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Immediate virological response predicts the success of shortterm peg-interferon monotherapy for chronic hepatitis C

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World Journal of Gastroenterology 2010年第12期16卷 1506-1511页

作者： Masayoshi Yada Akihide Masumoto naoki Yamashita Kenta Motomura Toshimasa Koyanagi Shigeru Sakamoto Department of Hepatology Iizuka Hospital

AIM:To investigate the efficacy of short-term peginterferon(PEG-IFN)monotherapy for chronic hepatitis C patients who achieved an immediate virological ***:Defining an"immediate virological response(IVR)"as the loss of serum hepatitis C virus(HCV) RNA 7 d after the first administration of PEG-IFNα,we conducted a 12-wk course of PEG-IFNα2a monotherapy without the addition of ribavirin for 38 patients who had low pretreatment HCV RNA load and exhibited *** patients included 21 men and 17 women,whose ages ranged from 22 to 77 years(mean±SD:52.0±17.8 years).There were 4 patients with HCV genotype 1b,23 patients with genotype 2a and 4 patients with genotype *** genotype was not determined for the remaining 7 *** were categorized into a sustained virological response(SVR)group,if serum HCV RNA remained negative for 24 wk after the end of treatment,or into a relapse ***:Based on the intention-to-treat analysis,35 patients(92.1%)achieved *** patient(2.6%)relapsed with serum HCV RNA 12 wk after the end of *** patients(5.3%)withdrew from the study during the 24-wk follow-up *** regard to the HCV RNA genotype,the SVR rates were 100%(4/4) for genotype 1b,95.7%(22/23)for genotype 2a and 100%(4/4)for genotype *** SVR rate in 7 patients,whose HCV RNA genotypes were not determined,was 71.4%(5/7).CONCLUSION:Short-term PEG-IFNα2a monotherapy is highly effective for chronic hepatitis C patients who have low pretreatment HCV RNA load and exhibit IVR.

关键词： Chronic hepatitis C Immediate virological response Interferon therapy

Improvement in mechanical properties of hypereutectic Al-Si-Cu alloys through sonosolidified slurry

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China Foundry 2014年第4期11卷 396-401页

作者： Yoshiki Tsunekawa Shinpei Suetsugu Masahiro Okumiya naoki Nishikawa Yoshikazu Genma Toyota Technological Institute TenpakuNagoya 468-8511Japan Toyota Motor Corporation Toyota 471-8571Japan

For the wider applications,it is necessary to improve the ductility as well as the strength and wear-resistance of hypereutectic AlSi-Cu alloys,which are typical light-weight wear-resistant *** increase in the amounts of primary silicon particles causes the modified wear-resistance of hypereutectic Al-Si-Cu alloys,but leads to the poor strength and *** is known that dual phase steels composed of hetero-structure have succeeded in bringing contradictory mechanical properties of high strength and ductility *** order to apply the idea of hetero-structure to hypereutectic Al-Si-Cu alloys for the achievement of high strength and ductility along with wear resistance,ultrasonic irradiation of the molten metal during the solidification,which is called sono-solidification,was carried out from its molten state to just above the eutectic *** sono-solidified Al-17Si-4Cu alloy is composed of hetero-structure,which are,hard primary silicon particles,soft non-equilibrium a-Al phase and the eutectic ***-casting was performed at just above the eutectic temperature with sono-solidified slurry to shape a disk *** the rheo-casting with modified sonosolidified slurry held for 45 s at 570 oC,the quantitative optical microscope observation exhibits that the microstructure is composed of 18area%of hard primary silicon particles and 57area%of soft a-Al *** contrast,there exist only 5 area%of primary silicon particles and no a-Al phase in rheo-cast specimen with normally solidified *** the tensile tests of T6 treated rheo-cast specimens with modified sono-solidified slurry exhibit improved strength and 5%of elongation,regardless of having more than 3 times higher amounts of primary silicon particles compared to that of rheo-cast specimen with normally solidified slurry.

关键词： semisolid casting slurry ultrasonic vibration sonosolidification hetero-structure hypereutectic aluminum alloy primary silicon a-Al solid solution

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Comparison of the effects of retrieval balloons and basket catheters for bile duct stone removal on the rate of post-ERCP pancreatitis

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Hepatobiliary & Pancreatic Diseases International 2021年第2期20卷 203-204页

作者： Kotaro Takeshita Satoshi Asai naoki Fujimoto Takumi Ichinona Eisuke Akamine Department of Gastroenterology Tane General HospitalOsaka 550-0025Japan

To the Editor:Endoscopic retrograde cholangiopancreatography(ERCP)is one of the most important techniques for diagnosis and treatment in pancreatobiliary ***-ERCP pancreatitis(PEP)is a common complication of ERCP with incidence about 3.8%–15.1%[1–4].The precutting technique,contrast injection into the pancreatic duct,prolonged cannulation and procedure times,sphincterotomy.

