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Neuroprotective role of Noggin in spinal cord injury

Neural Regeneration Research 2023年第3期18卷 492-496页

作者： nadia Al-Sammarraie Mohammed Mahmood Swapan K.Ray Department of Pathology Microbiologyand ImmunologyUniversity of South Carolina School of MedicineColumbiaSCUSA

Spinal cord injury is one of the leading causes of morbidity and mortality among young adults in many countries including the United *** in the regeneration of neurons is one of the main obstacles that leave spinal cord injury patients with permanent paralysis in most *** research has found that preventing acute and subacute secondary cellular damages to the neurons and supporting glial cells can help slow the progression of spinal cord injury pathogenesis,in part by reactivating endogenous regenerative proteins including Noggin that are normally present during spinal cord *** is a complex protein and natural inhibitor of the multifunctional bone morphogenetic proteins,and its expression is high during spinal cord development and after induction of spinal cord *** this review article,we first discuss the change in expression of Noggin during pathogenesis in spinal cord ***,we discuss the current research knowledge about the neuroprotective role of Noggin in preclinical models of spinal cord ***,we explain the gap in the knowledge for the use of Noggin in the treatment of spinal cord *** results from extensive in vitro and in vivo research have revealed that the therapeutic efficacy of Noggin treatment remains debatable due to its neuroprotective effects observed only in early phases of spinal cord injury but little to no effect on altering pathogenesis and functional recovery observed in the chronic phase of spinal cord ***,clinical information regarding the role of Noggin in the alleviation of progression of pathogenesis,its therapeutic efficacy,bioavailability,and safety in human spinal cord injury is still lacking and therefore needs further investigation.

关键词： apoptosis astrocyte differentiation axon myelination axon regeneration bone morphogenetic protein glial scar heterotrophic ossification neurogenesis neuropathic pain Noggin spinal cord injury

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Effect of nettle(Urtica dioica) extract on gentamicin induced nephrotoxicity in male rabbits

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Asian Pacific Journal of Tropical Biomedicine 2015年第9期5卷 729-732页

作者： nadia Abdulkarim Salih Pharmacology Department of Basic Sciences College of Veterinary Medicine University of Sulaimani

Objective:To investigate the antioxidant ef ect of an orally administered ethanol extract of nettle(Urtica dioica) and its protective role in preventing or ameliorating oxidative stress as a major factor in gentamicin-induced nephrotoxicity in male rabbits. Methods: Twenty rabbits were divided into 4 equal groups:(G1) control group,(G2) gentamicin treated group(100 mg/kg),(G3) nettle treated group(100 mg/kg),(G4) combination treated group with both gentamicin(100 mg/kg) and nettle(100 mg/kg) for 10 days. The antioxidant properties of nettle were evaluated using dif erent antioxidant tests, such as determination of glutathione and malondialdehyde levels and total phenolic content analysis. Results: Biochemical and histopathological study revealed that gentamicin caused nephrotoxicity observed clearly in the histopathological section of the kidney in the gentamicin treated group. Serum creatinine and blood urea nitrogen were biochemical indicators for nephrotoxicity which increased signii cantly in gentamicin treated group; other groups have no signii cant change in these two parameters. Nettle extract protected the rabbits from alteration in the level of blood urea nitrogen and serum creatinine when given after inducing of gentamicin nephrotoxicity. The nettle treated group showed a great ef ect as an antioxidant factor by increasing the glutathione level and reducing malondialdehyde level. No signii cant changes in biochemical parameters and no renal histopathological changes observed in the groups treated with nettle extract, which meant nettle had powerful antioxidant activity. Conclusions: Therefore, it can be assumed that the nephroprotective ef ect shown by nettle in gentamicin-induced nephrotoxicity can reserve intracellular levels of biological pathways and supportively enhance excretion of toxic levels of gentamicin.

