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Strain sensor on a chip for quantifying the magnitudes of tensile stress on cells

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Microsystems & nanoengineering 2024年第3期10卷 305-315页

作者： Yuyin Zhang Yue Wang Hongze Yin Jiahao Wang na liu Songyi Zhong Long Li Quan Zhang Tao Yue School of Mechatronics Engineering and Automation Shanghai UniversityShanghaiChina School of Future Technology Shanghai UniversityShanghaiChina Key Laboratory of Advanced Manufacturing Technology of Zhejiang Province School of Mechanical EngineeringZhejiang UniversityHangzhouChina Shanghai Key Laboratory of Intelligent Manufacturing and Robotics Shanghai UniversityShanghaiChina Shanghai Institute of Intelligent Science and Technology Tongji UniversityShanghaiChina

During cardiac development,mechanotransduction from the in vivo microenvironment modulates cardiomyocyte growth in terms of the number,area,and arrangement ***,the response of cells to different degrees of mechanical stimuli is ***-on-a-chip,as a platform for investigating mechanical stress stimuli in cellular mimicry of the in vivo microenvironment,is limited by the lack of ability to accurately quantify externally induced ***,previous technology lacks the integration of external stimuli and feedback sensors in microfluidic platforms to obtain and apply precise amounts of external ***,we designed a cell stretching platform with an in-situ *** in-situ liquid metal sensors can accurately measure the mechanical stimulation caused by the deformation of the vacuum cavity exerted on *** platform was applied to human cardiomyocytes(AC16)under cyclic strain(5%,10%,15%,20 and 25%),and we found that cyclic strain promoted cell growth induced the arrangement of cells on the membrane to gradually unify,and stabilized the cells at 15%amplitude,which was even more effective after 3 days of *** platform’s precise control and measurement of mechanical forces can be used to establish more accurate in vitro microenvironmental models for disease modeling and therapeutic research.

关键词： stress deformation arrangement

A Scoping Review of Real-World Study in Vaccine Evaluation

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China CDC weekly 2024年第16期6卷 357-362页

作者： Lei Wang Hong Yang Lanfang Xia Quanwei Song na liu Guomin Zhang Fuzhen Wang Huaqing Wang national Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases(NITFID) BeijingChina national Immunization Program Chinese Center for Disease Control and PreventionBeijingChina

Real-world study(RWS)gained prominence starting with a significant investigation on ramipril’s impact on hypertension in 1993(1).A key advancement for the Food and Drug Administration(FDA)occurred with the enactment of the 21st Century Cures Act in 2016,emphasizing RWS(2).The FDA’s Real-world Evidence Program establishes real-world data(RWD)as“data relating to patient health status and/or the delivery of health care routinely collected from a variety of sources”,while real-world evidence(RWE)is“clinical evidence about the usage and potential benefits or risks of a medical product derived from analysis of RWD”(3).The proliferation of big data,electronic medical records(EMR),electronic health records(EHR),and medical claims data offers vast information resources facilitating *** access to RWD allows for worldwide monitoring of the impacts of various public health initiatives like vaccination *** randomized clinical trials(RCTs)traditionally gauge vaccine efficacy and shortterm safety,RWS can assess vaccine performance and safety across larger,more diverse populations and are adept at identifying rare events not easily discernible in RCTs due to their infrequency.

关键词： routine gained traditionally

尖晶石LiNi_(0.5)Mn_(1.5)O_(4)材料表面Li_(3)PO_(4)包覆改性与电化学性能

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硅酸盐学报 2024年第6期52卷 2032-2039页

作者：柳娜宁德时代新能源科技股份有限公司福建宁德352106

尖晶石结构LiNi_(0.5)Mn_(1.5)O_(4)(LNMO)材料因具备高工作电压、低成本和环境友好等优点,被认为是最具有发展前景的正极材料之一。然而,LNMO材料在充放电过程中表现出严重的表面失氧和Mn溶出反应,导致其整体电化学性能较差。采用前驱... 详细信息

尖晶石结构LiNi_(0.5)Mn_(1.5)O_(4)(LNMO)材料因具备高工作电压、低成本和环境友好等优点,被认为是最具有发展前景的正极材料之一。然而,LNMO材料在充放电过程中表现出严重的表面失氧和Mn溶出反应,导致其整体电化学性能较差。采用前驱体Li_(3)PO_(4)包覆技术,在LNMO材料颗粒表面构建均匀的纳米包覆层,不仅提高了LNMO的循环稳定性和倍率性能,而且有效抑制了循环过程中阴极材料过渡金属溶出。结合X射线衍射仪、扫描电子显微技术、透射电子显微镜和电化学分析等测试手段,充分对比和分析Li_(3)PO_(4)包覆LNMO材料前后对微观结构和电化学性能的影响。该方法实现了Li_(3)PO_(4)的均匀包覆,并且没有改变LNMO正极材料的晶体结构。前驱体包覆3%Li_(3)PO_(4)的LNMO材料在1 C倍率下循环300圈容量保持率从无包覆的81.82%提升至包覆后的90.47%,2 C高倍率下的放电容量保持率从87.72%提升至92.39%,且EOL电芯阳极极片中过渡金属Mn溶出量明显降低。前驱体Li_(3)PO_(4)包覆策略是一种有效的材料表面改性策略,可以有效提升尖晶石型LNMO正极材料在循环过程中的结构稳定性和电化学性能。

