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Detection and pathogenesis of a novel swine H3N2 influenza virus containing three genes from the 2009 pandemic H1N1 influenza viruses in Korea in 2015

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Virologica Sinica 2016年第6期31卷 513-516页

作者： Tran Bac Le In hong Lee Byung Jun Kim Hyun soo Kim Sang Heui Seo Laboratory of Public Health College of Veterinary Medicine Chungnam National University Daejeon 34134 Republic of Korea.

Dear Editor,Influenza A viruses cause pandemics at an interval of approximately 10-40 years,and pigs are regarded as a＂mixing vessel＂because they are easily infected with avian and human influenza viruses（Ito et al.,1998）.According to previous studies,H3N2,H1N2,and H1N1 subtypes o（swine influenza viruses have been detected in Korean pigs （Pascua et al., 2013; Kim et al., 2014; Song et al., 2007）. Moreover, a novel H3N2 influenza virus containing the matrix （34） gene from a 2009 pandemic influenza virus was detected in Korean pigs in 2013 （Pascua et al., 2013）, an H1N2 influenza virus con- taining the internal genes from a 2009 pandemic influ- enza virus was found in Korean pigs in 2014 （Kim et al., 2014）, and an H1N1 influenza virus containing all genes from the classical swine influenza viruses was isolated from Korean pigs in 2007 （Song et al., 2007）.

关键词： gene Detection and pathogenesis of a novel swine H3N2 influenza virus containing three genes from the 2009 pandemic H1N1 influenza viruses in Korea in 2015

EFFECTS OF MODIFICATION OF THE CARBIDE CHARACTERISTICS THROUGH GRAIN BOUNDARY SERRATION ON CREEP-FATIGUE LIFE IN AUSTENITIC STAINLESS STEELS

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Acta Metallurgica Sinica(English Letters) 2004年第5期17卷 632-638页

作者： K.J.Kim H.U.hong K.S.Min S.W.nam Dept. of Materials Science and Engineering Korea Advanced Institute of Science and Technology 373-1 Guseong-dong Yuseong-gu Deajeon 305-701 KoreaPosco Technical Research Laboratory #1 Koedong-dong Nam-gu Pohang 790-300 KoreaProcess Solution Development Team 1 LCD R&D Center AMLCD Division Device Solution Network Samsung Electronics Co. LTD.San 24 Nongseo-ri Giheung-eup Yongin Gyeonggi-do 449-771 KoreaDept. of Materials Science and Engineering Korea Advanced Institute of Science and Technology 373-1 Guseong-dong Yuseong-gu Deajeon 305-701 Korea

Modification of the carbide characteristics through the grain boundary serration is investigated, using an AISI 316 and 304 stainless steels. In both steels, triangular carbides were observed at straight grain boundaries while planar carbides were observed at the serrated grain boundaries. The serrated grain boundary energy is observed to be much lower than that of the straight one. Therefore, the carbide morphology is found to be changed from triangular to planar along the serrated boundary to reduce the interfacial energy between the carbide and the matrix. The creep-fatigue properties of these steels at 873K have been investigated. The creep-fatigue life of the sample with planar carbide at the serrated grain boundary was found to be much longer than that with triangular carbide at the straight one. These results imply that the planar carbides with lower interfacial energy have higher cavitation resistance, resulting in the retardation of cavity nucleation and growth to increase creep-fatigue life.

