was performed by fluorometric kit, while activities of SOD and GPx were determined using kinetic methods. Results: We found higher plasma SOD activity in HD (8.58 U/ml) and CAPD (10.14 U/ml), compared to C (3.73 U/ml) group, while GPx activity was decreased in HD (115.38 nmol/h/ml) and CAPD (122.76 nmol/h/ml) groups compared to HC group (275.83 nmol/h/ml). Total serum NO concentration was decreased in HD (14.09 pmol/μl) and CAPD (10.26 pmol/μl), compared to non-CKD patients (49.65 pmol/μl). Conclusion: decreased total serum NO and GPx activities may lead to endothelial dysfunction and consequently a higher prevalence of CVD in CKD patients.

关键词： Hemodialysis CAPD SOD GPx NO

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Non-alcoholic fatty liver disease and the impact of genetic,epigenetic and environmental factors in the offspring

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World Journal of Gastroenterology 2022年第25期28卷 2890-2899页

作者： natalia Balassiano Wajsbrot Nathalie carvalho Leite Gil F Salles Cristiane A Villela-Nogueira Division of Hepatology Clementino Fraga Filho University HospitalFederal University of Rio de JaneiroRio de Janeiro 20941-913Brazil department of Internal Medicine Medical SchoolFederal University of Rio de JaneiroRio de Janeiro 22750-240Brazil

Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease worldwide and is strongly associated with metabolic *** recently,a significant impact of parental NAFLD in the offspring was demonstrated and has been widely ***,pathogenetic pathways implicated in the inheritance by the offspring and relatives are still under ***,multiple mechanisms are involved as well as in NAFLD pathogenesis *** the multifactorial involved mechanisms,genetic,epigenetic and environmental backgrounds are strongly related to NAFLD development in the ***,based on recent evidence from the available literature concerning genetic,epigenetic and environmental disease modifiers,this review aimed to discuss the relationship between parental NAFLD and its impact on the offspring.

关键词： Steatosis Genetic Epigenetic Environmental Offspring Non-alcoholic fatty liver disease

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Prediction of SARS-CoV-2 hosts among Brazilian mammals and new coronavirus transmission chain using evolutionary bioinformatics

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Animal Diseases 2022年第1期2卷 16-26页

作者： Luciano Rodrigo Lopes Giancarlo de Mattos Cardillo natalia carvalho de Lucca Pina Antonio Carlos da Silva Junior Silvana Kertzer Kasinski Paulo Bandiera-Paiva SPBrasil SPBrasil

Severe acute respiratory syndrome coronavirus(SARS-CoV)and SARS-CoV-2 are thought to transmit to humans via wild mammals,especially ***,evidence for direct bat-to-human transmission is *** of intermediate hosts is considered a reason for SARS-CoV-2 transmission to humans and emergence of *** biodiversity is found in tropical territories,such as *** the similar line,this study aimed to predict potential coronavirus hosts among Brazilian wild mammals based on angiotensin-converting enzyme 2(ACE2)sequences using evolutionary ***,maned wolf,and bush dogs were predicted as potential hosts for *** indigenous carnivores are philogenetically closer to the known SARS-CoV/SARS-CoV-2 hosts and presented low ACE2 divergence.A new coronavirus transmission chain was developed in which white-tailed deer,a susceptible SARS-CoV-2 host,have the central *** play an important role because of its low divergent ACE2 level in deer and *** discovery of these potential coronavirus hosts will be useful for epidemiological surveillance and discovery of interventions that can contribute to break the transmission chain.

关键词： SARS-CoV-2 Angiotensin-converting enzyme 2 Coronavirus Brazilian mammals White-tailed deer

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Disentangling spatial,environmental and historical effects on tropical forest tree species turnover

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Journal of Plant Ecology 2021年第4期14卷 717-729页

作者： Alisson Borges Miranda Santos Vinicius Andrade Maia Cleber Rodrigo de Souza Nathalle Cristine Alencar Fagundes Fernanda Moreira Gianasi Aurelio de Jesus Rodrigues Pais natalia de Aguiar-Campos Gabriela Gomes Pires Diego Teixeira Girardelli Jean Daniel Morel Mariana Caroline Moreira Morelli Felipe de carvalho Araujo Rubens Manoel dos Santos department of Forestry Sciences Federal University of LavrasUniversity CampusLavrasBrazil Biological Sciences University of the State of Minas GeraisItuiutaba UnitItuiutabaBrazil department of Biology Federal University of LavrasUniversity CampusLavrasBrazil Faculty of Environmental Engineering and Natural Resources Zambeze UniversityChimoioMozambique