关键词： diagnosis ERCP injection

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Microarray Analysis of the Developing Rat Mandible

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Acta Biochimica et Biophysica Sinica 2007年第6期39卷 399-405页

作者： Hideo KABURAGI Naoyuki SUGANO Maiko OSHIKAWA Ryosuke KOSHI naoki SENDA Kazuhiro KAWAMOTO Koichi ITO Department of Periodontology. Nihon University School of Dentistry Tokyo 101-8310 Japan Department of Periodontology. Nihon University School of Dentistry Tokyo 101-8310 Japan Division of Advanced Dental Treatment Dental Research Center Nihon University School of Dentistry Tokyo 101-8310 Japan Department of Periodontology. Nihon University School of Dentistry Tokyo 101-8310 JapanDivision of Advanced Dental Treatment Dental Research Center

To analyze the molecular events that occur in the developing mandible, we examined the expression of 8803 genes from samples taken at different time points during rat postnatal mandible development. Total RNA was extracted from the mandibles of 1-day-old, 1-week-old, and 2-week-old rats. Complementary RNA (cRNA) was synthesized from cDNA and biotinylated. Fragmented cRNA was hybridized to RGU34A GeneChip arrays. Among the 8803 genes tested, 4344 were detectable. We identified 148 genes with significantly increased expression, and 19 genes with significantly decreased expression. A comprehensive analysis appears to be an effective method of studying the complex process of development.

关键词： gene expression microarray rat mandible

Talking with Children about Cancer: A Content Analysis of Text in Children’s Picture Books

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Health 2020年第7期12卷 750-763页

作者： Noyuri yamaji Megumi Sawaguchi Erika Ota Department of Global Health Nursing Graduate School of Nursing Science St. Luke’s International University Tokyo Japan Department of Child Health Nursing School of Nursing Tokyo Women’s Medical University Tokyo Japan

Introduction: To tell children that they are diagnosed with cancer is challenging for any healthcare professional and family. Pictures books are one of the communication tools for talking with children about severe diseases. However, little research is available about the contents of picture books about cancer for children. Therefore, this study aimed to examine the contents of children’s picture books about cancer and explore the advantages and disadvantages of using picture books to communicate with children about cancer. Methods: We searched the picture books about cancer written for children aged under ten years old on the *** Web site on 5 July 2019 and hand-searched on the cancer-related institutes’ Web site. We extracted the texts of relevant picture books and conducted a content analysis of them. Results: We identified 2555 picture books and included 30 of them. We identified three main contents, 1) cancer-related knowledge, 2) impacts of cancer, and 3) dealing with cancer. These contents were written with simple words and illustrations. Some of them included the essential contents, which might be misunderstood by children. Conclusions: Picture books might be helpful for children to understand about cancer. However, as these books do not include all contents, it is necessary to select and use multiple books depending on the content which is wanted to tell the child. Further research should evaluate the impacts of these books as a communication tool when talking with children diagnosed with cancer.

关键词： Cancer Oncology Pediatrics Communication Picture Books Contents Analysis

Simultaneous bile duct and portal venous branch ligation in two-stage hepatectomy

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World Journal of Gastroenterology 2011年第30期17卷 3554-3559页

作者： Hiroya Iida Chiaki Yasui Tsukasa Aihara Shinichi Ikuta Hidenori Yoshie naoki Yamanaka Department of Surgery Meiwa Hospital 4-31 Agenaruo-choNisinomiya663-8186 HyogoJapan

Hepatectomy is an effective surgical treatment for multiple bilobar liver metastases from colon cancer;however,one of the primary obstacles to completing surgical resection for these cases is an insufficient volume of the future remnant liver,which may cause postoperative liver *** induce atrophy of the unilateral lobe and hypertrophy of the future remnant liver,procedures to occlude the portal vein have been conventionally used prior to major *** report a case of a 50-year-old woman in whom two-stage hepatectomy was performed in combination with intraoperative ligation of the portal vein and the bile duct of the right hepatic *** procedure was designed to promote the atrophic effect on the right hepatic lobe more effectively than the conventional technique,and to the best of our knowledge,it was used for the first time in the present *** successful induction of liver volume shift as well as the following procedure,the patient died of subsequent liver failure after developing recurrent *** discuss the first case in which simultaneous ligation of the portal vein and the biliary system was successfully applied as part of the first step of two-stage hepatectomy.

关键词： Two-stage hepatectomy Bile duct ligation Portal vein ligation Synchronous liver metastases

People-Centered Care: Concept Analysis

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Health 2022年第11期14卷 1130-1142页

作者： Aya Nitamizu Noyuri yamaji Erika Ota Department of Global Health Nursing Graduate School of Nursing Science St. Luke’s International University Tokyo Japan Tokyo Foundation for Policy Research Tokyo Japan