关键词： cavity nucleation factor grain boundary serration carbide morphology austenitic stainless steel grain boundary cavitation

Plasma Levels of Monocyte Chemotactic Protein 3 and Beta-Nerve Growth Factor Increase with Amnestic Mild Cognitive Impairment

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Cellular & Molecular Immunology 2009年第2期6卷 143-147页

作者： Kang soo Lee Ji Hyung Chung Kyung Hye Lee Min-Jeong Shin Byoung Hoon Oh soo Hyung Lee Chang Hyung hong Department of Psychiatry Yonsei University College of Medicine Institution of Behavioral Science in Medicine Yonsei University College of Medicine Yonsei University Research Institute of Science for Aging Yonsei University Department of Food and Nutrition College of Health Science Korea University Department of Family Medicine Seoul Medical Center Department of Psychiatry Ajou University School of Medicine Memory Impairment Center Ajou University Hospital Ajou University School of Medicine

A number of studies have investigated peripheral inflammatory indices, including plasma cytokines and related molecules according to subtypes of dementia, but not in mild cognitive impairment （MCI）. In this study, we used multiplex cytokine assay to assess the plasma levels of 22 cytokines in patients with MCI subtyped as amnestic and non-amnestic, according to cognitive features. When comparing the levels of plasma growth factors, chemokines and cytokines, plasma levels of monocyte chemotactic protein 3 （MCP-3）, and beta-nerve growth factor （β-NGF） in these two groups, they were found to be significantly higher in amnestic MCI patients than in non-amnestic MCI patients, after adjusting for age and gender. This suggests that plasma MCP-3 and β-NGF may be useful in differentiating subtypes of MCI.

关键词： mild cognitive impairment cytokine plasma inflammation biomarker

Anti-inflammatory effects of traditional mixed extract of medicinal herbs(MEMH)on monosodium urate crystal-induced gouty arthritis

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Chinese Journal of Natural Medicines 2017年第8期15卷 561-575页

作者： Ju-Suk nam Supriya Jagga Ashish Ranjan Sharma Joon-Hee Lee Jong Bong Park Jun-Sub Jung Sang-soo Lee Institute For Skeletal Aging&Orthopedic Surgery Hallym University-Chuncheon Sacred Heart HospitalChuncheonGangwon-do24252Republic of Korea Institute of Natural Medicine College of MedicineHallym UniversityChucheonGangwon-do 24252Republic of Korea Hana Oriental Clinic ChucnheonGangwon-do 24433Republic of Korea

Korean oriental medicine prescription is widely used for the treatment of gouty diseases. In the present study, we investigated anti-inflammatory effects of modified Korean herbal formulation, mixed extract of medicinal herbs(MEMH), and its modulatory effects on inflammatory mediators associated with gouty arthritis. Both in vitro and in vivo studies were carried out to assess the anti-inflammatory efficacy of MEMH on monosodium urate(MSU) crystals-induced gouty inflammation. MSU crystals stimulated human chondrosarcoma cell line, SW1353, and human primary chondrocytes were treated with MEMH in vitro. The expression levels of pro-inflammatory mediators and metalloproteases were analyzed. The effect of MEMH on NFκB signaling pathway in SW1353 cells was examined. Effect of MEMH on the mR NA expression level of pro-inflammatory mediators and chemotactic factor from human monocytic cell line, THP-1, was also analyzed. The probable role of MEMH in the differentiation process of osteoblast like cells, SaO S-2, after MSU treatment was also observed. To investigate the effects of MEMH in vivo, MSU crystals-induced ankle arthritic model was established. Histopathological changes in affected joints and plasma levels of pro-inflammatory mediators(IL-1β and TNFα) were recorded. MEMH inhibited NFκB signaling pathway and COX-2 protein expression in chondrocytes. MSU-induced mR NA expressions of pro-inflammatory mediators and chemotactic cytokines were suppressed by MEMH. In MSU crystals-induced ankle arthritic mouse model, administration of MEMH relieved inflammatory symptoms and decreased the plasma levels of IL-1β and TNFα. The results indicated that MEMH can effectively inhibit the expression of inflammatory mediators in gouty arthritis, demonstrating its potential for treating gouty arthritis.

