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Anti-inflammatory potential of human corneal stroma-derived stem cells determined by a novel in vitro corneal epithelial injury model

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World Journal of Stem Cells 2019年第2期11卷 84-99页

作者： mariana Lizeth Orozco morales nagi m marsit Owen D mcIntosh Andrew Hopkinson Laura E Sidney Academic Ophthalmology Division of Clinical Neuroscience University of Nottingham

BACKGROUND An in vitro injury model mimicking a corneal surface injury was optimised using human corneal epithelial cells(hCEC).AIm To investigate whether corneal-stroma derived stem cells(CSSC) seeded on an amniotic membrane(Am) construct manifests an anti-inflammatory, healing *** Treatment of hCEC with ethanol and pro-inflammatory cytokines were compared in terms of viability loss, cytotoxicity, and pro-inflammatory cytokine release, in order to generate the in vitro injury. This resulted in an optimal injury of 20%(v/v) ethanol for 30 s with 1 ng/mL interleukin-1(IL-1) beta. Co-culture experiments were performed with CSSC alone and with CSSC-Am *** effect of injury and co-culture on viability, cytotoxicity, IL-6 and IL-8 production, and IL1 B, TNF, IL6, and CXCL8 mRNA expression were *** Co-culture with CSSC inhibited loss of hCEC viability caused by injury. Enzyme linked immunosorbent assay and polymerase chain reaction showed a significant reduction in the production of IL-6 and IL-8 pro-inflammatory cytokines, and reduction in pro-inflammatory cytokine mRNA expression during co-culture with CSSC alone and with the Am construct. These results confirmed the therapeutic potential of the CSSC and the possible use of Am as a cell carrier for application to the ocular *** CSSC were shown to have a potentially therapeutic anti-inflammatory effectwhen treating injured hCEC, demonstrating an important role in corneal regeneration and wound healing, leading to an improved knowledge of their potential use for research and therapeutic purposes.

关键词： Cornea Corneal injuries Injury model epithelium stromaderived stem cells Amnion Anti-inflammatory Cell therapy

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Generation of rogue waves at model scale

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Journal of Ocean Engineering and Science 2019年第2期4卷 100-112页

作者： Bailey Groves nagi Abdussamie National Centre for maritime Engineering and Hydrodynamics Australian Maritime CollegeUniversity of TasmaniaLauncestonTasmaniaAustralia

The study of rogue waves is becoming increasingly important,as the offshore oil and gas,as well as renewable energy industries,*** unpredictability of such disastrous waves poses a significant risk to floating and fixed structures,making it necessary to develop methods capable of recreating rogue waves for model testing *** this paper,an investigation into the useability of the NewWave theory,a theoretical formula for producing focused waves,was conducted in model test facilities with a *** numerical modelling of rogue waves was performed using mATLAB codes developed to create several types of wave *** success of the numerical generation of design rogue waves was dependent on the number of wave components used during construction such that a suitable rogue wave(H max/H s>2.0)could be created using 400 or more *** was found that the NewWave technique could construct and physically generate design rogue waves within a close range of the predicted height provided the main wavemaker stroke was smooth enough(at around 0.8 s trough-crest for the tested model scale).The measured rogue waves were found to be complex;highly non-linear in amplitude with the behaviour of up to the 3rd ***,it was observed that rogue waves,created based on a 100-year sea state,were very similar to the New Year Wave confirming that such extreme waves,approximately 25-27 m high at full scale,can indeed occur in severe sea states.

关键词： Rogue waves Numerical modelling Design rogue waves model testing New Year Wave

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multi-component synthesis of methylene bis isoxazolo[4,5-b]-pyridine-N-oxides

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Chinese Chemical Letters 2010年第8期21卷 927-930页

作者： E.Rajanarendar m.nagi Reddy K.Rama murthy Department of Chemistry Kakatiya University

A three component one-pot protocol was investigated for the synthesis of methylene bis isoxazolo[4,5-b]-pyridine-N-oxides from commercially available materials.

关键词： multi-component synthesis Knoevenagel condensation michael addition New methodology

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Finding the needle in a haystack - A proteomic study of brassinosteroid signal transduction

Finding the needle in a haystack - A proteomic study of bras...

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中国科学院植物分子生物学前沿国际研讨会

作者： Srini S.Gampala Joshua m.Gendron nagi Suzuki Robert Chalkley Burlingame Al Department of Plant Biology Carnegie Institution StanfordCA 94305 Department of Plant Biology Carnegie Institution StanfordCA 94305 Department of Pharmaceutical Chemistry University of California San FranciscoCA 94143 Department of Pharmaceutical Chemistry University of California San FranciscoCA 94143 Department of Pharmaceutical Chemistry University of California San FranciscoCA 94143

＜正＞Brassinosteroid （BR） plays important roles in a wide range of plant developmental and physiological processes. molecular genetic studies have shown that BR is perceived by the cell surface receptor-like kinase BRI1, and that the downstream signal transduction involves the receptor-like kinase BAK1, the GSK3-like kinase BIN2, and the nuclear transcription factors of the BZR family. BR binding to the extracellular domain of BRI1 activates the BRI1 kinase activity and induces BRI1-BAK1 dimerization and BAK1

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Fabella Syndrome: A Typical Case of misdiagnosis and Discussion

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Case Reports in Clinical medicine 2019年第9期8卷 258-273页

作者： mohammed H. Karrar Alsharif Juman m. Almasaad nagi m. Bakhit Khalid m. Taha mohammed I. Eltahir mamoun A. Alfaki Abubaker Y. Elamin mohammed A. Noureddin Department of Basic medical Science College of Medicine Prince Sattam Bin Abdulaziz University Al Kharj KSA Department of Histology & Embryology Medical Faculty Ondukuz Mayis University Samsun Turkey Department of Anatomy Faculty of Medicine National University Khartoum Sudan College of medicine King Saud Bin Abdulaziz for Health Sciences University Jeddah KSA Department of Anatomy Faculty of Medicine El Deain University El Deain Sudan Department of Anatomy Faculty of Medicine University of Science and Technology Khartoum Sudan Department of Anatomy Faculty of Medicine University of Bahri Khartoum Sudan Department of medicine College of Medicine Prince Sattam Bin Abdulaziz University Al Kharj KSA

Background: Fabella is a natural occurring sesamoid bone, cartilage or a mixture of both that is usually located at the posterolateral corner (PLC) of the knee [1]. Recently the PLC of the knee has been extensively investigated because it is a common site of injuries and diseases [2] [3]. The complexity of PLC anatomy needs to be fully understood because the fabella could be missed diagnosis as an osteochondral defect, osteochondritis dissecans (OCD), calcific tendinitis, or foreign body. We present a case report of fabella syndrome triggered by trauma and also performed a review of literature for the various diagnoses that might be confused with fabella syndrome. Case presentation: A 29-year-old, Sudanese male presented to the trauma center in King Khalid Hospital in KSA, complaining of pain and partial swelling in his left knee joint due to trauma. Fabella was detected in the posterior lateral corner (PLC) of the knee joint embedded in the lateral head of the gastrocnemius muscle. All other pathological conditions were excluded. Conclusion: Fabella is sesamoid bone with variable size, found in the PLC. Commonly if present it causes periodic pain especially in the fully extended knee or it remains asymptomatic. Trauma, surgery, sports or heavy extreme activities may trigger the pain of asymptomatic fabella. Clinicians should consider that pain in the PLC of the knee can result from the presence of the fabella in a condition called fabella syndrome.

关键词： Fabella Syndrome Sesamoid Bone Osteochondral Defect Osteochondritis Dissecans Calcific Tendinitis Foreign Body

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