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Complete resection of a huge hypervascular inflammatory myofibroblastic tumor in right hemithorax after embolization

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World Journal of Pediatrics 2016年第4期12卷 498-500页

作者： kyu-nam kim Dong-Won kim Department of Anesthesiology and Pain Medicine Hanyang University HospitalRepublic of Korea

Background:Inflammatory myofibroblastic tumor(IMT)is a rare and mostly benign tumor that has the possibility of malignant ***:Radiological findings revealed a huge mass that filled most of the right hemithorax of a 17-month-old female *** extirpation was stopped due to massive bleeding and limited exposure of the *** was conducted to obstruct the arteries feeding the *** resection was ***:Histopathologic examination led to the diagnosis of *** recovery was ***:Hypervascularity of IMT should be *** embolization can be effective to reduce intraoperative blood loss and facilitate the surgical procedure.

关键词： embolization granuloma mediastinal neoplasms plasma cell

Contemporary management of locally advanced rectal cancer:Resolving issues, controversies and shifting paradigms

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Chinese Journal of Cancer Research 2018年第1期30卷 131-146页

作者： Aeris Jane D.Nacion Youn Young Park nam kyu kim Department of Surgery Eastern Visayas Regional Medical Center Division of Colorectal Surgery Department of Surgery Yonsei University College of Medicine

Advancements in rectal cancer treatment have resulted in improvement only in locoregional control and have failed to address distant relapse, which is the predominant mode of treatment failure in rectal cancer. As the efficacy of conventional chemoradiotherapy（CRT） followed by total mesorectal excision（TME） reaches a plateau, the need for alternative strategies in locally advanced rectal cancer（LARC） has grown in relevance. Several novel strategies have been conceptualized to address this issue, including： 1） neoadjuvant induction and consolidation chemotherapy before CRT; 2） neoadjuvant chemotherapy alone to avoid the sequelae of radiation; and 3） nonoperative management for patients who achieved pathological or clinical complete response after CRT. This article explores the issues, recent advances and paradigm shifts in the management of LARC and emphasizes the need for a personalized treatment plan for each patient based on tumor stage, location, gene expression and quality of life.

关键词： Locally advanced rectal cancer neoadjuvant treatment chemoradiotherapy

Keystone design perforator island flap in facial defect reconstruction

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World Journal of Clinical Cases 2020年第10期8卷 1832-1847页

作者： Soo Yeon Lim Chi Sun Yoon Hyun Gun Lee kyu nam kim Department of Plastic and Reconstructive Surgery Konyang University HospitalUniversity of Konyang College of MedicineMyunggok Medical Research CenterDaejeon 35365South Korea Department of Plastic and Reconstructive Surgery Wonkwang University HospitalWonkwang University School of MedicineIksan 54538South Korea

Facial defect coverage is a common subject in the field of reconstructive *** are many methods for facial defect reconstruction,and reconstructive surgeons should choose the most appropriate method on a case-by-case basis to achieve both functional and aesthetic *** various options for facial reconstruction,the local flap technique is considered the best reconstructive modality to provide good tissue matches of color and texture,which is consistent with the ideal goal of reconstruction(replacement of like-with-like).Keystone design perforator island flap(KDPIF),devised by Behan in 2003,has been applied to various fields of reconstructive surgery in the past decade due to its design simplicity,robust vascular supply,and *** studies have reported KDPIF reconstruction of facial defects,such as large parotid defects,small-to-moderate nasal defects,and eyelid ***,KDPIF has been used relatively less in facial defects than in other body regions,such as the trunk and *** purpose of this review is to provide an organized overview of facial KDPIF reconstruction including the classification of KDPIF,modifications,physiology,mechanism of flap movement,consideration of facial relaxed skin tension lines and aesthetics,surgical techniques,clinical applications,and precautions for successful execution of KDPIF reconstruction.

关键词： Keystone design perforator island flap Reconstructive surgery Facial defects Aesthetics Plastic surgery Flap surgery

Nomogram for prediction of pathologic complete remission using biomarker expression and endoscopic finding after preoperative chemoradiotherapy in rectal cancer

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Chinese Journal of Cancer Research 2020年第2期32卷 228-241页

作者： Hyuk Hur Min Soo Cho Woong Sub Koom Joon Seok Lim Tae Il kim Joong Bae Ahn Hoguen kim nam kyu kim Division of Colon and Rectal Surgery Department of SurgerySeverance HospitalYonsei University College of MedicineSeoul 03722Korea Department of Radiation Oncology Severance HospitalYonsei University College of MedicineSeoul 03722Korea Departm ent of Radiology Research Institute of Radiological ScienceSeverance HospitalYonsei University College of MedicineSeoul 03722Korea Department of Internal Medicine Institute of Gastroenterology Department of Medical Oncology Severance HospitalYonsei University College of MedicineSeoul 03722Korea Department of Pathology Severance HospitalYonsei University College of MedicineSeoul 03722Korea

