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Pediatric living donor liver transplantation for congenital hepatic fibrosis using a mother's graft with von Meyenburg complex: A case report

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World Journal of Gastroenterology 2016年第44期22卷 9865-9870页

作者： naoya Yamada Yukihiro Sanada Takumi Katano Masahisa Tashiro Yuta Hirata Noriki Okada Yoshiyuki Ihara Atsushi Miki Hideki Sasanuma Taizen Urahashi Yasunaru Sakuma Koichi Mizuta Department of Transplant Surgery Jichi Medical University Department of Surgery Jichi Medical University

This is the first report of living donor liver transplantation(LDLT) for congenital hepatic fibrosis(CHF) using a mother's graft with von Meyenburg complex. A 6-year-old girl with CHF, who suffered from recurrent gastrointestinal bleeding, was referred to our hospital for liver transplantation. Her 38-year-old mother was investigated as a living donor and multiple biliary hamartoma were seen on her computed tomography and magnetic resonance imaging scan. The mother's liver function tests were normal and she did not have any organ abnormality, including polycystic kidney disease. LDLT using the left lateral segment(LLS) graft from the donor was performed. The donor LLS graft weighed 250 g; the graft recipient weight ratio was 1.19%. The operation and post-operative course of the donor were uneventful and she was discharged on post-operative day(POD) 8. The graft liver function was good, and the recipient was discharged on POD 31. LDLT using a graft with von Meyenburg complex is safe and useful. Long-term follow-up is needed with respect to graft liver function and screening malignant tumors.

关键词： Congenital hepatic fibrosis Von Meyenburg complex Living donor liver transplantation Pediatric liver transplantation

Effects of Orbital Motion on the Boundary Layer Flow on a Spinning Disk

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Open Journal of Fluid Dynamics 2012年第4期2卷 187-194页

作者： Mizue Munekata naoya Jobi Koichi Ikebe Hiroyuki Yoshikawa Graduate School of Science and Technology Kumamoto University Kumamoto Japan Mechanical Engineering Department Kumamoto University Kumamoto Japan

The objective of this study is to experimentally examine the effects of orbital motion on the boundary layer flow on a spinning disk. The boundary layer flow on the disk is visualized by the oil flow method, and velocity in the boundary layer is measured by the hot-wire method. For the oil flow pattern in the case of spinning motion only, streaks are clearly observed on the disk as transient vortices, but by adding orbital motion to the spinning motion, we find that streaks are not observed in a certain range of orbital conditions. With increasing orbital motion speed, the laminar re- gion becomes narrower and transition is promoted from the inward region of the disk, regardless of the direction of ro- tation. Also, with the addition of orbital motion, the velocity profile in the boundary layer becomes more asymmetric with respect to the spin axis of the disk. Furthermore, stationary vortices do not appear on the disk when the orbital speed is beyond a certain critical value. Therefore, the lack of streaks in the oil film pattern when orbital motion is added is due to the spatiotemporal unsteadiness of the flow field on the disk.

关键词： Rotating Disk Transition Boundary Layer Flow Visualization Velocity Measurement

Experiments and Considerations through the Phase Diagram in Open Tubular Capillary Chromatography Based on Tube Radial Distribution of Ternary Mixed Solvents Using a Fused-Silica Capillary Tube

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American Journal of Analytical Chemistry 2012年第4期3卷 300-305页

作者： Yusuke Tanigawa naoya Jinno Masahiko Hashimoto Kazuhiko Tsukagoshi Department of Chemical Engineering and Materials Science Faculty of Science and Engineering Doshisha University Kyotanabe Japan

Capillary chromatography using an untreated open tubular capillary tube and a ternary solvent mixture consisting of water-hydrophilic/hydrophobic organic solvent as a carrier solution has been developed. The system is called tube radical distribution chromatography (TRDC). Separation performance of the TRDC system using a fused-silica capillary tube was examined through the phase diagram for the ternary water-acetonitrile-ethyl acetate solvent mixture. The TRDC system required homogeneous carrier solutions with solvent component ratios around the boundary curve between homogeneous and heterogeneous solution in the phase diagram. The data obtained using the fused-silica capillary tube were compared with those obtained using a polytetrafluoroethylene capillary tube in our previous study.

关键词： Open Tubular Capillary Chromatography Phase Diagram Fused-Silica Capillary Tube Water-Acetonitrile-Ethyl acetate Mixture Tube Radial Distribution Phenomenon (TRDP)

Influence of the safety and diagnostic accuracy of preoperative endoscopic ultrasound-guided fine-needle aspiration for resectable pancreatic cancer on clinical performance

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World Journal of Gastroenterology 2014年第13期20卷 3620-3627页

作者： Taiki Kudo Hiroshi Kawakami Masaki Kuwatani Kazunori Eto Shuhei Kawahata Yoko Abe Manabu Onodera Nobuyuki Ehira Hiroaki Yamato Shin Haba Kazumichi Kawakubo naoya Sakamoto Department of Gastroenterology and Hepatology Hokkaido University Graduate School of MedicineSapporo 060-8638Japan

AIM: To evaluate the safety and diagnostic accuracy of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in a cohort of pancreatic cancer patients.