关键词： Antioxidant activity Nettle Urtica dioica Gentamicin Herbal medicine Histopathological study and nephrotoxicity

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The differential benefit of laparoscopic over open minor liver resection for lesions situated in the anterolateral or posterosuperior segments

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Hepatobiliary Surgery and Nutrition 2024年第4期13卷 604-615,I0015-I0021页

作者： Jasper P.Sijberden Guido Fiorentini Jacopo Lanari Davit Aghayan Daniel Osei-Bordom nadia Russolillo Arjun Takhar Andrea Benedetti Cacciaguerra Santi Lopez-Ben Mathieu D’Hondt Felice Giuliante David Fuks Fernando Rotellar Andrea Ruzzenente Adnan Alseidi Mikhail Efanov Burak Görgec Giuseppe Zimmitti Enrico Gringeri Federica Cipriani Åsmund Avdem Fretland Ravi Marudanayagam Marco Vivarelli John N.Primrose Alessandro Ferrero Robert P.Sutcliffe Bjørn Edwin Umberto Cillo Marc G.Besselink Mohammad Abu Hilal Luca A.Aldrighetti Department of Surgery Fondazione Poliambulanza Istituto OspedalieroBresciaItaly Amsterdam UMC location University of Amsterdam Department of SurgeryAmsterdamthe Netherlands Cancer Center Amsterdam Amsterdamthe Netherlands Hepatobiliary Surgery Division IRCCS San Raffaele HospitalMilanItaly Department of Surgical Oncological and Gastroenterological SciencesGeneral Surgery 2Hepatobiliary Surgery and Liver TransplantationPadua University HospitalPaduaItaly The Intervention Centre and Department of HPB Surgery Oslo University Hospital and Institute of Clinical MedicineUniversity of OsloOsloNorway Department of Surgery Ringerike HospitalVestre Viken Hospital TrustDrammenNorway Liver Unit Queen Elizabeth HospitalBirminghamUK Department of General and Oncological Surgery Umberto I Mauriziano HospitalLargo TuratiTurinItaly Department of Surgery University Hospital Southampton NHS Foundation TrustSouthamptonUK Hepatobiliary and Abdominal Transplantation Surgery Department of Experimental and Clinical MedicineRiuniti HospitalPolytechnic University of MarcheAnconaItaly Servei de Cirurgia General i Digestiva Hospital Doctor Josep Trueta de GironaGironaCataloniaSpain Department of Digestive and Hepatobiliary/Pancreatic Surgery Groeninge HospitalKortrijkBelgium Chirurgia Epatobiliare UniversitàCattolica del Sacro Cuore-IRCCSRomeItaly Department of Digestive Oncologic and Metabolic SurgeryInstitut Mutualiste MontsourisUniversitéParis DescartesParisFrance HPB and Liver Transplantation Unit Department of SurgeryUniversity ClinicUniversidad de NavarraNavarraSpain Institute of Health Research of Navarra(IdisNA) PamplonaSpain Department of Surgery University of VeronaVeronaItaly Department of Surgery Virginia Mason Medical CenterSeattleWAUSA Department of Surgery University of California San FranciscoSan FranciscoCAUSA Department of Hepato-Pancreato-Biliary Surgery Moscow Clinical Research CentreMoscowRussia

Background:It is well known that laparoscopic liver surgery can offer advantages over open liver surgery in selected ***,what type of procedures can benefit most from a laparoscopic approach has been investigated poorly thus *** aim of this study is thus to define the extent of advantages of laparoscopic over open liver surgery for lesions in the anterolateral(AL)and posterosuperior(PS)***:In this international multicentre retrospective cohort study,laparoscopic and open minor liver resections for lesions in the AL and PS segments were compared after propensity score *** differential benefit of laparoscopy over open liver surgery,calculated using bootstrap sampling,was compared between AL and PS resections and expressed as a Delta of the ***:After matching,3,040 AL and 2,336 PS resections were compared,encompassing open and laparoscopic procedures in a 1:1 *** and PS laparoscopic liver resections were more advantageous in comparison to open in terms of blood loss,transfusion rate,complications,and length of ***,AL resections benefitted more from laparoscopy than PS in terms of overall and severe complications(D-difference were 4.8%,P=0.046 and 3%,P=0.046)and blood loss(D-difference was 195 mL,P<0.001).Similar results were observed in the subset for high-volume centres,while in recent years no significant differences were found in the differential benefit between AL and PS ***:The advantage of laparoscopic over open liver surgery is greater in the AL segments than in the PS segments.

