Feed supplementation with arginine and zinc on antioxidant status and inflammatory response in challenged weanling piglets

作     者：Nadia Bergeron Claude Robert Frédéric Guay 

作者机构：Département des sciences animales Université Laval 

出 版 物：《Animal Nutrition》 (动物营养（英文版）)

年 卷 期：2017年第3卷第3期

页      面：236-246页

核心收录：

学科分类：090502[农学-动物营养与饲料科学] 0905[农学-畜牧学] 09[农学] 

基　　金：provided by a grant from the Natural Science and Engineering Research Council(NSERC) a studentship from La Fédération des producteurs de porcs du Québec(FPPQ) 

主　　题：Antioxidant Inflammation Zinc Arginine Piglet Weanling 

摘      要：Although supplementing the diet with zinc oxide and arginine is known to improve growth in weanling piglets, the mechanism of action is not well understood. We measured the antioxidant status and inflammatory response in 48 weanling castrated male piglets fed diets supplemented with or without zinc oxide(2,500 mg Zn oxide per kg) and arginine(1%) starting at the age of 20 days. The animals were injected with lipopolysaccharide(100 μg/kg) on day 5. Half of them received another injection on day *** samples were taken just before and 6, 24 and 48 h after injection and the mucosa lining the ileum was recovered following euthanizing on days 7 and 14. Zinc supplementation increased reduced and total glutathione(GSH)(reduced and total) during days 5 to 7 and arginine decreased oxidized GSH measured on days 5 and 12 and the ratio of total antioxidant capacity to total oxidative status during days12 to 14. Zinc decreased plasma malondialdehyde measured on days 5 and 12 and serum haptoglobin measured on day 12 and increased both metallothionein-1 expression and total antioxidant capacity measured in the ileal mucosa on day 14. Tumour necrosis factor a concentration decreased from days 5 to12(all effects were significant at P 0.05). This study shows that the zinc supplement reduced lipid oxidation and lipopolysaccharide-induced inflammation during the post-weaning period, while the arginine supplementation had only a limited effect.