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Preliminary study of automatic gastric cancer risk classification from photofluorography

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World Journal of Gastrointestinal Oncology 2018年第2期10卷 62-70页

作者： Ren Togo Kenta Ishihara Katsuhiro Mabe Harufumi Oizumi Takahiro Ogawa Mototsugu Kato naoya Sakamoto Shigemi Nakajima Masahiro Asaka Miki Haseyama Graduate School of Information Science and Technology Hokkaido UniversityHokkaido 060-0814Japan Department of Gastroenterology National Hospital Organization Hakodate HospitalHokkaido 041-8512Japan Medical Examination Center of the Yamagata City Medical Association Yamagata 990-2473Japan Department of Gastroenterology Hokkaido University Graduate School of MedicineHokkaido 060-8648Japan Department of General Medicine Japan Community Healthcare Organization Shiga HospitalShiga 520-0846Japan Health Sciences University of Hokkaido Hokkaido 061-0293Japan

AIM To perform automatic gastric cancer risk classificationusing photofluorography for realizing effective mass screening as a preliminary study. METHODS We used data for 2100 subjects including X-ray images, pepsinogen Ⅰ and Ⅱ levels, PGⅠ/PGⅡ ratio, Helicobacter pylori (H. pylori) antibody, H. pylori eradication history and interview sheets. We performed two-stage classification with our system. In the first stage, H. pylori infection status classification was performed, and H. pylori-infected subjects were automatically detected. In the second stage, we performed atrophic level classification to validate the effectiveness of our *** Sensitivity, specificity and Youden index(YI) of H. pylori infection status classification were 0.884, 0.895 and 0.779, respectively, in the first stage. In the second stage, sensitivity, specificity and YI of atrophic level classification for H. pylori-infected subjects were 0.777, 0.824 and 0.601, respectively. CONCLUSION Although further improvements of the system are needed, experimental results indicated the effectiveness of machine learning techniques for estimation of gastric cancer risk.

关键词： Gastric cancer Helicobacter pylori Mass screening Photofluorography Automatic data processing

Transcatheter arterial infusion for advanced hepatocellular carcinoma: Who are candidates?

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World Journal of Gastroenterology 2015年第29期21卷 8888-8893页

作者： Eiichiro Suzuki Tetsuhiro Chiba Yoshihiko Ooka Sadahisa Ogasawara Akinobu Tawada Tenyu Motoyama naoya Kanogawa Tomoko Saito Masaharu Yoshikawa Osamu Yokosuka Department of Gastroenterology and Nephrology Graduate School of Medicine Chiba University

AIM: To elucidate anticancer effects of transcatheter arterial infusion chemotherapy(TAI) in patients with hepatocellular carcinoma(HCC). METHODS: Data from a total of 95 patients with HCC who received TAI were analyzed retrospectively. The efficacy of TAI was evaluated according to the Response Evaluation Criteria in Cancer of the Liver. Overall survival was calculated from the date of initial treatment to the date of death or last follow-up. Survival curves were calculated by the Kaplan-Meier method, and differences in survival were evaluated by the log rank test. Clinical variables that were identified as statistically different by a univariate analysis were included into the Cox proportional hazard regression model for multivariate analysis. A prognostic index based on the regression coefficients derived from variables identified by the multivariate analysis was constructed. Stratification of the patients was conducted using this prognostic index. RESULTS: The patient group was comprised of 76 men and 19 women with an average age of 68 years(range: 37-82 years). Six patients(6.3%) showedcomplete response and 18 patients(18.9%) showed partial response, for an overall response rate of 25.2%. The median overall survival was 27.6 mo, and the proportions of survivors at 1, 2, and 5 years were 67.4%, 54.0%, and 17.4%, respectively. Multivariate analysis demonstrated that no prior transcatheter arterial chemoembolization, lactate dehydrogenase < 230 IU/L, and performance status of 0 were the independent favorable prognostic factors. The development of a 0-3-point prognostic score index was based on the sum of these three prognostic factors. Subsequently, the patients were categorized into three groups: those with a good(prognostic index = 0-1; n = 54), intermediate(prognostic index = 2; n = 26), or poor(prognostic index = 3; n = 15) prognosis. The median survival times in these three groups were 41.0, 21.2, and 6.8 mo, respectively(P < 0.01). CONCLUSION: Our simple pro

关键词： Hepatocellular carcinoma Interventionalradiology Prognostic factor Survival Transcatheterarterial infusion

Recent advances in endoscopic ultrasonography-guided biliary interventions

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World Journal of Gastroenterology 2015年第32期21卷 9494-9502页

作者： Kazumichi Kawakubo Hiroshi Kawakami Masaki Kuwatani Shin Haba Shuhei Kawahata Yoko Abe Yoshimasa Kubota Kimitoshi Kubo Hiroyuki Isayama naoya Sakamoto Department of Gastroenterology and Hepatology Hokkaido University Graduate School of Medicine Department of Gastroenterology Graduate School of Medicine The University of Tokyo

Interventional endoscopic ultrasonography(EUS) based on EUS-guided fine-needle aspiration has rapidly spread as a minimally invasive procedure. Especially in patients with failed endoscopic retrograde cholangiopancreatography, EUS-guided biliary intervention is reported to be useful as salvage therapy. EUS-guided biliary interventions are carried out using three techniques: EUS-guided bilioenteric anastomosis, EUS-guided rendezvous procedure, and EUS-guided antegrade treatment. Although interventional EUS is not yet a standardized procedure, there have been recent advances in this field that address various biliary diseases. Here, we summarize the indications, techniques, clinical results of previous studies, and future perspectives.