关键词： Liver neoplasms hepatectomy laparoscopic liver resection open liver resection

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Design Principles-Based Interactive Learning Tool for Solving Nonlinear Equations

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Computer Systems Science & Engineering 2022年第3期40卷 1023-1042页

作者： Ahad Alloqmani Omimah Alsaedi nadia Bahatheg Reem Alnanih Lamiaa Elrefaei Computer Sciences Department Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddahSaudi Arabia Electrical Engineering Department Faculty of Engineering at ShoubraBenha UniversityCairoEgypt

Interactive learning tools can facilitate the learning process and increase student engagement,especially tools such as computer programs that are designed for human-computer ***,this paper aims to help students learn five different methods for solving nonlinear equations using an interactive learning tool designed with common principles such as feedback,visibility,affordance,consistency,and *** also compares these methods by the number of iterations and time required to display the *** study helps students learn these methods using interactive learning tools instead of relying on traditional teaching *** tool is implemented using the MATLAB app and is evaluated through usability testing with two groups of users that are categorized by their level of experience with *** with no knowledge in root-finding confirmed that they understood the root-finding concept when interacting with the designed *** positive results of the user evaluation showed that the tool can be recommended to other users.

关键词： Graphical user interface(GUI) interactive learning tool design principles nonlinear equations experimental design

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Alginate oligosaccharides preparation, biological activities and their application in livestock and poultry

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Journal of Integrative Agriculture 2021年第1期20卷 24-34页

作者： LIU Ming LIU Lei ZHANG Hong-fu YI Bao nadia EVERAERT State Key Laboratory of Animal Nutrition Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijing 100193P.R.China Precision Livestock and Nutrition Unit Gembloux Agro-BioTechUniversity of LiegeGembloux 5030Belgium Beijing China-Agri Hong Ke Bio-Technology Co. Ltd.Beijing 102206P.R.China

Alginate oligosaccharides(AOS), belonging to the class of functional marine oligosaccharides, are low-molecular polymers linked by β-1,4-mannuronic acid(M) and α-1,4-guluronic acid(G), which could be classically obtained by enzymatic hydrolysis of alginate. With low viscosity and good water solubility, as well as anti-oxidant, immune regulation, anti-bacterial and antiinflammatory activities, AOS have been widely used in medical science and functional food, green agriculture and other fields. As new bio-feed additives, AOS have broad potential applications in animal husbandry. In this review, the sources of alginate, chemical structure and preparation methods of AOS, and their biological activities and application in livestock and poultry are summarized. We expect this review could contribute to lay a foundation of application and further research for AOS in livestock and poultry.

关键词： alginate oligosaccharides preparation anti-oxidant immune livestock and poultry

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Ag-Co3O4：Synthesis,characterization and evaluation of its photo-catalytic activity towards degradation of rhodamine B dye in aqueous medium

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Chinese Journal of Chemical Engineering 2018年第6期26卷 1264-1269页

作者： Muhammad Saeed Majid Muneer Nida Mumtaz Mohsin Siddique nadia Akram Muhammad Hamayun Department of Chemisny Government College University Faisalabad Pakistan Department of Chemistry Bacha Khan University Charsadda Pakistan Department of Chemistry University of Gujrat Hafiz Hayat Campus Gujrat Pakistan