Objective:The aim of this study is to develop a nomogram for prediction of pathologic complete remission(p CR)after preoperative chemoradiotherapy(CRT)for rectal ***:m RNA expression levels of seven molecular markers[p53,p21,Ki-67,vascular endothelial growth factor(VEGF),CD133,CD24,CD44]were measured by reverse transcriptase polymerase chain reaction(RTPCR)in 120 rectal *** findings of clinical complete remission(c CR)and biologic variables were used to construct nomogram in the training group(n=80),which was validated in the validation group(n=40).Results:m RNA expression levels of four markers(p53,p21,Ki67,CD133)correlated with p CR(24/80,30.0%)in the training *** expression of p53 and/or high expression of p21,Ki67 and CD133 showed greater p CR rate.p CR was shown in 18(69.2%)of 26 cases showing endoscopic c CR in the training *** p CR rate was demonstrated in lower tumor location than middle tumor(19/49,38.8%vs.5/31,16.1%).A nomogram for prediction of p CR was developed from the multivariate prediction model using these six variables,which showed good discrimination ability in the training group[area under the curve(AUC)=0.945]and validation group(AUC=0.922).The calibration plot showed good agreement between actual and predicted p CR in both patient ***:Nomogram for assessment of p CR can be useful for making treatment decisions after CRT according to predicted responses.

关键词： Rectal cancer chemoradiotherapy treatment response molecular marker endoscopy nomogram

Serum Gamma-glutamyl Transferase Concentration Within the Reference Range is Related to the Coronary Heart Disease Risk Prediction in Korean Men： Analysis of the Korea National Health and Nutrition Examination Survey （V-1, 2010 and V-2, 2011）

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Chinese Medical Journal 2015年第15期128卷 2006-2011页

作者： kyung-Sun Han Doo-Yeoun Cho Young-Sang kim kyu-nam kim Department of Family Practice and Community Health Ajou University School of Medicine 164 Worldcup-Ro Youngtong-Gu Suwon Gyeonggi-Do Republic of Korea Department of Family Medicine Cha University Cha Bundang Medical Center Seongnam Gyeonggi-Do Republic of Korea

Background：Limited data exist on the association of serum gamma-glutamyl transferase （GGT） level within the reference range with the increased risk of coronary heart disease （CHD） prediction in *** study examined the association between serum GGT concentration within the reference range and the CHD risk prediction in Korean ***：The study employed data from Korean National Health and Nutrition Examination Survey （V-1,2010 and V-2,2011） where a total of 1301 individuals were analyzed.A 10-year CHD risk prediction was computed using the Framingham Risk Score （FRS） modified by the National Cholesterol Education Program （NCEP） Adult Treatment Panel Ⅲ （ATP Ⅲ）.Results：Positive correlations were established between log-transformed GGT concentration and FRS （r =0.237,P 〈 0.001）.After adjustment of body mass index,the amount of alcohol intake and low-density lipoprotein-cholesterol,the odds ratio （95% confidence interval） for intermediate risk and beyond of 10-year CHD prediction （10-year risk ≥10%） with lowest quartile of participants was 1.21 （0.78-1.87） for second quartiles,1.39 （0.88-2.21） for third quartiles and 2.03 （1.23-3.34） for highest ***：Higher serum GGT within its reference range was significantly correlated with a 10-year CHD risk prediction estimation using NCEP ATP Ⅲ in Korean men.

关键词： Framingham Risk Score Gamma-glutamyl Transferase Reference Range

Correction of Congenital Symmastia with Macromastia： Report of a Rare Case and Devised Treatment Algorithm

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Chinese Medical Journal 2016年第17期129卷 2134-2136页

作者： kyu nam kim Won Ha Chi Sun Yoon Hoon kim Department of Plastic and Reconstructive Surgery Konyang University Hospital University of Konyang College of Medicine Myunggok Medical Research Center Daejeon 35365 Korea Department of Plastic and Reconstructive Surgery Ulsan University Hospital University of Ulsan College of Medicine Ulsan 44033 Korea

INTRODUCTIONSymmastia is defined as the medial confluence of both breasts or unification of the breasts by soft tissue on the sternum rendering them inseparable. It was first described in the plastic surgery literature by Spence et al. in 1984. Two forms of symmastia exist; acquired and congenital,Acquired symmastia is a very common condition that results as an iatrogenic complication of over-dissecting a pocket, or using implants with a diameter that is too large in proportion to the chest wall during breast augmentation or reconstruction.