关键词：镍锰酸锂磷酸锂包覆电化学性能

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Synthesis of highly stable Ni nanoparticles via electrostatic self-assembly for enhanced hydrogen storage of MgH2

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Rare Metals 2024年第9期43卷 4356-4366页

作者： Qin-Ke Tang Jiang-Chuan liu Rui Shi Yun-Feng Zhu Ji-Guang Zhang Ya-na liu Jun Wang Yao Zhang Xiao-Hui Hu Zhi-Bin liu Li-Quan Li College of Materials Science and Engineering Jiangsu Collaborative Innovation Centre for Advanced Inorganic Function CompositesNanjing Tech University School of Materials Science and Engineering Southeast University

Magnesium-based hydrides have been widely recognized as an appropriate choice for solid-state hydrogen ***,its undesirable thermodynamics and sluggish hydrogenation/dehydrogenation kinetics are major bottlenecks for its ***,a highly stable and highly dispersed Ni-based catalyst （Ni/Al2O3/GN） was fabricated to promote the hydrogen storage performance of MgH2via the electrostatic effect of NiAl-LDH/GN precursor with a co-calcination reduction ***2-5wt % Ni/Al2O3/GN exhibits excellent hydrogen storage performance,releasing about 5.7 wt % hydrogen in 3500 s at 250℃,and can reach a saturation hydrogen absorption of about 6.15 wt% in 3000 s at 100℃.Furthermore,it also shows low dehydrogenation apparent activation energy of 89.1 and 118.2 kJ·***,the catalyst ensures the stability of both the physical phase and structure during ball milling and cycling *** role of each phase in Ni/Al2O3/GN on the hydrogen storage performance of MgH2was also discussed through experiments and theoretical calculation,and the synergistic catalytic mechanism of Ni/Al2O3/GN was clearly *** work provides a unique perspective for the preparation of highly stable and highly dispersible catalysts.

关键词： Catalytic mechanism Hydrogen storage performance Magnesium hydride Ni/Al2O3/GN

Observation of Arctic surface currents using data from a surface drifting buoy

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Acta Oceanologica Sinica 2024年第1期43卷 70-79页

作者： Hongxia Chen Lina Lin Long Fan Wangxiao Yang Yinke Dou Bingrui Li Yan He Bin Kong Guangyu Zuo na liu First Institute of Oceanography Ministry of Natural ResourcesQingdao 266061China Laboratory for Regional Oceanography and Numerical Modeling Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China Key Laboratory of Marine Science and Numerical Modeling Ministry of Natural ResourcesQingdao 266061China naval Research Academy Tianjin 300061China College of Electrical and Power Engineering Taiyuan University of TechnologyTaiyuan 030024China Polar Research Institute of China Shanghai 443005China

During the 10th Chinese Arctic scientific expedition carried out in the summer of 2019,the surface current in the high-latitude areas of the Arctic Ocean was observed using a self-developed surface drifting buoy,which was initially deployed in the Chukchi *** buoy traversed the Chukchi Sea,Chukchi Abyssal Plain,Mendeleev Ridge,Makarov Basin,and Canada Basin over a period of 632 *** returning to the Mendeleev Ridge,it continued to drift toward the ***,the track of the buoy reflected the characteristics of the transpolar drift and Chukchi Slope Current,as well as the inertial flow,cross-ridge surface flow,and even the surface disorganized flow for some time *** results showed that:(1)the transpolar drift mainly occurs in the Chukchi Abyssal Plain,Mendeleev Ridge,and western Canada Basin to the east of the ridge where sea ice concentration is high,and the average northward flow velocity in the region between 79.41°N and 86.32°N was 5.1 cm/s;(2)the average surface velocity of the Chukchi Slope Current was 13.5 cm/s,and while this current moves westward along the continental slope,it also extends northwestward across the continental slope and flows to the deep sea;and(3)when sea ice concentration was less than 50%,the inertial flow was more significant(the maximum observed inertial flow was 26 cm/s,and the radius of the inertia circle was 3.6 km).

