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miR-137 inhibits melanoma cell proliferation through downregulation of GLO1

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Science China(Life Sciences) 2018年第5期61卷 541-549页

作者： na lv Shuai Hao Chonglin Luo Alia Abukiwan Ying Hao Fei Gai Weiwei Huang Lingyun Huang Xueyuan Xiao Stefan B.Eichmüller Dacheng He Key Laboratory of Cell Proliferation and Regulation of Ministry of Education Universities of the Confederated Institute for ProteomicsBeijing Normal University Beijing Engineering and Technology Research Center of Food Additives Beijing Technology and Business University Gene & Care Health Technologies Co. Ltd. GMP & T Cell Therapy Unit German Cancer Research Center (DKFZ) College of Sports Northwest Normal University

Late-stage melanoma is refractory to current therapies. MicroRnas (miRnas) can modulate many physiological and pathological processes of melanoma. Studies have demonstrated that miR-137 acts as a tumor suppressor by inhibiting the proliferation of melanoma cells through targeting multiple mRnas. The glyoxalase system member glyoxalase 1 (GLO1) is the principal scavenging enzyme of methylglyoxal (MG), a toxic byproduct of glycolysis. Using 35S in vivo/vitro labelling analysis for dynamic proteomics (SiLAD), we found that miR-137 downregulated the expression of GLO1 in melanoma *** analysis predicted that GLO1 is a direct target of miR-137. This was validated by dual luciferase reporter *** RT-PCR (qRT-PCR) and western blot analysis indicated that miR-137 could decrease endogenous GLO1 ***, siRna targeting of GLO1 mimicked inhibition of melanoma cell proliferation caused by miR-137 ***-expression of GLO1 was able to restore miR-137-mediated suppression of melanoma cell proliferation. Therefore, these results suggest that miR-137 inhibits the proliferation of melanoma cells by targeting GLO1.

关键词：房间 proteomics RT-PCR siRna 病理学指向副产品 35S

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数字图书馆用户关系管理研究现状

情报科学 2007年第7期25卷 1093-1098页

作者：吕娜北京理工大学图书馆信息资源管理研究所北京100081

本文主要探索了企业领域的的客户关系管理与数字图书馆的融合研究,对数字图书馆用户关系管理理论与实践研究进展进行了分析,并对研究现状做出了的评价。

关键词：数字图书馆用户关系管理客户关系管理

Unlocking efficient energy storage via regulating ion and electron-active subunits:an(SbS)_(1.15)TiS_(2)superlattice for large and fast na^(+)storage

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Science China Chemistry 2024年第1期67卷 336-342页

作者： Baixin Peng Tianxun Cai Shaoning Zhang Yuqiang Fang Zhuoran lv Yusha Gao Fuqiang Huang State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China School of Physical Science and Technology ShanghaiTech UniversityShanghai 200031China Beijing national Laboratory for Molecular Sciences State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

Alloying-type metal sulfides with high sodiation activity and theoretical capacity are promising anode materials for high energy density sodium ion ***,the large volume change and the migratory and aggregation behavior of metal atoms will cause severe capacity decay during the charge/discharge ***,a robust and conductive TiS_(2)framework is integrated with a high-capacity SbS layer to construct a single phase(SbS)_(1.15)TiS_(2)superlattice for both high-capacity and fast na^(+)*** metallic TiS_(2)sublayer with high electron activity acts as a robust and conductive skeleton to buffer the volume expansion caused by conversion and alloying reaction between na+and SbS ***,high capacity and high rate capability can be synergistically realized in a single phase(SbS)_(1.15)TiS_(2)*** novel(SbS)_(1.15)TiS_(2)anode has a high charge capacity of 618 mAh g^(-1)at 0.2 C and superior rate performance and cycling stability(205 mAh g^(-1)at 35 C after 2,000 cycles).Furthermore,in situ and ex situ characterizations are applied to get an insight into the multi-step reaction *** integrity of robust na-Ti-S skeleton during(dis)charge process can be *** superlattice construction idea to integrate the na^(+)-active unit and electron-active unit would provide a new avenue for exploring high-performance anode materials for advanced sodium-ion batteries.

关键词： (SbS)_(1.15)TiS_(2) sulfides sodium ion battery superlattice fast-charging

Video Anomaly Detection using Ensemble One-class Classifiers

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Video Anomaly Detection using Ensemble One-class Classifiers

第37届中国控制会议

作者： Gang Li Zuren Feng na lv Systems Engineering Institute Xi'an Jiaotong University Inner Mongolia University of Science & Technology

In this paper we present a novel algorithm for video anomaly detection. It is based on multiple local cells, which are acquired by splitting entire monitor scene. At each local cell, we group all feature vectors with clustering algorithm based on minimum spanning tree, and further model all groups using improved one-class SVM to build ensemble classifiers. For any new features at each local node in incoming video clips, we use the corresponding learned ensemble classifiers to estimate maximum abnormality degree. The proposed approach has been tested on publicly available datasets with frame-level and pixel-level criteria, and outperforms other state-of-the-art approaches.