关键词： Endosonography-guided biliary intervention Choledo

Current status of diagnosis and therapy for intraductal papillary neoplasm of the bile duct

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World Journal of Gastroenterology 2021年第15期27卷 1569-1577页

作者： Yuji Sakai Masayuki Ohtsuka Harutoshi Sugiyama Rintaro Mikata Shin Yasui Izumi Ohno Yotaro Iino Jun Kato Toshio Tsuyuguchi naoya Kato Department of Gastroenterology and Nephrology Graduate School of MedicineChiba UniversityChiba 260-8670Japan Department of General Surgery Graduate School of MedicineChiba UniversityChiba 260-8670Japan

Bile duct epithelial tumours showing papillary neoplasm in the bile duct lumen are present in the intrahepatic and extrahepatic bile *** images of these tumours are distinctive and diverse,including histological images with a low to high grade dysplasia,infiltrating and noninfiltrating characteristics,excessive mucus production,and similarity to intraductal papillary mucinous neoplasm(IPMN)of the *** World Health Organization Classification of Tumours of the Digestive System in 2010 named these features,intraductal papillary neoplasm of the bile duct(IPNB),as precancerous lesion of biliary *** is currently classified into type 1 that is similar to IPMN,and type 2 that is not similar to *** of IPNB spreads superficially,and diagnosis with cholangioscopy is considered mandatory to identify accurate localization and *** of IPNB is said to be better than normal bile duct cancer.

关键词： Intraductal papillary neoplasm of the bile duct Intraductal papillary mucinous neoplasm of the pancreas Peroral cholangioscopy Cholangioscopy

Visualization and Management Platform with Augmented Reality for Wireless Sensor Networks

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Wireless Sensor Network 2015年第1期7卷 1-11页

作者： Kenya Sato naoya Sakamoto Hideki Shimada Department of Information Systems Design Doshisha University Kyoto Japan

Recently a ubiquitous sensor network which collects our environmental information gets increasingly popular, a visualization application is necessary for users to manage complicated wireless networks, however, these applications are developed individually for wireless communication standard or a type of wireless device. Therefore, users are forced to adopt and use the application individually according to the target of the wireless network. In this paper, we propose a visualization platform for wireless network environments using augmented reality technology, and evaluate the effectiveness of the platform. From the result of the evaluation, we have confirmed the proposed platform has availability for visualization and management of wireless networks.

关键词： Network Management Visualization Augmented Reality

Clinical characteristics and treatment outcomes of patients with small cell carcinoma of the urinary bladder

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Current Urology 2022年第3期16卷 136-141页

作者： Takashi Muranaka Kohei Hashimoto Tetsuya Shindo Kosuke Shibamori Yuki Kyoda Ko Kobayashi Toshiaki Tanaka naoya Masumori Department of Urology Sapporo Medical University School of MedicineSapporo060-8543Japan

Background:Small cell carcinoma of the urinary bladder(SCUB)is *** optimal treatment for SCUB remains *** address the problem of appropriate treatment for each case,we assessed single-modality and surgery-based multimodality treatments in patients with *** and methods:We retrospectively reviewed the medical records of 12 patients with SCUB between 1990 and *** pa-tients underwent transurethral resection of the bladder tumor and were diagnosed with *** clinicopathological characteristics were assessed,and the outcomes were compared according to the treatment ***:The median(range)age at diagnosis was 66 years(range,53-85 years).T1-4N0M0 was observed in 8 patients(66%),N1-3M0 in 2(17%),and NanyM1 in 2(17%).After transurethral resection of the bladder tumor,6 patients(50%)underwent cystectomy alone,and 4(33%)underwent cystectomy and presurgical or adjuvant chemotherapy with etoposide and *** the median follow-up period of 20.7 months,6 patients(50%)died of cancer,and 2 patients(17%)died of other *** median overall survival period was 1.9 *** 5-year overall survival rate in patients who underwent cystectomy and chemotherapy was 75%,whereas that in those who underwent cystectomy alone and transurethral resection alone were 22%and 0%,respectively(p=0.012).Recurrence-free survival was significantly correlated with cause-specific survival(r=0.95;95%confidence interval,0.81-0.99;p<0.001).Conclusions:Radical cystectomy with chemotherapy using the etoposide and cisplatin regimen improved the prognosis of patients with SCUB and *** time from initial progression to death due to cancer was very short,indicating that the initial treatment strategy is crucial.

