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Numerical Study of Air Chamber for Oscillating Water Column Wave Energy Convertor

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China Ocean Engineering 2011年第1期25卷 169-178页

作者：刘臻 HYUN Beom-soo hong Keyyong Shandong Key Laboratory of Ocean Engineering Ocean University of China College of Ocean Science and Technology Korea Maritime University Maritime & Ocean Engineering Research Institute Korea Ocean Research & Development Institute

Oscillating Water Column （OWC） wave energy converting system is one of the most widely used facilities all over the world. The air chamber is utilized to convert the wave energy into the pneumatic energy. The numerical wave tank based on the two-phase VOF model is established in the present study toinvestigate the operating performance of OWC air chamber. The RANS equations, standard k-ε turbulence model and dynamic mesh technology are employed in the numerical model. The effects of incident wave conditions and shape parameters on the wave energy converting efficiency are studied and the capability of the present numerical wave tank on the corresponding engineering application is validated.

关键词： Oscillating water column numerical wave tank operating performance air chamber shape parameter

Enhancement of liposomal stability and cellular drug uptake by incorporating tributyrin into celecoxib-loaded liposomes

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Asian Journal of Pharmaceutical Sciences 2013年第2期8卷 128-133页

作者： Sung nam Kang soon-Seok hong soo-Yeon Kim Heungchan Oh Mi-Kyung Lee soo-Jeong Lim Department of Bioscience and Biotechnology Sejong University98 Kunja-dongKwangjin-guSeoul 143-747Republic of Korea Hanil High School GongjuChungchungnam-Do 314-714Republic of Korea College of Pharmacy Woosuk UniversityWanju-gunJeollabuk-Do 565-701Republic of Korea

Tributyrin,a triglyceride analog of short chain fatty acid butyrate,can act as a prodrug of an anticancer agent *** view of other reports that demonstrated the improved characteristics of conventional liposomes by incorporating small amount of nonphospholipids such as Tween 80,herein we sought to investigate whether the incorporation of tributyrin into the liposomal layers may provide additional advantages for liposomes as an anticancer drug *** were prepared with dimyristoylphosphatidylcholine as a main phospholipid with or without addition of *** was loaded in liposomes as a model anticancer *** 80-incorporated liposomes were also prepared for ***-incorporated liposomes were ineffective in enhancing the skin permeation of celecoxib compared to Tween 80-incorporated ***,tributyrin-incorporated liposomes enhanced the entrapped celecoxib concentration to an extent comparable to Tween 80-incorporated ***,tributyrin-incorporated liposomes exhibited much higher stability compared to Tween 80-incorporated ***,the cellular uptake of celecoxib loaded in tributyrin-incorporated liposomes into mouse melanoma cells were more than 10-fold higher compared to that loaded in conventional-and Tween 80-incorporated *** together,the incorporation of tributyrin into conventional liposomes loaded with anticancer drugs may provide an advanced anticancer drug carrier delivering both drug and tributyrin.

关键词： Tributyrin Liposomes Celecoxib Cancer Formulation

Predictors of pain resolution after varicocelectomy for painful varicocele

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Asian Journal of Andrology 2011年第5期13卷 754-758页

作者： Hyun Jun Park Seung soo Lee nam Cheol Park Department of Urology Pusan National University School of MedicineMedical Research InstitutePusan National University.Busan 602-739Korea

Varioocelectomny is a management option for patients with painful varicocele. In this study, we assessed the effectiveness of varicocelectomy for painful varicocele and examined the factors that might be predictive of outcome. All patients who underwent a varicocelectomy for pain between February 2007 and July 2009 were includecL A review of patient medical records was conducted; patient age,body mass index （BMI）, uede, iocatien of the vericocele, tasticular volume, duration and quality of the pain （dull, draaing, throbbing or sharp） and surgical technique （ingulnal versus subinguinal） were documented. All parameters were compared with the rasolution of pain （complete, partial or failure）. We followed up on 53 of 104 patients （51.0%）. Complete postopanntive resolution of pain was reported by 28 patients （52.8%）, whereas 22 （41.5%） reported partial resolution, Only three patients （5.7%） mpaded failure. No relationship was observed between postoperative pain resolution and age, BMI, grade of varicoceio, location of varicocele, ipsilateral testicular, quality of pain or surgical technique. The duration of pain before surllery was the only factor that correlated with postopaative pain resolution （univariate, P=-0.004; multivariate, P=0.002）. Our rasults indicatethat varicocelectomy isan effective treatmentfar painful varicocele in properly selected patients, and that duration of pain before surgery may be predictive of outcome.