关键词： Gout Monosodium urate crystals Inflammation Chondrocyte Oriental medicine

Comparative study of tensile and high-cycle fatigue properties of extruded AZ91 and AZ91-0.3Ca-0.2Y alloys

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Journal of Materials Science & Technology 2021年第34期93卷 41-52页

作者： Ye Jin Kim Young Min Kim Seong-Gu hong Dae Woong Kim Chong soo Lee Sung Hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Implementation Research Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea Division of Industrial Metrology Korea Research Institute of Standards and ScienceDaejeon 34113Republic of Korea Energy Infra Material Measure Team Korea Research Institute of Standards and ScienceDaejeon 34113Republic of Korea Graduate Institute of Ferrous Technology Pohang University of Science and Technology.Pohang 37673Republic of Korea

Mg-Al-Zn-Ca-Y alloys with excellent ignition and corrosion resistances—termed SEN alloys(where the letters"S,""E,"and"N"stand for stainless,environmentally friendly,and non-flammable,respectively)—have been developed *** this study,the microstructure,tensile properties,and high-cycle fatigue properties of an extruded Mg-9.0Al-0.8Zn-0.1Mn-0.3Ca-0.2Y(SEN9)alloy are investigated and compared with those of a commercial Mg-9.0Al-0.8Zn-0.1Mn(AZ91)alloy extruded under the same *** the extruded SEN9 alloy and the extruded AZ91 alloy have a fully recrystallized structure comprising equiaxed grains,but the former has a smaller average grain size owing to the promoted dynamic recrystallization during *** extruded AZ91 alloy contains coarse Mg_(17)Al_(12) discontinuous precipitate(DP)bands parallel to the extrusion direction,which are formed during its cool down after *** contrast,the extruded SEN9 alloy contains relatively fine undissolved Al_(2)Ca,Al_(8)Mn_(4)Y,and Al_(2)Y second-phase particles,which are formed during the solidification stage of the casting *** tensile strength of the extruded SEN9 alloy,which has finer grains and more abundant particles,is slightly higher than that of the extruded AZ91 ***,the difference in their strengths is relatively small because the stronger solid-solution hardening and precipitation hardening effects in the extruded AZ91alloy offset the stronger grain-boundary hardening and dispersion hardening effects in the extruded SEN9alloy to some *** tensile elongation of the extruded AZ91 alloy is significantly lower than that of the extruded SEN9 alloy because the large cracks formed in the DP bands in the former cause its premature *** the extruded SEN9 alloy has higher tensile properties than the extruded AZ91alloy,the high-cycle fatigue life and fatigue strength of the former are shorter and lower,respectively,than those of the *** DP bands in the extruded

关键词： Mg-Al-Zn-Ca-Y alloy Extrusion Tensile properties High-cycle fatigue Crack source

A study on effects of ceramic foam filter on flow aspect through water modeling experiment

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China Foundry 2017年第3期14卷 216-225页

作者： Ho-Young Hwang Cheol-Hee nam Young-Sim Choi Jun-Ho hong Xun Sun Cyber Manufacturing Process Group Korea Institute of Industrial Technology Incheon 21999 South Korea Department of Robotics and Virtual Engineering Korea University of Science and Technology Daejeon 34113 South Korea Materials Science and Engineering Kyoto University Kyoto 606-8501 Japan Shenyang Research Institute of Foundry Shenyang 110022 China

Casting defects that are closely related to entrapped air bubbles and metallic oxides occur very frequently in the sand mold casting process. Many researchers have shown that these defects can be reduced by adopting an appropriate gating system design. However, it is difficult for field engineers to identify a specific gating system that is more appropriate for their products. In this study, we tried to draw a comparison between two gating system designs with and without a ceramic foam filter. The ceramic foam filter was added to the horizontal runner just after the down sprue to prevent air bubble generation and reduce turbulence without a change of gating system design. The water modeling experiment was conducted with four different amounts of the initial volumes of water in the reservoir to verify the effects of initial pouring velocity. The results of the experiment applying the filter showed remarkably changed flow characteristics. The use of the filter was found to convert the flow pattern of water in the desired direction. The ceramic foam filter performed well to reduce flow velocity and stabilize the water *** flow pattern without a filter can be improved significantly even with the the use of just a 10 PPI irregular filter. Although the study confirmed that use of the filter may change the flow characteristics, it needs to be noted that the use of the ceramic filter alone cannot solve all the problems caused by a poorly designed gating system.