Synthesis,characterization of Co_3O_4 and Ag-Co_3O_4 composites and evaluation of their photo-catalytic activities towards photo-degradation of aqueous solution of rhodamine B dye under irradiation of visible light have been described in this ***_3O_4 was prepared by solid phase mechano chemical process using Co(NO_3)_2·6H_2O and NH_4 HCO_3 as precursor *** was deposited on Co_3O_4 from AgNO_3 using Calotropis gigantea extract as reducing ***,SEM and FTIR were used for characterization of prepared ***-catalytic efficiencies of as-prepared Co_3O_4 and Ag-Co_3O_4 were evaluated for aqueous phase photo-degradation of rhodamine *** was found that deposition of Ag on Co_3O_4 highly enhanced the photo-catalytic activity of Co_3O_***-catalytic degradation followed the Eley–Rideal *** 100% and 91% photo-degradation of 40 ml dye solution achieved at 313 K in 90 and 120 min over 0.05 g of Ag-Co_3O_4 as photo-catalyst using 100 and 200 mg·L^(-1) as initial concentration of dye respectively.

关键词： Co3O4 Ag-Co3O4 Photo-catalysis Photo-degradation Calotropis gigantea Rhodamine B Elay–Rideal mechanism

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Feed supplementation with arginine and zinc on antioxidant status and inflammatory response in challenged weanling piglets

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Animal Nutrition 2017年第3期3卷 236-246页

作者： nadia Bergeron Claude Robert Frédéric Guay Département des sciences animales Université Laval

Although supplementing the diet with zinc oxide and arginine is known to improve growth in weanling piglets, the mechanism of action is not well understood. We measured the antioxidant status and inflammatory response in 48 weanling castrated male piglets fed diets supplemented with or without zinc oxide(2,500 mg Zn oxide per kg) and arginine(1%) starting at the age of 20 days. The animals were injected with lipopolysaccharide(100 μg/kg) on day 5. Half of them received another injection on day *** samples were taken just before and 6, 24 and 48 h after injection and the mucosa lining the ileum was recovered following euthanizing on days 7 and 14. Zinc supplementation increased reduced and total glutathione(GSH)(reduced and total) during days 5 to 7 and arginine decreased oxidized GSH measured on days 5 and 12 and the ratio of total antioxidant capacity to total oxidative status during days12 to 14. Zinc decreased plasma malondialdehyde measured on days 5 and 12 and serum haptoglobin measured on day 12 and increased both metallothionein-1 expression and total antioxidant capacity measured in the ileal mucosa on day 14. Tumour necrosis factor a concentration decreased from days 5 to12(all effects were significant at P < 0.05). This study shows that the zinc supplement reduced lipid oxidation and lipopolysaccharide-induced inflammation during the post-weaning period, while the arginine supplementation had only a limited effect.

关键词： Antioxidant Inflammation Zinc Arginine Piglet Weanling

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Invariant of Enhanced AES Algorithm Implementations Against Power Analysis Attacks

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Computers, Materials & Continua 2022年第7期72卷 1861-1875页

作者： nadia Mustaqim Ansari Rashid Hussain Sheeraz Arif Syed Sajjad Hussain Department of Electronic Engineering Dawood University of Engineering&TechnologyKarachiPakistan Faculty of Engineering Sciences and Technology Hamdard UniversityKarachiPakistan Faculty of Information Technology Salim Habib UniversityKarachiPakistan Faculty of Computer Sciences SZABISTKarachiPakistan

The security of Internet of Things(IoT)is a challenging task for researchers due to plethora of IoT *** Channel Attacks(SCA)are one of the major *** prime objective of SCA is to acquire the information by observing the power consumption,electromagnetic(EM)field,timing analysis,and acoustics of the ***,the attackers perform statistical functions to recover the *** Encryption Standard(AES)algorithm has proved to be a good security solution for constrained IoT *** paper implements a simulation model which is used to modify theAES algorithm using logicalmasking *** invariant of the AES algorithm hides the array of bits during substitution byte transformation of *** model is used against SCAand particularly Power Analysis Attacks(PAAs).Simulation model is designed on MATLAB *** will give better solution by hiding power profiles of the IoT devices against *** future,the lightweight AES algorithm with false key mechanisms and power reduction techniques such as wave dynamic differential logic(WDDL)will be used to safeguard IoT devices against side channel attacks by using Arduino and field programmable gate array(FPGA).