关键词： Bladder cancer Small cell carcinoma Treatment Chemotherapy Radical cystectomy

Huge capacity spacial division multiplexing transmission and integrated optical switching technologies(Invited Paper)

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Chinese Optics Letters 2016年第12期14卷 12-16页

作者： naoya Wada Ben J.Puttnam Ruben S.Luis Werner Klaus Jun Sakaguchi Jose M.D.Mendinueta Yoshinari Awaji Satoshi Shinada Hideaki Furukawa National Institute of Information and Communications Technology Tokyo 184-8795 Japan

We review the research and development of beyond Pb/s capacity space-division-multiplexed transmission technology using multi-core optical fibers for satisfying the ever-increasing traffic demand. Moreover, we present an optical packet and circuit integrated network technology to improve switching capacity and flexibility in network nodes for the rapid traffic fluctuation and the data service diversification.

关键词： switching multiplexing satisfying fluctuation traffic packet frames transmit throughput overhead

Analysis of Mechanical Combined-Type CVT Consisting of Closed Links,Grooved Cam and Non-invertible Elements

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Journal of Energy and Power Engineering 2018年第12期12卷 553-564页

作者： Toshihiro Yukawa Takuto Yoshikawa naoya Matsumoto Faculty of Science and Engineering Iwate University4-3-5 UedaMoriokaIwate 020-8551Japan Graduate School of Engineering Iwate University4-3-5 UedaMoriokaIwate 020-8551Japan

As one of transmission mechanisms,continuously variable transmission(CVT)can transfer energy depending upon rotation speed or torque generated by rotation power transferred from input axis to output *** is known that the CVT is mechanism that can change gear ratios continuously in power transmission installed in vehicles,or power generation and its transfer *** this paper,we propose a CVT using a new type of mechanism in which four-bar linkages(quadric crank chains)and non-invertible elements such as one-way clutches or ratchets are *** conventional CVTs which are classified as belt-type CVTs or toroidal CVTs are driven by friction force between conduction *** to slippage or high-pressure between the transmission components in the conduction mechanism,the transfer efficiency in the conduction energy becomes ***,the proposed CVT does not depend upon any friction forces,and it is considered that its transfer efficiency is superior.

关键词： CVT closed link four-bar linkage lever-crank mechanism one-way clutch power efficiency friction tribology

Cytokines in adipose-derived mesenchymal stem cells promote the healing of liver disease

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World Journal of Stem Cells 2018年第11期10卷 146-159页

作者： Saifun Nahar Yoshiki Nakashima Chika Miyagi-Shiohira Takao Kinjo Zensei Toyoda naoya Kobayashi Issei Saitoh Masami Watanabe Hirofumi Noguchi Jiro Fujita Department of Infectious Respiratory and Digestive Medicine Graduate School of Medicine University of the Ryukyus Okinawa 903-0215 Japan Department of Regenerative Medicine Graduate School of Medicine University of the Ryukyus Okinawa 903-0215 Japan Department of Basic Laboratory Sciences School of Health Sciences in the Faculty of Medicine University of the Ryukyus Okinawa 903-0215 Japan Okayama Saidaiji Hospital Okayama 704-8192 Japan Division of Pediatric Dentistry Graduate School of Medical and Dental Science Niigata University Niigata 951-8514 Japan Department of Urology Okayama Univer sity Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama 700-8558 Japan

Adipose-derived mesenchymal stem cells （ADSCs） are a treatment cell source for patients with chronic liver injury. ADSCs are characterized by being harvested from the patient’s own subcutaneous adipose tissue, a high cell yield （ i.e. , reduced immune rejection res-ponse）, accumulation at a disease nidus, suppression of excessive immune response, production of various growth factors and cytokines, angiogenic effects, anti-apoptotic effects, and control of immune cells via cell-cell interaction. We previously showed that conditioned medium of ADSCs promoted hepatocyte proliferation and improved the liver function in a mouse model of acute liver failure. Furthermore, as found by many other groups, the administration of ADSCs improved liver tissue fbrosis in a mouse model of liver cirrhosis. A comprehensive protein expression analysis by liquid chromatography with tandem mass spectrometry show-ed that the various cytokines and chemokines produced by ADSCs promote the healing of liver disease. In this review, we examine the ability of expressed protein com-ponents of ADSCs to promote healing in cell therapy for liver disease. Previous studies demonstrated that ADSCs are a treatment cell source for patients with chronic liver injury. This review describes the various cytokines and chemokines produced by ADSCs that promote the healing of liver disease.

关键词： Cell transplantation therapy Cytokine Hepatocytes Liquid chromatography with tandem mass spectrometry Liver cirrhosis Adipose-derived mesenchymal stem cells