关键词： ceramic foam filter sprue gating system design sand mold casting casting defect

Super-elastic and mechanically durable MXene-based nanocomposite aerogels enabled by interfacial engineering with dual crosslinking strategy

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Nano Research 2023年第5期16卷 8025-8035页

作者： Yan Sun Xin Yang Ruonan Ding Sung Yong hong Jinwoo Lee Zongfu An Mei Wang Yifei Ma Jae-Do nam Jonghwan Suhr China Copper Institute of Engineering and Technology Chinalco Research Institute of Science and Technology Co.Ltd.Beijing 102200China Center for Composite Materials and Concurrent Design Sungkyunkwan UniversitySuwon 16419Republic of Korea Key Laboratory for Light-weight Materials Nanjing Tech UniversityNanjing 210009China Department of Energy Science Sungkyunkwan UniversitySuwon 16419Republic of Korea MPP PJT.PO R&D Center Polyolefin Business Petrochemicals DivisionLG ChemDaejeon 34122Republic of Korea Department of Polymer Science and Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea School of Chemical Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Laser SpectroscopyCollaborative Innovation Center of Extreme OpticsShanxi UniversityTaiyuan 030006China School of Mechanical Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea

Recently,MXenes have attracted considerable attention owing to their unique physical and chemical *** of MXenes to three-dimensional(3D)porous aerogel structures can play a critical role in realizing the profound implications of MXenes,especially for environmental ***,developing mechanically robust MXene-based aerogels with reversible compressibility under harsh conditions,such as liquid environments,remains challenging due to the insufficient interfacial strength between MXene ***,3D porous MXene-based nanocomposite aerogels are developed by dual physical and chemical crosslinking strategy with poly(vinyl alcohol)and formaldehyde in this *** developed MXenebased nanocomposite aerogels with designed interfacial engineering exhibit outstanding structural stability and extremely high reversible compressibility up to 98%strain as well as unprecedented mechanical durability(2000 cycles at 50%strain)in water ***,the aerogels show adaptable compressibility when exposed to different solvents,which is explained with the Hansen solubility *** to their high compressibility in water,the robust MXene-based aerogels exhibit excellent methylene blue adsorption performance(adsorption capacity of 117.87 mg·g^(−1))and superior recycling efficiency(89.48%at the 3rd cycle).The porous MXene-based nanocomposite aerogels are also demonstrated with outstanding thermal insulation ***,by synergistically taking their porous structure and super elasticity in liquid environment,the MXene-based aerogels show great promise in diverse applications including adsorption and separation,wastewater purification desalination,and thermal management.

关键词： MXenes-based nanocomposite aerogels dual crosslinking strategy reversible compressibility methylene blue adsorption thermal insulation

Serum prostate-specific antigen as a predictor of prostate volume and lower urinary tract symptoms in acommunity-based cohort： a large-scale Korean screening study

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Asian Journal of Andrology 2013年第2期15卷 249-253,I0008页

作者： Dong soo Park Jong Jin Oh Jae Yup hong Young Kwon hong Don Kyung Choi In Hyuck Gong Jin HoHwang Sung Won Kwon Department of Urology CHA Bundang Medical Center CHA University Seongnam 463-712 Korea CHA Cancer Research Center Seou1135-081 Korea Department of Urology CHA Gangnam Medical Center CHA University Seou1135-081 Korea Korea Prostate Health Council Seou1137-070 Korea