关键词： duration pain testis vadcocele vadcocelectemy

Dynamic modeling and analysis of vortex filament motion using a novel curve-fitting method

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Chinese Journal of Aeronautics 2016年第1期29卷 53-65页

作者： Chang-Joo Kim soo Hyung Park Sang Kyung Sung Sung-nam Jung Department of Aerospace Information Engineering Konkuk UniversitySeoul 05029Republic of Korea

Applications of a novel curve-fitting technique are presented to efficiently predict the motion of the vortex filament, which is trailed from a rigid body such as wings and rotors. The gov- erning equations of the motion, when a Lagrangian approach with the present curve-fitting method is applied, can be transformed into an easily solvable form of the system of nonlinear ordinary dif- ferential equations. The applicability of Bezier curves, B-spline, and Lagrange interpolating polyno- mials is investigated. Local Lagrange interpolating polynomials with a shift operator are proposed as the best selection for applications, since it provides superior system characteristics with minimum computing time, compared to other methods. In addition, the Gauss quadrature formula with local refinement strategy has been developed for an accurate prediction of the induced velocity computed with the line integration of the Biot-Savart law. Rotary-wing problems including a vortex ring problem are analyzed to show the efficiency, accuracy, and flexibility in the applications of the pro- posed method.

关键词： Aerodynamics Biot-Savart law Curve-fitting method Free-vortex wake Rotary wing Vortex filament

Younger patients have poorer biochemical outcome after radical prostatectomy in high-risk prostate cancer

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Asian Journal of Andrology 2011年第5期13卷 719-723页

作者： Sung Kyu hong Jung soo nam Woong Na Jong Jin Oh Cheol Yong Yoon Chang Wook Jeong Hyun June Kim Seok-soo Byun Sang Eun Lee Department of Urology Seoul National University Bundang Hospital Seongnam Kyunggi-do 463-707 Korea

The aim of this study was to investigate the prognostic significance of patient age with respect to tumour aggressiveness in men who underwent radical prostatectomy （RP） for prostate cancer. In this study, we reviewed the records of 743 patients who received RP without neoadjuvant or adjuvant therapy at our institution and were followed up for 〉2 years postoperatively. For our analyses, the patients were divided into two groups according to age： younger （〈60 years） and older （≥ 60 years）. Through uni- and multivariate analyses, associations of various clinicopathological parameters, including biochemical recurrence-free survival, with patient age, were evaluated among all patients, and the patients were stratified according to their D＇Amico risk classification. Among all subjects, younger （n= 126） and older （n=617） patients showed no significant differences regarding pathological parameters and biochemical recurrence-free survival （P=0.288）. For the high-risk group （n= 206）, younger patients had a lower rate of biochemical recurrence-free survival following surgery than older patients （P=0.017）, despite the fact that no significant differences were observed regarding various known prognostic parameters between the two age groups. In addition, multivariate analysis revealed that age was an independent predictor of biochemical recurrence-free survival among the high-risk group （P=O.O03）. Our results showed that relatively younger patients have a comparable biochemical outcome compared with their older counterparts following RP performed for prostate cancer. However, among patients with high-risk disease, younger patients have a worse biochemical outcome following RP compared with older patients.

关键词： age factors biochemical outcome prostate prostatic neoplasms prostatectomy

Stud welding for fixation of cryogenic insulation of membrane tanks in LNG ship building

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中国有色金属学会会刊：英文版 2009年第B9期19卷 271-275页

作者： Jeong-soo LEE Young-soo RYU nam-In KIM Bong-Joon KIM Yoo-Kyung KIM Myung-Hyun KIM Hanjin Heavy Industries & Construction Co. Ltd Department of Naval Architecture and Ocean Engineering Pusan National University

The support plates including all of the inner hulls such as E grade steel, weld seams and SUS304L were considered to establish the optimal stud welding condition in LNG ship building. The stainless steel plate was especially applied to the bracket on the liquid dome. The polished and etched surfaces of the welded stud and support plate were examined if the bead was properly formed. With the micrographic examination, the fusion boundary of metal weld zone formed by stud welding was analyzed to optimize the welding parameters. And also the analysis of the unacceptable welding faults such as cold and hot weld were performed. The mechanical tests such as tensile tests and bending tests were carried out to reveal any abnormal variation in the relationship of process parameters and the strength.