关键词： Chinese national Arctic Research Expedition(CHInaRE) surface drifting buoy transpolar drift Chukchi Slope Current inertial flow

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Rise in Stratospheric Water Vapor over the Past Two Decades: An Association with Tropical Atlantic Sea Surface Temperature

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Journal of Earth Science 2024年

作者： Yingli NIU Fei XIE Yan XIA na liu Yuanyuan HAN Faculty of Geographical Science/School of Systems Science， Beijing Normal University Key Laboratory of Textile Chemical Engineering Auxiliaries， School of Environmental and Chemical Engineering， Xi'an Polytechnic University

Variations in stratospheric water vapor (SWV) impact not only dynamic and chemical stratospheric processes but also the rate of global warming by influencing the Earth’s energy budget. Multiple observations have indicated a significant increasing trend in SWV since 2005. Here， using both observations and idealized sensitivity experiments with a numerical model， we find that the warming in the tropical Atlantic is the main contributor to the increasing SWV trend since 2005. The warming of both the tropical Indian and Atlantic oceans elicits a Gill-Matsuno responses， and the tropopause warming caused by Atlantic warming is located over the Indo-Pacific warm pool， which tends to efficiently increase the SWV after 2005. The North Pacific warming， which weakens the Hadley cell， results in a reduction in the tropical tropopause height and consequential tropopause warming， especially over the warm pool， which also contributes to the SWV increase.

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Differential expression profile of circular Rnas in mouse peritoneum with peritoneal fibrosis and the potential regulatory role of novel_circ_0007527

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Genes & Diseases 2024年第3期11卷 59-62页

作者： Yingfeng Shi Yan Hu Hui Chen Jinqing Li Min Tao Xun Zhou Qin Zhong Andong Qiu Shougang Zhuang na liu Department of Nephrology Shanghai East HospitalTongji University School of MedicineShanghai 200120China School of Life Science and Technology Advanced Institute of Translational MedicineTongji UniversityShanghai 200092China Department of Medicine Rhode Island Hospital and Alpert Medical SchoolBrown UniversityProvidenceRI 02912USA

CircRnas,a novel type of endogenous non-coding Rnas(ncRnas),are typically produced by back-splicing from exons of protein-coding genes,which are characterized by a covalently closed structure with neither 5'to 3'polarity nor a poly(A)tail.'On the one hand,circRnas are involved in the regulation of a variety of important biological processes,such as apoptosis,proliferation,migration,and inflammatory responses.'On the other hand,the relationship between circRnas and several fibrotic diseases has been reported.2 However.

关键词： endogenous peritoneal diseases

Study on site selection planning of urban electric vehicle charging station

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High Technology Letters 2024年第1期30卷 75-84页

作者：刘娜 CHENG Jiaxin DUAN Yukai School of Business Shanghai Dianji UniversityShanghai201306 P.R.China

The large-scale development of electric vehicles(EVs)requires numerous charging stations to serve them,and the charging stations should be reasonably laid out and planned according to the charging demand of electric *** the costs of both operators and users,a site selection model for optimal layout planning of charging stations is constructed,and a queuing theory approach is used to determine the charging pile configuration to meet the charging demand in the planning *** solve the difficulties of particle swarm global optimization search,the improved random drift particle swarm optimization(IRDPSO)and Voronoi diagram are used to jointly solve for the optimal layout of electric *** final arithmetic analysis verifies the feasibility and practicality of the model and algorithm,and the results show that the total social cost is minimized when the charging station is 9,the location of the charging station is close to the center of gravity and the layout is reasonable.

关键词： charging station electric vehicle(EV) improved random drift particle swarm optimization(IRDPSO) optimal planning

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Scarcity and Mental Health—Multiple Mediators of Sleep Quality and Life Satisfaction

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International Journal of Mental Health Promotion 2024年第6期26卷 449-462页

作者： na liu Yan Zhang Junxiu Wang School of Sociology and Ethnology University of Chinese Academy of Social SciencesBeijing102488China Institute of Sociology Chinese Academy of Social ScienceBeijing100732China School of Mental Health Wenzhou Medical UniversityWenzhou325000China Institute of Psychosocial Services Kangning Hospital of Wenzhou Medical UniversityWenzhou325000China

Background:In the current social environment,scarcity,as a universally present objective state,profoundly impacts individuals’decision-making and health through the subjective feeling it induces,known as a“scarcity mindset.”Particularly,the feeling of scarcity related to money and sleep time is not only widespread but also directly linked to an individual’s mental ***:This study aims to delve into the relationship between the feeling of scarcity and mental health,with a specific focus on the relationship between the feeling of money scarcity or sleep time scarcity and mental health,as well as the role of sleep quality or life satisfaction in this ***:We determined the sampling quotas based on the population and economic development levels of each province in the“China Statistical Yearbook(2021)”(national Bureau of Statistics,2021).Participants were selected using the Probability Proportional to Size(PPS)sampling *** was collected by distributing online questionnaires to participants,and the relationships between the main variables were explored using structural equation ***:*** China,the feeling of sleep time scarcity is stronger than the feeling of money scarcity among the *** feeling of money scarcity is positively correlated with depression and anxiety,whereas the feeling of sleep time scarcity is only positively correlated with *** feeling of scarcity mainly leads to depression and self-denial through reducing life satisfaction,and it leads to anxiety through reducing sleep ***:The feeling of scarcity in money and sleep time is related to different dimensions of mental ***,reasonably planning financial allocation and ensuring an adequate amount of sleep can reduce the sense of scarcity,thereby improving mental ***,improving sleep quality and increasing life satisfaction can alleviate the adverse effects of scarcity on mental health.

关键词： Scarcity sleep quality life satisfaction mental health multiple mediators