关键词： Side channel attacks power analysis attacks network security masking advance encryption standard

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Stable Silver Nanoparticles Synthesis by Citrus Sinensis(Orange) and Assessing Activity Against Food Poisoning Microbes

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Biomedical and Environmental Sciences 2014年第10期27卷 815-818页

作者： Naila Arooj nadia Dar Zahoor Qadir Samra Institute of Biochemistry and Biotechnology Quaid-i-Azam Campus University of the Punjab Department of Biology Jinnah Degree College for Women

Silver nanoparticles are considerecl as good antimicrobial agent. AgNPs were synthesized by mixing silver nitrate solution with citrus sinesb extract for 2 h at 37 and analyzed by UV-visible spectra, SEM, XRD, and FTIR. AgNPs were tested against B. subtilis, Shigello, S. oureus, ond E. coli. Minimum inhibitory concentration of AgNPs was 20 I^g/mL for B. subtilis and Shigello and 30 I^g/mL for S. oureus and E. coll. Antibiofilm activity （80% to 90%） was observed at 25 IJg/mL. AgNPs were stable for five months with sustained an＇timicrobial activity. Biosynthesized AgNPs can bE： used to inhibit food poisoning microbial growth.

关键词： Figure Stable Silver Nanoparticles Synthesis by Citrus Sinensis and Assessing Activity Against Food Poisoning Microbes Orange

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Hyper-Convergence Storage Framework for EcoCloud Correlates

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Computers, Materials & Continua 2022年第1期70卷 1573-1584页

作者： nadia Tabassum Tahir Alyas Muhammad Hamid Muhammad Saleem Saadia Malik Department of Computer Science Virtual University of PakistanLahore54000Pakistan Department of Computer Science Lahore Garrison UniversityLahore54000Pakistan Department of Statistics and Computer Science University of Veterinary and Animal SciencesLahore54000Pakistan Department of Industrial Engineering Faculty of EngineeringRabighKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Information Systems Faculty of Computing and Information Technology-RabighKing Abdulaziz UniversityJeddah21589Saudi Arabia

Cloud computing is an emerging domain that is capturing global users from all walks of life—the corporate sector,government sector,and social arena as *** cloud providers have offered multiple services and facilities to this audience and the number of providers is increasing very *** enormous pace is generating the requirement of a comprehensive ecosystem that shall provide a seamless and customized user environment not only to enhance the user experience but also to improve security,availability,accessibility,and *** technology is providing robust solutions to many of our problems,the cloud platform is one of *** is worth mentioning that these solutions are also amplifying the complexity and need of sustenance of these rapid *** with cloud computing,new entrants as cloud service providers,resellers,tech-support,hardware manufacturers,and software developers appear on a daily *** actors playing their role in the growth and sustenance of the cloud *** objective is to use convergence for cloud services,software-defined networks,network function virtualization for infrastructure,cognition for pattern development,and knowledge *** order to gear up these processes,machine learning to induce intelligence to maintain ecosystem growth,to monitor performance,and to become able to make decisions for the sustenance of the *** may be programmed to“superficially”imitate most business applications and create large numbers using lightweight workload generators that merely stress the *** today’s current IT environment,when many enterprises use the cloud to service some of their application demands,a different performance testing technique that assesses more than the storage is *** and storage are merged into a single building block with HCI(Hyper-converged infrastructure),resulting in a huge pool of compute and storage resources when clustered with other building ***

关键词： Virtual cloud software define network network function virtualization hyper-convergence virtualization

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