Aims We aimed at disentangling the effects of spatial distance,current and past environmental dissimilarity,and their combinations on tree community taxonomic and phylogenetic turnover by addressing the following questions:(i)Is tree community taxonomic and phylogenetic turnover related to the indirect effects of spatial distance via environmental dissimilarity?(ii)Does tree community taxonomic and phylogenetic turnover respond to paleoclimate(Last Glacial Maximum and Mid-Holocene)?Methods The study was carried out in 14 Atlantic rainforest sites in Brazil(20.4 ha sampled)containing 615 tree species from 83 plant *** obtained plot-level geographic coordinates and soil variables and site-level bioclimatic variables in the current,Mid-Holocene and Last Glacial *** used structural equation models with a distance-based approach to(i)test the direct effects of spatial distance and environmental dissimilarity and(ii)test the indirect effects of spatial distance via environmental dissimilarity on taxonomic(Bray–Curtis distance)and phylogenetic turnover(Comdist and Comdistnt distances).Important Findings Our results suggest a weak indirect effect of spatial distance via environmental dissimilarity on taxonomic and phylogenetic *** community turnover was driven by the direct effects of neutral,niche-based and historical ***,we inferred that the paleoclimate(historical processes)promoted the selection of the clades that gave rise to the current flora,while spatial distances(neutral processes)limited the dispersal range of species from the regional pool and environmental conditions(niche-based processes)locally selected the taxa that are able to persist.

关键词： assembly processes phylogenetic communities environmental filtering neutral communities phylogenetic turnover ecological niche paleoclimate effects

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Review of anticancer mechanisms of isoquercitin

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世界临床肿瘤学杂志：英文版 2016年第2期7卷 189-199页

作者： Guilherme di Camillo Orfali Ana Carolina Duarte Vivien Bonadio natalia Peres Martinez Maria Elisa Melo Branco de Araújo Fernanda Bruschi Marinho Priviero Patricia Oliveira carvalho denise Gon?alves Priolli Scientific Initiation Program Sao Francisco University Medical School Postgraduate Program in Health Science Sao Francisco University Medical School

This review was based on a literature search of PubM ed and Scielo databases using the keywords "quercetin,rutin,isoquercitrin,isoquercitin(IQ),quercetin-3-glucoside,bioavailability,flavonols and favonoids,and cancer" and combinations of all the *** collected relevant scientific publications from 1990 to 2015 about the absorption,bioavailability,chemoprevention activity,and treatment effects as well as the underlying anticancer mechanisms of *** are a group of polyphenolic compounds widely distributed throughout the plant *** subclass of flavonols receives special attention owing to their health *** main components of this class are quercetin,rutin,and IQ,which is a flavonoid and although mostly found as a glycoside,is an aglycone(lacks a glycoside side chain).This compound presents similar therapeutic profiles to quercetin but with superior bioavailability,resulting in increased efficacy compared to the aglycone *** has therapeutic applications owing to its wide range of pharmacological effects including antioxidant,antiproliferative,anti-inflammatory,anti-hypertensive,and *** protective effects of IQ in cancer may be due to actions on lipid *** addition,the antitumor effect of IQ and its underlying mechanism are related to interactions with Wnt signaling pathway,mixed-lineage protein kinase 3,mitogen-activated protein kinase,apoptotic pathways,as well proinflammatory protein *** review contributed to clarifying the mechanisms of absorption,metabolism,and actions of IQ and isoquercitrin in cancer.

关键词： Drug screening assays Antitumor Cancer Flavonoids Flavonols Antioxidants Neoplasms

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Chromosomal Alterations in Patients with Alzheimer Disease in Manaus,Amazonas,Brazil

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Journal of Pharmacy and Pharmacology 2019年第8期7卷 451-458页

作者： Cleiton Fantin Kledson Moraes Nunes Ernanda Raquel de Queirós Goncalves de Sousa e Fernandes Diana Vieira Brito natalia Dayane Moura carvalho denise Corrêa Benzaquem Laboratório de Citogenética Escola Superior de Ciências da SaúdeUniversidade do Estado do AmazonasManausAmazonas 69065-001Brazil Laboratório de Análises Clínicas do Hospital Universitário Getúlio Vargas–HUGV ManausAmazonas 69020-170Brasil Secretaria Municipal de Saúde SEMSAManausAmazonas 69057-000Brasil

Alzheimer disease(AD)is a complex neurodegenerative pathology that is characterized by a cognitive *** causes and mechanisms are still largely *** has been suggested that both genetic and life exposure factors can contribute to AD *** are also evidences that chromosomal alterations can be related to this *** far,there is not a precise diagnosis for AD,which is given only after the exclusion of other dementia by clinical and neurological *** possible association of AD with chromosomal alterations and the easy access of classical cytogenetics analysis are important aspects to consider,given the difficulties in *** to the lack of similar studies in Brazil and the increasing number of AD cases in the state of Amazonas,the aim of this study was to investigate the presence of chromosomal alterations in patients diagnosed with AD in Manaus,Amazonas,*** blood lymphocytes of twelve patients and twelve healthy individuals with the same age were analyzed using conventional *** AD patients presented cells with autosomal aneuploidy,while no chromosomal alterations were found in the age-matched ***,rare events of double and multiple aneuploidies are being reported in association with AD for the first *** results corroborate that the increase in the frequencies of aneuploidies is not related to the aging process itself,but it might be associated to the disease ***,no chromosomes were preferentially affected in all AD patients,and no consistent karyotype pattern for AD lymphocytes was ***,our results do not support the use of standard cytogenetics as a tool for AD *** studies are necessary to understand better the association between chromosomal alterations and AD.

关键词： AD karyotyping numeric chromosomal alterations double aneuploidies multiple aneuploidies

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