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Liquid biopsies in primary and secondary bone cancers

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Cancer Drug Resistance 2022年第3期5卷 541-559页

作者： Argia Ucci nadia Rucci Marco Ponzetti Department of Biotechnological and Applied Clinical Sciences University of L’AquilaL’Aquila 67100Italy

Liquid biopsies are a powerful tool to non-invasively analyze tumor phenotype and progression as well as drug *** the bone oncology field,liquid biopsies would be particularly important to develop,since standard biopsies can be very painful,dangerous(e.g.,when found in proximity to the spinal cord),and hard to *** this review,we explore the recent advances in liquid biopsies in both primary(osteosarcoma and Ewing sarcoma)and secondary bone cancers(breast,prostate,and lung cancer-induced bone metastases),presenting their current role and highlighting their unexpressed potential,as well as the barriers limiting their possible adoption,including costs,scalability,reproducibility,and isolation *** discuss the use of circulating tumor cells,cell-free circulating tumor DNA,and extracellular vesicles for the purpose of improving diagnosis,prognosis,evaluation of therapy resistance,and driving therapy decisions in both primary and secondary bone malignancies.

关键词： Liquid biopsy bone metastasis osteosarcoma Ewing sarcoma extracellular vesicles minimal residual disease drug resistance

On the Combination of Silica Fume and Ceramic Waste for the Sustainable Production of Mortar

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Fluid Dynamics & Materials Processing 2023年第5期19卷 1083-1090页

作者： Zine El Abidine Rahmouni Mekki Maza nadia Tebbal Messaouda Belouadah Civil Engineering Department Faculty of TechnologyM’sila UniversityM’sila28000Algeria Institute of Technical Urban Management M’sila UniversityM’sila28000Algeria

The combined use of silica fume(SF)and ceramic waste(CW)for the production of mortar is *** is replaced by 5%,10%,15%and 20%of CW while a fixed 5%percentage(%wt of cement)of SF is *** results show that the best results are obtained by using silica fume and ceramic waste sand with 15%weight of sand and 5%wt of *** the addition of sand ceramic waste(SCW),the mortar compressive strength and density increase,while the porosity displays an opposite *** experimental analysis is complemented with theoretical considerations on the matrix strength and related improvements in mechanical *** is shown that the agreement between the experimental values and the estimated values is good.

关键词： Mortar silica fume ceramic waste full factorial arrangement mechanical properties

Observational study to assess pregnant women's knowledge and behaviour related to toxoplasmosis in Essaouira province, Morocco

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Asian Pacific Journal of Tropical Medicine 2019年第2期12卷 87-90页

作者： nadia Ouzennou Samia Boussaa Safa Ben Alla Ali Boumezzough ISPITS-Higher Institute of Nursing and Health Technology Ecology and the Environment Laboratory L2E(URAC 32 CNRST ERACNERS 06) Faculty of Sciences Semlalia Cadi Ayyad University

Objective: To assess knowledge and behaviour related to toxoplasmosis which remains a neglected disease in ***: Observational investigations were conducted among 600 pregnant women from Essaouira *** interview items covered respondents' knowledge of the disease, its preventive practices and risk ***: A total of 22/600 women had already carried out the anti-toxoplasmosis test, while, 96% have never done any screening of anti-Toxoplasma *** 16/600 women have good information about the disease, its mode of transmission and its complications in both the fetus and his *** most women adopt a healthy diet, the consumption of raw or undercooked meat is far to be considered as a risk factor, along with other potential factors that may foster the acquisition of the disease, such as possessing a domestic cat, educational status and knowledge of the ***, in this study, contact with soil was revealed the most important risk factor(P = 0.045), followed by the hygiene conditions after handling raw meat(P = 0.048).Conclusion: The underestimation of the Toxoplasma gondii sero-prevalence in Essaouira Province can be explained by the absence of toxoplasmosis serology in health institutions, as well as the gap of knowledge about the disease by local population.

关键词： Toxoplasmosis Knowledge Risk behaviour Pregnant women Morocco

Double inferior vena cava does not complicate para-aortic nodal dissection for the treatment of pancreatic carcinoma

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Hepatobiliary & Pancreatic Diseases International 2012年第2期11卷 220-222页

作者： nadia Peparini Roberto Luca Meniconi Gianfranco Fanello Piero Chirletti Department of Surgical Sciences La Sapienza University viale del Policlinico 155-00161 RomeItaly

Duplication of the inferior vena cava(IVC) involves large veins on both sides of the aorta that join anteriorly at the level of the renal arteries to become the suprarenal *** report CT scan and intraoperative images of a patient with duplication of the IVC who underwent pancreaticoduodenectomy with para-aortic lymphadenectomy for carcinoma of the pancreatic head:nodal dissection along the left caval vein was not carried *** anatomical background of the lymphatic flow to the para-aortic lymph nodes and the theoretic basis for lymph node dissection of the para-aortic area in cases of double IVC are *** along the left caval vein is not necessary in patients with double IVC who undergo pancreaticoduodenectomy with extended lymphadenectomy for carcinoma of the pancreatic head in the absence of preoperative appearance of para-aortic disease.