关键词：螺柱焊接 LNG船绝缘膜优化工艺参数低温坦克不锈钢板最佳条件

Pancreatic parenchymal injection of ethanol and octreotide to induce focal pancreatic fibrosis in rats: Strategies to eliminate postoperative pancreatic fistula

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Hepatobiliary & Pancreatic Diseases International 2018年第1期17卷 81-85页

作者： soo Ho Lee Tae Ho hong Department of Surgery Uijeongbu St.Mary’s Hospital College of Medicine The Catholic University of Korea Department of Surgery Seoul St.Mary’s Hospital College of Medicine The Catholic University of Korea

Background: Postoperative pancreatic fistula(POPF) is more likely to occur in a soft pancreas compared to a hard pancreas in which fibrosis has progressed. There is almost no leakage at the anastomosis site or cut surface of a hard pancreas. The aim of this study was to induce localized fibrosis at the cut surface of the pancreas in a rat ***: Thirty-six rats were divided into three groups(group S: normal saline group; group E: ethanol group; and group O: octreotide group). Each rat was directly injected with a particular compound at the duodenal lobe of the pancreatic parenchyma. Each group was divided into three subgroups according to the time of post-injection sacrifice(1, 2, or 4 weeks). The hardness, suture holding capacity(SHC), and histological fibrosis grade of each pancreas were ***: The hardness, SHC, and fibrosis grade of groups E and O were increased at week 1, with greater increases in group E(all P < 0.001). In a subgroup comparison, the hardness, SHC, and fibrosis grade of group E tended to decrease gradually over time, with no regular pattern evident in group O. A comparison between the injected site(duodenal lobe) and non-injected site(splenic lobe) of the pancreas revealed increases in the three parameters of group E only in the duodenal lobe, with increases in group O at both the duodenal and splenic ***: Parenchymal injection of ethanol and octreotide increased pancreatic fibrosis. Unlike octreotide, ethanol provoked localized fibrosis that was maintained over time. It is expected that ethanol injection could eliminate POPF during pancreatic surgery.

关键词： Ethanol Octreotide Pancreatic fibrosis Pancreatic fistula Rat model

Toward Systems Understanding of Leaf Senescence： An Integrated Multi-Omics Perspective on Leaf Senescence Research

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Molecular Plant 2016年第6期9卷 813-825页

作者： Jeongsik Kim Hye Ryun Woo hong Gil nam Center for Plant Aging Research Institute for Basic Science (IBS) Daegu 42988 Republic of Korea Department of New Biology DGIST Daegu 42988 Republic of Korea

Leaf senescence is a complex but tightly regulated developmental process involving a coordinated sequence of multiple molecular events, which ultimately leads to death of the leaf. Efforts to understand the mechanistic principles underlying leaf senescence have been largely made by transcriptomic, proteomic, and metabolomic studies over the past decade. This review focuses on recent milestones in leaf senes- cence research obtained using multi-omics technologies, as well as future endeavors toward systems understanding of leaf senescence processes. In particular, we discuss recent advances in understanding molecular events during leaf senescence through genome-wide transcriptome analyses in Arabidopsis. We also describe comparative transcriptome analyses used to unveil the commonality and diversity of regulatory mechanisms governing leaf senescence in the plant kingdom. Finally, we provide current illustrations of epigenomic, proteomic, and metabolomic landscapes of leaf senescence. We envisage that integration of multi-omics leaf senescence data will enable us to address unresolved questions regarding leaf senescence, including determining the molecular principles that coordinate concurrent and ordered changes in biological events during leaf senescence.

关键词： leaf senescence transcriptomics epigenomics proteomics metabolomics multi-omics

Leaf Senescence in Plants:From Model Plants to Crops,Still so Many Unknowns

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Journal of Integrative Plant Biology 2012年第8期54卷 514-515页

作者： Hai-Chun Jing hong Gil nam Key Laboratory of Plant Resources Institute of Botany Chinese Academy of Sciences Beijing China Department of Life Sciences Pohang University of Science and Technology Republic of Korea

Senescence is a developmental process in the life cycle of a plant or a plant organ which has an intrinsic link with longevity. In human and animal sciences, the question of what controls the length of life is a fundamental biological query which has been puzzling scientists for centuries. Plant senescence is an even more complicated topic, since plants have many life-forms which differ greatly in their maximal life-spans. On the applied side, plant senescence has a great impact on landscape, agriculture, and our daily lives, being tightly linked to crop yield and quality as well as biomass production and bio-energy development, which are of increasing concern in the current age of climate change and parallel population growth.

关键词： GENE NETWORK ARABIDOPSIS MUTANTS LEAVES WHEAT L.