关键词： anomaly detection clustering algorithm minimum spanning tree one-class classifier

来源： cnki会议评论

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图书馆培养硕士研究生现状调查

图书馆杂志 2008年第3期27卷 62-64,79页

作者：吕娜北京理工大学图书馆信息资源管理研究所 100081

越来越多的图书馆开始申报图书馆学或情报学硕士点和培养硕士研究生,对图书馆硕士点的申请、建设和研究生培养方式等现状进行调研,有利于图书馆研究生培养工作的推进和改善。

关键词：图书馆硕士点研究生培养

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基于频繁下载集的数字图书馆日志挖掘实验

图书情报工作 2007年第5期51卷 138-141页

作者：吕娜北京理工大学图书馆信息资源管理研究所北京100081

数字图书馆网站服务系统中存有大量有关用户访问信息的日志文件,通过对这些日志文件的挖掘可以得到有关数字图书馆资源利用情况和用户兴趣的信息。但实际上,这些日志文件很少被利用。针对这一现状,作者对日志文件进行挖掘试验分析,得出... 详细信息

数字图书馆网站服务系统中存有大量有关用户访问信息的日志文件,通过对这些日志文件的挖掘可以得到有关数字图书馆资源利用情况和用户兴趣的信息。但实际上,这些日志文件很少被利用。针对这一现状,作者对日志文件进行挖掘试验分析,得出用户的频繁下载集合,以用于推荐链接和评价数据库资源。

关键词：数字图书馆日志挖掘频繁下载集

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数字图书馆用户访问日志模型的研究与应用

现代图书情报技术 2006年第12期 5-8页

作者：吕娜北京理工大学图书馆北京100081

通过对数字图书馆的日志记录现状进行分析,找到目前存在的问题,进而提出基于XML的用户日志格式,并将该日志格式应用于实验系统,通过用户使用该实验系统收集一定量的用户行为数据。

关键词：数字图书馆日志Schema 用户行为

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大学英语测试目前存在的问题及对策

外语学刊 2016年第1期 116-118页

作者：吕娜齐齐哈尔大学齐齐哈尔161006

本文简要回顾语言测试理论的发展历程,详细阐述语言测试与英语教学的关系,分析目前国内高校语言测试的基本类型:成绩测试和水平测试。在此基础上,分析当前大学英语测试存在的弊端,同时提出端正英语测试是根本目的,英语测试服务于教学和... 详细信息

本文简要回顾语言测试理论的发展历程,详细阐述语言测试与英语教学的关系,分析目前国内高校语言测试的基本类型:成绩测试和水平测试。在此基础上,分析当前大学英语测试存在的弊端,同时提出端正英语测试是根本目的,英语测试服务于教学和推行科学化考试模式的对策,从而实现《大学英语课程教学要求》所提出的培养目标。

关键词：语言测试语言教学问题与对策

Doping engineering of lithium-aluminum layered double hydroxides for high-efficiency lithium extraction from salt lake brines

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nano Research 2024年第3期17卷 1646-1654页

作者： Lingjie Zhang Tingting Zhang Yunliang Zhao Guangfeng Dong Shuaike lv Songliang Ma Shaoxian Song Mildred Quintana School of Chemical and Environmental Engineering Wuhan Polytechnic UniversityWuhan 430023China School of Resources and Environmental Engineering Wuhan University of TechnologyWuhan 430070China Facultad de Ciencias Universidad Autonoma de San Luis PotosiAv.Parque Chapultepec 1570San Luis Potosi 78210Mexico Wuhan Clayene Technology Co. Ltd.Wuhan 430223China State Development Investment Xinjiang Lop Nur Potash Corporation Hami 839000China

Lithium-aluminum layered double hydroxides(LiAl-LDH)have been be successfully applied in commercial-scale for lithium extraction from salt lake brine,however,further advancement of their applications is hampered by suboptimal Li^(+)adsorption performance and ambiguous extraction ***,a doping engineering strategy was developed to fabricate novel Zn^(2+)-doped LiAl-LDH(LiZnal-LDH)with remarkable higher Li^(+)adsorption capacity(13.4 mg/g)and selectivity(separation factors of 213,834,171 for Li^(+)/K^(+),Li^(+)/na^(+),Li^(+)/Mg^(2+),respectively),as well as lossless reusability in Luobupo brine compared to the pristine ***,combining experiments and simulation calculations,it was revealed that the specific surface area,hydrophilic,and surface attraction for Li^(+)of LiZnal-LDH were significantly improved,reducing the adsorption energy(Ead)and Gibbs free energy(ΔG),thus facilitating the transfer of Li^(+)from brine into interface followed by insertion into ***,the intrinsic oxygen vacancies derived from Zn-doping depressed the diffusion energy barrier of Li^(+),which accelerated the diffusion process of Li^(+)in the internal bulk of *** work provides a general strategy to overcome the existing limitations of Li^(+)recovery and deepens the understanding of Li^(+)extraction on LiAl-LDH.

关键词： lithium extraction salt lake brines doping engineering lithium-aluminum layered double hydroxides density functional theory