关键词： vena cava,inferior lymph node excision pancreatic neoplasms

Current status of the efficacy and effectiveness of albendazole and mebendazole for the treatment of Ascaris lumbricoides in North-Western Indonesia

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Asian Pacific Journal of Tropical Medicine 2012年第8期5卷 605-609页

作者： Inke nadia Diniyanti Lubis Syahril Pasaribu Chairuddin Panusunan Lubis Department of Paediatrics School of MedicineUniversity of North SumateraMedanIndonesia

Objective:To investigate the efficacy and effectiveness of albendazole and mebendazole in the treatment of Ascaris lumbricoides(***) in the North-Western ***: 229 primary school children who were positive for *** in their stool were recruited in the study.123 children received single-dose of 400 mg albendazole and 106 children received single-dose 500 mg of *** 1 week,their stools were examined for the cure rate (CR) and egg reduction rate(ERR).Egg culture was also performed and observation was made on week-1,-3,-***:have shown a non-significant difference in CR 96.7%vs.100%:and ERR of 99.3%vs.100.0%for albendazole and mebendazole groups respectively(P>0.05).In-vitro egg culture has shown trends of decrease in the percentage of the unfertilized eggs and in≥2 cell eggs in both treatment groups(P<0.05).The embryonated eggs from the albendazole groups has shown an increase from 7.3%on week-1 to 13.8%on week-4,whilst the mebendazole group has shown a constant increase during the whole 4 weeks of culture from 7.5%to 28.3%(P<0.01). Conclusions:No evidence of drug resistance is noted so far from the area of North-Western part of *** addition,although both drugs showed incomplete ovicidal effects,single-dose albendazole is better than mebendazole in sterilizing *** eggs.

关键词： Ascaris lumbricoides Albendazole Mebendazole Drug resistance

Diabetes in French Guiana,adapting national standards of therapeutic education and care to the amazonian challenge

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World Journal of Diabetes 2021年第2期12卷 98-107页

作者： nadia Sabbah Gabriel Carles Magalie Demar Mathieu Nacher Endocrinology Diabetology Nutrition Centre Hospitalier Andree RosemonCayenne 97300French Guiana Department of Obstetrics and Gynaecology Centre Hospitalier Franck JolySt Laurent Du Maroni 97320French Guiana Department of Laboratory University of French GuianaCayenne 97300French Guiana Department of Medicine COREVIH Centre Hospitalier Andree RosemonCayenne 97300French Guiana

French Guiana is a territory located more than 7000 km from *** is also the largest French territory,with almost 84000 km2 and 90%of it is covered by *** municipalities are isolated due to the scarcity of transportation and the poor road *** population is extremely diverse ethnically and culturally,and includes more than thirty ethnic *** is high because it is one of the richest countries in the area bordering northern Brazil,Suriname,Guyana,and as a result of socio-economic crises in some other countries such as Haiti,and it has permeable natural *** and obesity,are emerging issues,with double the prevalence of Mainland France,whereas infectious diseases,such as HIV,take second *** and educational management are challenging because they require the adaptation of tools and treatments to the multiculturalism and precariousness often encountered in these *** French and European recommendations are unsuited to the needs of the territory and must take into account the epidemiological,sociological and cultural parameters of these populations in order to provide appropriate and graded management of diabetes in the French Amazon.

关键词： French Guiana Diabetes mellitus Ethnicity Consensus workshops Poverty Immigration

L-Moments Based Calibrated Variance Estimators Using Double Stratified Sampling

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Computers, Materials & Continua 2021年第9期68卷 3411-3430页

作者： Usman Shahzad Ishfaq Ahmad Ibrahim Mufrah Almanjahie nadia H.Al–Noor Department of Mathematics and Statistics International Islamic UniversityIslamabad44000Pakistan Department of Mathematics and Statistics PMAS-Arid Agriculture UniversityRawalpindi46300Pakistan Department of Mathematics College of ScienceKing Khalid UniversityAbha62529Saudi Arabia Statistical Research and Studies Support Unit King Khalid UniversityAbha62529Saudi Arabia Department of Mathematics College of ScienceMustansiriyah UniversityBaghdad10011Iraq

Variance is one of the most vital measures of dispersion widely employed in practical aspects.A commonly used approach for variance estimation is the traditional method of moments that is strongly influenced by the presence of extreme values,and thus its results cannot be relied *** momentum from Koyuncu’s recent work,the present paper focuses first on proposing two classes of variance estimators based on linear moments(L-moments),and then employing them with auxiliary data under double stratified sampling to introduce a new class of calibration variance estimators using important properties of L-moments(L-location,L-cv,L-variance).Three populations are taken into account to assess the efficiency of the new *** first and second populations are concerned with artificial data,and the third populations is concerned with real *** percentage relative efficiency of the proposed estimators over existing ones is *** the presence of extreme values,our findings depict the superiority and high efficiency of the proposed classes over traditional ***,when auxiliary data is available along with extreme values,the proposed classes of estimators may be implemented in an extensive variety of sampling surveys.