关键词： Congenital Lipectomy Mammoplasty Symmastia

Relationship of plasminogen activator inhibitor 1 gene 4G/5G polymorphisms to hypertension in Korean women

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Chinese Medical Journal 2012年第7期125卷 1249-1253页

作者： kyu-nam kim Kwang-min kim Bom-taeck kim nam-seok Joo Doo-yeoun Cho Duck-joo Lee Department of Family Practice and Community Health Ajou University School of MedicineSuwonRepublic of Korea

Background Hypertension （HTN） is a major determinant of various cardiovascular events. Plasma levels of plasminogen activator inhibitor 1 （PAl-l） modulate this risk. A deletion/insertion polymorphism within the PAl-1 loci （4G/4G, 4G/5G, 5G/5G） affects the expression of this gene. The present study investigated the association between PAl-1 loci polymorphisms and HTN in Korean women. Methods Korean women （n=1312） were enrolled in this study to evaluate the association between PAl-1 4G/5G gene polymorphisms and HTN as well as other metabolic risk factors. PAl-1 loci polymorphisms were investigated using polymerase chain reaction amplification and single-strand conformation polymorphism analysis. Results The three genotype groups differed with respect to systolic blood pressure （P=0.043）, and diastolic blood pressure （P=0.009） but not with respect to age, body mass index, total cholesterol, low or high density lipoprotein cholesterol, triglycerides, or fasting blood glucose. Carriers of the PAl-1 4G allele had more hypertension significantly （PAl-1 4G/5G vs. PAl-1 5G/5G, P=0.032; PAl-1 4G/4G vs. PAl-1 5G/5G, P=0.034）. When stratified according to PAl-1 4G/5G polymorphism, there was no significant difference in all metabolic parameters among PAl-1 genotype groups in patients with HTN as well as subjects with normal blood pressure. The estimated odds ratio of the 4G/4G genotype and 4G/5G for HTN was 1.7 （P=0.005）, and 1.6 （P=0.015）, respectively. Conclusion These findings might indicate that PAl-1 loci polymorphisms independently contribute to HTN and that gene-environmental interaction may be not associated in Korean women.

关键词： hypertension plasminogen activator inhibitor 1 polymorphism

Mass-forming ischemic colitis that mimics colon cancer

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Chinese Medical Journal 2020年第10期133卷 1253-1254页

作者： Ho Seung kim Fozan Sauri Jae Hyun Kang nam kyu kim Division of Colorectal Surgery Department of SurgerySeverance HospitalYonsei University College of MedicineSeoul 03722Korea.

To the Editor:Rarely,ischemic colitis can also mimic a carcinoma during colonoscopy and on computed tomography(CT)*** colonoscopy,an ulceration,a submucosal mass,and a narrowed colon segment with an ulcerated mucosa have all been described as mimicking this kind of *** reports have documented this type of mass-forming ischemic colitis variant.[1-4]Here,we described two patients with ischemic colitis who presented with lesions mimicking colon cancer.

关键词： colon cancer. colitis

Magnetic resonance imaging based rectal cancer classification: Landmarks and technical standardization

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World Journal of Gastroenterology 2015年第2期21卷 423-431页

作者： Sami Alasari Daero Lim nam kyu kim Department of General Surgery Section of Colorectal Surgery at Yonsei UniversitySeverance HospitalSeoul 120-527South Korea

Rectal cancer classification is important to determine the preoperative chemoradiation therapy and to select appropriate surgical technique. We reviewed the Western and Japanese rectal cancer classification and we propose our new classification based of Magnetic resonance imaging(MRI). We determine the relation of the tumor to fixed parameters in MRI, which areperitoneal reflection and levator ani muscle. Then, we classify the rectal cancer into four levels based on tumor distal margin and invasion to MRI parameters. We applied all three classifications to 60 retrospectively collected patients of different rectal cancer distance and we compared our classifications to the others. Based on each level we standardize our surgical approach. For stages Ⅰ-Ⅲ, We found that level Ⅰ where tumor distal margin is located above the peritoneal reflection and all of them were received low anterior resection(LAR) without chemoradiation. Level Ⅱ where tumor distal margin is located from the peritoneal reflection and above the levator ani insertion on the rectum. 90% of them were received LAR ± chemoradiation. Level Ⅲ where tumor distal margin is located at the level of levator ani insertion or invading any part of the levator ani. 60% of them had ULAR + coloanal anastomosis ± chemoradiation. Level Ⅳ where the tumor distal margin is located below the levator ani insertion; 77% were received APR ± chemoradiation. The overall kappa for all levels between surgeons and radiologist was 0.93(95%CI: 0.87-0.99), which is indicating almost perfect agreement. We concluded that the management of rectal tumors differed among each tumor level and our new MRI based classification might facilitate the prediction of surgical and chemoradiation management with better communication among a multidisciplinary team comparing to other classifications.

关键词： Rectal cancer Rectal classification Surgical appro