The aim of this study is to assess the ability of serum prostate-specific antigen （PSA） to predict prostate volume （PV） and lower urinary tract symptoms （LUTS） represented by the international prostate symptom score （IPSS）. From January 2001 to December 2011, data were collected from men who first enrolled in the Korean Prostate Health Council Screening Program. Patients with a serum PSA level of 10 ng ml^-1 or age 〈40 years were excluded. Accordingly, a total of 34 857 men were included in our study, and serum PSA, PV and the IPSS were estimated in all patients. Linear and age-adjusted multivariate logistic analyses were used to assess the potential association between PSA and PV or IPSS. The predictive value of PSA for estimating PV and IPSS was assessed based on the receiver operating characteristics-derived area under the curve （AUC）. The mean PV was 29.9 ml, mean PSA level was 1.49 ng ml^-1 and mean IPSS was 15.4. A significant relationship was shown between PSA and PV, and the IPSS and PSA were also significantly correlated after adjusting by age. The AUCs of PSA for predicting PV ~20 ml, 〉25 ml and 〉35 ml were 0.722, 0.728 and 0.779, respectively. The AUCs of PSA for predicting IPSS 〉 7, 〉 13 and 〉 19 were 0. 548, 0.536 and 0. 537, respectively. Serum PSA was a strong predictor of PV in a community-based cohort in a large-scale screening study. Although PSA was also significantly correlated with IPSS, predictive values of PSA for IPSS above the cutoff levels were not excellent. Further investigations are required to elucidate the exact interactions between PSA and LUTS and between PSA and PV in prospective controlled studies. Such studies may suggest how PSA can be used to clinically predict PV and the IPSS.

关键词： lower urinary tract symptoms (LUTS) prostate prostate-specific antigen (PSA) prostate volume (PV)

Effects of planting distance and depth on PTO load spectrum of a small riding-type transplanter

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International Journal of Agricultural and Biological Engineering 2020年第2期13卷 57-63页

作者： Wan-soo Kim Yeon-soo Kim Taek-Jin Kim Kyu-Chul nam Tae-Bum Kim Tae-Ho Han Ryu-Gap Im Yong-Hyeon Kim Yong-Joo Kim Department of Biosystems Machinery Engineering Chungnam National UniversityDaejeon 34134Republic of Korea Department of Smart Agriculture Systems Chungnam National UniversityDaejeon 34134Republic of Korea Convergence Agricultural Machinery Group Korea Institute of Industrial TechnologyGimje 54325Republic of Korea Certification WarrantyInspection and Standardization TeamKorea Agricultural Machinery Industry CooperativeCheonan 31041Republic of Korea Diesel Service Korea Co.Ltd. Daejeon 34357Republic of Korea Agricultural Machinery Certification Team Foundation of Agricultural Technology Commercialization and TransferIksan 54667Republic of Korea Gint Co.Ltd. Suwon 16225Republic of Korea

The aim of this study was to analyze the effects of the planting distance and depth on the power take-off(PTO)load spectrum of a small riding-type transplanter for the optimal design of the *** measure load data during actual planting operation,a load measurement system was developed using a torque sensor,a data acquisition system,and an *** experiments were conducted at four planting distances(26 cm,35 cm,43 cm,and 80 cm)and three planting depths(85 mm,105 mm,and 136 mm)in a field with similar soil *** measured load data were inverted into a load spectrum using rain-flow counting and Smith-Watson-Topper(SWT)*** safety factor of a transplanter according to the planting conditions was analyzed using the converted load spectrum and commercial *** load spectrum for all planting conditions showed torque ratios similar within a high cycle region of 108 to *** torque ratio increased when the planting depth increased and planting distance decreased in the low cycle region under less than 108 *** safety factors of the PTO driving gear and the driven gear increased as the planting distance increased at all planting *** the planting depth decreased at the same planting distance,the safety factor of the PTO gears *** results of this study might provide useful information for a transplanter PTO design considering the working load according to the various planting conditions.

关键词： transplanter planting distance planting depth power take-off load spectrum safety factor