关键词： Variance estimation L-moments calibration approach double sampling stratified random sampling

Effect of vitamin D treatment in children with attention-deficit hyperactivity disorder

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World Journal of Pediatrics 2019年第1期15卷 78-84页

作者： nadia Dehbokri Gholamreza Noorazar Aida Ghaffari Gita Mehdizadeh Parvin Sarbakhsh Saba Ghaffary Faculty of Pharmacy Tabriz University of Medical SciencesTabrizIran Research Center of Psychiatry and Behavioral Sciences Tabriz University of Medical SciencesTabrizIran Pediatrics Health Research Center Tabriz University of Medical SciencesTabrizIran Road Traffic Injury Research Center Tabriz University of Medical SciencesTabrizIran Department of Pharmacotherapy Drug Applied Research CenterTabriz University of Medical SciencesTabrizIran

Background In this research the symptom improvement of attention-deficit hyperactivity disorder (ADHD) of children was assessed by oral vitamin D administration in Tabriz,*** In this double-blind,randomized clinical trials,96 children (2-18 years) were enrolled to placebo and vitamin D *** took vitamin D pearl (50,000 IU/week) or placebo for 6 ***,who had the change in methylphenidate dosage and received any anticonvulsants and corticosteroids were excluded from the *** symptoms were diagnosed by Conners parent rating scale (CPRS) test at baseline and after *** Conners divided into inattention (IA),hyperactivity/impulsivity (H/I) and combination type (C) *** D serum level was assessed at baseline and after 8 weeks in both *** The differences between CPRS and its subscales were not significant at baseline (P > 0.05).The Conners IA score was decreased in vitamin D group (P < 0.05;adjusted with age and baseline values).ADHD Conners and all subscale scores reduced remarkably after intervention in patients with insufficient level of vitamin D compared to placebo (P < 0.05).Conclusions Oral vitamin D improved ADHD symptoms with a particular effect on inattention *** addition,symptoms related to all subscales were improved remarkably in patients with insufficient level of vitamin *** D treatment in children with ADHD could be considered due to the expand benefit of vitamin D in body.

关键词： Attention-deficit hyperactivity disorder Children Conners parent rating scale Vitamin D

X-ray Structure and Density Functional Theory Investigations of 4-((2R)-2-(3,4-dibromophenyl)-1-fluoro cyclopropyl)-N-(o-tolyl)benzamide Compound

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Chinese Journal of Structural Chemistry 2020年第9期39卷 1601-1614,1554页

作者： BENELHADJ-DJELLOUL Yamina BOUKABCHA Nourdine BENHALIMA nadia YAHIAOUI Salem CHOUAIH Abdelkader ZANOUN Abdelouahab Laboratory of Technology and Solid Properties(LTPS) Abdelhamid Ibn Badis University of MostaganemMostaganem 27000Algeria Département de Génie des Procédés UniversitéAhmed Zabana de RelizaneRelizane 48000Algeria Département de Physique Facultédes SciencesUniversitéDr.Moulay Tahar de SaidaSaida 20000Algeria Ecole Normale Supérieure de Mostaganem Mostaganem 27000Algeria

In this work,the structure of 4-((2R)-2-(3,4-dibromophenyl)-1-fluorocyclopropyl)-N-(o-tolyl)benzamide(DBFB)has been determined at room temperature using single-crystal X-ray diffraction *** structure of the compound was solved using 1464 observed reflections with I≥2σ(I).It crystallizes in monoclinic space group P21 with a=20.0820(10),b=10.2770(10),c=4.860(2)?,β=95.9600(10)°,V=997.6(4)?3,Z=2,Dc=1.675 g/m3,F(000)=500,Μr=503.18,μ=4.09 mm-1 and the final R=*** molecular packing of the title compound exhibits C–H???O and C–H???F hydrogen bonds forming a supramolecular ***,conformational analysis has been performed in order to confirm the most stable conformer of the title *** parameters of the keto conformer in the ground state have been obtained using density functional theory(DFT)method with B3LYP/6-31G(d,p)level of *** general,a good agreement between the calculated and experimental results was *** normal modes of vibration,molecular boundary orbitals(HOMO and LUMO),reactivity descriptors,Mullikan atomic charges and molecular electrostatic potential for the title compound have been evaluated and discussed.

关键词： C23H18Br2FNO insecticide crystal structure DFT HOMO-LUMO