关键词： Pancreatic cancer Diagnosis Biopsy Endoscopic ultrasound-guided fine-needle aspiration Preoperative diagnosis

OBSERVATION ON THE EFFECTS OF CHINESE MEDICINE ZHENXUANYIN FOR IMPROVING CEREBRAL BLOOD FLOW IN RATS WITH CEREBRAL ISCHEMIA

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Journal of Traditional Chinese Medicine 1997年第4期17卷 299-303页

作者：王静怡 Yasuhiro Magata naoya Hattori Yoshiharu Yonekura Nagara Tamaki Fumiko Tanaka Junji Konishi Seok Rye Choi Shigeru Matsuzaki Department of Nuclear Medicine Faculty of Medicine Kyoto University Japan Chemistry Department of Radio Medicine Faculty of Pharmacy Kyoto University Japan Department of Neurological Internal Medicine Faculty of Medicine Kyoto University Japan Mailing Address of Jingyi Wang: Department of Neurological Internal Medicine Hospital of Traditional Chinese Medicine Xi'an 710001 China

Zhenxuanyin (镇眩饮) is composed of pure Chinese medicinal herbs, such as gastrodia tuber, poria cocos, ligusticum wallichii etc. 4-verssel occlusion (4VO) model rats were reperfused after 30 minutes’ complete occlusion, and Zhenxuanyin was administered 3 times a day. 24 hours later, 123I-IMP uptake in the brain was evaluated as an index of cerebral blood flow (CBF). The results show that Zhenxuanyin (0.03g kg, 0.3g kg, Ig kg, or 3g/ kg a day) can greatly improve the blood flow in the main cerebral regions, and 0.3g/ kg can increase cerebral blood flow (CBF) to the normal level.

关键词：镇眩饮

Enhancing clinical proficiency through laparoscopic training using Japanese origami

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第3期7卷 102-106页

作者： Shunsuke Furukawa Masatsugu Hiraki naoya Kimura Ryota Sakurai Ryo Kohata Naohiko Kohya Masashi Sakai Akashi Ikubo Ryuichiro Samejima Department of Surgery Japanese Red Cross Society Karatsu Red Cross HospitalSaga847-8588Japan Department of Surgery Saga University Faculty of MedicineSaga849-8501Japan

Objective This study aimed to investigate the clinical efficacy of laparoscopic training using origami,a traditional Japanese papercraft,using laparoscopic forceps to create origami *** In this retrospective study,4 surgeons were randomly divided into 2 groups:The training group,consisting of surgeons 1 and 2,and the non-training group,consisting of surgeons 3 and *** the course of a one-year study period,the training group regularly underwent laparoscopic surgery training with a dry box,wherein they folded a total of 1000 origami cranes using laparoscopic *** non-training group periodically underwent common laparoscopic surgery training of techniques such as suturing and *** surgeon regularly performed the transabdominal preperitoneal approach for inguinal *** training was conducted concurrently with the *** procedure time(peritoneum detachment,mesh placement,and closure of the peritoneum),total operation time(time from peritoneum detachment to closure of the peritoneum),and surgical outcomes were *** The training group showed greater improvement in the total operation time and more stable performance than the non-training ***,the time taken for peritoneum detachment was significantly shorter in the training *** Laparoscopic training using origami has the potential to enhance laparoscopic surgical skills and improve surgical outcomes.

关键词： Laparoscopic surgery Training Dry box Origami

Improving recognition of hepatic perivascular epithelioid cell tumor:Case report and literature review

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World Journal of Gastroenterology 2015年第17期21卷 5432-5441页

作者： Toshiya Maebayashi Katsumi Abe Takuya Aizawa Masakuni Sakaguchi naoya Ishibashi Osamu Abe Tadatoshi Takayama Hisashi Nakayama Shunichi Matsuoka Kazushige Nirei Hitomi Nakamura Masahiro Ogawa Masahiko Sugitani Department of Radiology Nihon University School of MedicineItabashi-kuTokyo 173-8610Japan Department of Digestive Surgery Nihon University School of MedicineItabashi-kuTokyo 173-8610Japan Department of Gastroenterology and Hepatology Nihon University School of MedicineItabashi-kuTokyo 173-8610Japan Department of Pathology Nihon University School of MedicineItabashi-kuTokyo 173-8610Japan

A 58-year-old man presented with the chief complaint of abdominal bloating and was incidentally found to have a liver *** diagnostic imaging studies could not rule out malignancy,the patient underwent partial resection of segment 3 of the *** lesion pathologically showed eosinophilic proliferation,in addition to immunohistochemical positivity for human melanoma black 45 and Melan-A,thereby leading to the diagnosis of a hepatic perivascular epithelioid cell tumor(PEComa).A PEComa arising from the liver is relatively ***,the name ‘PEComa' has not yet been widely recognized,and the same disease entity has been called epithelioid angiomyolipoma(EAML),further diminishing the recognition of *** addition,PEComa imaging findings mimic those of malignant liver tumors,and clinically,this tumor tends to ***,a PEComa is difficult to *** conducted a systematic review of PEComa and EAML cases and discuss the results,including findings useful for differentiating perivascular epithelioid cell tumors from malignant liver tumors.