Purpose: This study aims to clarify the definition, attributes, antecedents, and consequences of the concept of people-centered care (PCC). Method: Rogers and Knafl’s evolutionary method was used to analyze the concept of People-centered care. The cords such as “Attributes,” “Antecedent,” and “Consequences” were extracted on the coding sheet. The extracted contents of each of the “Attributes,” “Antecedent,” and “Consequences” from the created coding sheets were summarized as codes, and similar codes were categorized. Result: We included 33 studies in the analysis. As a result of the analysis, we identified four attributes (the subject is people, approaches to improving and enhancing health issues, relationships as a basis for partnership building, and behavioral attitudes for building partnerships), four antecedents (changes in social conditions, increasing people’s ownership of their health, health issues in modern society, and care in a variety of settings), and three consequences (achieving goals set by the people themselves, self-transformations of both people and healthcare providers, and social transformations). Discussion: Based on the analysis results, PCC was defined as “an initiative in which people step forward and partner with health care providers to improve and enhance health issues in individuals and communities.” In various social and individual changes, the realization of PCC is expected to result in the achievement of goals set by the people themselves together with health care providers and the transformation of individuals and society.

关键词： People-Centered Care Community Members Health Care Providers Partnership Concept Analysis

Characteristics of multiple nodules in a patient with pulmonary Langerhans cell histiocytosis: A case report

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World Journal of Clinical Cases 2019年第17期7卷 2519-2525页

作者： Nobuhiro Kanaji Yoshimasa Tokunaga Ryou Ishikawa naoki Watanabe Norimitsu Kadowaki Department of Internal Medicine Division of HematologyRheumatology and Respiratory MedicineFaculty of MedicineKagawa UniversityKagawa 761-0793Japan Department of General Thoracic Surgery Breast and Endocrinological SurgeryFaculty of MedicineKagawa UniversityKagawa 761-0793Japan Department of Diagnostic Pathology Faculty of MedicineKagawa UniversityKagawa 761-0793Japan

BACKGROUND The common computed tomography findings of pulmonary Langerhans cell histiocytosis (PLCH) are multiple cysts and micronodules predominantly in middle to upper lung ***-cystic nodules and large nodules are atypical findings of *** SUMMARY The patient was a 48-year-old Japanese man with a smoking history (20 cigarettes/d,28 years) and no *** nodules existed in all lung lobes,predominantly in the right lower *** nodules seemed to be distributed randomly,and others were adjacent to *** nodules were solid;some small ones were *** largest nodule was 22 mm in *** metastatic lung tumors were suspected,thoracoscopic lung biopsy led to the diagnosis of *** 6 months after he quit smoking,all nodules had almost *** investigated the characteristics of nodules at diagnosis in *** 349 nodules in total,116 were in upper and 199 were in lower ***-six (27.5%) were cystic;the remaining 253 (72.5%) were *** prevalence of cystic nodules was higher in upper lobes than in lower lobes (right upper 37.5% vs lower 18.2%,P = 0.0068;left upper 48.1% vs lower 24.4%,P = 0.0078).The average size (dia.) of cystic nodules was smaller than that of noncystic nodules (5.03 mm vs 7.40 mm,respectively,P < 0.0001).CONCLUSION Although multiple non-cystic nodules including large nodules (over 20 mm) are atypical,PLCH should be included in differential *** presence of small cystic nodules predominantly in upper lobes and asymptomatic situation are also important for differential diagnoses to distinguish from metastatic cancers.

关键词： Langerhans cell histiocytosis Multiple Non-cystic Nodule Distribution Size Case report

Polymer and Polymer Gel of Liquid Crystalline Semiconductors

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仪器仪表学报 2004年第S3期 80-83页

作者： Teppei Shimakawa,naoki Yoshimoto,Jun-ichi Hanna Imaging Science and Engineering Laboratory Tokyo Institute of Technology Nagatsuta Midori-ku Yokohama 226-8503 Japan Imaging Science and Engineering Laboratory Tokyo Institute of Technology Nagatsuta Midori-ku Yokohama 226-8503 Japan Imaging Science and Engineering Laboratory Tokyo Institute of Technology Nagatsuta Midori-ku Yokohama 226-8503 Japan

It prepared a polymer and polymer gel of a liquid crystalline (LC) semiconductor having a 2-phenylnaphthalene moiety and studied their charge carrier transport properties by the time-of-flight technique. It is found that polyacrylate having the mesogenic core moiety of 2-phenylnaphtalene (PNP-acrylate) exhibited a comparable mobility of 10 -4 cm2/Vs in smectic A phase to those in smectic A (SmA) phase of small molecular liquid crystals with the same core moiety, e.g., 6-(4'-octylphenyl)- 2-dodecyloxynaphthalene (8-PNP-O12), and an enhanced mobility up to 10 -3cm2/Vs in the LC-glassy phase at room temperature, when mixed with a small amount of 8-PNP-O12. On the other hand, the polymer gel consisting of 20 wt%-hexamethylenediacrylate (HDA)-based cross-linked polymer and 8-PNP-O12 exhibited no degraded mobility when cross-linked at the mesophase. These results indicate that the polymer and polymer composite of liquid crystalline semiconductors provide us with an easy way to realize a quality organic semiconductor thin film for the immediate device applications.

关键词： Smectic liquid crystalline polyacrylate Polymer liquid crystalline composite Mobility Charge carrier transport