关键词： Angiomyolipoma Tuberous sclerosis Melan-A Perivascular epithelioid cell tumor Humanmelanoma black 45 Imaging

Prospect of lenvatinib for unresectable hepatocellular carcinoma in the new era of systemic chemotherapy

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World Journal of Gastrointestinal Oncology 2021年第12期13卷 2076-2087页

作者： Takuya Sho Kenichi Morikawa Akinori Kubo Yoshimasa Tokuchi Takashi Kitagataya Ren Yamada Taku Shigesawa Mugumi Kimura Masato Nakai Goki Suda Mitsuteru Natsuizaka Koji Ogawa naoya Sakamoto Department of Gastroenterology and Hepatology Hokkaido University Faculty of Medicine and Graduate School of MedicineSapporo 060-8638HokkaidoJapan

The phase III clinical trial of the novel molecular targeted agent(MTA)lenvatinib for patients with advanced hepatocellular carcinoma(HCC)(REFLECT trial)found that lenvatinib was non-inferior to sorafenib in overall ***,the efficacy of multiple MTAs,including lenvatinib,in practice has been reported,and therapeutic strategies for Barcelona Clinic Liver Cancer(BCLC)intermediate stage HCC are undergoing major *** on these results,lenvatinib could be recommended for patients with transcatheter arterial chemoembolization(TACE)-refractory,ALBI grade 1,within the up-to-seven criteria in the BCLC intermediate *** provides a more favorable outcome than TACE,even in cases with large or multinodular HCC beyond the up-to-seven criteria with Child-Pugh grade *** patients meet the definitions of TACE-refractory or TACE-unsuitable,switching to systemic chemotherapy,including lenvatinib,is for favorable for preserving liver *** initial treatment,including MTA,has a significant therapeutic effect and downstaging of HCC is obtained,additional TACE or surgical resection should be *** also has a therapeutic effect for poorly differentiated type and non-simple nodular type HCC thanks to the survival-prolonging effect of this ***,a significant therapeutic effect is expected in tumors with more than 50%liver involvement or main portal vein invasion,which have traditionally been considered to have a poor prognosis in *** suggests that at the start of lenvatinib treatment,HCC patients with ALBI grade 1 may be able to maintain liver functional reserve.

关键词： Hepatocellular carcinoma Lenvatinib Molecular targeted agent TACE refractory TACE-unsuitable Barcelona Clinic Liver Cancer intermediate stage

Immunohistochemical evaluation for outflow reconstruction using opened round ligament in living donor right posterior sector graft liver transplantation: A case report

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World Journal of Gastroenterology 2016年第34期22卷 7851-7856页

作者： Yukihiro Sanada Yasunaru Sakuma Hideki Sasanuma Atsushi Miki Takumi Katano Yuta Hirata Noriki Okada naoya Yamada Yoshiyuki Ihara Taizen Urahashi Naohiro Sata Yoshikazu Yasuda Koichi Mizuta Department of Transplant Surgery Jichi Medical University Department of Surgery Jichi Medical University

Utilizing the opened round ligament as venous grafts during liver transplantation is useful but controversial,and there are no pathological analyses of this procedure. Herein,we describe the first reported case of a pathological analysis of an opened round ligament used as a venous patch graft in a living donor liver transplantation(LDLT). A 13-year-old female patient with biliary atresia underwent LDLT using a posterior segment graft from her mother. The graft had two hepatic veins(HVs),which included the right HV(RHV; 15 mm) and the inferior RHV(IRHV; 20 mm). The graft RHV and IRHV were formed into a single orifice using the donor's opened round ligament(60 mm × 20 mm) as a patch graft during bench surgery; it was then anastomosed end-to-side with the recipient inferior vena cava. The recipient had no post-transplant complications involving the HVs,but she died of septic shock with persistent cholangitis and jaundice 86 d after LDLT. The HV anastomotic site had no stenosis or thrombus on autopsy. On pathology,there was adequate patency and continuity between the recipient's HV and the donor's opened round ligament. In addition,the stains for CD31 and CD34 on the inner membrane of the opened round ligament were positive. Hepatic venous reconstruction using the opened round ligament as a venous patch graft is effective in LDLT,as observed on pathology.

关键词： Opened round ligament Venous patch graft Hepatic venous reconstruction Living donor liver transplantation All-in-one venoplasty